| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liaqat Hussain, Ina Masood, Matloob Ahmad, Muhammad Yasir Ali, Uzma Saleem, Musaddique Hussain, Syed Haroon Khalid, Zunera Chauhdar. Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies. Toxicology and applied pharmacology. 2023-09-08. PMID:37683697. |
in parkinson's disease (pd), degradation of dopaminergic neurons in substantia nigra causes striatal deficiency of dopamine, which results in tremors, bradykinesia with instability in posture, rigidity and shuffled gait. |
2023-09-08 |
2023-10-07 |
mouse |
| Ze-Xian Yang, Yu Zhang, Qing Wang, Lei Zhang, Yi-Fei Liu, Ye Zhang, Yu Ren, Chen Zhou, Hui-Wen Gao, Nai-Xia Zhang, Lin-Yin Fen. Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems. Acta pharmacologica Sinica. 2023-09-08. PMID:37684382. |
particularly in a53t mice, pff induced significant behavioral disorders, intestinal inflammation, α-synuclein deposition, microbiota dysbiosis, glial activation as well as degeneration of dopaminergic neurons in the substantia nigra. |
2023-09-08 |
2023-10-07 |
mouse |
| Ashley Adamson, Neda Ilieva, William J Stone, Briana R De Mirand. Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents. Toxicological sciences : an official journal of the Society of Toxicology. 2023-09-05. PMID:37669148. |
tce exposure also induced accumulation of pser129-αsyn in dopaminergic neurons as well as microglial activation within the substantia nigra of rats. |
2023-09-05 |
2023-10-07 |
mouse |
| Dong Yeol Kim, Jin Young Shin, Ji Eun Lee, Ha Na Kim, Seok Jong Chung, Han Soo Yoo, Sang Jin Kim, Hwa Jin Cho, Eun-Jae Lee, Soo Jeong Nam, Seong Heon Kim, Jaewon Jang, Seung Eun Lee, Phil Hyu Le. A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669380. |
overexpression of α-synuclein in the er of the substantia nigra (sn) resulted in marked loss of dopaminergic neurons and motor deficits, mimicking pd characteristics. |
2023-09-05 |
2023-10-07 |
Not clear |
| Eun-Jin Heo, Youngsun Lee, Min Hyung Seo, Sujung Ye. Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model. Neuroscience letters. 2023-08-27. PMID:37634811. |
parkinson's disease (pd) is a neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra and it is known to involve the accumulation of α-synuclein (α-syn), which is a neuroprotein that promotes degeneration of dopaminergic neurons. |
2023-08-27 |
2023-09-07 |
mouse |
| Agnese Gugliandolo, Santino Blando, Stefano Salamone, Federica Pollastro, Emanuela Mazzon, Simone D'Angiolin. Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson's Disease In Vitro Model. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627228. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates, known as lewy bodies. |
2023-08-26 |
2023-09-07 |
Not clear |
| Saud A Alnaaim, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of Brain Liver X Receptor in Parkinson's Disease: Hidden Treasure and Emerging Opportunities. Molecular neurobiology. 2023-08-22. PMID:37606719. |
parkinson's disease (pd) is a neurodegenerative disease due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-08-22 |
2023-09-07 |
Not clear |
| Mengdi Wang, Fengjiao Sun, Xiaofeng Han, Nan Wang, Yalan Liu, Jinfeng Cai, Shanshan Tong, Rui Wang, Hongcai Wan. Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response. Molecular neurobiology. 2023-08-21. PMID:37603153. |
the increased α-synuclein (α-syn)-dependent activation of cd4 t cells leads to the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2023-08-21 |
2023-09-07 |
rat |
| Naser Salari Khish, Pooran Ghiasizadeh, Abolhasan Rasti, Omid Moghimi, Arash Zeynali Zadeh, Alireza Bahiraee, Reyhane Ebrahim. Regulatory Non-coding RNAs Involved in Oxidative Stress and Neuroinflammation: An Intriguing Crosstalk in Parkinson's Disease. Current medicinal chemistry. 2023-08-18. PMID:37592769. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the accumulation of α-synuclein and the degeneration of dopaminergic neurons in the substantia nigra. |
2023-08-18 |
2023-09-07 |
Not clear |
| Pei-Ning Yang, Wan-Ling Chen, Jun-Wei Lee, Chih-Hsin Lin, Yi-Ru Chen, Chung-Yin Lin, Wenwei Lin, Ching-Fa Yao, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen, Guey-Jen Lee-Che. Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity. Aging. vol 15. 2023-08-14. PMID:37578928. |
