| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Marcos Freitas Cordeiro, Ana Paula Horn, Mariana Appel Hor. Experimental models of chemically induced Parkinson's disease in zebrafish at the embryonic larval stage: a systematic review. Journal of toxicology and environmental health. Part B, Critical reviews. 2023-03-02. PMID:36859813. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels, resulting in motor-type disturbances. |
2023-03-02 |
2023-08-14 |
zebrafish |
| Takahiro Fuchigami, Yutaka Itokazu, John C Morgan, Robert K Y. Restoration of Adult Neurogenesis by Intranasal Administration of Gangliosides GD3 and GM1 in The Olfactory Bulb of A53T Alpha-Synuclein-Expressing Parkinson's-Disease Model Mice. Molecular neurobiology. 2023-02-28. PMID:36849668. |
these motor symptoms are associated with the neurodegeneration of dopaminergic neurons in the substantia nigra. |
2023-02-28 |
2023-08-14 |
mouse |
| Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Francisco J Padilla-Godínez, Luis Daniel Bernal-Conde, Marcela Palomero-Rivero, Faria Zafar, Omar Collazo-Navarrete, Luis O Soto-Rojas, Birgitt Schüle, Magdalena Guerra-Cresp. Embryoid Body Cells from Human Embryonic Stem Cells Overexpressing Dopaminergic Transcription Factors Survive and Initiate Neurogenesis via Neural Rosettes in the Substantia Nigra. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831872. |
embryoid body cells from human embryonic stem cells overexpressing dopaminergic transcription factors survive and initiate neurogenesis via neural rosettes in the substantia nigra. |
2023-02-25 |
2023-08-14 |
mouse |
| Yu-Hsuan Chen, Yi-Ying Kuo, Yi-Qian You, Ya-Tin Lin, Pei-Chun Che. Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease. Journal of neurochemistry. 2023-02-25. PMID:36840377. |
parkinson's disease (pd) is a common movement disorder caused by a characteristic loss of dopaminergic neurons in the substantia nigra (sn) and degeneration of dopamine terminals in the dorsal striatum. |
2023-02-25 |
2023-08-14 |
mouse |
| Anthony J Roecker, Kathy M Schirripa, H Marie Loughran, Ling Tong, Tao Liang, Kerry L Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D Altman, Melissa C Ford, Robert E Drolet, Mali Cosden, Sarah Jinn, Nathan G Hatcher, Lihang Yao, Monika Kandebo, Joshua D Vardigan, Rosemarie B Flick, Xiaomei Liu, Christina Minnick, Laura A Price, Marla L Watt, Wei Lemaire, Christine Burlein, Gregory C Adam, Lauren A Austin, Jacob N Marcus, Sean M Smith, Mark E Frale. Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease. ACS medicinal chemistry letters. vol 14. issue 2. 2023-02-16. PMID:36793422. |
parkinson's disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. |
2023-02-16 |
2023-08-14 |
Not clear |
| Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yan. microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease. Brain and behavior. 2023-02-16. PMID:36795044. |
parkinson's disease (pd) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. |
2023-02-16 |
2023-08-14 |
mouse |
| Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yan. microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease. Brain and behavior. 2023-02-16. PMID:36795044. |
several studies verified that microrna (mirnas) targeting the bim/bax/caspase-3 signaling axis is involved in the apoptosis of dopaminergic neurons in substantia nigra. |
2023-02-16 |
2023-08-14 |
mouse |
| Tatiana Gerasimova, Ekaterina Stepanenko, Lyudmila Novosadova, Elena Arsenyeva, Darya Shimchenko, Vyacheslav Tarantul, Igor Grivennikov, Valentina Nenasheva, Ekaterina Novosadov. Glial Cultures Differentiated from iPSCs of Patients with International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768317. |
glial cultures differentiated from ipscs of patients with parkinson's disease (pd) is the second most common neurodegenerative diseases characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra. |
2023-02-11 |
2023-08-14 |
Not clear |
| Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You, Jun Ga. The deficiency of Maged1 attenuates Parkinson's disease progression in mice. Molecular brain. vol 16. issue 1. 2023-02-11. PMID:36774489. |
in this study, we observed that maged1 was expressed in the dopaminergic (da) neurons of the substantia nigra in mice and humans, which could be upregulated by the in vivo or in vitro treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or 1-methyl-4-phenylpyridinium iodide (mpp |
2023-02-11 |
2023-08-14 |
mouse |
| Ji Wu, Chengjian Qin, Yuankun Cai, Jiabin Zhou, Dongyuan Xu, Yu Lei, Guoxing Fang, Songshan Chai, Nanxiang Xion. Machine learning screening for Parkinson's disease-related cuproptosis-related typing development and validation and exploration of personalized drugs for cuproptosis genes. Annals of translational medicine. vol 11. issue 1. 2023-02-10. PMID:36760248. |
parkinson's disease (pd) is a common, degenerative disease of the nervous system that is characterized by the death of dopaminergic neurons in the substantia nigra densa (snpc). |
2023-02-10 |
2023-08-14 |
Not clear |
