| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xi. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell death discovery. vol 9. issue 1. 2023-10-21. PMID:37865662. |
however, a much severer olfactory dysfunction was observed without severer pathology in olfactory bulb when the loss of dopaminergic neurons in the substantia nigra occurred. |
2023-10-21 |
2023-11-08 |
mouse |
| Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xi. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell death discovery. vol 9. issue 1. 2023-10-21. PMID:37865662. |
then, we established the mice models by intrastriatal α-synuclein preformed fibrils injection and demonstrated the performance in the olfactory discrimination test was correlated to the loss of dopaminergic neurons in the substantia nigra, without any changes in the olfactory bulb analyzed by rna-sequence. |
2023-10-21 |
2023-11-08 |
mouse |
| Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xi. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell death discovery. vol 9. issue 1. 2023-10-21. PMID:37865662. |
in mice with intranasal ferric ammonium citrate administration, we observed olfactory dysfunction when dopaminergic neurodegeneration in substantia nigra occurred and was restored when dopaminergic neurons were rescued. |
2023-10-21 |
2023-11-08 |
mouse |
| Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xi. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell death discovery. vol 9. issue 1. 2023-10-21. PMID:37865662. |
finally we demonstrated that chemogenetic inhibition of dopaminergic neurons in the substantia nigra was sufficient to cause hyposmia and motor incoordination. |
2023-10-21 |
2023-11-08 |
mouse |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Ieshita Pan, Praveen Kumar Issac, Md Mostafizur Rahman, Ajay Guru, Jesu Arockiara. Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases. Molecular neurobiology. 2023-10-18. PMID:37851313. |
parkinson's disease is a chronic neuropathy characterised by the formation of lewy bodies (misfolded alpha-synuclein) in dopaminergic neurons of the substantia nigra and other parts of the brain. |
2023-10-18 |
2023-11-08 |
Not clear |
| Jinmei Sun, Wei Zhang, Zheng Zachory Wei, Xiaopeng Song, Liu Jian, Feng Jiang, Shuanglin Wang, Haibo Li, Yongbo Zhang, Houzhen Tu. Mesenchymal stromal cell biotherapy for Parkinson's disease premotor symptoms. Chinese neurosurgical journal. vol 9. issue 1. 2023-10-14. PMID:37833807. |
pathological change of progressive pd includes degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2023-10-14 |
2023-10-15 |
Not clear |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-10-11. PMID:37820786. |
parkinson's disease (pd) is characterized by motor impairments and progressive dopaminergic neuronal death in the substantia nigra (sn). |
2023-10-11 |
2023-10-15 |
rat |
| Romain Geelhand de Merxem, Sandrine Launay, Catherine Hana. Association Between Bipolar Disorder and Parkinson's Disease. Psychiatria Danubina. vol 35. issue Suppl 2. 2023-10-06. PMID:37800205. |
similarly, parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra, resulting in motor symptoms. |
2023-10-06 |
2023-10-07 |
Not clear |
| Ali Sarbazi-Golezari, Hashem Haghdoost-Yazd. Retraction Note: Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta. Metabolic brain disease. 2023-09-26. PMID:37751123. |
retraction note: chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta. |
2023-09-26 |
2023-10-07 |
Not clear |
| Xv-Shen Ding, Li Gao, Zheng Han, Simona Eleuteri, Wei Shi, Yun Shen, Zi-Yao Song, Mingming Su, Qian Yang, Yan Qu, David K Simon, Xue-Lian Wang, Bao Wan. Ferroptosis in Parkinson's Disease: Molecular Mechanisms and Therapeutic Potential. Ageing research reviews. 2023-09-24. PMID:37742785. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), leading to motor and non-motor symptoms. |
