| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Yi Han, Eun-Hye Lee, Sang-Mi Kim, Chang-Hwan Par. Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. Biomolecules & therapeutics. 2023-01-15. PMID:36642416. |
pd is caused by loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn) and therefore, replenishment of da neurons via stem cell-based therapy is a potential treatment option. |
2023-01-15 |
2023-08-14 |
mouse |
| Carmen F M van Hooijdonk, Marieke van der Pluijm, Iris Bosch, Therese A M J van Amelsvoort, Jan Booij, Lieuwe de Haan, Jean-Paul Selten, Elsmarieke van de Giesse. The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 68. 2023-01-14. PMID:36640734. |
despite being one of the main origins of dopaminergic input to the striatum, the (dys)functioning of the substantia nigra (sn) has been relatively understudied in schizophrenia. |
2023-01-14 |
2023-08-14 |
Not clear |
| Shu-Yi Huang, Zong-Ying Su, Yuan-Yuan Han, Li Liu, Ying-Jie Shang, Zi-Fan Mai, Zhi-Wei Zeng, Chu-Hua L. Cordycepin improved the cognitive function through regulating adenosine A Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 110. 2023-01-12. PMID:36634379. |
cordycepin improved the cognitive function through regulating adenosine a parkinson's disease (pd), the most common neurodegenerative disorder, primarily affects dopaminergic neurons in the substantia nigra (sn). |
2023-01-12 |
2023-08-14 |
Not clear |
| Tian-Kuo Lee, K Ashok Kumar, Chih-Yang Huang, Po-Hsiang Liao, Tsung-Jung Ho, Wei-Wen Kuo, Shih-Chieh Liao, Dennis Jine-Yuan Hsieh, Ping-Ling Chiu, Yung-Ming Chang, Da-Tong J. Garcinol protects SH-SY5Y cells against MPP+-induced cell death by activating DJ-1/SIRT1 and PGC-1α mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy. Environmental toxicology. 2023-01-11. PMID:36629037. |
parkinson's disease (pd), a chronic and progressive neurodegenerative disease, can reduce the population of dopaminergic neurons in the substantia nigra. |
2023-01-11 |
2023-08-14 |
human |
| Hualong Wang, Guiqin Chen, Eun Hee Ahn, Yiyuan Xia, Seong Su Kang, Xia Liu, Chang Liu, Ming-Hu Han, Shengdi Chen, Keqiang Y. C/EBPβ/AEP is age-dependently activated in Parkinson's disease and mediates α-synuclein in the gut and brain. NPJ Parkinson's disease. vol 9. issue 1. 2023-01-07. PMID:36609384. |
parkinson's disease (pd) is the most common neurodegenerative motor disorder, and its pathologic hallmarks include extensive dopaminergic neuronal degeneration in the substantia nigra associated with lewy bodies, predominantly consisting of phosphorylated and truncated α-synuclein (α-syn). |
2023-01-07 |
2023-08-14 |
mouse |
| Zhaofei Yang, Ying Wang, Min Wei, Song Li, Congcong Jia, Cheng Cheng, Murad Al-Nusaif, Jun Zhang, Cong Liu, Weidong L. Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain. Cell death & disease. vol 14. issue 1. 2023-01-05. PMID:36604420. |
strikingly, such an injection induced dopaminergic neurodegeneration and α-syn depositions in the striatum, substantia nigra, and other brain regions, including the frontal cortex, somatosensory cortex, hypothalamus, brain stem, and cerebellum. |
2023-01-05 |
2023-08-14 |
rat |
| Jun Cui, Joseph Carey, Renee A Reijo Per. Identification of DOT1L inhibitor in a screen for factors that promote dopaminergic neuron survival. Frontiers in aging neuroscience. vol 14. 2022-12-29. PMID:36578445. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra region of the midbrain. |
2022-12-29 |
2023-08-14 |
Not clear |
| Jin-Huan Deng, Han-Wen Zhang, Xiao-Lei Liu, Hua-Zhen Deng, Fan Li. Morphological changes in Parkinson's disease based on magnetic resonance imaging: A mini-review of subcortical structures segmentation and shape analysis. World journal of psychiatry. vol 12. issue 12. 2022-12-29. PMID:36579355. |
parkinson's disease (pd) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra, resulting in clinical symptoms, including bradykinesia, resting tremor, rigidity, and postural instability. |
2022-12-29 |
2023-08-14 |
Not clear |
| Ana Beatriz Ramalho Leite Silva, Roger Wilson Gonçalves de Oliveira, DiogenesGuilherme Pinheiro Diógenes, Marina Feitosa de Castro Aguiar, Camilla Costa Sallem, Micael Porto Portela Lima, Luciano Barroso de Albuquerque Filho, Sara Diógenes Peixoto de Medeiros, Lucas Lopes Penido de Mendonça, Paulo Cesar de Santiago Filho, Diogo Pasquali Nones, Pamella Mendes Martiniano da Silva Cardoso, Michelle Zonkowski Ribas, GalvaoStéfani Lara Galvão, Gabriel Felipe Gomes, Amanda Rebouças Bezerra de Menezes, Nayla Lima Dos Santos, Mororo Victor Monteiro Mororó, Fairane Sousa Duarte, Júlio César Claudino Dos Santo. Premotor, Nonmotor And Motor Symptoms Of Parkinson's Disease: A New Clinical State Of The Art. Ageing research reviews. 2022-12-29. PMID:36581178. |
parkinson's disease (pd) is a neurodegenerative disorder that affects dopaminergic neurons in the mesencephalic substantia nigra, causing a progressive clinical course characterized by pre-motor, non-motor and motor symptoms, which negatively impact the quality of life of patients and cause high health care costs. |
2022-12-29 |
2023-08-14 |
Not clear |