| Zijie Wang, Dingting Yang, Yiru Jiang, Yong Wang, Mengxi Niu, Chong Wang, Hong Luo, Huaxi Xu, Jingwen Li, Yun-Wu Zhang, Xian Zhan. Loss of RAB39B does not alter MPTP-induced Parkinson's disease-like phenotypes in mice. Frontiers in aging neuroscience. vol 15. 2023-02-10. PMID:36761179. |
a major pathological hallmark of pd is the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2023-02-10 |
2023-08-14 |
mouse |
| Waijiao Cai, Kazumasa Wakamatsu, Fabio A Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Che. DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease. Progress in neurobiology. 2023-02-06. PMID:36746222. |
neuromelanin (nm) in dopaminergic neurons of human substantia nigra (sn) has a melanic component that consists of pheomelanin and eumelanin moieties and has been proposed as a key factor contributing to dopaminergic neuron vulnerability in parkinson's disease (pd). |
2023-02-06 |
2023-08-14 |
human |
| Liping Zhou, Deqiang Han, Xingzhe Wang, Zhiguo Che. Probiotic Formulation VSL#3 Interacts with Mesenchymal Stromal Cells To Protect Dopaminergic Neurons via Centrally and Peripherally Suppressing NOD-Like Receptor Protein 3 Inflammasome-Mediated Inflammation in Parkinson's Disease Mice. Microbiology spectrum. 2023-02-02. PMID:36728426. |
hmscs, vsl#3 alone, and their combination markedly ameliorated the decreased striatal dopamine content, loss of dopaminergic neurons in the substantia nigra, increased levels of proinflammatory cytokines in serum, as well as tumor necrosis factor alpha (tnf-α) and interleukin-1β (il-1β) mrnas in striatum and peripheral tissues induced by mptp. |
2023-02-02 |
2023-08-14 |
mouse |
| Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Núria Peñuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Giménez, Joana M Cladera-Sastre, Ariadna Laguna, Miquel Vil. In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease. Brain : a journal of neurology. 2023-01-31. PMID:36717986. |
neurons with the highest neuromelanin levels are particularly susceptible to degeneration in parkinson's disease, especially dopaminergic neurons of the substantia nigra, the loss of which leads to characteristic motor parkinson's disease symptoms. |
2023-01-31 |
2023-08-14 |
human |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ajeet Kaushik, Małgorzata Kujawska, Eman A Ahmed, Gaber El-Saber Batih. SARS-COV-2 infection and Parkinson's disease: Possible links and perspectives. Journal of neuroscience research. 2023-01-30. PMID:36717481. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2023-01-30 |
2023-08-14 |
Not clear |
| Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L Miguel Martin. Increased cysteine metabolism in PINK1 models of Parkinson's disease. Disease models & mechanisms. vol 16. issue 1. 2023-01-25. PMID:36695500. |
parkinson's disease (pd), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2023-01-25 |
2023-08-14 |
human |
| Rui Wang, Shu-Chao Pang, Jing-Ya Li, Chan-Lian Li, Jun-Miao Liu, Yu-Ming Wang, Mei-Ling Chen, Yu-Bo L. A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson's disease. Analytical and bioanalytical chemistry. 2023-01-23. PMID:36688984. |
alpha-synuclein (α-syn) is the pathological basis of pd, it can abnormally aggregate into insoluble forms such as oligomers, fibrils, and plaques, causing degeneration of nigrostriatal dopaminergic neurons in the substantia nigra in the patient's brain and the formation of lewy bodies (lbs) and lewy neuritis (ln) inclusions. |
2023-01-23 |
2023-08-14 |
Not clear |
| Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhan. Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson's Disease Models by Alleviating Oxidative Stress. Antioxidants (Basel, Switzerland). vol 12. issue 1. 2023-01-21. PMID:36671015. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2023-01-21 |
2023-08-14 |
Not clear |
| Alfredo Gonzalez-Alcocer, Ana Patricia Duarte-Jurado, Adolfo Soto-Dominguez, Maria de Jesus Loera-Arias, Eliud Enrique Villarreal-Silva, Odila Saucedo-Cardenas, Roberto Montes de Oca-Luna, Aracely Garcia-Garcia, Humberto Rodriguez-Roch. Unscrambling the Role of Redox-Active Biometals in Dopaminergic Neuronal Death and Promising Metal Chelation-Based Therapy for Parkinson's Disease. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674772. |
indeed, biometals have been shown to induce a dopaminergic neuronal loss in the substantia nigra. |
2023-01-21 |
2023-08-14 |
Not clear |
| Qionghui Cai, Na Xu, Yan He, Jiamin Zhu, Fenfen Ye, Zhi Luo, Ruojun Lu, Linshan Huang, Feiyang Zhang, Jiang-Fan Chen, Yan L. α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674880. |
here, we coupled two unique behavioral paradigms with two pd models to reveal the following: (i) focally injecting α-syn fibrils into the dorsolateral striatum (dls) and the transgenic expression of a53t-α-syn in the dopaminergic neurons in the substantia nigra (sn, pitx3-ires2-tta/teto-a53t mice) selectively impaired forelimb fine movements induced by the single-pellet reaching task. |
2023-01-21 |
2023-08-14 |
mouse |