| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanxin Li, Yang Zhang, Zhengqian Chen, Ruyong Yao, Zhongqiu Xu, Can Xu, Fujie He, Haitao Pei, Cui Ha. SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury. Heliyon. vol 9. issue 11. 2023-12-01. PMID:38027872. |
parkinson's disease (pd) is the second most common neurodegenerative disease in the world, which is distinguished by the loss of dopaminergic (da) neurons in the substantia nigra and the formation of intraneuronal. |
2023-12-01 |
2023-12-10 |
mouse |
| Shruti S Bhoge, Pallavi Harjpal, Swati Gupt. Physiotherapy Approach to a Stage V Parkinson's Disease Patient: A Case Report. Cureus. vol 15. issue 10. 2023-12-01. PMID:38022080. |
there is a death of dopamine-producing neurons (dopaminergic neurons) in the substantia nigra. |
2023-11-29 |
2023-12-07 |
Not clear |
| Priyanshu Sharma, Payal Mitta. Paraquat (herbicide) as a cause of Parkinson's Disease. Parkinsonism & related disorders. 2023-11-26. PMID:38008593. |
the pathogenic causes of parkinsonism include lewy bodies, intracellular protein clumps of αsynuclein, and the degeneration of dopaminergic neurons in the substantia nigra's pars compacta region. |
2023-11-26 |
2023-11-28 |
Not clear |
| Serena Silvestro, Ivana Raffaele, Emanuela Mazzo. Modulating Stress Proteins in Response to Therapeutic Interventions for Parkinson's Disease. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003423. |
parkinson's disease (pd) is a neurodegenerative illness characterized by the degeneration of dopaminergic neurons in the substantia nigra, resulting in motor symptoms and without debilitating motors. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yaping Chu, Warren D Hirst, Howard J Federoff, Ashley S Harms, A Jon Stoessl, Jeffrey H Kordowe. Nigrostriatal tau pathology in parkinsonism and Parkinson's disease. Brain : a journal of neurology. 2023-11-25. PMID:38006313. |
here we demonstrate that loss of nigral dopaminergic neurons, loss of putamenal dopaminergic innervation, and loss of th-phenotype in the substantia nigra and putamen occur equally in mild motor deficit groups with and without nigral alpha-synuclein aggregates. |
2023-11-25 |
2023-11-28 |
human |
| Zhixin Xiao, Xiaoya Wang, Xuening Pan, Junxia Xie, Huamin X. Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease. Experimental neurology. 2023-11-25. PMID:38007207. |
understanding how iron damages dopaminergic neurons in the substantia nigra (sn) of pd is particularly important for developing targeted neurotherapeutic strategies for the disease. |
2023-11-25 |
2023-11-28 |
Not clear |
| De-Wen Kong, Li-da Du, Run-Zhe Liu, Tian-Yi Yuan, Shou-Bao Wang, Yue-Hua Wang, Yang Lu, Lian-Hua Fang, Guan-Hua D. Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels. Acta pharmacologica Sinica. 2023-11-22. PMID:37993535. |
dopaminergic neurons in the substantia nigra (sn) expressing sur1/kir6.2 type atp-sensitive potassium channels (k-atp) are more vulnerable to rotenone or metabolic stress, which may be an important reason for the selective degeneration of neurons in parkinson's disease (pd). |
2023-11-22 |
2023-11-29 |
Not clear |
| Zhiyong Liu, Arpine Sokratian, Addison M Duda, Enquan Xu, Christina Stanhope, Amber Fu, Samuel Strader, Huizhong Li, Yuan Yuan, Benjamin G Bobay, Joana Sipe, Ketty Bai, Iben Lundgaard, Na Liu, Belinda Hernandez, Catherine Bowes Rickman, Sara E Miller, Andrew B Wes. Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation. Science advances. vol 9. issue 46. 2023-11-17. PMID:37976362. |
in mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra. |
2023-11-17 |
2023-11-20 |
mouse |
| Haneen Y Khidr, Noha F Hassan, S S Abdelrahman, Mona R El-Ansary, Mohammed F El-Yamany, Mostafa A Rabi. Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis. International immunopharmacology. vol 125. issue Pt B. 2023-11-13. PMID:37956489. |
formoterol treatment succeeded in upregulating β2-adrenoreceptor expression in pd rats and preserving the function and integrity of dopaminergic neurons as witnessed by enhancement of muscular performance in tests, open field, grip strength-meter, and rotarod, besides the increment in substantia nigra and striatal tyrosine hydroxylase immunoexpression. |
