| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiumin Liu, Weiwei Liu, Chenkang Wang, Yinzhe Chen, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy. Physiology & behavior. vol 239. 2021-10-20. PMID:34181930. |
pd is a neurodegenerative disease that causes a debilitating movement disorder, characterized by a progressive loss of nigrostriatal (substantia nigra and striatum) dopaminergic neurons. |
2021-10-20 |
2023-08-13 |
mouse |
| Xiumin Liu, Weiwei Liu, Chenkang Wang, Yinzhe Chen, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy. Physiology & behavior. vol 239. 2021-10-20. PMID:34181930. |
immunohistochemical analysis shows that mptp injection results in the loss of dopaminergic neurons in the substantia nigra, and the decrease of the striatal tyrosine hydroxylase. |
2021-10-20 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. International journal of molecular sciences. vol 22. issue 17. 2021-10-20. PMID:34502283. |
parkinson's disease (pd) is characterized by a loss of dopaminergic cells in the substantia nigra, and its histopathological features include the presence of fibrillar aggregates of α-synuclein (α-syn), which are called lewy bodies and lewy neurites. |
2021-10-20 |
2023-08-13 |
Not clear |
| Carlos Eduardo Mantese, Tulio Becker Hainzenrede. Neuromelanin accumulation in Substantia nigra in vascular parkinsonism. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 7. 2021-10-15. PMID:32328796. |
however, only ischemic or hemorrhagic lesions in the substantia nigra or nigrostriatal pathway, leading to a reduction of dopaminergic stimulus are pure vap. |
2021-10-15 |
2023-08-13 |
Not clear |
| Pei Shang, Matthew Baker, Samantha Banks, Sa-Ik Hong, Doo-Sup Cho. Emerging Nondopaminergic Medications for Parkinson's Disease: Focusing on A2A Receptor Antagonists and GLP1 Receptor Agonists. Journal of movement disorders. vol 14. issue 3. 2021-10-15. PMID:34399565. |
parkinson's disease (pd) is a severe neurodegenerative disease characterized by classic motor features associated with the loss of dopaminergic neurons and appearance of lewy bodies in the substantia nigra. |
2021-10-15 |
2023-08-13 |
Not clear |
| Garrett Salzman, Jocelyn Kim, Guillermo Horga, Kenneth Wengle. Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra. Journal of visualized experiments : JoVE. issue 175. 2021-10-15. PMID:34570093. |
neuromelanin is a byproduct of dopamine synthesis that accumulates in dopaminergic neurons of the substantia nigra. |
2021-10-15 |
2023-08-13 |
Not clear |
| Garrett Salzman, Jocelyn Kim, Guillermo Horga, Kenneth Wengle. Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra. Journal of visualized experiments : JoVE. issue 175. 2021-10-15. PMID:34570093. |
neuromelanin-sensitive magnetic resonance imaging (nm-mri) is a noninvasive method for measuring neuromelanin in those dopaminergic neurons, providing a direct measure of dopaminergic cell loss in the substantia nigra and a proxy measure of dopamine function. |
2021-10-15 |
2023-08-13 |
Not clear |
| Nor Haliza Mohamad Najib, Mohamad Fairuz Yahaya, Srijit Das, Seong Lin Teo. The effects of metallothionein in paraquat-induced Parkinson disease model of zebrafish. The International journal of neuroscience. 2021-10-15. PMID:34623211. |
parkinson's disease (pd) is the second most common neurodegenerative disease caused by selective degeneration of dopaminergic neurons in the substantia nigra. |
2021-10-15 |
2023-08-13 |
human |
| Minghao Zhang, Qingping He, Guisheng Chen, P Andy L. Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease. Neuro-degenerative diseases. vol 20. issue 2-3. 2021-10-14. PMID:33176317. |
parkinson's disease (pd) is characterized by the selective death of dopaminergic neurons in the substantia nigra. |
2021-10-14 |
2023-08-13 |
Not clear |
| Benjamin Huynh, Yuhong Fu, Deniz Kirik, James M Shine, Glenda M Hallida. Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 9. 2021-10-13. PMID:33899954. |
