| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dexter N Dean, Jennifer C Le. Linking Parkinson's Disease and Melanoma: Interplay Between α-Synuclein and Pmel17 Amyloid Formation. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 7. 2021-07-29. PMID:34021920. |
parkinson's disease (pd) is a neurodegenerative disorder associated with the death of dopaminergic neurons within the substantia nigra of the brain. |
2021-07-29 |
2023-08-13 |
Not clear |
| Yadan Zhao, Zichen Zhang, Siru Qin, Wen Fan, Wei Li, Jingyi Liu, Songtao Wang, Zhifang Xu, Meidan Zha. Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit. Neural plasticity. vol 2021. 2021-07-29. PMID:34221005. |
parkinson's disease (pd) is a chronic and progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra. |
2021-07-29 |
2023-08-13 |
Not clear |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33230666. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-07-28 |
2023-08-13 |
mouse |
| Tsu-Kung Lin, Kai-Jung Lin, Hung-Yu Lin, Kai-Lieh Lin, Min-Yu Lan, Pei-Wen Wang, Tzu-Jou Wang, Feng-Sheng Wang, Po-Chin Tsai, Chia-Wei Liou, Jiin-Haur Chuan. Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress. Frontiers in molecular neuroscience. vol 14. 2021-07-27. PMID:34305527. |
this disease has pathological features of lewy bodies with α-synuclein aggregation being the major component and selective dopaminergic neuronal loss over the substantia nigra. |
2021-07-27 |
2023-08-13 |
mouse |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garrau. Parkinson's disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34238927. |
parkinson's disease (pd) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (nm)-containing dopaminergic neurons and deposition of iron in the substantia nigra (sn). |
2021-07-24 |
2023-08-13 |
Not clear |
| Yaqi Ding, Deqin Kong, Tong Zhou, Nai-di Yang, Chenqi Xin, Jiajia Xu, Qi Wang, Hang Zhang, Qiong Wu, Xiaomei Lu, Kahleong Lim, Bo Ma, Chengwu Zhang, Lin Li, Wei Huan. α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo. Neuromolecular medicine. vol 22. issue 1. 2021-07-23. PMID:31401719. |
parkinson's disease (pd), the most common neurodegenerative movement disorder, is characterized by the progressive loss of dopaminergic neurons in substantia nigra. |
2021-07-23 |
2023-08-13 |
human |
| Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Cho. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-20. PMID:34206041. |
parkinson's disease (pd) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (sn) mediated via oxidative stress. |
2021-07-20 |
2023-08-13 |
Not clear |
| Xiao-Yu Cheng, Sangita Biswas, Juan Li, Cheng-Jie Mao, Olga Chechneva, Jing Chen, Kai Li, Jiao Li, Jin-Ru Zhang, Chun-Feng Liu, Wen-Bin Den. Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria. Translational neurodegeneration. vol 9. issue 1. 2021-07-19. PMID:32345341. |
parkinson's disease (pd) is one of the neurodegeneration diseases characterized by the gradual loss of dopaminergic (da) neurons in the substantia nigra region of the brain. |
2021-07-19 |
2023-08-13 |
human |
| Yanyun Sun, Xiao-Jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-Lin Xi. Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-19. PMID:33070275. |
parkinson's disease (pd) is a disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra and a depletion of the neurotransmitter dopamine in the striatum. |
2021-07-19 |
2023-08-13 |
rat |
| Kelly L L Wong, Aditya Nair, George J Augustin. Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34054437. |
such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. |
2021-07-16 |
2023-08-13 |
Not clear |
