| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Gan, Jiahan Ren, Tianzhuang Huang, Kunhua Wu, Shulin Li, Yanchao Duan, Zhengbo Wang, Wei Si, Jingkuan We. Pathological α-Synuclein Accumulation, CSF Metabolites Changes and Brain Microstructures in Cynomolgus Monkeys Treated with 6-hydroxydopamine. Neurotoxicology. 2022-12-08. PMID:36476940. |
we found the dopaminergic neurons were significantly reduced and had fragmented morphology in substantia nigra (sn). |
2022-12-08 |
2023-08-14 |
monkey |
| Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Lijun Dai, Min Xiong, Zhaohui Zhang, Liam Chen, Zhentao Zhan. Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-12-08. PMID:36479526. |
microglial activation and neuroinflammation play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2022-12-08 |
2023-08-14 |
mouse |
| Gehan El-Akabawy, Sherif Othman Fathy El Kersh, Laila Ahmed Rashed, Shaimaa Nasr Amin, Azza El-Sheik. Transplantation of bone marrow-derived mesenchymal stem cells ameliorated dopamine system impairment in a D-galactose-induced brain ageing in rats. Folia morphologica. 2022-12-06. PMID:36472399. |
bmmsc transplantation improved locomotor activity, restored dopaminergic system function, preserved atrophic dopaminergic neurones in the substantia nigra, exerted antioxidative effects, and restored neurotrophic factors. |
2022-12-06 |
2023-08-14 |
rat |
| Wei Liang, Lulu Yao, Jiahao Chen, Zhiying Chen, Xiling Wu, Xiaobo Huan. Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-11-28. PMID:36437828. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-11-28 |
2023-08-14 |
rat |
| Aleksandra Pytel, Jan Aleksander Beszlej, Monika Biercewicz, Anna Roszmann, Dorota Krówczyńska, Aleksandra Kołtuniu. The Effect of Frailty Syndrome on the Quality of Life of Individuals with Parkinson's Disease: A Pilot Observational and Multicenter Study on the Polish Population. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429942. |
parkinson's disease (pd) is a neurodegenerative disorder involving decreased dopamine release and atrophy of dopaminergic neurons of the substantia nigra. |
2022-11-26 |
2023-08-14 |
Not clear |
| Vandana Zaman, Kelsey P Drasites, Ali Myatich, Ramsha Shams, Donald C Shields, Denise Matzelle, Azizul Haque, Narendra L Bani. Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430329. |
calpain, a calcium-dependent neutral protease, is widely expressed in the brain, including substantia nigra (sn) dopaminergic (da) neurons. |
2022-11-26 |
2023-08-14 |
human |
| Yura Jang, Olga Pletnikova, Juan C Troncoso, Alexander Y Pantelyat, Ted M Dawson, Liana S Rosenthal, Chan Hyun N. Mass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease. Molecular & cellular proteomics : MCP. 2022-11-24. PMID:36423813. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) of the brain. |
2022-11-24 |
2023-08-14 |
human |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
mutations in the snca gene cause autosomal dominant parkinson's disease (pd), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. |
2022-11-24 |
2023-08-14 |
human |
| Zhen Chen, Hui Zhan. A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson's disease patients. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2022-11-18. PMID:36398374. |
brain-derived neurotrophic factor (bdnf) is essential for the development of dopaminergic neurons in the substantia nigra. |
2022-11-18 |
2023-08-14 |
Not clear |
| Siwei Zhou, Xiaofang Zhou, Zewen Jiang, Jinrong Ma, Yuanmei Li, Zhiyong Qian, Hua L. The Mechanism of SNHG8/Microrna-421-3p/Sorting Nexin 8 Axis on Dopaminergic Neurons in Substantia Nigra in a Mouse Model of Parkinson's Disease. Neurochemical research. 2022-11-18. PMID:36401052. |
the mechanism of snhg8/microrna-421-3p/sorting nexin 8 axis on dopaminergic neurons in substantia nigra in a mouse model of parkinson's disease. |
2022-11-18 |
2023-08-14 |
mouse |
| Komal Latif, Aman Ullah, Anastasiia D Shkodina, Dmytro I Boiko, Zakia Rafique, Badrah S Alghamdi, Mohamed A Alfaleh, Ghulam Md Ashra. Drug reprofiling history and potential therapies against Parkinson's disease. Frontiers in pharmacology. vol 13. 2022-11-17. PMID:36386233. |
we describe strategies of drug repurposing for parkinson's disease, which is a neurodegenerative condition that primarily affects dopaminergic neurons in the substantia nigra. |
