| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo Vinueza-Gavilanes, Jorge Juan Bravo-González, Leyre Basurco, Chiara Boncristiani, Joaquín Fernández-Irigoyen, Enrique Santamaría, Irene Marcilla, Alberto Pérez-Mediavilla, María Rosario Luquin, Africa Vales, Gloria González-Aseguinolaza, María Soledad Aymerich, Tomás Aragón, Montserrat Arrasat. Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models. Neurobiology of disease. 2023-05-28. PMID:37245833. |
furthermore, fc-a treatment protects dopaminergic neuronal somas in the substantia nigra of a parkinson's disease mouse model. |
2023-05-28 |
2023-08-14 |
mouse |
| Lu Zou, Zhen Che, Kun Ding, Chao Zhang, Xia Liu, Luman Wang, Aiping Li, Jianwei Zho. JAC4 Alleviates Rotenone-Induced Parkinson's Disease through the Inactivation of the NLRP3 Signal Pathway. Antioxidants (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37238000. |
parkinson's disease (pd) is the fastest-growing neurodegeneration disease, characterized typically by a progressive loss of dopaminergic neurons in the substantia nigra, and there are no effective therapeutic agents to cure pd. |
2023-05-27 |
2023-08-14 |
mouse |
| Yiyuan Xu, Xinyu Huang, Xin Geng, Fei Wan. Meta-analysis of iron metabolism markers levels of Parkinson's disease patients determined by fluid and MRI measurements. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-05-24. PMID:37224790. |
parkinson' s disease (pd) is a progressive neurodegenerative disease featured neuropathologically by the loss of dopaminergic neurons of the substantia nigra (sn). |
2023-05-24 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Majid S Jabir, Hebatallah M Saad, Gaber El-Saber Batih. NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective. Journal of cellular and molecular medicine. 2023-05-21. PMID:37210624. |
particularly, insulin resistance (ir) in t2dm promotes the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-05-21 |
2023-08-14 |
Not clear |
| Juan García-Revilla, Antonio Boza-Serrano, Yiyun Jin, Devkee M Vadukul, Jesús Soldán-Hidalgo, Lluís Camprubí-Ferrer, Marta García-Cruzado, Isak Martinsson, Oxana Klementieva, Rocío Ruiz, Francesco A Aprile, Tomas Deierborg, José Luis Vener. Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease. Acta neuropathologica. 2023-05-18. PMID:37202527. |
parkinson's disease (pd) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called lewy bodies (lb) and degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-05-18 |
2023-08-14 |
mouse |
| Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
a well-established dopamine replacement therapy for pd is based on dopamine deficiency, primarily due to dopaminergic neuronal loss in the substantia nigra. |
2023-05-17 |
2023-08-14 |
Not clear |
| Chuanxi Tang, Mengting Liu, Zihang Zhou, Hao Li, Chenglin Yang, Li Yang, Jie Xian. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175535. |
the dopaminergic projections from the substantia nigra to the hippocampus are critical in regulating hippocampal plasticity. |
2023-05-14 |
2023-08-14 |
mouse |
| Chuanxi Tang, Mengting Liu, Zihang Zhou, Hao Li, Chenglin Yang, Li Yang, Jie Xian. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175535. |
regarding the indirect protection effect, fndc5 promotes the dopaminergic connection from the substantia nigra to the hippocampus by mediating the interaction between the integrin αvβ5 of the hippocampal neurons and the cd90 molecules on the membrane of dopaminergic terminals. |
2023-05-14 |
2023-08-14 |
mouse |
| Ana Catarina Martins, Illyane Sofia Lima, Ana Catarina Pêgo, Inês Sá Pereira, Gracelino Martins, Antonino Kapitão, Raffaella Gozzelin. Pro-Inflammatory Priming of the Brain: The Underlying Cause of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175654. |
parkinson's disease (pd) is a multifactorial neurodegenerative pathology characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the brain. |
2023-05-14 |
2023-08-14 |
mouse |
| Mitali A Tambe, Aurelie de Rus Jacquet, Katherine E Strathearn, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163110. |
parkinson's disease (pd) is a neurodegenerative disorder involving motor symptoms caused by a loss of dopaminergic neurons in the substantia nigra region of the brain. |
2023-05-10 |
2023-08-14 |
Not clear |
| Guy C Brown, Marta Camacho, Caroline H Williams-Gra. The Endotoxin Hypothesis of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-05-09. PMID:37157885. |
communication to the brain via circulating lps and cytokines in the blood and/or the gut-brain axis leads to neuroinflammation and spreading of α-synuclein pathology, exacerbating neurodegeneration in brainstem nuclei and loss of dopaminergic neurons in the substantia nigra, and manifesting in the clinical symptoms of pd. |
2023-05-09 |
2023-08-14 |
Not clear |
