| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Jung Bae, Jong-Min Kim, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Jae Hyoung Kim, Sang Eun Ki. [MRI Findings in Parkinson's Disease: Radiologic Assessment of Nigrostriatal Degeneration]. Taehan Yongsang Uihakhoe chi. vol 83. issue 3. 2022-10-14. PMID:36238511. |
parkinson's disease (pd) is a movement disorder that develops due to degenerative loss of dopaminergic cells in the substantia nigra of the midbrain. |
2022-10-14 |
2023-08-14 |
Not clear |
| Qing Guan, Wei Liu, Ketao Mu, Qi Hu, Jiazhao Xie, Liming Cheng, Xiong Wan. Single-cell RNA sequencing of CSF reveals neuroprotective RAC1 Frontiers in immunology. vol 13. 2022-10-10. PMID:36211372. |
results showed that nk cells infiltrate the substantia nigra (sn) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd model mice and colocalize with dopaminergic neurons and α-syn. |
2022-10-10 |
2023-08-14 |
mouse |
| Irina Ivan, Laura Irincu, Ştefania Diaconu, Cristian Falup-Pecurari. Parkinsonism associated with viral infection. International review of neurobiology. vol 165. 2022-10-08. PMID:36208896. |
in some cases, lesions or inflammatory processes in the basal ganglia or substantia nigra have been found to cause reversible or permanent impairment of the dopaminergic pathway, leading to the occurrence of extrapyramidal symptoms. |
2022-10-08 |
2023-08-14 |
human |
| Sushmaa Chandralekha Selvakumar, K Auxzilia Preethi, Deusdedit Tusubira, Durairaj Seka. MicroRNAs in the epigenetic regulation of disease progression in Parkinson's disease. Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187290. |
the loss of dopaminergic neurons in the substantia nigra (sn) is thought to be the primary cause of pd disease progression. |
2022-10-03 |
2023-08-14 |
Not clear |
| Yao Liu, Jingshan Luo, Yujing Liu, Wen Liu, Guangtao Yu, Yuting Huang, Yu Yang, Xiaojia Chen, Tongkai Che. Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson's Disease. ACS central science. vol 8. issue 9. 2022-10-03. PMID:36188350. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates called lewy bodies. |
2022-10-03 |
2023-08-14 |
mouse |
| Song-Yu Guo, Rong-Xiao Guan, Xiao-Dong Chi, Yue-Zhang, Ao-Ran Sui, Wei Zhao, Supratik Kundu, Jin-Yi Yang, Jie Zhao, Shao L. Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans. Brain research bulletin. 2022-10-03. PMID:36191729. |
the main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. |
2022-10-03 |
2023-08-14 |
caenorhabditis_elegans |
| Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Min. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-24. PMID:36152409. |
the mechanism of parkinson's disease still remains unknown, however, studies already proved that the damage or absence of dopaminergic neurons located in the substantia nigra and the decreased dopamine in the striatum are significantly related to parkinson's disease. |
2022-09-24 |
2023-08-14 |
Not clear |
| Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Åke Gustafsso. Liver X Receptor Regulation of Glial Cell Functions in the CNS. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140266. |
the study of lxr knockout mice has revealed that lxrβ plays a key role in maintaining the health of dopaminergic neurons in the substantia nigra, large motor neurons in the spinal cord and retinal ganglion cells in the eye. |
2022-09-23 |
2023-08-14 |
mouse |
| Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Le. Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142491. |
we found that dietary morin prevented mptp-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (str) and substantia nigra (sn) in our mouse model. |
2022-09-23 |
2023-08-14 |
mouse |
| Li Li, Wenlong Ya. The therapeutic potential of salidroside for Parkinson's disease. Planta medica. 2022-09-21. PMID:36130710. |
parkinson's disease (pd), a neurological disorder, is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2022-09-21 |
2023-08-14 |
Not clear |
| Jui-Ming Sun, Surbhi Agarwal, Tushar Dnyaneshwar Desai, Da-Tong Ju, Yung-Ming Chang, Shih-Chieh Liao, Tsung-Jung Ho, Yu-Lan Yeh, Wei-Wen Kuo, Yu-Jung Lin, Chih-Yang Huan. Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model. Environmental toxicology. 2022-09-20. PMID:36124540. |
parkinson's disease (pd) is a common neurodegenerative disorder associated with striatal dopaminergic neuronal loss in the substantia nigra. |
2022-09-20 |
2023-08-14 |
mouse |
| Xin Li, Xiao-Wen Jiang, Hai-Xiao Chu, Qing-Chun Zhao, Huai-Wei Ding, Chao-Hong Ca. Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition. Chinese herbal medicines. vol 13. issue 1. 2022-09-19. PMID:36117765. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in substantia nigra (sn). |
