| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D N Voronkov, A V Stavrovskaya, I A Potapov, A S Guschina, A S Olshanski. Glial Reaction in a Neuroinflammatory Model of Parkinson's Disease. Bulletin of experimental biology and medicine. 2023-04-12. PMID:37043065. |
sixty and 90 days after unilateral intranigral injection of lps to wistar rats (10 μg), activation of microglia, neuronal death, and formation of synuclein-positive inclusions were observed in the substantia nigra, but not in dopaminergic neurons. |
2023-04-12 |
2023-08-14 |
rat |
| Yi Zhuo, Xuan Li, Zhengwen He, Ming L. Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson's disease. Stem cell research & therapy. vol 14. issue 1. 2023-04-11. PMID:37041580. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn); the etiology and pathological mechanism of the disease are still unclear. |
2023-04-11 |
2023-08-14 |
Not clear |
| Zihua Liu, Qiang Ye, Ying Jian. Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson's disease. Chinese neurosurgical journal. vol 9. issue 1. 2023-04-04. PMID:37013627. |
the pathologic characteristic feature is the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-04 |
2023-08-14 |
Not clear |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Gurkaran Singh Baweja, Shankar Gupta, Bhupinder Kumar, Preeti Patel, Vivek Asat. Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach. Molecular diversity. 2023-03-28. PMID:36977955. |
parkinson's disease is a neurodegenerative disorder characterized by slow movement, tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's substantia nigra. |
2023-03-28 |
2023-08-14 |
Not clear |
| Julia Obergasteiger, Anne-Marie Castonguay, Sara Pizzi, Stefano Magnabosco, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A Hicks, Peter P Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, Mattia Volt. The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology. NPJ Parkinson's disease. vol 9. issue 1. 2023-03-27. PMID:36973269. |
in parkinson's disease (pd) misfolded alpha-synuclein (asyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. |
2023-03-27 |
2023-08-14 |
Not clear |
| Yogeshachar Chithra, Gourav Dey, Vivek Ghose, Vivek Chandramohan, Niya Gowthami, V Vasudev, M M Srinivas Bharat. Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease. Neurochemical research. 2023-03-25. PMID:36964824. |
mitochondrial dysfunction in pd entails inhibition of the mitochondrial complex i (ci) in the dopaminergic neurons of substantia nigra. |
2023-03-25 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects. Inflammopharmacology. 2023-03-24. PMID:36961665. |
parkinson's disease (pd) is an advanced neurodegenerative disease (ndd) caused by the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-03-24 |
2023-08-14 |
Not clear |
| Maryam Abrishamdar, Maryam Sadat Jalali, Neda Yazdanfa. The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-23. PMID:36949298. |
the predominant pathology of pd is the loss of dopaminergic cells in the substantia nigra. |
2023-03-23 |
2023-08-14 |
Not clear |
| Jeongmin Park, Jeong Heon Gong, Yubing Chen, Thu-Hang Thi Nghiem, Sonam Chandrawanshi, Eunyeong Hwang, Chae Ha Yang, Byung-Sam Kim, Jeong Woo Park, Stefan W Ryter, Byungyong Ahn, Yeonsoo Joe, Hun Taeg Chung, Rina Y. Activation of ROS-PERK-TFEB by Filbertone Ameliorates Neurodegenerative Diseases via Enhancing the Autophagy-Lysosomal Pathway. The Journal of nutritional biochemistry. 2023-03-23. PMID:36958418. |
we also demonstrate that filbertone prevented the loss of dopaminergic neurons in the substantia nigra and striatum of mice on high-fat diet (hfd). |
2023-03-23 |
2023-08-14 |
mouse |
| Alexander Grotemeyer, Judith F Fischer, James B Koprich, Jonathan M Brotchie, Robert Blum, Jens Volkmann, Chi Wang I. Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-03-22. PMID:36945016. |
we have used a human α-synuclein mouse model of progressive pd to examine the anti-inflammatory and neuroprotective effects of inflammasome inhibition on dopaminergic (da) neurons in the substantia nigra (sn). |
2023-03-22 |
2023-08-14 |
mouse |
| Fayard Audrey, Fenyi Alexis, Lavisse Sonia, Dovero Sandra, Bousset Luc, Tracy Bellande, Lecourtois Sophie, Jouy Christophe, Guillermier Martine, Jan Caroline, Gipchtein Pauline, Dehay Benjamin, Bezard Erwan, Melki Ronald, Hantraye Philippe, Aron Badin Romin. Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates. Neurobiology of disease. 2023-03-18. PMID:36933673. |