2022-11-17 |
2023-08-14 |
Not clear |
| Min Hyung Seo, Sujung Ye. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Molecular neurobiology. 2022-11-12. PMID:36369636. |
parkinson's disease (pd) is the second most common neurodegenerative disorder and is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-11-12 |
2023-08-14 |
mouse |
| Uttam Ojha, Shristi Khanal, Pil-Hoon Park, Jin Tae Hong, Dong-Young Cho. Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice. The Journal of nutritional biochemistry. 2022-11-12. PMID:36370926. |
we observed that alternate-day fasting attenuated mptp-induced dopaminergic neuronal loss and astroglial activation in the substantia nigra and the striatum. |
2022-11-12 |
2023-08-14 |
mouse |
| Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, Ryuichi Ishida, Syuhei Chiba, Ryosuke Takahashi, Toshifumi Takao, Shinji Hirotsun. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nature communications. vol 13. issue 1. 2022-11-12. PMID:36371400. |
parkinson's disease is a progressive neurodegenerative disorder characterized by the preferential loss of tyrosine hydroxylase (th)-expressing dopaminergic neurons in the substantia nigra. |
2022-11-12 |
2023-08-14 |
mouse |
| Shashank Vasudevan, Andrea Dotti, Janko Kajtez, Alberto Martínez-Serrano, Carsten Gundlach, Sandrina Campos Maçãs, Karin Lauschke, Anne-Marie Vinngaard, Silvia García López, Marta Pereira, Arto Heiskanen, Stephan S Keller, Jenny Emnéu. Omnidirectional leaky opto-electrical fiber for optogenetic control of neurons in cell replacement therapy. Bioelectrochemistry (Amsterdam, Netherlands). vol 149. 2022-11-08. PMID:36345111. |
the pathophysiological progress of parkinson's disease leads through degeneration of dopaminergic neurons in the substantia nigra to complete cell death and lack of dopamine in the striatum where it modulates motor functions. |
2022-11-08 |
2023-08-14 |
Not clear |
| Jiaqi Wen, Tao Guo, Jingjing Wu, Xueqin Bai, Cheng Zhou, Haoting Wu, Xiaocao Liu, Jingwen Chen, Zhengye Cao, Luyan Gu, Jiali Pu, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun X. Nigral Iron Deposition Influences Disease Severity by Modulating the Effect of Parkinson's Disease on Brain Networks. Journal of Parkinson's disease. 2022-11-07. PMID:36336939. |
in parkinson's disease (pd), excessive iron deposition in the substantia nigra may exacerbate α-synuclein aggregation, facilitating the degeneration of dopaminergic neurons and their neural projection. |
2022-11-07 |
2023-08-14 |
Not clear |
| Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren-Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelende. SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease. Aging cell. 2022-10-29. PMID:36307912. |
parkinson's disease (pd) is characterized by degeneration of neurons, particularly dopaminergic neurons in the substantia nigra. |
2022-10-29 |
2023-08-14 |
Not clear |
| Katherine L Houlihan, Petros P Keoseyan, Amber N Juba, Tigran Margaryan, Max E Voss, Alexander M Babaoghli, Justin M Norris, Greg J Adrian, Artak Tovmasyan, Lori M Buhlma. Folic Acid Improves Parkin-Null Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290790. |
folic acid improves parkin-null loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic neurons in the substantia nigra. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ellen Niederberger, Annett Wilken-Schmitz, Christine Manderscheid, Yannick Schreiber, Robert Gurke, Irmgard Tegede. Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293513. |
immunofluorescence studies were used to analyze the morphology of dopaminergic neurons, the expression of alpha-synuclein (α-syn), and inflammatory gliosis or infiltration in the substantia nigra. |
2022-10-27 |
2023-08-14 |
mouse |
| Seunghwan Shim, Da Un Jeong, Hyemi Kim, Chae Yun Kim, Hyejun Park, Yinglan Jin, Kyung Min Kim, Hwa Jeong Lee, Dong Hwan Kim, Yun Soo Bae, Yongseok Cho. Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease. European journal of medicinal chemistry. vol 244. 2022-10-24. PMID:36274279. |
oral administration of compound 11 (30 mg/kg/daily, 4 weeks) into the mice resulted in suppression of dopaminergic neuronal death in substantia nigra (sn) and in striatum as well as inhibition of microglial migration into sn. |
2022-10-24 |
2023-08-14 |
mouse |