| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Çınar, Banu Cahide Tel, Gürdal Şahi. Neuroinflammation in Parkinson's Disease and its Treatment Opportunities. Balkan medical journal. 2022-08-29. PMID:36036436. |
parkinson's disease (pd) is a complex, chronic, and progressive neurodegenerative disease that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. |
2022-08-29 |
2023-08-14 |
Not clear |
| Elif Çınar, Banu Cahide Tel, Gürdal Şahi. Neuroinflammation in Parkinson's Disease and its Treatment Opportunities. Balkan medical journal. 2022-08-29. PMID:36036436. |
neuroinflammation is one of the key factors involved in pd pathogenesis as well as alpha-synuclein accumulation, synaptic dysfunction, or dopaminergic neuronal loss, especially in the substantia nigra. |
2022-08-29 |
2023-08-14 |
Not clear |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| André Saraiva Leão Marcelo Antune. Post-translational Modifications in Parkinson's Disease. Advances in experimental medicine and biology. vol 1382. 2022-08-27. PMID:36029405. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterised by progressive degeneration of the dopaminergic neurons in the substantia nigra leading to severe motor complications. |
2022-08-27 |
2023-08-14 |
Not clear |
| Jannette Rodríguez-Pallares, María García-Garrote, Juan A Parga, José Luis Labandeira-Garcí. Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018150. |
parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. |
2022-08-26 |
2023-08-14 |
human |
| María Paula Bonaccorso Marinelli, Gustavo Baiardi, Susana Ruth Valdez, Ricardo Jorge Cabrer. Automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software. Medical & biological engineering & computing. 2022-08-26. PMID:36018532. |
automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software. |
2022-08-26 |
2023-08-14 |
rat |
| María Paula Bonaccorso Marinelli, Gustavo Baiardi, Susana Ruth Valdez, Ricardo Jorge Cabrer. Automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software. Medical & biological engineering & computing. 2022-08-26. PMID:36018532. |
our aim was to develop a software for immunohistochemical analysis of brain dopaminergic neurons combining several computational approaches to automatically analyze and quantify their number in the substantia nigra after a neurotoxic injury. |
2022-08-26 |
2023-08-14 |
rat |
| María Paula Bonaccorso Marinelli, Gustavo Baiardi, Susana Ruth Valdez, Ricardo Jorge Cabrer. Automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software. Medical & biological engineering & computing. 2022-08-26. PMID:36018532. |
the dopaminergic neurotoxin, 6-hydroxydopamine, was administered in adult male rats to damage dopaminergic neurons in substantia nigra and to induce hemiparkinsonism. |
2022-08-26 |
2023-08-14 |
rat |
| Pooja Rai, Jagat Kumar Ro. Rab11 regulates mitophagy signaling pathway of Parkin and Pink1 in the Drosophila model of Parkinson's disease. Biochemical and biophysical research communications. vol 626. 2022-08-22. PMID:35994827. |
parkinson's disease (pd) is a common neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. |
2022-08-22 |
2023-08-14 |
drosophila_melanogaster |
| Qian Zhou, Ying Zhang, Lu Lu, Hu Zhang, Chao Zhao, Yuepu Pu, Lihong Yi. Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-08-19. PMID:35985369. |
based on the inflammatory changes in mouse brain tissues, the activation of microglia, the loss of dopaminergic neurons and the aggregation of α-syn were found in the substantia nigra. |
2022-08-19 |
2023-08-14 |
mouse |
| Erin John Rieger de Almeida, Hélio Jungkenn Ibrahim, Maria Rosa Chitolina Schetinger, Cinthia Melazzo de Andrade, Andréia Machado Cardos. Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases. Neurochemical research. 2022-08-13. PMID:35962936. |
however, pd is characterized by the loss of dopaminergic neurons in the substantia nigra and accumulation of alpha-synuclein in the cortical regions, spinal cord, and brain stem, which occurs by microglial activation, contributing to the neuroinflammatory process. |
2022-08-13 |
2023-08-14 |
Not clear |
| Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari Taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami, Hamed Taheri, Ashraf Mohamadkhani, Ramtin Hajibeygi, Mostafa Rezaei Tavirani, Fatemeh Sayehmir. Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review. Frontiers in aging neuroscience. vol 14. 2022-08-01. PMID:35912090. |