histology showed a decreased number of dopaminergic tyrosine hydroxylase-positive cells in the substantia nigra to different extents according to the inoculum used. |
2023-03-18 |
2023-08-14 |
Not clear |
| Jiajia Liao, Qinxin Zhang, Jinjun Huang, Honghu He, Jiang Lei, Yuefei Shen, Jin Wang, Yousheng Xia. The emerging role of circular RNAs in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-03-17. PMID:36925739. |
it involves a gradual loss of dopaminergic neurons in the substantia nigra. |
2023-03-17 |
2023-08-14 |
Not clear |
| Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyo. Nigrosome 1 visibility and its association with nigrostriatal dopaminergic loss in Parkinson's disease. European journal of neurology. 2023-03-14. PMID:36915220. |
nigrosome 1 (ng1), a small cluster of dopaminergic cells in the substantia nigra and visible in the susceptibility map weighted mr image (smwi), is severely affected in parkinson's disease (pd). |
2023-03-14 |
2023-08-14 |
Not clear |
| Mustafa Ertuğrul Yaşa, Ali Rıza Sonkaya, Buse Korkmaz, Özge Çoban, Necmiye Ün Yıldırı. Altered Trunk Position Sense and Its Relationship With Spinal Posture and Spinal Mobility in Patients With Parkinson's Disease. Motor control. 2023-03-13. PMID:36913947. |
parkinson's disease (pd), which is characterized by progressive loss of the dopaminergic neurons of the substantia nigra, leads to a variety of motor and nonmotor symptoms throughout the course of the disease. |
2023-03-13 |
2023-08-14 |
Not clear |
| Francesco Cavallieri, Rubens G Cury, Thiago Guimarães, Valentina Fioravanti, Sara Grisanti, Jessica Rossi, Edoardo Monfrini, Marialuisa Zedde, Alessio Di Fonzo, Franco Valzania, Elena Mor. Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope? Cells. vol 12. issue 5. 2023-03-11. PMID:36899899. |
its pathology is characterized by a prominent early death of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of lewy bodies with aggregated α-synuclein. |
2023-03-11 |
2023-08-14 |
Not clear |
| Olga Lebedeva, Daniil Poberezhniy, Ekaterina Novosadova, Tatiana Gerasimova, Lyudmila Novosadova, Elena Arsenyeva, Ekaterina Stepanenko, Darya Shimchenko, Egor Volovikov, Ksenia Anufrieva, Sergey Illarioshkin, Maria Lagarkova, Igor Grivennikov, Vyacheslav Tarantul, Valentina Nenashev. Overexpression of Parkin in the Neuronal Progenitor Cells from a Patient with Parkinson's Disease Shifts the Transcriptome Towards the Normal State. Molecular neurobiology. 2023-03-08. PMID:36884134. |
parkinson's disease (pd) is a neurodegenerative pathology caused by the progressive loss of dopaminergic neurons in the substantia nigra. |
2023-03-08 |
2023-08-14 |
Not clear |
| Tushar Kamath, Evan Z Macosk. Insights into Neurodegeneration in Parkinson's Disease from Single-Cell and Spatial Genomics. Movement disorders : official journal of the Movement Disorder Society. 2023-03-07. PMID:36881930. |
parkinson's disease (pd) is pathologically defined by the death of dopaminergic (da) neurons within the pars compacta of the substantia nigra. |
2023-03-07 |
2023-08-14 |
Not clear |
| Meghan Robinson, Suk-Yu Yau, Lin Sun, Nicole Gabers, Emma Bibault, Brian R Christie, Stephanie M Willert. Optimizing Differentiation Protocols for Producing Dopaminergic Neurons from Human Induced Pluripotent Stem Cells for Tissue Engineering Applications: Supplementary Issue: Stem Cell Biology. Biomarker insights. vol 10 Suppl 1. 2023-03-06. PMID:36876191. |
parkinson's disease (pd) is a neurodegenerative disorder that results when the dopaminergic neurons (dns) present in the substantia nigra necessary for voluntary motor control are depleted, making patients with this disorder ideal candidates for cell replacement therapy. |
2023-03-06 |
2023-08-14 |
human |
| Jayantee Kalita, Abhilasha Tripathi, Mahesh Jadhav, Ravindra S Thakur, Devendra K Pate. A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder. Molecular neurobiology. 2023-03-06. PMID:36879138. |
the central nervous system dopaminergic pathway is not enhanced in nwd, which may be due to structural damage to the corpus striatum and/or substantia nigra. |
2023-03-06 |
2023-08-14 |
Not clear |