| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Af Bjerkén, Rasmus Stenmark Persson, Anna Barkander, Nina Karalija, Noelia Pelegrina-Hidalgo, Greg A Gerhardt, Ana Virel, Ingrid Strömber. Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance. Neurochemistry international. vol 131. 2020-09-03. PMID:31542295. |
in conclusion, long-term noradrenergic denervation reduces the number of dopaminergic neurons in the substantia nigra and affects the functionality of the nigrostriatal system. |
2020-09-03 |
2023-08-13 |
rat |
| b' Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A F Nicolaes, Jos C S Kleinjans, Jacco J Bried\\xc3\\xa. Acetaminophen Overdose as a Potential Risk Factor for Parkinson\'s Disease. Clinical and translational science. vol 12. issue 6. 2020-08-31. PMID:31305025.' |
thus, it is plausible that acetaminophen is taken up by the dopaminergic transport system into the substantia nigra (sn). |
2020-08-31 |
2023-08-13 |
human |
| Ellen T Koch, Lynn A Raymon. Dysfunctional striatal dopamine signaling in Huntington's disease. Journal of neuroscience research. vol 97. issue 12. 2020-08-21. PMID:31304622. |
the striatum is preferentially degenerated in hd, and this region receives dopaminergic input from the substantia nigra. |
2020-08-21 |
2023-08-13 |
mouse |
| Xiao-Hui Zhao, Yong-Bing Wang, Juan Yang, Hui-Qin Liu, Ling-Ling Wan. MicroRNA-326 suppresses iNOS expression and promotes autophagy of dopaminergic neurons through the JNK signaling by targeting XBP1 in a mouse model of Parkinson's disease. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31135066. |
parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons, and substantia nigra is primarily one of the damaged brain regions. |
2020-08-17 |
2023-08-13 |
mouse |
| Konrad M Ricke, Thomas Paß, Sammy Kimoloi, Kai Fährmann, Christian Jüngst, Astrid Schauss, Olivier R Baris, Marijana Aradjanski, Aleksandra Trifunovic, Therese M Eriksson Faelker, Matteo Bergami, Rudolf J Wiesne. Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 9. 2020-08-17. PMID:32005765. |
mitochondrial dysfunction is critically involved in parkinson's disease, characterized by loss of dopaminergic neurons (dans) in the substantia nigra (snc), whereas dans in the neighboring ventral tegmental area (vta) are much less affected. |
2020-08-17 |
2023-08-13 |
mouse |
| Zhan Liu, Ao-Wang Qiu, Yan Huang, Ya Yang, Jin-Na Chen, Ting-Ting Gu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Pen. IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31351185. |
neuroinflammation has been involved in pathogenesis of parkinson's disease (pd), a chronic neurodegenerative disease characterized neuropathologically by progressive dopaminergic neuronal loss in the substantia nigra (sn). |
2020-08-14 |
2023-08-13 |
mouse |
| Eoin O'Neill, Rosa Chiara Goisis, Ruth Haverty, Andrew Harki. L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. Journal of neuroscience research. vol 97. issue 7. 2020-08-13. PMID:30924171. |
neuroinflammation is a contributory factor underlying the progressive nature of dopaminergic neuronal loss within the substantia nigra (sn) of parkinson's disease (pd) patients, albeit the role of astrocytes in this process has been relatively unexplored to date. |
2020-08-13 |
2023-08-13 |
rat |
| Daniela Elgueta, Francisco Contreras, Carolina Prado, Andro Montoya, Valentina Ugalde, Ornella Chovar, Roque Villagra, Claudio Henríquez, Miguel A Abellanas, María S Aymerich, Rarael Franco, Rodrigo Pachec. Dopamine Receptor D3 Expression Is Altered in CD4 Frontiers in immunology. vol 10. 2020-08-13. PMID:31118938. |
microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. |
2020-08-13 |
2023-08-13 |
Not clear |
| Filip Bergquist, Anders Johansson, Nil Dizdar, Håkan Widner, Dag Nyholm, Per Odin, Per Svenningsso. [Parkinson's disease - heterogeneous and complex in its clinical presentation]. Lakartidningen. vol 117. 2020-08-10. PMID:32154902. |
lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. |
2020-08-10 |
2023-08-13 |
Not clear |
| Debashis Dutta, Madhuchhanda Kundu, Susanta Mondal, Avik Roy, Samantha Ruehl, Deborah A Hall, Kalipada Paha. RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31445159. |
