| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danlei Wang, Hongling Gao, Qixiong Qin, Jingyi Li, Jingwei Zhao, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Zhijuan Mao, Zheng Xu. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease. Journal of translational medicine. vol 22. issue 1. 2024-01-16. PMID:38229084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-16 |
2024-01-19 |
mouse |
| Elena S Yarkova, Elena V Grigor'eva, Sergey P Medvedev, Sophia V Pavlova, Suren M Zakian, Anastasia A Malakhov. IPSC-Derived Astrocytes Contribute to In Vitro Modeling of Parkinson's Disease Caused by the International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203497. |
recently, there has been an increase in data regarding the involvement of not only dopaminergic neurons of the substantia nigra but also astrocytes in the pathogenesis of pd. |
2024-01-11 |
2024-01-13 |
Not clear |
| Kamil Saramowicz, Natalia Siwecka, Grzegorz Galita, Aleksandra Kucharska-Lusina, Wioletta Rozpędek-Kamińska, Ireneusz Majstere. Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson's Disease. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203531. |
parkinson's disease (pd) is a complex neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the widespread accumulation of alpha-synuclein (αsyn) protein aggregates. |
2024-01-11 |
2024-01-13 |
Not clear |
| Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G Beaumont, Robert Sebra, Claudia De Sanctis, John F Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph Powell, David A Davis, Xiaoyan Sun, Bin Zhang, Zhenyu Yu. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease. Science advances. vol 10. issue 2. 2024-01-10. PMID:38198537. |
parkinson's disease (pd) is characterized pathologically by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-10 |
2024-01-13 |
human |
| Ge Shi, Chunhui Zhang, Xinghua Bai, Jian Sun, KaiDong Wang, Qi Meng, Yang Li, Guiling Hu, Rong Hu, Qian Cai, Min Huan. A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure. Environmental toxicology. 2024-01-08. PMID:38189626. |
in addition, we observed the fluorescence intensity enhancement of iba-1 activated microglia with released pro-inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. |
2024-01-08 |
2024-01-10 |
mouse |
| Wang Wang, Yang Zhao, Guoxue Zh. The role of sphingosine-1-phosphate in the development and progression of Parkinson's disease. Frontiers in cellular neuroscience. vol 17. 2024-01-05. PMID:38179204. |
although the loss of dopaminergic neurons in the substantia nigra is the major clinical manifestation of pd, the etiology of it is largely unknown. |
2024-01-05 |
2024-01-07 |
Not clear |
| Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wan. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson's disease mice model. Folia neuropathologica. 2024-01-04. PMID:38174686. |
using open field, rotarod, and pole climbing tests, we have found that b-ecd alleviates motor disorder in mptp/pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra (sn). |
2024-01-04 |
2024-01-06 |
mouse |
| Ramesha Hanumanthappa, Deepa Mugudthi Venugopal, Nethravathi P C, Ahesanulla Shaikh, Siddaiah B M, Geetha B Heggannavar, Akshay A Patil, Hemalatha Nanjaiah, D Suresh, Mahadevappa Y Kariduraganavar, Shamprasad Varija Raghu, Kuramkote Shivanna Devaraj. Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a ACS omega. vol 8. issue 50. 2023-12-25. PMID:38144104. |
the disease is characterized by the loss of dopaminergic neurons in the substantia nigra, pars compacta of the midbrain. |
2023-12-25 |
2023-12-27 |
Not clear |
| Sora Kang, Youngjin Noh, Seung Jun Oh, Hye Ji Yoon, Suyeol Im, Hung Taeck Kwon, Youngmi Kim Pa. Neuroprotective Effects of Aldehyde-Reducing Composition in an LPS-Induced Neuroinflammation Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 28. issue 24. 2023-12-23. PMID:38138478. |
oral administration of arc at 10 or 20 units/kg/day for 3 days prior to intraperitoneal injection of lps (10 mg/kg) effectively preserved dopaminergic neurons in the substantia nigra (sn) and striatum by preventing lps-induced cell death. |
2023-12-23 |
2023-12-25 |
Not clear |
| Nianping Zhang, Zhaoli Yan, Hua Xin, Shuai Shao, Song Xue, Raymond Cespuglio, Shijun Wan. Relationship among α‑synuclein, aging and inflammation in Parkinson's disease (Review). Experimental and therapeutic medicine. vol 27. issue 1. 2023-12-21. PMID:38125364. |
the main pathological characteristics of pd are the selective death of dopaminergic (da) neurons in the pars compacta of the substantia nigra and the presence of lewy bodies containing α-synuclein (α-syn) within these neurons. |
