| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deepa Dash, Vinay Goya. Anticancer Drugs for Parkinson's Disease: Is It a Ray of Hope or Only Hype? Annals of Indian Academy of Neurology. vol 22. issue 1. 2020-10-01. PMID:30692753. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the death of dopaminergic (da) neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shu-Yin Xu, Qi-Lei Zhang, Qi Zhang, Lily Wan, Juan Jiang, Tian Tu, Jim Manavis, Aihua Pan, Yan Cai, Xiao-Xin Ya. Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain. Frontiers in neuroanatomy. vol 13. 2020-10-01. PMID:30914927. |
dopaminergic neurons in the substantia nigra, cholinergic neurons in the basal nuclei of meynert and noradrenergic neurons in the locus coeruleus co-expressed strong sortilin ir in double immunofluorescence. |
2020-10-01 |
2023-08-13 |
human |
| Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Ca. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson's disease. vol 2019. 2020-10-01. PMID:30944722. |
th immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (sn) dopaminergic neurons and the da terminals in the striatum. |
2020-10-01 |
2023-08-13 |
rat |
| Kyung Hwa Kim, Seung Young Lee, Jaekwon Shin, Jae-Taeg Hwang, Hat Nim Jeon, Hyunsu Ba. Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31024294. |
dose-dependent neuroprotective effect of standardized bee venom phospholipase a parkinson's disease (pd) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons within the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
bee |
| Nicholas G Norwitz, Michele T Hu, Kieran Clark. The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease. Frontiers in nutrition. vol 6. 2020-10-01. PMID:31139630. |
parkinson's disease, a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, is strongly associated with the death of dopaminergic neurons in the brain's substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Morgan Sturgeon, Perry Wu, Robert Cornel. SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson's disease. Journal of neurology & neuromedicine. vol 1. issue 9. 2020-10-01. PMID:31187092. |
parkinson's disease (pd) is a neurodegenerative disorder of the central nervous system with a clinically heterogeneous presentation that includes progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
zebrafish |
| Hendrik Schöneborn, Fabian Raudzus, Emilie Secret, Nils Otten, Aude Michel, Jérome Fresnais, Christine Ménager, Jean-Michel Siaugue, Holm Zaehres, Irmgard D Dietzel, Rolf Heuman. Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. Journal of functional biomaterials. vol 10. issue 3. 2020-10-01. PMID:31315182. |
parkinson's disease (pd) is a neurodegenerative disease associated with loss or dysfunction of dopaminergic neurons located in the substantia nigra (sn), and there is no cure available. |
2020-10-01 |
2023-08-13 |
human |
| Nicoletta L Lilli, Delphine Révy, Sandra Robelet, Béatrice Lejeun. Effect of the micro-immunotherapy medicine 2LPARK Degenerative neurological and neuromuscular disease. vol 9. 2020-10-01. PMID:31372089. |
effect of the micro-immunotherapy medicine 2lpark parkinson's disease (pd) is a neurodegenerative disease characterized by motor impairments and resulting from progressive degenerative loss of midbrain dopaminergic (daergic) neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dong Hee Kim, Jeong June Choi, Byung-Jun Par. Herbal medicine (Hepad) prevents dopaminergic neuronal death in the rat MPTP model of Parkinson's disease. Integrative medicine research. vol 8. issue 3. 2020-10-01. PMID:31467840. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
rat |
| Martina Mazzocchi, Sean L Wyatt, Daniela Mercatelli, Michele Morari, Noelia Morales-Prieto, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:31572723. |
to provide insight into this, we used gene co-expression analysis to identify which, if any, of the class-iia hdacs had a positive correlation with markers of dopaminergic neurons in the human substantia nigra. |
2020-10-01 |
2023-08-13 |
human |
| Domenico Sergi, Justine Renaud, Nicola Simola, Maria-Grazia Martinol. Diabetes, a Contemporary Risk for Parkinson's Disease: Epidemiological and Cellular Evidences. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31787891. |
indeed, dopaminergic neurons located in the mesencephalic substantia nigra appear to be particularly vulnerable to oxidative stress and degeneration, likely because of their intrinsic susceptibility to mitochondrial dysfunction, which may represent a direct consequence of hyperglycemia and hyperglycemia-induced oxidative stress. |
2020-10-01 |
2023-08-13 |
Not clear |
| Caroline Wagenbreth, Maria Kuehne, Hans-Jochen Heinze, Tino Zaehl. Deep Brain Stimulation of the Subthalamic Nucleus Influences Facial Emotion Recognition in Patients With Parkinson's Disease: A Review. Frontiers in psychology. vol 10. 2020-10-01. PMID:31849760. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor symptoms following dopaminergic depletion in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shiqing Zhang, Peng Sun, Kaili Lin, Florence Hiu Ling Chan, Qi Gao, Wai Fung Lau, Vellaisamy A L Roy, Hongqi Zhang, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yun. Extracellular Nanomatrix-Induced Self-Organization of Neural Stem Cells into Miniature Substantia Nigra-Like Structures with Therapeutic Effects on Parkinsonian Rats. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871862. |
substantia nigra (sn) is a complex and critical region of the brain wherein parkinson's disease (pd) arises from the degeneration of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
rat |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
in parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. |
2020-10-01 |
2023-08-13 |
human |
| Renrong Wei, Cuiping Rong, Qingfeng Xie, Shouhai Wu, Yuchao Feng, Ruihua Wang, Zhenhui Dai, Tongxiang Li. Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson's Disease through the Inflammation Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31929812. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn)-striatum circuit, which is associated with glial activation and consequent chronic neuroinflammation. |
2020-10-01 |
2023-08-13 |
mouse |
| Qunhua Bai, Junlin He, Yong Tang, Shibo Wang, Jingfu Qiu, Yang Wang, Chao Y. Rotenone-induced energy stress decompensated in ventral mesocerebrum is associated with Parkinsonism progression in rats. Experimental and therapeutic medicine. vol 12. issue 2. 2020-09-30. PMID:27446321. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, which is characterized by the hallmark feature of loss of dopaminergic neurons in the substantia nigra. |
2020-09-30 |
2023-08-13 |
rat |
| Tineke K Steiger, Nico Bunzec. Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28174533. |
importantly, analyses of structural mri data revealed that individual reward-related differences in the elderlies' response time could be predicted by the structural integrity of the dopaminergic substantia nigra (sn; as measured by magnetization transfer (mt)). |
2020-09-30 |
2023-08-13 |
human |
| Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D Marshall, Bradley Worley, Ronald L Cerny, Eric D Dodds, Yuting Huang, Mihalis I Panayiotidis, Aglaia Pappa, Rodrigo Franc. Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. Metabolites. vol 7. issue 2. 2020-09-30. PMID:28538683. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Bigg. Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:28649601. |
in parkinson's disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Malabika Maulik, Swarup Mitra, Abel Bult-Ito, Barbara E Taylor, Elena M Vayndor. Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in Frontiers in genetics. vol 8. 2020-09-30. PMID:28659967. |
pathologically, pd is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
Not clear |