2022-09-19 |
2023-08-14 |
Not clear |
| Arvie Camille V de Guzman, Seunghun Kang, Eun Ji Kim, Jin Ho Kim, Nari Jang, Joong Hee Cho, Shin Sik Cho. High-Glucose Diet Attenuates the Dopaminergic Neuronal Function in ACS omega. vol 7. issue 36. 2022-09-19. PMID:36120016. |
high-glucose diet attenuates the dopaminergic neuronal function in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective degeneration of neurons, primarily in the substantia nigra. |
2022-09-19 |
2023-08-14 |
Not clear |
| Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G Murzin, Holly J Garringer, Patrick W Cullinane, Yuko Saito, Tatiana Foroud, Thomas T Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H W Scheres, Michel Goeder. Structures of α-synuclein filaments from human brains with Lewy pathology. Nature. 2022-09-15. PMID:36108674. |
neuropathologically, it is characterised by the presence of abundant filamentous inclusions of α-synuclein in the form of lewy bodies and lewy neurites in some brain cells, including dopaminergic nerve cells of the substantia nigra (2). |
2022-09-15 |
2023-08-14 |
human |
| Naomi J Thorne, David A Tumbarell. The relationship of alpha-synuclein to mitochondrial dynamics and quality control. Frontiers in molecular neuroscience. vol 15. 2022-09-12. PMID:36090250. |
mitochondrial dysfunction has been implicated in driving the pathology of several neurodegenerative diseases, including parkinson's disease (pd) where dopaminergic neurons in the substantia nigra are selectively degenerated. |
2022-09-12 |
2023-08-14 |
Not clear |
| Debora M G Cunha, Marcela Becegato, Ywlliane S R Meurer, Alvaro C Lima, Narriman Gonçalves, Vinícius S Bioni, Sheila A Engi, Paula C Bianchi, Fabio C Cruz, Jose R Santos, Regina H Silv. Neuroinflammation in early, late and recovery stages in a progressive parkinsonism model in rats. Frontiers in neuroscience. vol 16. 2022-09-12. PMID:36090265. |
parkinson's disease (pd) is characterized by motor and non-motor signs, which are accompanied by progressive degeneration of dopaminergic neurons in the substantia nigra. |
2022-09-12 |
2023-08-14 |
rat |
| Padmashri Naren, Anjali Cholkar, Suchita Kamble, Khan Sabiya Samim, Saurabh Srivastava, Jitender Madan, Neelesh Mehra, Vinod Tiwari, Shashi Bala Singh, Dharmendra Kumar Khatr. Pathological and Therapeutic Advances in Parkinson's Disease: Mitochondria in the Interplay. Journal of Alzheimer's disease : JAD. 2022-09-12. PMID:36093711. |
progressive dopaminergic neuronal loss and the collective assemblage of misfolded alpha-synuclein in the substantia nigra, remain notable neuro-pathological hallmarks of the disease. |
2022-09-12 |
2023-08-14 |
Not clear |
| Nina Aghazadeh, Elmira Aboutalebi Vand Beilankouhi, Farima Fakhri, Morad Kohandel Gargari, Parisa Bahari, Aliasghar Moghadami, Zhila Khodabandeh, Mohammad Valil. Involvement of heat shock proteins and parkin/α-synuclein axis in Parkinson's disease. Molecular biology reports. 2022-09-12. PMID:36097120. |
from a pathological point of view, pd is characterized by the loss of dopaminergic neurons in the substantia nigra, which causes the abnormal accumulation of α-synuclein (α-syn) (a component of lewy bodies), which subsequently interact with heat shock proteins (hsps), leading to apoptosis. |
2022-09-12 |
2023-08-14 |
Not clear |
| Erlânia Alves de Siqueira, Emanuel Paula Magalhães, Albert Layo Costa de Assis, Tiago Lima Sampaio, Danya Bandeira Lima, Marcia Machado Marinho, Alice Maria Costa Martins, Geanne Matos de Andrade, Glauce Socorro de Barros Vian. 1α,25-Dihydroxyvitamin D3 (VD3) Shows a Neuroprotective Action Against Rotenone Toxicity on PC12 Cells: An In Vitro Model of Parkinson's Disease. Neurochemical research. 2022-09-06. PMID:36066698. |
parkinson's disease (pd) is characterized by dopaminergic cell loss in the substantia nigra, and pd brains show neuroinflammation, oxidative stress, and mitochondrial dysfunction. |
2022-09-06 |
2023-08-14 |
Not clear |
| Nishant Sharma, Ritu Soni, Monika Sharma, Sayan Chatterjee, Nidhi Parihar, Mohd Mukarram, Ruhi Kale, Adil Ali Sayyed, Santosh Kumar Behera, Amit Khairna. Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson's Disease by GLP-1 Secretion. Molecular neurobiology. 2022-09-01. PMID:36048341. |
cga treatment ameliorated rotenone-induced dopaminergic nerve degeneration and alpha-synuclein accumulation in substantia nigra and augmented mean density of dopaminergic nerve fibers in striatum. |
2022-09-01 |
2023-08-14 |
mouse |