| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arianna Manini, Elena Abati, Giacomo Pietro Comi, Stefania Corti, Dario Ronch. Mitochondrial DNA Homeostasis Impairment and Dopaminergic Dysfunction: A Trembling Balance. Ageing research reviews. 2022-02-03. PMID:35114397. |
in the past decades, studies have demonstrated a progressive accumulation of multiple mtdna deletions in dopaminergic neurons of the substantia nigra in elderly population and, to a greater extent, in parkinson's disease patients. |
2022-02-03 |
2023-08-13 |
Not clear |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
all three agents work through similar mechanisms and lead to degeneration of dopaminergic neurons in the substantia nigra (sn) and more recently discovered in motor neurons of the spinal cord (sc). |
2022-01-29 |
2023-08-13 |
Not clear |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
we previously reported that after prolonged phi, the dopaminergic neurons of the human neonate showed a dramatic reduction of tyrosine hydroxylase (th) in the substantia nigra, without important signs of neuronal degeneration despite the significant reduction in their cell size. |
2022-01-29 |
2023-08-13 |
human |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Victor Blokhin, Maria Shupik, Ulyana Gutner, Ekaterina Pavlova, Albert T Lebedev, Olga Maloshitskaya, Vsevolod Bogdanov, Sergey Sokolov, Alice Alessenko, Michael Ugrumo. The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053241. |
it has been shown that in pd models, the expression of five of the nine studied genes (cers1, cers5, asah1, asah2, and gba1) increases but only in the substantia nigra (sn) containing dopaminergic cell bodies. |
2022-01-21 |
2023-08-13 |
mouse |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Qingyu Ren, Xin Jiang, Shanshan Zhang, Xin Gao, Yam Nath Paudel, Pengyu Zhang, Rongchun Wang, Kechun Liu, Meng Ji. Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-01-14. PMID:35030435. |
parkinson's disease (pd) is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-01-14 |
2023-08-13 |
cat |
| Hossein Piri, Sahar Sharifi, Sepideh Nigjeh, Hashem Haghdoost-Yazd. Dopaminergic neuronal death in the substantia nigra associates with change in serum levels of TNF-α and IL-1β; evidence from early experimental model of Parkinson's disease. Neurological research. 2022-01-06. PMID:34986749. |
dopaminergic neuronal death in the substantia nigra associates with change in serum levels of tnf-α and il-1β; evidence from early experimental model of parkinson's disease. |
2022-01-06 |
2023-08-13 |
human |
| Gian-Carlo Eyer, Stefano Di Santo, Ekkehard Hewer, Lukas Andereggen, Stefanie Seiler, Hans Rudolf Widme. Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease. Cells. vol 10. issue 12. 2021-12-24. PMID:34943877. |
our previous findings of a higher survival of dopaminergic neurons in the substantia nigra co-expressing nogo-a in an animal model of parkinson's disease suggested that nogo-a may be associated with dopaminergic neurons resilience against parkinson's disease neurodegeneration. |
2021-12-24 |
2023-08-13 |
human |
| Gian-Carlo Eyer, Stefano Di Santo, Ekkehard Hewer, Lukas Andereggen, Stefanie Seiler, Hans Rudolf Widme. Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease. Cells. vol 10. issue 12. 2021-12-24. PMID:34943877. |
in the present study, we have addressed the expression of nogo-a in the dopaminergic neurons in the substantia nigra in postmortem specimens of diseased and non-diseased subjects of different ages. |
2021-12-24 |
2023-08-13 |
human |
| James A Conway, Edgar R Krame. Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic. Neural regeneration research. vol 17. issue 7. 2021-12-17. PMID:34916419. |
this prompted the idea to try gdnf/ret signaling as a therapeutic approach to treat parkinson's disease with the hallmark of dopaminergic cell death in the substantia nigra of the midbrain. |