| Diego Castillo-Barnes, Francisco J Martinez-Murcia, Andres Ortiz, Diego Salas-Gonzalez, Javier RamÍrez, Juan M Górri. Morphological Characterization of Functional Brain Imaging by Isosurface Analysis in Parkinson's Disease. International journal of neural systems. vol 30. issue 9. 2021-07-15. PMID:32787634. |
finding new biomarkers to model parkinson's disease (pd) is a challenge not only to help discerning between healthy control (hc) subjects and patients with potential pd but also as a way to measure quantitatively the loss of dopaminergic neurons mainly concentrated at substantia nigra. |
2021-07-15 |
2023-08-13 |
human |
| Mai Wada, Mary Jasmin Ang, Poornima D E Weerasinghe-Mudiyanselage, Sung-Ho Kim, Jong-Choon Kim, Taekyun Shin, Changjong Moo. Behavioral characterization in MPTP/p mouse model of Parkinson's disease. Journal of integrative neuroscience. vol 20. issue 2. 2021-07-14. PMID:34258929. |
we confirmed dopaminergic degeneration in terms of decreased expression levels of tyrosine hydroxylase in the substantia nigra and striatum of mptp/p-lesioned mice. |
2021-07-14 |
2023-08-13 |
mouse |
| Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Cho. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416093. |
immunohistochemical analysis revealed that when tat‑ar protein was transduced into the substantia nigra (sn) of mice with pd, it markedly inhibited dopaminergic neuronal cell death. |
2021-07-12 |
2023-08-13 |
mouse |
| Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou, Ilias Kazani. Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20. Stem cell research & therapy. vol 12. issue 1. 2021-07-12. PMID:34112234. |
characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin bnn-20. |
2021-07-12 |
2023-08-13 |
mouse |
| Jara M Baena-Montes, Sahar Avazzadeh, Leo R Quinla. α-synuclein pathogenesis in hiPSC models of Parkinson's disease. Neuronal signaling. vol 5. issue 2. 2021-07-10. PMID:34239711. |
parkinson's disease (pd) is a neurodegenerative disorder that affects mainly the dopaminergic (da) neurons in the substantia nigra of the brain. |
2021-07-10 |
2023-08-13 |
Not clear |
| Viktoria C Ruf, Song Shi, Felix Schmidt, Daniel Weckbecker, Georg S Nübling, Uwe Ködel, Brit Mollenhauer, Armin Gies. Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC. FEBS open bio. vol 10. issue 5. 2021-07-09. PMID:32190992. |
parkinson's disease (pd) is a progressive neurodegenerative disease which is histologically characterized by loss of dopaminergic neurons in the substantia nigra and deposition of aggregated alpha-synuclein (asyn) in the brain. |
2021-07-09 |
2023-08-13 |
Not clear |
| Atsushi Takeda, Masahiko Tomiyama, Ritsuko Hanajim. [The Relationship Between Pathophysiology and Neurotransmitters in Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 73. issue 7. 2021-07-09. PMID:34234041. |
the major motor symptoms of pd are mainly caused by dopamine (da) deficiency due to the loss of dopaminergic neurons in the substantia nigra. |
2021-07-09 |
2023-08-13 |
Not clear |
| Yiqiu Liu, Junyu Deng, Ye Liu, Wei Li, Xuqiang Ni. FGF, Mechanism of Action, Role in Parkinson's Disease, and Therapeutics. Frontiers in pharmacology. vol 12. 2021-07-09. PMID:34234672. |
the death or dysfunction of dopaminergic neurons in the dense part of the substantia nigra leads to dopamine deficiency in the basal ganglia and motor dysfunction. |
2021-07-09 |
2023-08-13 |
Not clear |
| Jing-Da Qiao, Yu-Ling Ma. Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites. Invertebrate neuroscience : IN. vol 20. issue 3. 2021-07-08. PMID:32766952. |
electrophysiological and behavioral tests indicated that pink1 elimination enhances the neural transmission from the presynaptic part of dopaminergic neurons in the protocerebral posterior medial region 3 (ppm3) to ppm3 neurons (which are homologous to those in the substantia nigra in humans). |
2021-07-08 |
2023-08-13 |
drosophila_melanogaster |