| Zhenwang Ma, Hao Liang, Bingcheng Hu, Shaojie Cai, Dong Ya. Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review). International journal of molecular medicine. vol 51. issue 6. 2023-05-05. PMID:37144489. |
parkinson's disease (pd) is a neurodegenerative disorder that has a high incidence during the aging process and is characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunctions and non‑motor symptoms. |
2023-05-05 |
2023-08-14 |
Not clear |
| Fei Tang, Liu-Yao Zhou, Ping Li, Ling-Ling Jiao, Kang Chen, Yu-Jie Guo, Xu-Long Ding, Si-Yu He, Biao Dong, Ru-Xiang Xu, Huan Xiong, Peng Le. Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-05-03. PMID:37133631. |
here, we report that acsl4 expression in the substantia nigra (sn) was increased in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated model of pd and in dopaminergic neurons in pd patients. |
2023-05-03 |
2023-08-14 |
mouse |
| Amirah E-E Aly, Tao Sun, Yongzhi Zhang, Zejun Li, Margee Kyada, Qingxi Ma, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Nathan J McDannold, Barbara L Waszcza. Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions. Journal of controlled release : official journal of the Controlled Release Society. 2023-05-01. PMID:37127076. |
additionally, fus with intranasal delivery increased transgene expression in the sonicated hemisphere by over 80%, altered cellular transfection patterns at the sonication sites, and improved penetration of plasmid nps into the brain parenchyma (with a 1-fold and 3-fold increase in proximity of transgene expression to neurons in the forebrain and midbrain respectively, and a 40% increase in proximity of transgene expression to dopaminergic neurons in the substantia nigra). |
2023-05-01 |
2023-08-14 |
Not clear |
| Merry Chen, Danielle E Mo. Gut-to-Brain α-Synuclein Transmission in Parkinson's Disease: Evidence for Prion-like Mechanisms. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108366. |
parkinson's disease (pd) is a multifactorial disorder involving both motor and non-motor symptoms caused by the progressive death of distinct neuronal populations, including dopaminergic neurons in the substantia nigra. |
2023-04-28 |
2023-08-14 |
human |
| Yunan Zhou, Zhihui Li, Chunling Chi, Chunmei Li, Meimei Yang, Bin Li. Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson's Disease via Bioinformatics Analysis. Parkinson's disease. vol 2023. 2023-04-24. PMID:37089789. |
one of the crucial pathological features of pd is the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-24 |
2023-08-14 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Yaser Hosny Ali Elewa, Mahmoud Hosny Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Parkinson's Disease Risk and Hyperhomocysteinemia: The Possible Link. Cellular and molecular neurobiology. 2023-04-19. PMID:37074484. |
parkinson's disease (pd) is one of the most common degenerative brain disorders caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-19 |
2023-08-14 |
Not clear |
| Cláudia Saraiva, Jéssica Lopes-Nunes, Marta Esteves, Tiago Santos, Ana Vale, Ana Clara Cristóvão, Raquel Ferreira, Liliana Bernardin. CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival. Molecular neurobiology. 2023-04-15. PMID:37060501. |
herein, we showed that ctbp1 and ctbp2 are expressed in neurons, dopaminergic neurons, astrocytes, and microglia in the substantia nigra (sn) and striatum of adult mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khann. Lambda-cyhalothrin Enhances Inflammation in Nigrostriatal Region in Rats:Regulatory Role of NF-κβ and JAK-STAT Signaling. Neurotoxicology. 2023-04-15. PMID:37060950. |
exposure of rats to lct also caused alteration in the levelsof heat shock protein 60 (hsp60) and mrna expression of toll-like receptors(tlr2 and tlr4) in the substantia nigra and corpus striatum.an increase in the phosphorylation of key proteins involved in nf-kβ (p65, iκβ, ikkα, ikkβ)signalingand stat1 and stat3 and alteration in the protein levels of jak1 and jak2 were prominent in lct-treated rats.histological studies revealed damage of dopaminergic neurons and reactive gliosis as evidenced by the presence of darkly stained pyknotic neurons anddecrease in nisslsubstance and an increase in infiltration of immune cells both in substantia nigra and corpus striatum of lct-treated rats. |
2023-04-15 |
2023-08-14 |
rat |
| Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khann. Lambda-cyhalothrin Enhances Inflammation in Nigrostriatal Region in Rats:Regulatory Role of NF-κβ and JAK-STAT Signaling. Neurotoxicology. 2023-04-15. PMID:37060950. |
the results exhibit that lct may damage dopaminergic neurons in the substantia nigra and corpus striatum by inducing inflammation as a result of stimulation of neuroglial cells involving activation of nf-κβ and jak/stat signaling. |
2023-04-15 |
2023-08-14 |
rat |