2021-12-17 |
2023-08-13 |
Not clear |
| Semra Smajić, Cesar A Prada-Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre, Carola Dietrich, Javier Jarazo, Jana Henck, Saranya Balachandran, Sinthuja Pachchek, Christopher M Morris, Paul Antony, Bernd Timmermann, Sascha Sauer, Sandro L Pereira, Jens C Schwamborn, Patrick May, Anne Grünewald, Malte Spielman. Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain : a journal of neurology. 2021-12-17. PMID:34919646. |
to date, parkinson's disease research has mainly focused on nigral dopaminergic neurons, although recent studies suggest disease-related changes also in non-neuronal cells and in midbrain regions beyond the substantia nigra. |
2021-12-17 |
2023-08-13 |
human |
| Min Hyung Seo, Sabina Lim, Sujung Ye. Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model. BMC neuroscience. vol 22. issue 1. 2021-12-11. PMID:34736417. |
parkinson's disease (pd) represent a loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain. |
2021-12-11 |
2023-08-13 |
mouse |
| Meiqiu Liu, Qian Jiao, Xixun Du, Mingxia Bi, Xi Chen, Hong Jian. Potential Crosstalk Between Parkinson's Disease and Energy Metabolism. Aging and disease. vol 12. issue 8. 2021-12-11. PMID:34881082. |
parkinson's disease (pd) is characterized by the accumulation of alpha-synuclein (α-syn) in the substantia nigra (sn) and the degeneration of nigrostriatal dopaminergic (daergic) neurons. |
2021-12-11 |
2023-08-13 |
Not clear |
| Wisberty J Gordián-Vélez, Dimple Chouhan, Rodrigo A España, H Isaac Chen, Jason A Burdick, John E Duda, D Kacy Culle. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain research bulletin. vol 175. 2021-12-10. PMID:34332016. |
the death of dopaminergic neurons in the substantia nigra and the axonal fibers that constitute the nigrostriatal pathway leads to a loss of dopamine in the striatum that causes the motor symptoms of this disease. |
2021-12-10 |
2023-08-13 |
human |
| Emma Biondetti, Mathieu D Santin, Romain Valabrègue, Graziella Mangone, Rahul Gaurav, Nadya Pyatigorskaya, Matthew Hutchison, Lydia Yahia-Cherif, Nicolas Villain, Marie-Odile Habert, Isabelle Arnulf, Smaranda Leu-Semenescu, Pauline Dodet, Miquel Vila, Jean-Christophe Corvol, Marie Vidailhet, Stéphane Lehéric. The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33978742. |
in parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. |
2021-12-09 |
2023-08-13 |
Not clear |
| Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, Youngmi Kim Pa. DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 145. 2021-12-08. PMID:34775235. |
oral administration of da-9805 (10 or 30 mg/kg/day for 3 days before lps injection) prevented loss of dopaminergic neurons and activation of microglia and astrocytes in the substantia nigra in lps-injected mouse models. |
2021-12-08 |
2023-08-13 |
mouse |
| Maria Vizziello, Linda Borellini, Giulia Franco, Gianluca Ardolin. Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson's Disease. Cells. vol 10. issue 11. 2021-12-08. PMID:34831247. |
the progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying parkinson's disease (pd), while the mechanism of susceptibility of this specific neuronal population is largely unclear. |
2021-12-08 |
2023-08-13 |
Not clear |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
parkinson's disease (pd) occurs when dopaminergic cells in the substantia nigra (sn) region are destroyed; however, the cause of the destruction of dopamine cells has not yet been determined. |
2021-12-07 |
2023-08-13 |
rat |
| Xin Yuan, Ye Tian, Chaoyang Liu, Zhentao Zhan. Environmental factors in Parkinson's disease: new insights into the molecular mechanisms. Toxicology letters. 2021-12-05. PMID:34864130. |
the pathological hallmarks are intracellular inclusions containing α-synuclein aggregates and the loss of dopaminergic neurons in the substantia nigra. |
2021-12-05 |
2023-08-13 |
Not clear |