| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izabela Berdowska, Małgorzata Matusiewicz, Małgorzata Krzystek-Korpack. HDL Accessory Proteins in Parkinson's Disease-Focusing on Clusterin (Apolipoprotein J) in Regard to Its Involvement in Pathology and Diagnostics-A Review. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326174. |
parkinson's disease (pd)-a neurodegenerative disorder (ndd) characterized by progressive destruction of dopaminergic neurons within the substantia nigra of the brain-is associated with the formation of lewy bodies containing mainly α-synuclein. |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
the pathology of parkinson's disease (pd) is characterized by α-synuclein aggregation, microglia-mediated neuroinflammation, and dopaminergic neurodegeneration in the substantia nigra with collateral striatal dopamine signaling deficiency. |
2022-03-25 |
2023-08-13 |
Not clear |
| Marie-Laure Arotcarena, Federico N Soria, Anthony Cunha, Evelyne Doudnikoff, Geoffrey Prévot, Jonathan Daniel, Mireille Blanchard-Desce, Philippe Barthélémy, Erwan Bezard, Sylvie Crauste-Manciet, Benjamin Deha. Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function. Aging cell. 2022-03-23. PMID:35318803. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of misfolded α-synuclein and lysosomal impairment, two events deemed interconnected. |
2022-03-23 |
2023-08-13 |
mouse |
| Predrag Jovanovic, Yidan Wang, Jean-Philippe Vit, Edward Novinbakht, Nancy Morones, Elliot Hogg, Michele Tagliati, Celine E Rier. Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy. PloS one. vol 17. issue 3. 2022-03-22. PMID:35316276. |
we show that norepinephrine neurons send complex axonal projections to the dopaminergic neurons in the substantia nigra, confirming physical communication between these regions. |
2022-03-22 |
2023-08-13 |
mouse |
| Federico Miozzo, Eva P Valencia-Alarcón, Luca Stickley, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagosh. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Nature communications. vol 13. issue 1. 2022-03-18. PMID:35301315. |
progressive degeneration of dopaminergic (da) neurons in the substantia nigra is a hallmark of parkinson's disease (pd). |
2022-03-18 |
2023-08-13 |
mouse |
| Colleen S Stein, Jared M McLendon, Nathan H Witmer, Ryan L Boudrea. Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. Molecular therapy. Nucleic acids. vol 28. 2022-03-14. PMID:35280925. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-03-14 |
2023-08-13 |
mouse |
| Richard M Kostrzew. Neonatal 6-hydroxydopamine lesioning of rats and dopaminergic neurotoxicity: proposed animal model of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-03-13. PMID:35279767. |
when given to rats, neonatal 6-ohda (n6-ohda) crosses the blood-brain barrier to destroy 90-99% of dopaminergic nerves in pars compacta substantia nigra (snpc). |
2022-03-13 |
2023-08-13 |
human |
| Liyan Yao, Peng Li, Qilei Chen, Anxue Hu, Yanping Wu, Baixiang L. Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury. Immunopharmacology and immunotoxicology. 2022-03-09. PMID:35260024. |
parkinson's disease is a common chronic neurodegenerative disease characterized by massive loss of dopaminergic neurons in the substantia nigra. |
2022-03-09 |
2023-08-13 |
Not clear |
| Shui Yu, Hai-Rong Peng, Yu-Kai Zhang, Yan-Qing Yin, Jia-Wei Zho. Central dopaminergic control of cell proliferation in the colonic epithelium. Neuroscience research. 2022-03-08. PMID:35257836. |
parkinson's disease (pd) is an age-related neurodegenerative disease, mainly characterized by the loss of dopaminergic (da) neurons in the substantia nigra. |
2022-03-08 |
2023-08-13 |
mouse |
| Ekaterina Novosadova, Ksenia Anufrieva, Elizaveta Kazantseva, Elena Arsenyeva, Viya Fedoseyeva, Ekaterina Stepanenko, Daniil Poberezhniy, Sergey Illarioshkin, Lyudmila Novosadova, Tatiana Gerasimova, Valentina Nenasheva, Igor Grivennikov, Maria Lagarkova, Vyacheslav Tarantu. Transcriptome datasets of neural progenitors and neurons differentiated from induced pluripotent stem cells of healthy donors and Parkinson's disease patients with mutations in the Data in brief. vol 41. 2022-03-04. PMID:35242938. |
transcriptome datasets of neural progenitors and neurons differentiated from induced pluripotent stem cells of healthy donors and parkinson's disease patients with mutations in the parkinson's disease (pd) is a complex systemic disorder caused by neurodegenerative processes in the brain that are mainly characterized by progressive loss of dopaminergic neurons in the substantia nigra. |
2022-03-04 |
2023-08-13 |
Not clear |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yua. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022-03-01. PMID:35229270. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) is one of the major pathological changes. |
2022-03-01 |
2023-08-13 |
mouse |
| Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D Hammock, Xiao-Chi M. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 9. 2022-02-26. PMID:35217618. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn), causing bradykinesia and rest tremors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Jee-Young Lee, Antonio Martin-Bastida, Ane Murueta-Goyena, Iñigo Gabilondo, Nicolás Cuenca, Paola Piccini, Beomseok Jeo. Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease. Nature reviews. Neurology. 2022-02-18. PMID:35177849. |
the development of parkinsonism is preceded by a long prodromal phase, and >50% of dopaminergic neurons can be lost from the substantia nigra by the time of the initial diagnosis. |
2022-02-18 |
2023-08-13 |
Not clear |
| Anaïs Marie, Julien Leroy, Morgane Darricau, Serge Alfos, Veronique De Smedt-Peyrusse, Emmanuel Richard, Sylvie Vancassel, Clementine Bosch-Bouj. Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats. Frontiers in nutrition. vol 9. 2022-02-18. PMID:35178422. |
the mechanisms leading to a loss of dopaminergic (da) neurons from the substantia nigra |
2022-02-18 |
2023-08-13 |
rat |
| Jannik Prasuhn, Robert Strautz, Felicitas Lemmer, Shalida Dreischmeier, Meike Kasten, Henrike Hanssen, Marcus Heldmann, Norbert Brüggeman. Neuroimaging Correlates of Substantia Nigra Hyperechogenicity in Parkinson's Disease. Journal of Parkinson's disease. 2022-02-18. PMID:35180131. |
degeneration of dopaminergic neurons within the brainstem substantia nigra (sn) is both a pathological hallmark of parkinson's disease (pd) and a major contributor to symptom expression. |
2022-02-18 |
2023-08-13 |
Not clear |
| Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. Molecular neurobiology. 2022-02-17. PMID:35175558. |
parkinson's disease (pd) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (sn), and accumulation and spread of inclusions of aggregated α-synuclein (α-syn). |
2022-02-17 |
2023-08-13 |
human |
| Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Ku. Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits. Cells. vol 11. issue 3. 2022-02-15. PMID:35159290. |
parkinson's disease (pd) is an age-related neurodegenerative disease caused by a selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-02-15 |
2023-08-13 |
mouse |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Justyna Barut, Katarzyna Rafa-Zabłocka, Agnieszka M Jurga, Monika Bagińska, Irena Nalepa, Rosanna Parlato, Grzegorz Kreine. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain. Neurochemistry international. 2022-02-12. PMID:35150790. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor deficits caused by the loss of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta). |
2022-02-12 |
2023-08-13 |
mouse |