| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the reduction of dopamine levels in the striatum. |
2020-04-07 |
2023-08-13 |
mouse |
| Stefanie Köhler, Gerd Wagner, Karl-Jürgen Bä. Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia. Human brain mapping. vol 40. issue 1. 2020-04-06. PMID:30184301. |
we sought to investigate the putatively abnormal activation pattern of the dopaminergic midbrain nuclei, that is, ventral tegmental area (vta) and substantia nigra as well as that of the noradrenergic locus coeruleus (lc) in patients with schizophrenia during cognitive control. |
2020-04-06 |
2023-08-13 |
Not clear |
| Liang Zhu, Chenxi Sun, Jie Ren, Guangming Wang, Rongjie Ma, Lixin Sun, Danjing Yang, Shane Gao, Ke Ning, Zhigang Wang, Xu Chen, Shengdi Chen, Hongwen Zhu, Zhengliang Gao, Jun X. Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson's disease. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30718471. |
parkinson's disease (pd) is an aging-related degenerative disorder arisen from the loss of dopaminergic neurons in substantia nigra. |
2020-04-06 |
2023-08-13 |
Not clear |
| Benjamin Chew, Tobias U Hauser, Marina Papoutsi, Joerg Magerkurth, Raymond J Dolan, Robb B Rutledg. Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 37. 2020-04-06. PMID:31451671. |
here, using real-time functional magnetic resonance imaging, we tested whether risky decision making is influenced by endogenous fluctuations in blood oxygenation level-dependent (bold) activity in the dopaminergic midbrain, encompassing ventral tegmental area and substantia nigra. |
2020-04-06 |
2023-08-13 |
human |
| Elham Haghparast, Vahid Sheibani, Mehdi Abbasnejad, Saeed Esmaeili-Mahan. Apelin-13 attenuates motor impairments and prevents the changes in synaptic plasticity-related molecules in the striatum of Parkinsonism rats. Peptides. vol 117. 2020-04-02. PMID:31121196. |
in addition, it could rescue the dopaminergic neurons of the substantia nigra. |
2020-04-02 |
2023-08-13 |
rat |
| Kai-Jung Lin, Kai-Lieh Lin, Shang-Der Chen, Chia-Wei Liou, Yao-Chung Chuang, Hung-Yu Lin, Tsu-Kung Li. The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease. International journal of molecular sciences. vol 20. issue 21. 2020-04-01. PMID:31731450. |
there are two neuropathological hallmarks of pd, the dopaminergic neuronal loss and the alpha-synuclein-containing lewy body inclusions in the substantia nigra. |
2020-04-01 |
2023-08-13 |
Not clear |
| Chang Shan, Yan-Ling Gong, Qian-Qian Zhuang, Yan-Fang Hou, Shu-Min Wang, Qin Zhu, Guo-Rui Huang, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Sheng-Tian Li, Jian-Min Li. Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31220519. |
preinjection with nad in the striatum ameliorated motor deficits and dopaminergic neuronal damage in the substantia nigra and striatum of a mouse model of pd. |
2020-03-30 |
2023-08-13 |
mouse |
| Wojciech Paslawski, Justyna Zareba-Paslawska, Xiaoqun Zhang, Katharina Hölzl, Henrik Wadensten, Mohammadreza Shariatgorji, Shorena Janelidze, Oskar Hansson, Lars Forsgren, Per E Andrén, Per Svenningsso. α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 30. 2020-03-30. PMID:31270237. |
moreover, in contrast to controls, we observed the presence of apoe-positive neuromelanin-containing dopaminergic neurons in substantia nigra of pd patients. |
2020-03-30 |
2023-08-13 |
human |
| Sonia Lavisse, Susannah Williams, Sophie Lecourtois, Nadja van Camp, Martine Guillermier, Pauline Gipchtein, Caroline Jan, Sébastien Goutal, Leopold Eymin, Julien Valette, Thierry Delzescaux, Anselme L Perrier, Philippe Hantraye, Romina Aron Badi. Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates. Neurobiology of disease. vol 130. 2020-03-24. PMID:31132407. |
post-mortem analyses revealed a significant loss of medium-sized spiny neurons in the striatum, a loss of neurons and fibers in the globus pallidus, a unilateral decrease in dopaminergic neurons of the substantia nigra and a loss of neurons in the motor and dorsolateral prefrontal cortex. |
2020-03-24 |
2023-08-13 |
Not clear |
| Nazareno González, Trinidad Arcos-López, Annekatrin König, Liliana Quintanar, Mauricio Menacho Márquez, Tiago F Outeiro, Claudio O Fernánde. Effects of alpha-synuclein post-translational modifications on metal binding. Journal of neurochemistry. vol 150. issue 5. 2020-03-23. PMID:31099098. |
neurodegeneration in this pathology is characterized by the loss of dopaminergic neurons in the substantia nigra, coupled with cytoplasmic inclusions known as lewy bodies containing α-synuclein. |
2020-03-23 |
2023-08-13 |
Not clear |
| Guy C Brow. The endotoxin hypothesis of neurodegeneration. Journal of neuroinflammation. vol 16. issue 1. 2020-03-23. PMID:31519175. |
intestinal permeability increases early in parkinson's disease, and injection of endotoxin into mice induces α-synuclein production and aggregation, as well as loss of dopaminergic neurons in the substantia nigra. |
2020-03-23 |
2023-08-13 |
mouse |
| Ya-Shuo Feng, