| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Júlia Leão Batista Simões, Geórgia de Carvalho Braga, Samantha Webler Eichler, Gilnei Bruno da Silva, Margarete Dulce Bagatin. Implications of COVID-19 in Parkinson's disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration. Purinergic signalling. 2024-03-09. PMID:38460075. |
the pathophysiology of parkinson's disease (pd) is marked by degeneration of dopaminergic neurons in the substantia nigra. |
2024-03-09 |
2024-03-12 |
Not clear |
| Saumya Maheshwari, Harith Akram, Harry Bulstrode, Suneil K Kalia, Asuka Morizane, Jun Takahashi, Ammar Natalwal. Dopaminergic Cell Replacement for Parkinson's Disease: Addressing the Intracranial Delivery Hurdle. Journal of Parkinson's disease. 2024-03-08. PMID:38457149. |
α-synucleinopathy in pd is considered to cause dopaminergic neuronal loss in the substantia nigra, resulting in characteristic motor dysfunction that is the target for current medical and surgical therapies. |
2024-03-08 |
2024-03-10 |
Not clear |
| Junhyeong Yim, Yoon Soo Hwang, Jae-Jin Lee, Ju Hee Kim, Jeong Yeob Baek, Jaeyeong Jeong, Young Il Choi, Byung Kwan Jin, Seung Bum Par. Inflachromene ameliorates Parkinson's disease by targeting Nrf2-binding Keap1. Chemical science. vol 15. issue 10. 2024-03-08. PMID:38455026. |
despite current therapeutic efforts, pd progression and the loss of dopaminergic neurons in the substantia nigra remain challenging to prevent due to the complex and unclear molecular mechanism involved. |
2024-03-08 |
2024-03-10 |
Not clear |
| Yina Jia, Jing Li, Yutong Wang, Yiqing Ma, Lei Chen, Huaqi Zhang, Meilan Xue, Hui Lian. Folic Acid Rescues Dopaminergic Neurons in MPTP-Induced Mice by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. Journal of agricultural and food chemistry. 2024-03-07. PMID:38453725. |
parkinson's disease (pd) is marked by the degeneration of dopaminergic neurons of the substantia nigra (sn), with neuroinflammation and mitochondrial dysfunction being key contributors. |
2024-03-07 |
2024-03-10 |
mouse |
| Juan Carlos Rubilar, Tiago Fleming Outeiro, Andrés D Klei. The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson's therapeutics. Brain : a journal of neurology. 2024-03-04. PMID:38437875. |
parkinson's disease (pd) is a neurodegenerative disorder primarily known for typical motor features that arise due to the loss of dopaminergic neurons in the substantia nigra. |
2024-03-04 |
2024-03-07 |
Not clear |
| Noah Lubben, Julia K Brynildsen, Connor M Webb, Howard L Li, Cheryl E G Leyns, Lakshmi Changolkar, Bin Zhang, Emily S Meymand, Mia O'Reilly, Zach Madaj, Daniella DeWeerd, Matthew J Fell, Virginia M Y Lee, Dani S Bassett, Michael X Henderso. LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression. Translational neurodegeneration. vol 13. issue 1. 2024-03-04. PMID:38438877. |
lrrk2-pd patients consistently present with loss of dopaminergic neurons in the substantia nigra but show variable development of lewy body or tau tangle pathology. |
2024-03-04 |
2024-03-07 |
mouse |
| Samir Ranjan Panda, Pallabi Panja, Ujjawal Soni, V G M Naid. Neurobehavioral Analysis to Assess Olfactory and Motor Dysfunction in Parkinson's Disease. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427259. |
the striatum, a structure essential for motor control, is impaired in function due to the significant loss of dopaminergic neurons in the substantia nigra and the development of lewy bodies in the surviving nigral dopaminergic neurons. |
2024-03-01 |
2024-03-03 |
Not clear |
| Ankul Singh S, Aarita Sood, Chitra Vellapandia. The Role of Ocimene in Decreasing α-Synuclein Aggregation using Rotenone-induced Rat Model. Central nervous system agents in medicinal chemistry. 2024-02-27. PMID:38409725. |
parkinson's disease is defined by the loss of dopaminergic neurons in the midbrain of substantia nigra associated with lewy bodies. |
2024-02-27 |
2024-03-02 |
rat |
| Poojitha Pinjala, Kamatham Pushpa Tryphena, Amrita Kulkarni, Prince Giri Goswami, Dharmendra Kumar Khatr. Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP Journal of Alzheimer's disease reports. vol 8. issue 1. 2024-02-26. PMID:38405353. |
dimethyl fumarate exerts a neuroprotective effect by enhancing mitophagy via the nrf2/bnip3/pink1 axis in the mpp parkinson's disease (pd) is a progressive neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. |
