| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linlin Zhang, Yanan Zheng, Junxia Xie, Limin Sh. Potassium channels and their emerging role in parkinson's disease. Brain research bulletin. vol 160. 2021-08-31. PMID:32305406. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, which is associated with a selective loss of dopaminergic neurons in the substantia nigra (sn) and a reduction of dopamine in the striatum. |
2021-08-31 |
2023-08-13 |
Not clear |
| Rasem Mustafa, Chahinaz Rawas, Nadja Mannal, Grzegorz Kreiner, Björn Spittau, Katarzyna Kamińska, Rüstem Yilmaz, Christina Pötschke, Joachim Kirsch, Birgit Liss, Kerry L Tucker, Rosanna Parlat. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants (Basel, Switzerland). vol 10. issue 8. 2021-08-30. PMID:34439532. |
here, we report that pc are required for maintenance of substantia nigra (sn) dopaminergic (da) neurons highly vulnerable in parkinson's disease (pd). |
2021-08-30 |
2023-08-13 |
mouse |
| Guoxue Zhu, Wang Wang, Chang Chen, Lili Tang, Yan Liang, Zhennian Zhang, Yan Lu, Yang Zha. UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction. Aging. vol 13. issue 15. 2021-08-28. PMID:34339394. |
parkinson's disease (pd), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-28 |
2023-08-13 |
mouse |
| Bao-Yan Wang, Yong-Yi Ye, Chen Qian, Hong-Bo Zhang, Heng-Xu Mao, Long-Ping Yao, Xiang Sun, Guo-Hui Lu, Shi-Zhong Zhan. Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease. Neural regeneration research. vol 16. issue 12. 2021-08-26. PMID:33907043. |
the expression of major histocompatibility complex class i (mhc-i), a key antigen-presenting protein, can be induced in dopaminergic neurons in the substantia nigra, thus indicating its possible involvement in the occurrence and development of parkinson's disease. |
2021-08-26 |
2023-08-13 |
Not clear |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Priyobrata Sinha, Nilkanta Chakrabarti, Nabanita Ghosh, Soham Mitra, Shauryabrota Dalui, Arindam Bhattacharyy. Alterations of thyroidal status in brain regions and hypothalamo-pituitary-blood-thyroid-axis associated with dopaminergic depletion in substantia nigra and ROS formation in different brain regions after MPTP treatment in adult male mice. Brain research bulletin. vol 156. 2021-08-20. PMID:31891753. |
alterations of thyroidal status in brain regions and hypothalamo-pituitary-blood-thyroid-axis associated with dopaminergic depletion in substantia nigra and ros formation in different brain regions after mptp treatment in adult male mice. |
2021-08-20 |
2023-08-13 |
mouse |
| Priyobrata Sinha, Nilkanta Chakrabarti, Nabanita Ghosh, Soham Mitra, Shauryabrota Dalui, Arindam Bhattacharyy. Alterations of thyroidal status in brain regions and hypothalamo-pituitary-blood-thyroid-axis associated with dopaminergic depletion in substantia nigra and ROS formation in different brain regions after MPTP treatment in adult male mice. Brain research bulletin. vol 156. 2021-08-20. PMID:31891753. |
mptp depleted tyrosine hydroxylase protein expressions that signify the dopaminergic neuronal damage in substantia nigra. |
2021-08-20 |
2023-08-13 |
mouse |
| Silvio A Fernandes-Junior, Luiz M Oliveira, Catherine M Czeisler, Xiaokui Mo, Sashwati Roy, Arpad Somogyi, Liewn Zhang, Thiago S Moreira, José J Otero, Ana C Takakur. Stimulation of retrotrapezoid nucleus Phox2b-expressing neurons rescues breathing dysfunction in an experimental Parkinson's disease rat model. Brain pathology (Zurich, Switzerland). vol 30. issue 5. 2021-08-16. PMID:32497400. |
emerging evidence from multiple studies indicates that parkinson's disease (pd) patients suffer from a spectrum of autonomic and respiratory motor deficiencies in addition to the classical motor symptoms attributed to substantia nigra degeneration of dopaminergic neurons. |
2021-08-16 |
2023-08-13 |
rat |
| Tomoyuki Maru. [The Diagnosis and Indication for Surgical Treatment in Parkinson's Disease]. No shinkei geka. Neurological surgery. vol 49. issue 4. 2021-08-12. PMID:34376607. |
parkinson's disease(pd), a neurodegenerative disorder is caused due to damage in the dopaminergic neurons of the substantia nigra, a part of the midbrain. |
2021-08-12 |
2023-08-13 |
Not clear |
| Shaozhi Zhang, Sijie Wang, Xingzhu Shi, Xizeng Fen. Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons. Neurochemistry international. vol 139. 2021-08-11. PMID:32758587. |
pld reduced the mptp-induced loss of dopaminergic neurons in substantia nigra and striatum, inhibited the occurrence of neural apoptosis, and restored motor function in mice. |
2021-08-11 |
2023-08-13 |
mouse |
| Joe Shimizu, Takashi Kasai, Hideki Yoshida, Anh M Huynh, Yumiko Nakao-Azuma, Makiko Shinomoto, Takahiko Tokuda, Toshiki Mizuno, Masamitsu Yamaguch. Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase. Neurochemistry international. vol 139. 2021-08-11. PMID:32758590. |
patients with parkinson's disease (pd) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. |
2021-08-11 |
2023-08-13 |
human |
| Kei-Ichi Ishikawa, Risa Nonaka, Wado Akamats. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells. Methods in molecular biology (Clifton, N.J.). vol 2322. 2021-08-10. PMID:34043194. |
the midbrain dopaminergic neurons of the substantia nigra are mainly affected in parkinson's disease, but it is impossible to obtain and analyze viable dopaminergic neurons from live patients. |
2021-08-10 |
2023-08-13 |
human |
| Isaac Deng, Frances Corrigan, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice. International journal of molecular sciences. vol 22. issue 14. 2021-08-10. PMID:34299000. |
parkinson's disease (pd) is the most common movement disorder, characterized by progressive degeneration of the nigrostriatal pathway, which consists of dopaminergic cell bodies in substantia nigra and their neuronal projections to the striatum. |
2021-08-10 |
2023-08-13 |
mouse |
| Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huan. Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model. Neuroscience letters. vol 759. 2021-08-06. PMID:34119603. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-06 |
2023-08-13 |
mouse |
| Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zen. Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33261640. |
subsequently, dab staining analysis of substantia nigra (sn) dopaminergic neurons with the marker for tyrosine hydroxylase (th) was performed. |
2021-08-05 |
2023-08-13 |
mouse |
| Shruti Sharma, Shalini Trivedi, Taruna Pandey, Sachin Ranjan, Mashu Trivedi, Rakesh Pande. Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32894501. |
parkinsonism is an age-associated neurodegenerative disorder characterized by aggregation of α-synuclein (α-syn) protein in the substantia nigra region, degeneration of dopaminergic neurons, and deregulated lipid metabolism. |
2021-08-04 |
2023-08-13 |
caenorhabditis_elegans |
| Paula Perez-Pardo, Yvonne Grobben, Nicole Willemsen-Seegers, Mitch Hartog, Michaela Tutone, Michelle Muller, Youri Adolfs, Ronald Jeroen Pasterkamp, Diep Vu-Pham, Antoon M van Doornmalen, Freek van Cauter, Joeri de Wit, Jan Gerard Sterrenburg, Joost C M Uitdehaag, Jos de Man, Rogier C Buijsman, Guido J R Zaman, Aletta D Kranevel. Pharmacological validation of TDO as a target for Parkinson's disease. The FEBS journal. vol 288. issue 14. 2021-08-03. PMID:33471408. |
both inhibitors had beneficial effects on rotenone-induced motor and cognitive dysfunction as well as rotenone-induced dopaminergic cell loss and neuroinflammation in the substantia nigra. |
2021-08-03 |
2023-08-13 |
mouse |
| Derya Cansız, Unsal Veli Ustundag, Ismail Unal, A Ata Alturfan, Ebru Emekli-Alturfa. Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity. Drug and chemical toxicology. 2021-08-03. PMID:34340603. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. |
2021-08-03 |
2023-08-13 |
zebrafish |
| Luan Pereira Diniz, Ana Paula Bérgamo Araujo, Isadora Matias, Matheus N Garcia, Fernanda G Q Barros-Aragão, Ricardo Augusto de Melo Reis, Débora Foguel, Carolina Braga, Cláudia P Figueiredo, Luciana Romão, Flávia Carvalho Alcantara Gome. Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy. Neurochemistry international. vol 138. 2021-07-30. PMID:32439533. |
histopathological features of pd include preferential loss of dopaminergic neurons in the substantia nigra and formation of fibrillar intraneuronal inclusions called lewy bodies and lewy neurites, which are composed primarily of the α-syn protein. |
2021-07-30 |
2023-08-13 |
mouse |
| Ching-Hsiang Fan, Kuo-Chen Wei, Nai-Hua Chiu, En-Chi Liao, Hsien-Chu Wang, Ruo-Yu Wu, Yi-Ju Ho, Hong-Lin Chan, Tsung-Shing Andrew Wang, Ying-Zu Huang, Tsung-Hsun Hsieh, Chin-Hsien Lin, Yu-Chun Lin, Chih-Kuang Ye. Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson's Disease. Nano letters. vol 21. issue 14. 2021-07-30. PMID:34264082. |
in this study, we expressed mprestin in the dopaminergic neurons of the substantia nigra in parkinson's disease (pd) mice and used 0.5 mhz us for repeated and localized brain stimulation. |
2021-07-30 |
2023-08-13 |
mouse |