rantes-induced invasion of th17 cells into substantia nigra potentiates dopaminergic cell loss in mptp mouse model of parkinson's disease. |
2020-08-06 |
2023-08-13 |
mouse |
| Miquel Vila, Ariadna Laguna, Iria Carballo-Carbaja. Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology. Autophagy. vol 15. issue 11. 2020-08-06. PMID:31480882. |
in parkinson disease (pd), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (sn), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal pathological diagnostic criterion for pd. |
2020-08-06 |
2023-08-13 |
Not clear |
| Cláudia M Deus, Susana P Pereira, Teresa Cunha-Oliveira, Francisco B Pereira, Nuno Raimundo, Paulo J Oliveir. Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31759069. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra. |
2020-08-03 |
2023-08-13 |
human |
| Briana R De Miranda, Marco Fazzari, Emily M Rocha, Sandra Castro, J Timothy Greenamyr. Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence. Toxicological sciences : an official journal of the Society of Toxicology. vol 170. issue 1. 2020-07-31. PMID:30907971. |
female rats receiving 3.2 mg/kg, and 3.6 mg/kg rotenone displayed significant loss of dopaminergic neurons in the substantia nigra as assessed by stereology, which was accompanied by a loss of striatal dopaminergic terminals. |
2020-07-31 |
2023-08-13 |
human |
| Yang You, Mina B Botros, Alicia A Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikez. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. vol 422. 2020-07-29. PMID:31689387. |
in this study, we developed a novel strategy to express p301l mutant tau to the dopaminergic neurons of substantia nigra by coupling tyrosine hydroxylase promoter cre-driver mice with a cre-inducible adeno-associated virus (iaav). |
2020-07-29 |
2023-08-13 |
mouse |
| Yang You, Mina B Botros, Alicia A Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikez. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. vol 422. 2020-07-29. PMID:31689387. |
the results showed that p301l mutant tau was successfully transduced in the dopaminergic neurons of the substantia nigra at the presence of cre recombinase and iaav. |
2020-07-29 |
2023-08-13 |
mouse |
| Yang You, Mina B Botros, Alicia A Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikez. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. vol 422. 2020-07-29. PMID:31689387. |
immunochemical analysis revealed that tau gene transfer significantly resulted in loss of tyrosine hydroxylase-positive dopaminergic neurons and elevated phosphorylated tau in the substantia nigra. |
2020-07-29 |
2023-08-13 |
mouse |
| Yanqiang Zhan, Muhammad U Raza, Lian Yuan, Meng-Yang Zh. Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability. Neuroscience. vol 422. 2020-07-29. PMID:31698021. |
an important pathology in parkinson's disease (pd) is the earlier and more severe degeneration of noradrenergic neurons in the locus coeruleus (lc) than dopaminergic neurons in the substantia nigra. |
2020-07-29 |
2023-08-13 |
rat |
| Yiwen Luan, Dongliang Tang, Haichuan Wu, Weixin Gu, Yuqing Wu, Jun-Li Cao, Cheng Xiao, Chunyi Zho. Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 18. 2020-07-28. PMID:32312820. |
to test this hypothesis, we established a unilateral parkinsonian mouse model with moderate lesions of dopaminergic neurons in the substantia nigra. |
2020-07-28 |
2023-08-13 |
mouse |
| Keiko Nakahara, Keisuke Maruyama, Takuya Ensho, Kenji Mori, Mikiya Miyazato, Kenji Kangawa, Ryoko Uemura, Hideyuki Sakoda, Masamitsu Nakazato, Noboru Murakam. Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus. Biochemical and biophysical research communications. vol 521. issue 2. 2020-07-27. PMID:31677791. |
immunohistochemical analysis revealed that icv injection of nmu induced cfos expression in dopaminergic neurons of the arcuate nucleus, but not the substantia nigra. |
2020-07-27 |
2023-08-13 |
mouse |
| Buket Ucar, Christian Humpe. Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models. Brain research bulletin. vol 149. 2020-07-20. PMID:31004735. |
glial cell line-derived neurotrophic factor (gdnf) is a potent trophic factor that supports the survival of dopaminergic neurons of the substantia nigra (sn), which degenerate in parkinson's disease (pd). |
2020-07-20 |
2023-08-13 |
mouse |