pathology in the noradrenergic a6 locus coeruleus has not been compared with more rostral dopaminergic a9 substantia nigra and a10 ventral tegmental area, and cholinergic ch4 basal nucleus and ch1/2 septal regions in the same cases of parkinson's disease (pd). |
2021-10-13 |
2023-08-13 |
Not clear |
| Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
the dopamine level in the striatum is preserved because of the innervation of the substantia nigra (sn) dopaminergic neurons into it. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jacopo Troisi, Annamaria Landolfi, Pierpaolo Cavallo, Francesca Marciano, Paolo Barone, Marianna Ambon. Metabolomics in Parkinson's disease. Advances in clinical chemistry. vol 104. 2021-10-11. PMID:34462054. |
pd, the second most frequent neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneural inclusions of α-synuclein aggregates. |
2021-10-11 |
2023-08-13 |
Not clear |
| Banashree Chetia Phukan, Ankumoni Dutta, Satarupa Deb, Rubul Saikia, Muhammed Khairujjaman Mazumder, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir, Anupom Bora. Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson's disease: involvement of anti-inflammatory response. Experimental brain research. 2021-10-11. PMID:34633467. |
most importantly, the degeneration of dopaminergic cell bodies in the substantia nigra region was significantly prevented by garcinol. |
2021-10-11 |
2023-08-13 |
mouse |
| Yujing Huang, Ying Liu, Jing Huang, Lu Gao, Zhenggang Wu, Lu Wang, Lin Fa. Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Molecular medicine reports. vol 24. issue 5. 2021-10-08. PMID:34558637. |
parkinson's disease (pd), a common multifactorial neurodegenerative disease, is characterized by irreversible loss of dopaminergic neurons in the substantia nigra. |
2021-10-08 |
2023-08-13 |
mouse |
| Weitang Liu, Wenwen Lao, Renxing Zhang, Hongyan Zh. Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice. Brain research bulletin. vol 170. 2021-10-07. PMID:33610724. |
parkinson's disease (pd) is a motor disabling disorder owing to the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-10-07 |
2023-08-13 |
mouse |
| Li Zuo, Chunfang Dai, Lilin Yi, Zhifang Don. 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease. Cell death discovery. vol 7. issue 1. 2021-10-06. PMID:34545064. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and diminished dopamine content in the striatum. |
2021-10-06 |
2023-08-13 |
mouse |
| Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi L. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell death & disease. vol 12. issue 1. 2021-10-05. PMID:33441545. |
iron deposition is present in main lesion areas in the brains of patients with parkinson's disease (pd) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. |
2021-10-05 |
2023-08-13 |
human |
| Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi L. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell death & disease. vol 12. issue 1. 2021-10-05. PMID:33441545. |
at the cellular level, the iron deposits were specifically localized in microglia but not in dopaminergic neurons, nor in other types of glial cells in the substantia nigra, whereas the expression of transferrin (tf), tf receptor 1 (tfr1), tf receptor 2 (tfr2), and ferroportin (fpn) was increased in dopaminergic neurons. |
2021-10-05 |
2023-08-13 |
human |
| Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi L. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell death & disease. vol 12. issue 1. 2021-10-05. PMID:33441545. |
the brain region-enriched and cell-type-dependent iron localizations indicate that the intranasal α-syn pffs treatment-induced iron depositions in microglia in the substantia nigra may appear as an early cellular response that may initiate neuroinflammation in the dopaminergic system before cell death occurs. |
2021-10-05 |
2023-08-13 |
human |
| Joshna Gadhavi, Mohini Patel, Dhiraj Bhatia, Sharad Gupt. Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions. Biochimie. 2021-10-03. PMID:34582997. |
the loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of pd. |
2021-10-03 |
2023-08-13 |
Not clear |