| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tony Oosterveen, Pedro Garção, Emma Moles-Garcia, Clement Soleilhavoup, Marco Travaglio, Shahida Sheraz, Rosa Peltrini, Kieran Patrick, Valerie Labas, Lucie Combes-Soia, Ulrika Marklund, Peter Hohenstein, Lia Panma. Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem cell reports. vol 16. issue 11. 2021-11-20. PMID:34678205. |
in parkinson's disease (pd), substantia nigra (sn) dopaminergic (da) neurons degenerate, while related ventral tegmental area (vta) da neurons remain relatively unaffected. |
2021-11-20 |
2023-08-13 |
mouse |
| Brent J Ryan, Nora Bengoa-Vergniory, Matthew Williamson, Ecem Kirkiz, Rosalind Roberts, Gabriele Corda, Maximilian Sloan, Saba Saqlain, Marta Cherubini, Josse Poppinga, Helle Bogtofte, Milena Cioroch, Svenja Hester, Richard Wade-Martin. REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 16. 2021-11-19. PMID:33563726. |
alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's patients. |
2021-11-19 |
2023-08-13 |
mouse |
| Parastoo Zarrin, Mahmood Dehghani Ashkezari, Seyed Morteza Seifat. Liposomal Form of L-Dopa and SH-Sy5y Cell-Derived Exosomes Modulate the Tyrosine Hydroxylase/Dopamine Receptor D2 Signaling Pathway in Parkinson's Rat Models. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:34125397. |
parkinson's disease is a progressive neurodegenerative disorder in which dopaminergic neurons located in the substantia nigra are gradually lost. |
2021-11-19 |
2023-08-13 |
rat |
| Viola Volpat. Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease. Biochemical Society transactions. vol 49. issue 5. 2021-11-19. PMID:34581766. |
loss of dopaminergic neurons (dans) in the substantia nigra and intracellular alpha-synuclein inclusions are the main hallmarks of the disease but the events that cause this degeneration remain uncertain. |
2021-11-19 |
2023-08-13 |
Not clear |
| I Friedrich, K Reimann, S Jankuhn, E Kirilina, J Stieler, M Sonntag, J Meijer, N Weiskopf, T Reinert, T Arendt, M Morawsk. Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33752749. |
particularly in parkinson's disease (pd) changes in iron concentrations in the substantia nigra (sn) was suggested to play a key role in degeneration of dopaminergic neurons in nigrosome 1. |
2021-11-18 |
2023-08-13 |
Not clear |
| Zuné Jansen van Rensburg, Shameemah Abrahams, Soraya Bardien, Colin Kenyo. Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34426907. |
parkinson's disease (pd) is a movement disorder associated with severe loss of mainly dopaminergic neurons in the substantia nigra. |
2021-11-18 |
2023-08-13 |
Not clear |
| José Ángel Martínez-Menárguez, Emma Martínez-Alonso, Mireia Cara-Esteban, Mónica Tomá. Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson's Disease. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769517. |
it is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of large aggregates in the survival neurons called lewy bodies, which mainly contain α-synuclein (α-syn). |
2021-11-18 |
2023-08-13 |
Not clear |
| Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E Alway, Mohammad Moshahid Kha. Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 3. 2021-11-17. PMID:33221984. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and loss of both motor and non-motor features. |
2021-11-17 |
2023-08-13 |
mouse |
| Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E Alway, Mohammad Moshahid Kha. Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 3. 2021-11-17. PMID:33221984. |
mptp injected mice exhibited loss of dopaminergic neurons and fibers in substantia nigra and striatum respectively, along with impaired motor function at day 7 post mptp injection. |
2021-11-17 |
2023-08-13 |
mouse |
| Matthew D Demmings, Elizabeth C Tennyson, Gillian N Petroff, Heather E Tarnowski-Garner, Sean P Crega. Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates. Cell death and differentiation. vol 28. issue 5. 2021-11-17. PMID:33277577. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra resulting in severe and progressive motor impairments. |
2021-11-17 |
2023-08-13 |
mouse |
| Lina Pan, Lanxia Meng, Mingyang He, Zhentao Zhan. Tau in the Pathophysiology of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 71. issue 11. 2021-11-17. PMID:33459970. |
