| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Ni, Jiqin Zhou, Yating Ling, Xiaorui Lu, Dongdong Niu, Yu Zeng, Yun Qiu, Yu Si, Jia Wang, Weining Zhang, Ziyu Wang, Jiabo H. Neural stem cell secretome exerts a protective effect on damaged neuron mitochondria in Parkinson's disease model. Brain research. 2022-06-11. PMID:35690143. |
the results indicated that the injection of neural stem cell-conditioned medium (nsc-cm) into the striatum and substantia nigra could improve the motor and non-motor deficits of pd rats and rescue the loss of dopaminergic neurons. |
2022-06-11 |
2023-08-14 |
rat |
| Biqing Zhu, Dominic Yin, Hongyu Zhao, Le Zhan. The immunology of Parkinson's disease. Seminars in immunopathology. 2022-06-08. PMID:35674826. |
the neuropathological hallmarks include the loss of dopaminergic neurons in the substantia nigra, the presence of lewy bodies and lewy neurites caused by α-synuclein aggregation, and neuroinflammation in the brain. |
2022-06-08 |
2023-08-14 |
Not clear |
| Le Zhang, Yingshuang Zhang, Dongsheng Fa. Pathological Role of Natural Killer Cells in Parkinson's Disease: A Systematic Review. Frontiers in aging neuroscience. vol 14. 2022-06-06. PMID:35663564. |
parkinson's disease (pd) is one of the common neurodegenerative diseases that is characterized by selective degeneration of dopaminergic neurons in the substantia nigra, and misfolding of α-synuclein into aggregates is thought to contribute to its pathology. |
2022-06-06 |
2023-08-14 |
Not clear |
| Anindita Bose, Gregory A Petsko, Lorenz Stude. Induced pluripotent stem cells: a tool for modeling Parkinson's disease. Trends in neurosciences. 2022-06-06. PMID:35667922. |
among its pathologies, progressive loss of dopaminergic (da) neurons in the substantia nigra is characteristic and contributes to many of the most severe symptoms of pd. |
2022-06-06 |
2023-08-14 |
Not clear |
| Arash Heidari, Niloufar Yazdanpanah, Nima Rezae. The role of Toll-like receptors and neuroinflammation in Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-06-06. PMID:35668422. |
pathologically, pd is associated with the extensive degeneration of dopaminergic neurons in various regions of the central nervous system (cns), specifically the substantia nigra. |
2022-06-06 |
2023-08-14 |
Not clear |
| Sarah F McComish, Adina N MacMahon Copas, Maeve A Caldwel. Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson's Disease Research and Therapeutic Development. Frontiers in neuroscience. vol 16. 2022-06-02. PMID:35651633. |
pd is characterised by the loss of dopaminergic neurons from the substantia nigra, leading to debilitating motor symptoms including bradykinesia, tremor, rigidity, and postural instability. |
2022-06-02 |
2023-08-13 |
human |
| Cláudia M Deus, José Teixeira, Nuno Raimundo, Paolo Tucci, Fernanda Borges, Luciano Saso, Paulo J Oliveir. Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's Disease. European journal of clinical investigation. 2022-05-31. PMID:35638352. |
pathologically, pd is characterized by dopaminergic cell neurodegeneration in the substantia nigra, resulting in decreased dopamine levels in the nigrostriatal pathway, triggering motor symptoms. |
2022-05-31 |
2023-08-13 |
Not clear |
| Jolene Su Yi Tan, Bernett Lee, Jackwee Lim, Dong Rui Ma, Jia Xin Goh, Suh Yee Goh, Muhammad Yaaseen Gulam, Ser Mei Koh, Weiling Wendy Lee, Lei Feng, Qing Wang, Yinxia Chao, Olaf Rötzschke, Eng King Ta. Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1. Cells. vol 11. issue 10. 2022-05-28. PMID:35626686. |
parkinson's disease (pd) is a debilitating movement disorder characterised by the loss of dopaminergic neurons in the substantia nigra. |
2022-05-28 |
2023-08-13 |
mouse |
| Sangeun Han, Sabina Lim, Sujung Ye. Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628462. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn), reducing dopaminergic levels in the striatum and affecting motor control. |
2022-05-28 |
2023-08-13 |
mouse |
| Ankumoni Dutta, Banashree Chetia Phukan, Rubina Roy, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Diwakar Kumar, Pallab Bhattacharya, Joyobrato Nath, Sanjeev Kumar, Anupom Bora. Garcinia morella extract confers dopaminergic neuroprotection by mitigating mitochondrial dysfunctions and inflammation in mouse model of Parkinson's disease. Metabolic brain disease. 2022-05-27. PMID:35622265. |
administration of gme prevented the loss of dopaminergic cell bodies in the substantia nigra and its terminals in the corpus striatum of pd mice. |
2022-05-27 |
2023-08-13 |
mouse |
