| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne-Marie Castonguay, Claude Gravel, Martin Lévesqu. Treating Parkinson's Disease with Antibodies: Previous Studies and Future Directions. Journal of Parkinson's disease. vol 11. issue 1. 2021-11-12. PMID:33104039. |
parkinson's disease is a neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons in the substantia nigra. |
2021-11-12 |
2023-08-13 |
Not clear |
| Michele Salemi, Samanta Mazzetti, Mara De Leonardis, Federica Giampietro, Valentina Medici, Tino Emanuele Poloni, Rossella Cannarella, Giorgio Giaccone, Gianni Pezzoli, Graziella Cappelletti, Raffaele Ferr. Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain. Neurochemistry international. vol 144. 2021-11-12. PMID:33516746. |
parp1 positive nuclei in substantia nigra, mainly in dopaminergic neurons but also in astrocytes and oligodendrocytes, were decreased in pd. |
2021-11-12 |
2023-08-13 |
mouse |
| Fabrizio Sanna, Jessica Bratzu, Laura Angioni, Maria Pina Sorighe, Cristina Cocco, Antonio Argiolas, Maria Rosaria Meli. Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain research. vol 1773. 2021-11-12. PMID:34744015. |
oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: a behavioral and neurochemical study. |
2021-11-12 |
2023-08-13 |
rat |
| Ali Sarbazi-Golezari, Hashem Haghdoost-Yazd. Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta. Metabolic brain disease. 2021-11-12. PMID:34767157. |
chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta. |
2021-11-12 |
2023-08-13 |
human |
| Ali Sarbazi-Golezari, Hashem Haghdoost-Yazd. Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta. Metabolic brain disease. 2021-11-12. PMID:34767157. |
then, brain of the animals was perfused to assess survival of dopaminergic (daergic) neurons in substantia nigra by tyrosine hydroxylase (th) immunohistochemistry. |
2021-11-12 |
2023-08-13 |
human |
| Peng Li, Li-Yan Yao, Yu-Jia Jiang, Dan-Dan Wang, Ting Wang, Yan-Ping Wu, Bai-Xiang Li, Xue-Ting L. Soybean isoflavones protect SH-SY5Y neurons from atrazine-induced toxicity by activating mitophagy through stimulation of the BEX2/BNIP3/NIX pathway. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34673406. |
atrazine (atr) is a widely used herbicide that can induce the degeneration of dopaminergic (daergic) neurons in the substantia nigra, resulting in a parkinson's disease-like syndrome. |
2021-11-10 |
2023-08-13 |
Not clear |
| Natalia Lopez-Gonzalez Del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Bles. Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744683. |
consistent with the behavior and pathological findings, there was no loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2021-11-10 |
2023-08-13 |
mouse |
| Ye Tian, Mingyang He, Lina Pan, Xin Yuan, Min Xiong, Lanxia Meng, Zhaohui Yao, Zhui Yu, Keqiang Ye, Zhentao Zhan. Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744697. |
this model shows an abundant accumulation of pathological α-synuclein in the central nervous system, loss of dopaminergic neurons in the substantia nigra, and progressive striatal synaptic degeneration. |
2021-11-10 |
2023-08-13 |
mouse |
| Inka Brockhausen, John Schutzbach, Jiabei Wang, Beth Fishwick, Jennifer Brockhause. Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease. Glycoconjugate journal. 2021-11-10. PMID:34757539. |
this condition is characterized by the degeneration of dopaminergic neurons in the pars compacta region of the substantia nigra (snpc) and by aggregation of proteins, commonly α-synuclein (snca). |
2021-11-10 |
2023-08-13 |
Not clear |
| Mir Hilal Ahmad, Mahino Fatima, Mansoor Ali, Moshahid Alam Rizvi, Amal Chandra Monda. Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease. Neuropharmacology. vol 201. 2021-11-09. PMID:34655599. |
parkinson's disease (pd), a common neurodegenerative disease is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2021-11-09 |
2023-08-13 |
rat |