parkinson's disease (pd) is featured mainly by the loss of dopaminergic neurons and the presence of α-synuclein-containing aggregates in the substantia nigra of brain. |
2023-08-14 |
2023-09-07 |
mouse |
| Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Aswathy Chandran, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508001. |
parkinson's disease (pd) is a neurodegenerative disorder involving motor symptoms caused by a loss of dopaminergic neurons in the substantia nigra region of the brain. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ashley B Adamson, Neda M Ilieva, William J Stone, Briana R De Mirand. Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502893. |
tce exposure also induced accumulation of pser129-αsyn in dopaminergic neurons as well as microglial activation within the substantia nigra of rats. |
2023-07-28 |
2023-08-14 |
mouse |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
the higher expression of clec7a was observed in the substantia nigra (sn) and striatum of pd rats with dopaminergic neurons damage and was mainly localized in the microglial. |
2023-07-26 |
2023-08-14 |
rat |
| Jiangbo Qu, Na Liu, Lu Gao, Jia Hu, Miao Sun, Dongyi Y. Development of CRISPR Cas9, spin-off technologies and their application in model construction and potential therapeutic methods of Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-07-24. PMID:37483347. |
it is most typically characterized by neuronal death following the accumulation of lewis inclusions in dopaminergic neurons in the substantia nigra region, with clinical symptoms such as motor retardation, autonomic dysfunction, and dystonia spasms. |
2023-07-24 |
2023-08-14 |
Not clear |
| Laura Patricia Perez-Abshana, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Ri. Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445771. |
parkinson's disease (pd) is a neurodegenerative disorder caused by the progressive loss of dopaminergic (daergic) neurons in the substantia nigra and the intraneuronal presence of lewy bodies (lbs), composed of aggregates of phosphorylated alpha-synuclein at residue ser |
2023-07-14 |
2023-08-14 |
Not clear |
| Bilal Muhammad, Haiying Li, Yunlu Gu, Senlin Xue, Yao Gao, Zhou Xu, Xiaoli Fang, Haohan Ding, Fang Wu, Deqin Geng, Haichen Ni. IL-1β/IL-1R1 signaling is involved in the propagation of α-synuclein pathology of the gastrointestinal tract to the brain. Journal of neurochemistry. 2023-07-12. PMID:37434423. |
the pathological hallmark of parkinson's disease (pd) is the intraneuronal accumulation of misfolded alpha-synuclein (termed lewy bodies) in dopaminergic neurons of substantia nigra par compacta (snc). |
2023-07-12 |
2023-08-14 |
mouse |
| Yiming Wang, Yun Xia, Liang Kou, Sijia Yin, Xiaosa Chi, Jingwen Li, Yadi Sun, Jiawei Wu, Qiulu Zhou, Wenkai Zou, Zongjie Jin, Jinsha Huang, Nian Xiong, Tao Wan. Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease. Neurobiology of disease. 2023-07-11. PMID:37433411. |
the primary pathological features include a reduction in the number of dopaminergic neurons in the substantia nigra and decrease in dopamine levels in the nigrostriatal pathway. |
2023-07-11 |
2023-08-14 |
human |
| Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, Gary W Mille. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425736. |
dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high energy demand, and broad unmyelinated axonal arborizations. |
2023-07-10 |
2023-08-14 |
mouse |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Abdul-Karim Abd Ali Al-Mahammadawy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. The potential role of cholesterol in Parkinson's disease neuropathology: perpetrator or victim. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-07-10. PMID:37428278. |
additionally, cholesterol increases aggregation of α-synuclein and induces degeneration of dopaminergic neurons (dn) in the substantia nigra (sn). |
2023-07-10 |
2023-08-14 |
Not clear |
| Fenghua Chen, Junliang Qian, Zhongkai Cao, Ang Li, Juntao Cui, Limin Shi, Junxia Xi. Chemogenetic and optogenetic stimulation of zona incerta GABAergic neurons ameliorates motor impairment in Parkinson's disease. iScience. vol 26. issue 7. 2023-07-07. PMID:37416450. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra and leads to progressive motor dysfunction. |
2023-07-07 |
2023-08-14 |
mouse |