| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bobae Hyeon, Heeyoung Lee, Nury Kim, Won Do He. Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons. Molecular brain. vol 16. issue 1. 2023-07-04. PMID:37403137. |
importantly, we successfully modulated ret signaling in dopaminergic neurons of the substantia nigra in the mouse brain. |
2023-07-04 |
2023-08-14 |
mouse |
| Yong-Jie Yan, Hui-Xin Hu, Yi-Jing Zhang, Ling-Ling Wang, Yi-Ming Pan, Simon S Y Lui, Jia Huang, Raymond C K Cha. Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis. European archives of psychiatry and clinical neuroscience. 2023-07-03. PMID:37395812. |
the altered rsfcs in ns group involved regions in the prefrontal lobe, dopaminergic brain regions (ventral tegmental area, substantia nigra), hippocampus, thalamus and cerebellum. |
2023-07-03 |
2023-08-14 |
human |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death in the substantia nigra (sn). |
2023-06-29 |
2023-08-14 |
rat |
| Chen-Pei Lin, Lydian E J Knoop, Irene Frigerio, John G J M Bol, Annemieke J M Rozemuller, Henk W Berendse, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-06-22. PMID:37347552. |
motor and cognitive impairment in parkinson's disease (pd) is associated with dopaminergic dysfunction that stems from substantia nigra (sn) degeneration and concomitant α-synuclein accumulation. |
2023-06-22 |
2023-08-14 |
Not clear |
| Kaoru Yagita, Shoko Sadashima, Sachiko Koyama, Hideko Noguchi, Hideomi Hamasaki, Naokazu Sasagasako, Hiroyuki Hond. Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-06-21. PMID:37340992. |
marinesco bodies (mbs) of dopaminergic neurons in the substantia nigra are also intranuclear structures and are frequently seen in normal elderly people. |
2023-06-21 |
2023-08-14 |
Not clear |
| Dongling Zhang, Liche Zhou, Junye Yao, Yuting Shi, Hongjian He, Hongjiang Wei, Qiqi Tong, Jun Liu, Tao W. Increased Free Water in the Putamen in Idiopathic REM Sleep Behavior Disorder. Movement disorders : official journal of the Movement Disorder Society. 2023-06-21. PMID:37342973. |
it has been suggested that the loss of nigrostriatal dopaminergic axon terminals occurs before the loss of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2023-06-21 |
2023-08-14 |
Not clear |
| Adriano Zanardi da Silva, Dielise Debona Iucksch, Vera Lúcia Israe. Aquatic Dual-Task Training and Its Relation to Motor Functions, Activities of Daily Living, and Quality of Life of Individuals With Parkinson's Disease: A Randomized Clinical Trial. Health services insights. vol 16. 2023-06-19. PMID:37332292. |
parkinson's disease (pd) is a neurodegenerative disorder that impacts the dopaminergic neurons of the substantia nigra, leading to motor and non-motor symptoms, as well as changes in activities of daily living (adl) and quality of life (qol). |
2023-06-19 |
2023-08-14 |
Not clear |
| Sahar Mani, Houda Bouchnak, Solène Pradeloux, Jamil Kraiem, Denis Soulet, Imed Messaoud. 3-aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6-hydroxydopamine models of Parkinson's disease. Clinical and experimental pharmacology & physiology. 2023-06-18. PMID:37331719. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra, for which no disease-modifying treatments are available yet. |
2023-06-18 |
2023-08-14 |
rat |
| Sahar Mani, Houda Bouchnak, Solène Pradeloux, Jamil Kraiem, Denis Soulet, Imed Messaoud. 3-aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6-hydroxydopamine models of Parkinson's disease. Clinical and experimental pharmacology & physiology. 2023-06-18. PMID:37331719. |
most interestingly, phah restored 6-ohda-induced dopaminergic neurodegeneration in the substantia nigra and striatum and ameliorated 6-ohda-induced oxidative stress in the rat brain. |
2023-06-18 |
2023-08-14 |
rat |
| Yueqin Tian, Jianhua Xian, Yuehua Tian, Xiaoya Ga. Establishment of a staging model for Parkinson's disease in mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 4. 2023-06-17. PMID:37329535. |
the results showed that the mice injected with mptp for 3 days had no significant behavioral changes, no significant α-syn aggregation, but reduced th protein expression and 39.5% loss of dopaminergic neurons in the substantia nigra, similar to the performance in the prodromal phase of parkinson's disease. |
2023-06-17 |
2023-08-14 |
mouse |
| Yueqin Tian, Jianhua Xian, Yuehua Tian, Xiaoya Ga. Establishment of a staging model for Parkinson's disease in mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 4. 2023-06-17. PMID:37329535. |