| Shanshan Li, Meng Wang, Youlin Wang, Yuting Guo, Xiaoxiao Tao, Xuncui Wang, Yin Cao, Shasha Tian, Qinglin L. p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 73. 2021-11-08. PMID:33737050. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra and striatum. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ahsas Goyal, Aanchal Verma, Neetu Agrawa. Dietary Phytoestrogens: Neuroprotective Role in Parkinson's Disease. Current neurovascular research. vol 18. issue 2. 2021-11-08. PMID:34086550. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive damage of mesencephalic dopaminergic neurons of the substantia nigra and the striatal projections. |
2021-11-08 |
2023-08-13 |
human |
| Mohammad Sophiabadi, Nafiseh Rastgoo, Hashem Haghdoost-Yazd. Dopaminergic Neuronal Death in Substantia Nigra Associates with Serum Levels of Total Bilirubin, Selenium, and Zinc: Evidences from 6-Hydroxydopamine Animal Model of Parkinson's Disease. Biological trace element research. 2021-11-06. PMID:34741694. |
dopaminergic neuronal death in substantia nigra associates with serum levels of total bilirubin, selenium, and zinc: evidences from 6-hydroxydopamine animal model of parkinson's disease. |
2021-11-06 |
2023-08-13 |
rat |
| Valentina Bashkatov. Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity. World journal of psychiatry. vol 11. issue 10. 2021-11-05. PMID:34733645. |
parkinson's disease (pd) is a neurodegenerative disorder that primarily involves the loss of dopaminergic neurons in the substantia nigra. |
2021-11-05 |
2023-08-13 |
Not clear |
| Md Shahidul Islam, Fazli Azim, Hedaeytullah Saju, Arman Zargaran, Meysam Shirzad, Mostofa Kamal, Kaniz Fatema, Sumbul Rehman, M A Momith Azad, Somayeh Ebrahimi-Baroug. Pesticides and Parkinson's disease: Current and future perspective. Journal of chemical neuroanatomy. vol 115. 2021-11-04. PMID:33991619. |
pesticides strongly inhibit mitochondrial complex-i, causing mitochondrial dysfunction and death of dopaminergic neurons in the substantia nigra (sn), thus leading to pathophysiologic implications of pd. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yan Teng, Zhihao Liu, Xingmin Chen, Yanzhuo Liu, Fan Geng, Weidong Le, Haisong Jiang, Lu Yan. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34288397. |
to evaluate the necessity of m6a in dopaminergic neuron functions, we conditionally deleted mettl14, one of the most important part of m6a methyltransferase complexes, in the substantia nigra (sn) region enriched with dopaminergic neurons. |
2021-11-04 |
2023-08-13 |
mouse |
| Qing Lv, Xinlin Wang, Tetsuya Asakawa, Xiao Ping Wan. Pharmacologic Treatment of Restless Legs Syndrome. Current neuropharmacology. vol 19. issue 3. 2021-11-03. PMID:33380302. |
despite the efficacy of dopaminergic drugs in the treatment of this disorder, unlike in parkinson's disease dopaminergic cell loss in the substantia nigra has not been observed in rls. |
2021-11-03 |
2023-08-13 |
Not clear |
| Omar A Ahmed-Farid, Mohamed Taha, Rofanda M Bakeer, Omyma K Radwan, Hassan A M Hendawy, Ayman S Soliman, Einas Youse. Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson's disease rat model. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34707203. |
parkinson's disease (pd) is a progressive chronic neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. |
2021-11-03 |
2023-08-13 |
rat |
| Soumitra Ghosh, Seok Joon Won, Jiejie Wang, Rebecca Fong, Nicholas J M Butler, Arianna Moss, Candance Wong, June Pan, Jennifer Sanchez, Annie Huynh, Long Wu, Fredric P Manfredsson, Raymond A Swanso. α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism. Progress in neurobiology. vol 202. 2021-11-01. PMID:33951536. |
parallel findings were observed in mouse brain: pff-induced α-synuclein aggregation in the substantia nigra was associated with redox stress, c-abl activation, and dopaminergic neuronal loss, along with microglial activation and motor impairment, all of which were attenuated with oral n-acetyl cysteine. |
2021-11-01 |
2023-08-13 |
mouse |
| Iosif Pediaditakis, Konstantia R Kodella, Dimitris V Manatakis, Christopher Y Le, Chris D Hinojosa, William Tien-Street, Elias S Manolakos, Kostas Vekrellis, Geraldine A Hamilton, Lorna Ewart, Lee L Rubin, Katia Karali. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nature communications. vol 12. issue 1. 2021-11-01. PMID:34625559. |
parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. |
2021-11-01 |
2023-08-13 |
human |