2024-02-26 |
2024-02-28 |
Not clear |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405952. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-02-26 |
2024-02-28 |
Not clear |
| Fatema Currim, Shatakshi Shukla, Jyoti Singh, Dhruv Gohel, Minal Mane, Anjali Shinde, Milton Roy, Shani Goyani, Hitesh Vasiyani, Aswathy Chandran, Jean-Christophe Rochet, Jason Cannon, Rajesh Sing. Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions. Neurotoxicology. 2024-02-24. PMID:38401688. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra part of the brain. |
2024-02-24 |
2024-02-27 |
Not clear |
| Hadeel Khamis, Ohad Cohe. Coupled action potential and calcium dynamics underlie robust spontaneous firing in dopaminergic neurons. Physical biology. 2024-02-21. PMID:38382117. |
dopaminergic neurons are specialized cells in the substantia nigra, tasked with dopamine secretion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Rita Yu-Tzu Chen, Rebekah C Evan. Comparing tonic and phasic dendritic calcium in cholinergic pedunculopontine neurons and dopaminergic substantia nigra neurons. The European journal of neuroscience. 2024-02-21. PMID:38383047. |
comparing tonic and phasic dendritic calcium in cholinergic pedunculopontine neurons and dopaminergic substantia nigra neurons. |
2024-02-21 |
2024-02-24 |
Not clear |
| Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Sing. Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation. Ageing research reviews. 2024-02-18. PMID:38369026. |
post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of nft, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. |
2024-02-18 |
2024-02-21 |
human |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| Areej Turkistani, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Athanasios Alexiou, Marios Papadakis, Mohamed M Elfiky, Hebatallah M Saad, Gaber El-Saber Batih. Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue. Molecular neurobiology. 2024-02-17. PMID:38367137. |
parkinson's disease (pd) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-02-17 |
2024-02-20 |
Not clear |
| Audrey A Omidsalar, Carmel G McCullough, Lili Xu, Stanley Boedijono, Daniel Gerke, Michelle G Webb, Zarko Manojlovic, Adolfo Sequeira, Mark F Lew, Marco Santorelli, Geidy E Serrano, Thomas G Beach, Agenor Limon, Marquis P Vawter, Brooke E Hjel. Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets. Communications biology. vol 7. issue 1. 2024-02-17. PMID:38368460. |
a robust evaluation of 1570 samples from 14 rna-seq studies showed: (i) the abundance of some common deletions detected in pcr-amplified mtdna correlates with levels observed in rna-seq data; (ii) rna-seq library preparation method has a strong effect on deletion detection; (iii) deletions had a significant, positive correlation with age in brain and muscle; (iv) deletions were enriched in cortical grey matter, specifically in layers 3 and 5; and (v) brain regions with dopaminergic neurons (i.e., substantia nigra, ventral tegmental area, and caudate nucleus) had remarkable enrichment of common mtdna deletions. |
2024-02-17 |
2024-02-20 |
human |
| Chayan Banerjee, Raju Barman, Priya Darshani, Meghana Pillai, Sanchi Ahuja, Rupsha Mondal, V S Pragadheesh, Joy Chakraborty, Deepak Kuma. α-Viniferin, a dietary phytochemical, inhibits monoamine oxidase and alleviates Parkinson's disease-associated behavioral deficits in a mice model. Neurochemistry international. 2024-02-16. PMID:38364939. |
behavioral complexities worsen over time due to progressive dopaminergic (dargic) neuronal loss at substantia nigra region of brain. |
2024-02-16 |
2024-02-19 |
mouse |
| Pinky D Israni, Vaishnavi Yadav, Anam R Sasu. Effectiveness of Neurorehabilitation in Improving the Functional Recovery and Quality of Life of Patients With Parkinson's Disease: A Case Report. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344634. |
key neuropathological findings include lewy bodies containing synuclein and the loss of dopaminergic neurons in the substantia nigra, reducing the facilitation of voluntary movements. |
2024-02-13 |
2024-02-15 |
Not clear |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. |
2024-02-13 |
2024-02-16 |
mouse |