| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rika Yamashita, Goichi Beck, Yuki Yonenobu, Kimiko Inoue, Akihiko Mitsutake, Hiroyuki Ishiura, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuk. TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2022-05-09. PMID:35531755. |
accumulation of abnormal transactivation response dna-binding protein of 43 kda (tdp-43) independently induces dopaminergic neuronal loss in the substantia nigra without lewy pathology, and results in typical parkinson's disease-like motor symptoms. |
2022-05-09 |
2023-08-13 |
Not clear |
| Faezeh Sahebdel, Azita Parvaneh Tafreshi, Ehsan Arefian, Eleni Roussa, Samad Nadri, Bahman Zeynal. A Wnt/β-catenin signaling pathway is involved in early dopaminergic differentiation of trabecular meshwork-derived mesenchymal stem cells. Journal of cellular biochemistry. 2022-05-09. PMID:35533251. |
permanent degeneration and loss of dopaminergic (da) neurons in substantia nigra is the main cause of parkinson's disease. |
2022-05-09 |
2023-08-13 |
Not clear |
| Suárez-Pereira I, García-Domínguez I, Bravo L, Santiago M, García-Revilla J, Espinosa-Oliva A M, Alonso-Bellido I M, López-Martín C, Pérez-Villegas E M, Armengol J A, Berrocoso E, Venero J L, de Pablos R M, Ruiz . The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior. Frontiers in cell and developmental biology. vol 10. 2022-05-02. PMID:35493109. |
our results show that the number of dopaminergic neurons increases in the substantia nigra. |
2022-05-02 |
2023-08-13 |
mouse |
| Jian Zhang, Meng Wang, Yuan Zhao, Yidan Zhang, Ya Gao, Xiangjian Zhang, Guofeng Yan. Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord. Neuroscience letters. 2022-05-01. PMID:35490905. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder, resulting in dopaminergic (da) neuronal loss in the substantia nigra (sn) and injury of extranigral spinal cord neurons. |
2022-05-01 |
2023-08-13 |
mouse |
| Matthias Höllerhage, Markus Stepath, Michael Kohl, Kathy Pfeiffer, Oscar Wing Ho Chua, Linghan Duan, Franziska Hopfner, Martin Eisenacher, Katrin Marcus, Günter U Höglinge. Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein. Frontiers in neurology. vol 13. 2022-04-28. PMID:35481270. |
luhmes cells share many characteristics with human dopaminergic neurons in the substantia nigra, the cells, the demise of which is responsible for the motor symptoms in parkinson's disease (pd). |
2022-04-28 |
2023-08-13 |
human |
| Ilia M Golomidov, Evgenia M Latypova, Elena V Ryabova, Olga I Bolshakova, Artem E Komissarov, Svetlana V Sarantsev. Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Journal of neurogenetics. 2022-04-25. PMID:35467466. |
reduction of the α-synuclein expression promotes slowing down early neuropathology development in the parkinson's disease (pd) is a neurodegenerative disease characterised by the formation of lewy bodies and progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2022-04-25 |
2023-08-13 |
Not clear |
| Tsai-Wei Liu, Chiung-Mei Chen, Kuo-Hsuan Chan. Biomarker of Neuroinflammation in Parkinson's Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456966. |
parkinson's disease (pd) is caused by abnormal accumulation of α-synuclein in dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms. |
2022-04-23 |
2023-08-13 |
Not clear |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
in the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (sn) and the ventral tegmental area (vta). |
2022-04-22 |
2023-08-13 |
Not clear |
| Olivier Uwishema, Helen Onyeaka, Rawa Badri, Ayşe Nazlı Yücel, Ahmet Kayhan Korkusuz, Abayomi Oyeyemi Ajagbe, Amro Abuleil, Céline Chaaya, Baraa H M Alhendawi, Elie Chalhou. The understanding of Parkinson's disease through genetics and new therapies. Brain and behavior. 2022-04-22. PMID:35451243. |
the mechanism of this disease is associated with a decrease in the number of dopaminergic neurons in the substantia nigra (sn) while lewy bodies are still present. |
2022-04-22 |
2023-08-13 |
Not clear |
| Marie-Laure Pons, Neil Loftus, Jerome Vialaret, Stephane Moreau, Sylvain Lehmann, Christophe Hirt. Proteomics Challenges for the Assessment of Synuclein Proteoforms as Clinical Biomarkers in Parkinson's Disease. Frontiers in aging neuroscience. vol 14. 2022-04-18. PMID:35431896. |
