| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veronica A Antipova, Carsten Holzmann, Oliver Schmitt, Andreas Wree, Alexander Hawlitschk. Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson's Disease Differently Affects Behavior. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28680396. |
the loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. |
2020-09-30 |
2023-08-13 |
human |
| Juan M Viveros-Paredes, Rocio E González-Castañeda, Juerg Gertsch, Veronica Chaparro-Huerta, Rocio I López-Roa, Eduardo Vázquez-Valls, Carlos Beas-Zarate, Antoni Camins-Espuny, Mario E Flores-Sot. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP. Pharmaceuticals (Basel, Switzerland). vol 10. issue 3. 2020-09-30. PMID:28684694. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
Not clear |
| Mona Buhusi, Colten K Brown, Catalin V Buhus. Impaired Latent Inhibition in GDNF-Deficient Mice Exposed to Chronic Stress. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:29066960. |
glial-derived neurotrophic factor (gdnf) is essential for the physiology and survival of dopaminergic neurons in substantia nigra and of noradrenergic neurons in the locus coeruleus. |
2020-09-30 |
2023-08-13 |
mouse |
| Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan L. Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29071302. |
exposure to 10 mg/kg pq or 30 mg/kg mptp caused damage to nerve cells in the substantia nigra (sn) in both nrf2 (+/+) and nrf2 (-/-) icr mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (da) neurons. |
2020-09-30 |
2023-08-13 |
mouse |
| D E Korzhevskii, V V Gusel'nikova, O V Kirik, E G Sukhorukova, I P Grigore. The Spatial Organization of the Intranuclear Structures of Human Brain Dopaminergic Neurons. Acta naturae. vol 9. issue 3. 2020-09-30. PMID:29104779. |
we studied the intranuclear localization of protein nucleophosmin (b23) and ubiquitin in the dopaminergic neurons of human substantia nigra (n = 6, age of 25-87 years) using immunohistochemistry and confocal laser microscopy. |
2020-09-30 |
2023-08-13 |
human |
| Bridget Martinez, Philip V Peplo. MicroRNAs in Parkinson's disease and emerging therapeutic targets. Neural regeneration research. vol 12. issue 12. 2020-09-30. PMID:29323027. |
parkinson's disease (pd) is the second most common age-related neurodegenerative disorder, with the clinical main symptoms caused by a loss of dopaminergic neurons in the substantia nigra, corpus striatum and brain cortex. |
2020-09-30 |
2023-08-13 |
mouse |
| Guo-Qing Wang, Dai-Di Li, Chun Huang, Di-Sheng Lu, Chao Zhang, Shao-Yu Zhou, Jie Liu, Feng Zhan. Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375304. |
icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation parkinson's disease (pd) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (sn) dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
rat |
| Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisc. Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus, striatum and substantia nigra. Neural regeneration research. vol 13. issue 4. 2020-09-30. PMID:29722326. |
parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. |
2020-09-30 |
2023-08-13 |
Not clear |
| Tatiana V Tarasova, Olga A Lytkina, Valeria V Goloborshcheva, Larisa N Skuratovskaya, Alexandr I Antohin, Ruslan K Ovchinnikov, Michail S Kukharsk. Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain. PeerJ. vol 6. 2020-09-30. PMID:29785351. |
genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain. |
2020-09-30 |
2023-08-13 |
mouse |
| Akanksha Mishra, Sonu Singh, Shubha Shukl. Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease. Journal of experimental neuroscience. vol 12. 2020-09-30. PMID:29899667. |
reduction in dopamine content in the nigrostriatal pathway is associated with the development of pd, along with the degeneration of dopaminergic neurons in the substantia nigra region. |
2020-09-30 |
2023-08-13 |
Not clear |
| James Robert Brašić, Zoltan Mari, Alicja Lerner, Vanessa Raymont, Eram Zaidi, Dean F Won. Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. International journal of physical medicine & rehabilitation. vol 6. issue 3. 2020-09-30. PMID:30090843. |
the heat exposure may have altered at least temporarily his thermostat for normal heat-loss mechanisms through dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. |
2020-09-30 |
2023-08-13 |
Not clear |
| Margabandhu Gopi, Arambakkam Janardhanam Vanisre. Attenuated levels of phospholipids in the striatum of rats infused with rotenone causing hemiparkinsonism as detected by simple dye-lipid complex. IBRO reports. vol 3. 2020-09-30. PMID:30135937. |
parkinson's disease (pd), a progressive neurodegeneration, is characterized by loss of dopaminergic neurons in the substantia nigra (sn) and loss of motor co-ordination. |
2020-09-30 |
2023-08-13 |
rat |
| Yoshiki Nakashima, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takeshi Omas. The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson's Disease. Brain sciences. vol 8. issue 9. 2020-09-30. PMID:30200351. |
we searched for drugs that alleviate the reduction of dopaminergic neurons caused by the administration of lipopolysaccharide (lps) to the substantia nigra of the rat brain. |
2020-09-30 |
2023-08-13 |
mouse |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yousheng Mo, Erjin Xu, Renrong Wei, Baoluu Le, Lei Song, Dongli Li, Yonggen Chen, Xiaotian Ji, Shuhuan Fang, Jiangang Shen, Cong Yang, Qi Wan. Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-09-30. PMID:30224927. |
parkinson's disease (pd), the second most common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2020-09-30 |
2023-08-13 |
mouse |
| Xing-Zhi Guo, Chang Shan, Yan-Fang Hou, Geng Zhu, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Guang Ning, Sheng-Tian Li, Jian-Min Li. Osteocalcin Ameliorates Motor Dysfunction in a 6-Hydroxydopamine-Induced Parkinson's Disease Rat Model Through AKT/GSK3β Signaling. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30319352. |
as dopaminergic neuronal injury in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), we investigated whether ocn could exert protective effects on 6-hydroxydopamine (6-ohda)-induced pd rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Che. Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30524223. |
the results from animal experiments demonstrated that orexin-a attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (th) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Che. Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30524223. |
importantly, orexin-a increased the protein level of brain-derived neurotrophic factor (bdnf) in dopaminergic neurons of the substantia nigra. |
2020-09-30 |
2023-08-13 |
mouse |
| Da-Wei Li, Fa-Zhan Zhou, Xian-Chang Sun, Shu-Chen Li, Jin-Bin Yang, Huan-Huan Sun, Ai-Hua Wan. Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection. Neural regeneration research. vol 14. issue 10. 2020-09-30. PMID:31169200. |
these findings confirm that ginsenoside rb1 can inhibit inflammation induced by lipopolysaccharide injection into the substantia nigra and protect dopaminergic neurons, which may be related to its inhibition of the nuclear factor kappa b signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Thaisa M Cantu-Jungles, Heather E Rasmussen, Bruce R Hamake. Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease. Frontiers in neurology. vol 10. 2020-09-30. PMID:31281287. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. |
2020-09-30 |
2023-08-13 |
Not clear |