| Xiao-Yu Song, Wan-Fu Wu, Yu-Bing Dai, Hai-Wei Xu, Andrew Roman, Li Wang, Margaret Warner, Jan-Åke Gustafsso. Ablation of Liver X receptor β in mice leads to overactive macrophages and death of spiral ganglion neurons. Hearing research. vol 422. 2022-05-27. PMID:35623301. |
lxrβ plays a key role in maintenance of health of dopaminergic neurons in the substantia nigra, large motor neurons in the spinal cord, and retinal ganglion cells in adult mice. |
2022-05-27 |
2023-08-13 |
mouse |
| Seong Su Kang, Zhourui Wu, Xia Liu, Laura Edgington-Mitchell, Keqiang Y. Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-05-20. PMID:35595958. |
bdnf/trkb neurotrophic signalings are progressively reduced, whereas δ-secretase, a protease that cleaves α-synuclein (α-syn) at n103 and promotes its aggregation and neurotoxicity, is gradually escalated in pd patient brains, associated with dopaminergic neuronal loss in the substantia nigra. |
2022-05-20 |
2023-08-13 |
mouse |
| Qing Liu, Qiyao Li, Runjiao Zhang, Hongfang Wang, Yibo Li, Ziyu Liu, Wenmeng Xie, Dandan Geng, Lei Wan. circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease. Cell death & disease. vol 13. issue 5. 2022-05-19. PMID:35589691. |
circ-pank1 is highly expressed in the substantia nigra (sn) of pd model mice treated with rotenone and in the mn9d cell model of dopaminergic neurons. |
2022-05-19 |
2023-08-13 |
mouse |
| Seyed Zanyar Athari, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Daryoush Mohajeri, Mir Alireza Nourazar, Gisou Mohadde. Hydroxychloroquine attenuated motor impairment and oxidative stress in a rat 6-hydroxydopamine model of Parkinson's disease. The International journal of neuroscience. 2022-05-16. PMID:35522252. |
parkinson's disease (pd) is associated with the destruction of dopaminergic neurons in the substantia nigra (sn). |
2022-05-16 |
2023-08-16 |
rat |
| Kelly B Menees, Jae-Kyung Le. New Insights and Implications of Natural Killer Cells in Parkinson's Disease. Journal of Parkinson's disease. 2022-05-16. PMID:35570499. |
parkinson's disease (pd) is the second most common neurodegenerative disease and is characterized by the loss of dopaminergic neurons in the substantia nigra and the abnormal aggregation and accumulation of the alpha-synuclein (α-syn) protein into lewy bodies. |
2022-05-16 |
2023-08-13 |
mouse |
| Kathleen Bai, Ziming Cai, Ibrahim Cherif, Faltas C Compaore, Ayaka Fujikawa, Delilah Hao, Rachel Jia, Sabina C Koziakova, Lenore Liu, Elaine Qiu, Victoria Ramirez, Anna Christensen, Josh Zhang, James Greig, Brendan C MacGillivra. Parkinson's Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552291. |
parkinson's disease (pd) is a neurodegenerative disease that involves a progressive loss of dopaminergic neurons within the substantia nigra. |
2022-05-13 |
2023-08-13 |
Not clear |
| Emily E Anderson, Carl T Ash, Amy E Moritz, Patricia Dranchak, R Benjamin Free, James Inglese, Joseph P Steiner, David R Sibley, Emmanuel O Akan. Establishing an RNA interference (RNAi) screen for neuroprotection of dopaminergic neurons in Caenorhabditis elegans models of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553997. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the selective death of dopaminergic neurons in the substantia nigra of the midbrain, resulting in bradykinesia, tremors, muscle rigidity, and other motor and non-motor deficits. |
2022-05-13 |
2023-08-13 |
human |
| Frank Bearoff, Dhruva Dhavale, Paul Kotzbauer, Sandhya Kortager. Aggregated Alpha-Synuclein Activates Pro-Inflammatory NFKB Signaling Pathways Through TLR-Dependent and Independent Mechanisms in Peripheral Monocytic Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556652. |
prolonged neuroinflammation in the substantia nigra (sn) leading to accumulation of alpha-synuclein fibril (α-syn) containing lewy-bodies (lbs) and ultimately death of dopaminergic neurons is a pathological hallmark of parkinson's disease (pd) and is thought to be a major mechanism driving disease progression. |
2022-05-13 |
2023-08-13 |
Not clear |
| Maira Ayaz, Fareeha Anwar, Uzma Saleem, Irum Shahzadi, Bashir Ahmad, Ali Mir, Tariq Ismai. Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammation. ACS omega. vol 7. issue 17. 2022-05-13. PMID:35557705. |
parkinson disease (pd) is a neurodegenerative disorder of the motor activity of the brain, regulated by dopaminergic neurons of substantia nigra, resulting in an increased density of histaminergic fibers. |
2022-05-13 |
2023-08-13 |
Not clear |
| Cheng Chen, Yaohua Chen, Tingting Liu, Dan Song, Di Ma, Oumei Chen. Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK. Oxidative medicine and cellular longevity. vol 2022. 2022-05-09. PMID:35528513. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-05-09 |
2023-08-13 |
mouse |