2023-12-21 |
2023-12-23 |
Not clear |
| Nikolai I Novikov, Elena S Brazhnik, Valentina F Kitchigin. Pathological Correlates of Cognitive Decline in Parkinson's Disease: From Molecules to Neural Networks. Biochemistry. Biokhimiia. vol 88. issue 11. 2023-12-19. PMID:38105206. |
parkinson's disease (pd) is a progressive neurodegenerative disorder caused by the death of dopaminergic neurons in the substantia nigra and appearance of protein aggregates (lewy bodies) consisting predominantly of α-synuclein in neurons. |
2023-12-19 |
2023-12-21 |
Not clear |
| Nikolai I Novikov, Elena S Brazhnik, Valentina F Kitchigin. Pathological Correlates of Cognitive Decline in Parkinson's Disease: From Molecules to Neural Networks. Biochemistry. Biokhimiia. vol 88. issue 11. 2023-12-19. PMID:38105206. |
these changes can lead to the death of dopaminergic cells in the substantia nigra and affect the functioning of other neurotransmitter systems, thus disturbing neuronal networks involved in the transmission of information related to the regulation of motor activity and cognitive functions. |
2023-12-19 |
2023-12-21 |
Not clear |
| Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimiz. Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease. American journal of physiology. Gastrointestinal and liver physiology. 2023-12-19. PMID:38111988. |
pd model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the substantia nigra. |
2023-12-19 |
2023-12-21 |
rat |
| Shruti Rajan, Anika Sood, Rachit Jain, Kamatham Pushpa Tryphena, Dharmendra Kumar Khatr. Fingolimod exerts neuroprotection by regulating S1PR1 mediated BNIP3-PINK1-Parkin dependent mitophagy in rotenone induced mouse model of Parkinson's disease. Neuroscience letters. 2023-12-15. PMID:38101611. |
the motor impairments brought on by the loss of dopaminergic neurons in the substantia nigra are the most well-known symptoms of parkinson's disease (pd). |
2023-12-15 |
2023-12-18 |
mouse |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
the stem cell treatment group had significantly more tyrosine hydroxylase positive dopaminergic neurons in the striatum ([95% ci] = 1.04 [0.59 to 1.49], p = 0.0001, i2 = 65.1 %) and substantia nigra (smd [95% ci] = 1.38 [0.89 to 1.87], p = 0.0001, i2 = 75.3 %), indicating a protective effect on dopaminergic neurons. |
2023-12-05 |
2023-12-10 |
Not clear |
| Mohammad Yasin Zamanian, Mehraveh Sadeghi Ivraghi, Reena Gupta, K D V Prasad, Hashem O Alsaab, Beneen M Hussien, Hazem Ahmed, Montather F Ramadan, Maryam Golmohammadi, Nikta Nikbakht, Tuba Oz, Małgorzata Kujawsk. miR-221 and Parkinson's disease: A biomarker with therapeutic potential. The European journal of neuroscience. 2023-12-03. PMID:38043936. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to various motor and non-motor symptoms. |
2023-12-03 |
2023-12-10 |
Not clear |
| Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi L. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-12-02. PMID:38041169. |
parkinson's disease (pd), one of the most devastating neurodegenerative brain disorders, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) and deposits of α-synuclein aggregates. |
2023-12-02 |
2023-12-10 |
mouse |
| Rupert D Smit, Biswarup Ghosh, Thomas J Campion, Rachel Stingel, Emily Lavell, Robert Hooper, Xiaoxuan Fan, Jonathan Soboloff, George M Smit. STAT3 protects dopaminergic neurons against degeneration in animal model of Parkinson's disease. Brain research. vol 1824. 2023-12-01. PMID:38030102. |
parkinson's disease (pd) is the most prevalent disorder of the basal ganglia, propagated by the degeneration of axon terminals within the striatum and subsequent loss of dopaminergic neurons in the substantia nigra (sn). |
2023-12-01 |
2023-12-10 |
Not clear |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Heat Shock Protein 90 in Parkinson's disease: Profile of a serial killer. Neuroscience. 2023-12-01. PMID:38040085. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by abnormal α-synuclein misfolding and aggregation, mitochondrial dysfunction, oxidative stress, as well as progressive death of dopaminergic neurons in the substantia nigra. |
2023-12-01 |
2023-12-10 |
Not clear |
| Shruti S Bhoge, Pallavi Harjpal, Swati Gupt. Physiotherapy Approach to a Stage V Parkinson's Disease Patient: A Case Report. Cureus. vol 15. issue 10. 2023-12-01. PMID:38022080. |
there is a death of dopamine-producing neurons (dopaminergic neurons) in the substantia nigra. |
2023-12-01 |
2023-12-07 |
Not clear |