however, the behavior of the mice continuously treated with mptp for 14 days was significantly altered, with significant α-syn aggregation, significant reduction in th protein expression, and 58.1% loss of dopaminergic neurons in the substantia nigra, corresponding to the early clinical stage of parkinson's disease. |
2023-06-17 |
2023-08-14 |
mouse |
| Yueqin Tian, Jianhua Xian, Yuehua Tian, Xiaoya Ga. Establishment of a staging model for Parkinson's disease in mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 4. 2023-06-17. PMID:37329535. |
in the mice that were exposed to mptp for 21 days, the motor impairment was more obvious, the α-syn aggregation was more significant, the reduction of th protein expression was more evident, and the loss of dopaminergic neurons reached 80.5% in the substantia nigra, showing a clinical progression similar to that of parkinson's disease. |
2023-06-17 |
2023-08-14 |
mouse |
| Y-L Guo, X-J Wei, T Zhang, T Su. Molecular mechanisms of melatonin-induced alleviation of synaptic dysfunction and neuroinflammation in Parkinson's disease: a review. European review for medical and pharmacological sciences. vol 27. issue 11. 2023-06-15. PMID:37318481. |
the effectiveness of melatonin (mlt) in the restoration of dopaminergic neurons in the substantia nigra (snc) has been established. |
2023-06-15 |
2023-08-14 |
Not clear |
| Michele Salemi, Filomena Cosentino, Giuseppe Lanza, Mariagiovanna Cantone, Maria Grazia Salluzzo, Giorgio Giurato, Eugenia Borgione, Giovanna Marchese, Sandro Santa Paola, Bartolo Lanuzza, Corrado Romano, Raffaele Ferr. mRNA expression profiling of mitochondrial subunits in subjects with Parkinson's disease. Archives of medical science : AMS. vol 19. issue 3. 2023-06-14. PMID:37313207. |
parkinson's disease (pd) is a common adult-onset neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. |
2023-06-14 |
2023-08-14 |
human |
| Okina Sakakibara, Mikako Shimoda, Gaku Yamamoto, Youichirou Higashi, Mayumi Ikeda-Imafuku, Yu Ishima, Masahiro Kawahara, Ken-Ichiro Tanak. Effectiveness of Albumin-Fused Thioredoxin against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298708. |
parkinson's disease (pd) is a neurodegenerative disorder caused by oxidative stress-dependent loss of dopaminergic neurons in the substantia nigra and elevated microglial inflammatory responses. |
2023-06-11 |
2023-08-14 |
Not clear |
| Diego Cabezudo, George Tsafaras, Eva Van Acker, Chris Van den Haute, Veerle Baekeland. Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis. Acta neuropathologica. 2023-06-08. PMID:37289222. |
finally, combination of experimental colitis with overexpression of α-synuclein in the substantia nigra aggravated motor deficits and dopaminergic neurodegeneration in g2019s knock-in mice. |
2023-06-08 |
2023-08-14 |
mouse |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali K Al-Buhadily, Ali I Al-Gareeb, Engy Elekhnawy, Gaber El-Saber Batih. DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson's disease: a mutual relationship. Pharmacological reports : PR. 2023-06-03. PMID:37269487. |
parkinson's disease (pd) usually occurs due to the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-06-03 |
2023-08-14 |
Not clear |
| Mohamed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Nada A Ashour, Majid S Jabir, Walaa A Negm, Gaber El-Saber Batih. Metformin role in Parkinson's disease: a double-sword effect. Molecular and cellular biochemistry. 2023-06-02. PMID:37266747. |
parkinson's disease (pd) is a common neurodegenerative disease developed due to the degeneration of dopaminergic neurons in the substantia nigra. |
2023-06-02 |
2023-08-14 |
Not clear |
| Benxu Ma, Jianying Zhang, Yanlei Cui, Huanmin Ga. The Anatomy and Clinical Significance of Sensory Disturbance in Parkinson's Disease. Journal of integrative neuroscience. vol 22. issue 3. 2023-05-31. PMID:37258441. |
this change in retinal pigment cells has many similarities to the degeneration of dopaminergic neurons in the substantia nigra in pd. |
2023-05-31 |
2023-08-14 |
human |
| Yea-Hyun Leem, Do-Yeon Kim, Jung-Eun Park, Hee-Sun Ki. Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-05-31. PMID:37258791. |
furthermore, nsa inhibited the phosphorylation, ubiquitylation, and oligomerization of mlkl, all of which are associated with mlkl cell death-inducing activity in dopaminergic cells in the substantia nigra (sn). |
2023-05-31 |
2023-08-14 |
mouse |