parkinson's disease (pd), the second most common neurodegenerative disorder, is characterized by neuroinflammation, formation of lewy bodies, and progressive loss of dopaminergic neurons in the substantia nigra of the brain. |
2022-08-01 |
2023-08-14 |
Not clear |
| Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Deha. The Zinc Ionophore Clioquinol Reduces Parkinson's Disease Patient-Derived Brain Extracts-Induced Neurodegeneration. Molecular neurobiology. 2022-08-01. PMID:35915387. |
parkinson's disease (pd) is pathologically characterized by intracellular α-synuclein-rich protein aggregates, named lewy bodies (lb), and by the progressive loss of dopaminergic neurons in the substantia nigra. |
2022-08-01 |
2023-08-14 |
mouse |
| Marli Cardoso Martins-Pinge, Lorena de Jager, Blenda Hyedra de Campos, Lorena Oliveira Bezerra, Pamela Giovana Turini, Phileno Pinge-Filh. Nitric Oxide Involvement in Cardiovascular Dysfunctions of Parkinson Disease. Frontiers in pharmacology. vol 13. 2022-07-28. PMID:35899105. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra, causing motor changes. |
2022-07-28 |
2023-08-14 |
rat |
| Szu-Ju Chen, Chin-Hsien Li. Gut microenvironmental changes as a potential trigger in Parkinson's disease through the gut-brain axis. Journal of biomedical science. vol 29. issue 1. 2022-07-27. PMID:35897024. |
although pd is characterized by motor dysfunction resulting from intraneuronal alpha-synuclein accumulations, termed lewy bodies, and dopaminergic neuronal degeneration in the substantia nigra, multiple systems are involved in the disease process, resulting in heterogenous clinical presentation and progression. |
2022-07-27 |
2023-08-14 |
mouse |
| Núbia Ribeiro da Conceição, Caroline Ribeiro de Souza, Ávila de Oliveira Júlia, Andrea Cristina de Lima-Pardini, Carla Silva-Batista, Luis Augusto Teixeira, Daniel Boari Coelh. Between-leg asymmetry in automatic postural responses to stance perturbations in people with Parkinson's disease. Gait & posture. vol 97. 2022-07-25. PMID:35872481. |
people with parkinson's disease (pwpd) showed impairments of balance control which can be aggravated by the presence of higher interlateral postural asymmetry caused by a distinct dopaminergic loss in the substantia nigra between cerebral hemispheres. |
2022-07-25 |
2023-08-14 |
Not clear |
| Jaron T Colas, Neil M Dundon, Raphael T Gerraty, Natalie M Saragosa-Harris, Karol P Szymula, Koranis Tanwisuth, J Michael Tyszka, Camilla van Geen, Harang Ju, Arthur W Toga, Joshua I Gold, Dani S Bassett, Catherine A Hartley, Daphna Shohamy, Scott T Grafton, John P O'Dohert. Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T. Human brain mapping. 2022-07-21. PMID:35860954. |
with high-resolution high-field fmri targeting the dopaminergic midbrain, the grl model's rpe signals (alongside value and decision signals) were localized within not only the striatum but also the substantia nigra and the ventral tegmental area, including specific effects of generalization that also extend to the hippocampus. |
2022-07-21 |
2023-08-14 |
human |
| Sage S Frehner, Kip T Dooley, Michelle C Palumbo, Aaron L Smith, Mark M Goodman, Karen L Bales, Sara M Freema. Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 377. issue 1858. 2022-07-20. PMID:35858098. |
effect of sex and autism spectrum disorder on oxytocin receptor binding and mrna expression in the dopaminergic pars compacta of the human substantia nigra. |
2022-07-20 |
2023-08-14 |
human |
| Maximilian Wulf, Katalin Barkovits, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Britta Eggers, Katrin Marcu. Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-19. PMID:35852604. |
neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (nmgs) in the cell bodies of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-07-19 |
2023-08-14 |
Not clear |
| Juli Jain, Whidul Hasan, Pronit Biswas, Rajesh S Yadav, Deepali Ja. Neuroprotective effect of quercetin against rotenone-induced neuroinflammation and alterations in mice behavior. Journal of biochemical and molecular toxicology. 2022-07-13. PMID:35822592. |
the finding of the study indicated that rotenone 5 mg/kg body weight for 60 days through oral gavage leads to the release of inflammatory markers in blood serum, astrocytes activation in substantia nigra and hippocampus, and subsequently decreased density of dopaminergic fibers in the striatum. |
2022-07-13 |
2023-08-14 |
mouse |