2023-09-24 |
2023-10-07 |
Not clear |
| b' Oriol de F\\xc3\\xa0bregues, Maria Sell\\xc3\\xa9s, David Ramos-Vicente, Gerard Roch, Miquel Vila, Jordi Bov\\xc3\\xa. Relevance of tissue-resident memory CD8 T cells in the onset of Parkinson\'s disease and examination of its possible etiologies: infectious or autoimmune? Neurobiology of disease. 2023-09-23. PMID:37741513.' |
a recently published study demonstrated that cd8 t cells with markers of residency containing distinct granzymes and interferon-γ infiltrate the parenchyma of the substantia nigra and contact dopaminergic neurons in an early premotor stage of parkinson's disease. |
2023-09-23 |
2023-10-07 |
Not clear |
| Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Za. FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA. Journal of translational medicine. vol 21. issue 1. 2023-09-22. PMID:37737187. |
parkinson's disease (pd), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. |
2023-09-22 |
2023-10-07 |
human |
| Michaëla Majcin Dorcikova, Lou C Duret, Emma Pottié, Emi Nagosh. Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37737209. |
sleep and circadian rhythm disruptions are frequent comorbidities of parkinson's disease (pd), a disorder characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2023-09-22 |
2023-10-07 |
drosophila_melanogaster |
| Ayaka Fujimaki, Kazuki Ohuchi, Shinnosuke Takizawa, Takanori Murakami, Hisaka Kurita, Isao Hozumi, Xiaopeng Wen, Yoshihisa Kitamura, Zhiliang Wu, Yoichi Maekawa, Masatoshi Inde. The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells. Scientific reports. vol 13. issue 1. 2023-09-21. PMID:37731009. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. |
2023-09-21 |
2023-10-07 |
Not clear |
| Amin A Hafi. The neuroprotective effect of vitamin D in Parkinson's disease: association or causation. Nutritional neuroscience. 2023-09-21. PMID:37731327. |
parkinson's disease (pd) is a chronic neurodegenerative disease (ndd) due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-09-21 |
2023-10-07 |
Not clear |
| Anna Alwani, Katarzyna Maziarz, Gabriela Burda, Monika Jankowska-Kiełtyka, Adam Roman, Gabriela Łyszczarz, Safak Er, Justyna Barut, Olga Barczyk-Woźnicka, Elżbieta Pyza, Grzegorz Kreiner, Irena Nalepa, Piotr Chmielar. Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model. Pharmacological reports : PR. 2023-09-19. PMID:37725330. |
parkinson's disease (pd) is a motor disorder characterized by the degeneration of dopaminergic neurons, putatively due to the accumulation of α-synuclein (α-syn) in lewy bodies (lbs) in substantia nigra. |
2023-09-19 |
2023-10-07 |
mouse |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
despite this superficial connection, the possible role(s) of ferroptosis-related (fr) proteins in dopaminergic neurons and/or glial cells in the substantia nigra (sn) in pd have not been examined in depth. |
2023-09-16 |
2023-10-07 |
human |
| Yu Jin Shin, Yeon Ju Kim, Ji Eun Lee, Yi Seul Kim, Jung Wook Lee, HyeonJeong Kim, Jin Young Shin, Phil Hyu Le. Uric acid regulates α-synuclein transmission in Parkinsonian models. Frontiers in aging neuroscience. vol 15. 2023-09-15. PMID:37711993. |
moreover, ua elevation in α-syn-inoculated mice inhibited propagation of extracellular α-syn which decreased expression of phosphorylated α-syn in the dopaminergic neurons of the substantia nigra leading to their increased survival. |
2023-09-15 |
2023-10-07 |
mouse |
| Abhimannu Shome, Chahat, Viney Chawla, Pooja A Chawl. Neuroprotective Effect of Natural Indole and β-carboline Alkaloids against Parkinson's Disease: An Overview. Current medicinal chemistry. 2023-09-13. PMID:37702172. |
parkinson's disease (pd) is a devastating neurodegenerative condition that mostly damages dopaminergic neurons in the substantia nigra and impairs human motor function. |
2023-09-13 |
2023-10-07 |
human |