2023-11-13 |
2023-11-20 |
rat |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
deep learning-based image analysis identifies a dat-negative subpopulation of dopaminergic neurons in the lateral substantia nigra. |
2023-11-10 |
2023-11-20 |
mouse |
| Julia J Meerman, Juliette Legler, Aldert H Piersma, Remco H S Westerink, Harm J Heusinkvel. An Adverse Outcome Pathway for Chemical-induced Parkinson's disease: Calcium is Key. Neurotoxicology. 2023-11-05. PMID:37926220. |
pd symptoms are caused by loss of function and ultimately death of dopaminergic neurons in the substantia nigra (sn). |
2023-11-05 |
2023-11-08 |
human |
| Zhaoyang Liu, Jessica Lemus, Irina V Smirnova, Wen Li. Rehabilitation for non-motor symptoms for patients with Parkinson's disease from an α-synuclein perspective: a narrative review. Exploration of neuroprotective therapy. vol 3. issue 4. 2023-11-03. PMID:37920444. |
pd is characterized by neuronal lewy bodies present in the substantia nigra of the midbrain and the loss of dopaminergic neurons with various motor and non-motor symptoms associated with the disease. |
2023-11-03 |
2023-11-08 |
Not clear |
| Jiahua Yang, Chenchen Du, Yinghui Li, Rong Liu, Cuiting Jing, Junxia Xie, Jun Wan. Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1β-Induced Iron Regulatory Protein 1. Neurochemical research. 2023-11-02. PMID:37917337. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of iron in the substantia nigra. |
2023-11-02 |
2023-11-08 |
Not clear |
| Yasemin Açar, Duygu Ağagündüz, Paola De Cicco, Raffaele Capass. Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-01. PMID:37913731. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by the degeneration of progressive dopaminergic (da) neurons in the substantia nigra region of the human midbrain. |
2023-11-01 |
2023-11-08 |
human |
| Feng-Dan Zhu, Bin-Ding Wang, Da-Lian Qin, Xiao-Hui Su, Lu Yu, Jian-Ming Wu, Betty Yuen-Kwan Law, Min-Song Guo, Chong-Lin Yu, Xiao-Gang Zhou, An-Guo W. Carpesii fructus extract exhibits neuroprotective effects in cellular and Caenorhabditis elegans models of Parkinson's disease. CNS neuroscience & therapeutics. 2023-10-31. PMID:37905594. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2023-10-31 |
2023-11-08 |
caenorhabditis_elegans |
| Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Nataliia V Katolikova, Anastasia N Vaganova, Daria D Shafranskaya, Evgeniya V Efimova, Anna B Malashicheva, Raul R Gainetdino. Expression Pattern of Trace Amine-Associated Receptors during Differentiation of Human Pluripotent Stem Cells to Dopaminergic Neurons. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894992. |
in our work we analyzed the expression of taars (taar1, taar2, taar5, taar6, taar8 and taar9) in cells from the human substantia nigra and ventral tegmental areas and in human pluripotent stem cells at consecutive stages of their differentiation to dopaminergic neurons, using rna sequencing data from open databases, and taqman pcr data from the differentiation of human induced pluripotent stem cells in vitro. |
2023-10-30 |
2023-11-08 |
human |
| Su Hyoun Lee, Kwang Chul Chun. USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7. PloS one. vol 18. issue 10. 2023-10-27. PMID:37874827. |
parkinson's disease (pd) is a common neurodegenerative disease (ndd) characterized by the loss of dopaminergic neurons in the substantia nigra. |
2023-10-27 |
2023-11-08 |
Not clear |
| Zhiyong Liu, Arpine Sokratian, Addison Duda, Enquan Xu, Christina Stanhope, Amber Fu, Samuel Strader, Huizhong Li, Yuan Yuan, Benjamin Bobay, Joana Sipe, Ketty Bai, Iben Lundgaard, Na Liu, Belinda Hernandez, Catherine Bowes Rickman, Sara Miller, Andrew Wes. Anionic Nanoplastic Contaminants Promote Parkinson's Disease-Associated α-Synuclein Aggregation. Research square. 2023-10-27. PMID:37886561. |
in mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra. |
2023-10-27 |
2023-11-08 |
mouse |
| Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xi. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell death discovery. vol 9. issue 1. 2023-10-21. PMID:37865662. |
dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of parkinson's disease. |
2023-10-21 |
2023-11-08 |
mouse |