the pathological hallmarks of parkinson's disease (pd) are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of lewy bodies (lbs) in remaining neurons. |
2021-11-17 |
2023-08-13 |
Not clear |
| D Kempuraj, R Thangavel, P A Natteru, G P Selvakumar, D Saeed, H Zahoor, S Zaheer, S S Iyer, A Zahee. Neuroinflammation Induces Neurodegeneration. Journal of neurology, neurosurgery and spine. vol 1. issue 1. 2021-11-16. PMID:28127589. |
in ad, neurons of the hippocampus and entorhinal cortex are the first to degenerate, whereas in pd, dopaminergic neurons in the substantia nigra degenerate. |
2021-11-16 |
2023-08-13 |
Not clear |
| Amit Khairnar, Jana Ruda-Kucerova, Anas Arab, Constantinos Hadjistyllis, Alzbeta Sejnoha Minsterova, Qi Shang, Alexandra Chovsepian, Eva Drazanova, Nikoletta Szabó, Zenon Starcuk, Irena Rektorova, Francisco Pan-Montoj. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34107061. |
clinical diagnosis of parkinson's disease (pd) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (sn) already died, and the first motor symptoms appear. |
2021-11-16 |
2023-08-13 |
mouse |
| Sunil Bhurtel, Eugene Bok, Nikita Katila, Jaekwang Kim, Dong-Young Cho. Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP Biochemical pharmacology. vol 192. 2021-11-16. PMID:34352280. |
activation of nrf2 by methylene blue is associated with the neuroprotection against mpp the neuropathological hallmark of parkinson's disease (pd) is the preferential loss of dopaminergic neurons in the substantia nigra and presence of lewy bodies in the dying neurons. |
2021-11-16 |
2023-08-13 |
Not clear |
| Mónica Tomás, Emma Martínez-Alonso, Narcisa Martínez-Martínez, Mireia Cara-Esteban, José A Martínez-Menárgue. Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease. Histology and histopathology. vol 36. issue 1. 2021-11-15. PMID:33078843. |
fragmentation of the golgi complex of dopaminergic neurons in human substantia nigra: new cytopathological findings in parkinson's disease. |
2021-11-15 |
2023-08-13 |
human |
| Mónica Tomás, Emma Martínez-Alonso, Narcisa Martínez-Martínez, Mireia Cara-Esteban, José A Martínez-Menárgue. Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease. Histology and histopathology. vol 36. issue 1. 2021-11-15. PMID:33078843. |
in the present study, we analyzed the morphological characteristics of the golgi complex of dopaminergic neurons in human samples of substantia nigra of control and parkinson's disease patients. |
2021-11-15 |
2023-08-13 |
human |
| Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A Yacoubia. 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413679. |
14-3-3θ overexpression by aav in the substantia nigra (sn) also delayed αsyn aggregation in the sn and partially rescued pff-induced reduction in tyrosine hydroxylase (th)-positive dopaminergic cells in the sn. |
2021-11-15 |
2023-08-13 |
Not clear |
| Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wan. Molecular chaperones and Parkinson's disease. Neurobiology of disease. vol 160. 2021-11-15. PMID:34626793. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of lewy bodies (lbs). |
2021-11-15 |
2023-08-13 |
Not clear |
| Yasuko Toyoshima, Hitoshi Takahashi, Shinnichi Katada, Naoyuki Kojima, Mari Tada, Takashi Tani, Ryoko Koike, Takanori Nozawa, Izumi Aida, Takashi Nakajima, Osamu Onodera, Akiyoshi Kakit. Parkinson's disease and parkinsonism: Clinicopathological discrepancies on diagnosis in three patients. Neuropathology : official journal of the Japanese Society of Neuropathology. 2021-11-15. PMID:34779072. |
the cardinal neuropathological features of pd include selective and progressive loss of pigmented neurons in the substantia nigra, deficiencies in dopaminergic signaling in the striatum, and occurrence of phosphorylated α-synuclein-identified lewy bodies in the nervous system. |
2021-11-15 |
2023-08-13 |
Not clear |
| Jeerang Wongtrakul, Thananya Thongtan, Benjawan Kumrapich, Chonticha Saisawang, Albert J Ketterma. Neuroprotective effects of Heliyon. vol 7. issue 10. 2021-11-13. PMID:34765761. |
the clinical syndrome and pathology involve motor disturbance and the degeneration of dopaminergic neurons in the substantia nigra. |
2021-11-13 |
2023-08-13 |
Not clear |