| Tahereh Ghaedian, Ali Razmkon, Leila Kalhor, Vahid Reza Ostovan, Omid Yousefi, Raziyeh Rezaei, Mohammad Reza Hossein-Tehrani, Abbas Rakhsh. Correlation of response to subthalamic deep brain stimulation in Parkinson's disease patients with striatal dopamine transporter density on 99mtc-TRODAT-1 SPECT. Neurological research. 2022-12-27. PMID:36573915. |
since the loss of dopaminergic neurons in the substantia nigra is the main pathophysiology of pd, we aimed to evaluate the association of response to dbs with preoperative dopamine transporter density (dat) and its postoperative changes in pd patients who underwent the bilateral implantation of the electrodes in the subthalamic nucleus (stn). |
2022-12-27 |
2023-08-14 |
Not clear |
| Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumo. Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Frontiers in molecular neuroscience. vol 15. 2022-12-26. PMID:36568278. |
isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. |
2022-12-26 |
2023-08-14 |
mouse |
| Frank Bearoff, Dhruva Dhavale, Paul Kotzbauer, Sandhya Kortager. Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells. Molecular immunology. vol 154. 2022-12-26. PMID:36571978. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by chronic neuroinflammation, loss of dopaminergic neurons in the substantia nigra, and in several cases accumulation of alpha-synuclein fibril (α-syn) containing lewy-bodies (lbs). |
2022-12-26 |
2023-08-14 |
Not clear |
| Hayate Javed, Nagoor Meeran Mohamed Fizur, Niraj Kumar Jha, Ghulam Md Ashraf, Shreesh Ojh. Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer's and Parkinson's diseases. Current neuropharmacology. 2022-12-25. PMID:36567278. |
moreover, it also reduces the production of reactive oxygen species and proinflammatory cytokine levels in pd, which further prevent the loss of dopaminergic neurons in the substantia nigra and improves motor functions. |
2022-12-25 |
2023-08-14 |
human |
| Shima Tavako. The Twofold Role of Osteogenic Small Molecules in Parkinson's Disease Therapeutics: Crosstalk of Osteogenesis and Neurogenesis. BioMed research international. vol 2022. 2022-12-22. PMID:36545269. |
although bmp2 and smad1, 3, and 5 biomolecules promote neurite outgrowth and neuroprotection in dopaminergic cells as well, small molecules are quicker at crossing the bbb and reaching the damaged dopaminergic neurons located in the substantia nigra due to a molecular weight less than 500 da. |
2022-12-22 |
2023-08-14 |
Not clear |
| Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Ha. Application and progress of transcranial substantial ultrasound in Parkinson's disease. Frontiers in neurology. vol 13. 2022-12-19. PMID:36530621. |
when obvious pd manifestations are found, the number of dopaminergic neurons in substantia nigra of patients has been reduced by more than half, and the treatment is difficult (2). |
2022-12-19 |
2023-08-14 |
Not clear |
| Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang, Cheong-Meng Chon. The effects of bioactive components from the rhizome of Frontiers in pharmacology. vol 13. 2022-12-19. PMID:36532787. |
the effects of bioactive components from the rhizome of parkinson's disease (pd) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. |
2022-12-19 |
2023-08-14 |
Not clear |
| Hong-Yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-Jun Lu, Hai-Gang Ren, Guang-Hui Wan. Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway. Acta pharmacologica Sinica. 2022-12-19. PMID:36536076. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic (da) neurons and the accumulation of lewy bodies (lb) in the substantia nigra (sn). |
2022-12-19 |
2023-08-14 |
mouse |
| Chiara Santulli, Carlotta Bon, Elena De Cecco, Marta Codrich, Joanna Narkiewicz, Pietro Parisse, Fabio Perissinotto, Claudio Santoro, Francesca Persichetti, Giuseppe Legname, Stefano Espinoza, Stefano Gustincic. Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein. Cell death & disease. vol 13. issue 12. 2022-12-16. PMID:36526614. |
neuronal haemoglobin induces loss of dopaminergic neurons in mouse substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein. |
2022-12-16 |
2023-08-14 |
mouse |
| Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S Ho, Shiping Zhan. Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499080. |
pathologically, the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) and the accumulation of α-synuclein (α-syn)-composed lewy bodies (lbs) and lewy neurites (lns) are key hallmarks. |
2022-12-11 |
2023-08-14 |
Not clear |
| Ajay Elangovan, Dhivya Venkatesan, Priyanka Selvaraj, Md Younus Pasha, Harysh Winster Suresh Babu, Mahalaxmi Iyer, Arul Narayanasamy, Mohana Devi Subramaniam, Abilash Valsala Gopalakrishnan, Nachimuthu Senthil Kumar, Balachandar Vellingir. miRNA in Parkinson's disease: From pathogenesis to theranostic approaches. Journal of cellular physiology. 2022-12-11. PMID:36502506. |
dopaminergic neurons degradation in substantia nigra region and aggregation of αsyn are the classic signs of molecular defects noticed in pd pathogenesis. |
2022-12-11 |
2023-08-14 |
Not clear |