the motor features of the disorder are associated with the pathological form of alpha synuclein aggregates and fibrils in lewy bodies and loss of dopaminergic neurons in the substantia nigra. |
2022-04-18 |
2023-08-13 |
Not clear |
| Madison Wynne El-Saadi, Xinli Tian, Mychal Grames, Michael Ren, Kelsea Keys, Hanna Li, Erika Knott, Hong Yin, Shile Huang, Xiao-Hong L. Tracing brain genotoxic stress in Parkinson's disease with a novel single-cell genetic sensor. Science advances. vol 8. issue 15. 2022-04-15. PMID:35427151. |
the most affected cell type in pd, dopaminergic (da) neurons in substantia nigra, was distinguished by a high level of genotoxic stress following pq exposure. |
2022-04-15 |
2023-08-13 |
mouse |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
using a culture of mouse embryonic mesencephalic and luhmes cells (human embryonic mesencephalic cells), as well as slices of the substantia nigra of adult mice, we have obtained evidence that gbr-bp is internalized specifically into dopaminergic neurons in association with dat via a clathrin-dependent mechanism. |
2022-04-12 |
2023-08-13 |
mouse |
| Hairong Peng, Shui Yu, Yukai Zhang, Yanqing Yin, Jiawei Zho. Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration. Neuroscience bulletin. 2022-04-11. PMID:35399136. |
selective ablation of drd2, but not drd4, in the intestinal epithelium, caused a more severe loss of dopaminergic neurons in the substantia nigra following mptp challenge, and this was accompanied by a reduced abundance of succinate-producing alleoprevotella in the gut microbiota. |
2022-04-11 |
2023-08-13 |
mouse |
| Nikita Katila, Ramesh Duwa, Sunil Bhurtel, Shristi Khanal, Srijan Maharjan, Jee-Heon Jeong, Sooyeun Lee, Dong-Young Choi, Simmyung Yoo. Enhancement of blood-brain barrier penetration and the neuroprotective effect of resveratrol. Journal of controlled release : official journal of the Controlled Release Society. 2022-04-10. PMID:35398173. |
parkinson's disease (pd) is a debilitating neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. |
2022-04-10 |
2023-08-13 |
human |
| Samuel Peña-Díaz, Jordi Pujols, Eftychia Vasili, Francisca Pinheiro, Jaime Santos, Zoe Manglano-Artuñedo, Tiago F Outeiro, Salvador Ventur. The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains. The Journal of biological chemistry. 2022-04-07. PMID:35390347. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intra-neuronal proteinaceous inclusions known as lewy bodies and lewy neurites. |
2022-04-07 |
2023-08-13 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Ji. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology. 2022-03-31. PMID:35358621. |
parkinson's disease (pd) is the second most devastating age-related neurodegenerative diseases after alzheimer diseases (ad) and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-03-31 |
2023-08-13 |
zebrafish |
| Yan-Yan Li, Tian-Tian Zhou, Yi Zhang, Nai-Hong Chen, Yu-He Yua. Distribution of α-Synuclein Aggregation in the Peripheral Tissues. Neurochemical research. 2022-03-29. PMID:35348944. |
parkinson's disease (pd) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. |
2022-03-29 |
2023-08-13 |
Not clear |
| Ngo Binh Thao Nghi, Tran Thuc Uyen, Huynh Man Anh, Dao My Linh, Dang Thi Phuong Tha. Rumdul ( Oxidative medicine and cellular longevity. vol 2022. 2022-03-28. PMID:35340209. |
rumdul ( parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by progressive deterioration of motor function and loss of dopaminergic neurons in the substantia nigra. |
2022-03-28 |
2023-08-13 |
Not clear |
| Bo Niklasson, Lars Lindquist, William Klitz, Sten Fredrikson, Roland Morgell, Reza Mohammadi, Netherlands Brain Bank, Yervand Karapetyan, Elisabet Englun. Picornavirus May Be Linked to Parkinson's Disease through Viral Antigen in Dopamine-Containing Neurons of Substantia Nigra. Microorganisms. vol 10. issue 3. 2022-03-26. PMID:35336174. |
parkinson's disease (pd) is a neurodegenerative disease linked with the loss of dopaminergic neurons in the brain region called substantia nigra and caused by unknown pathogenic mechanisms. |
2022-03-26 |
2023-08-13 |
human |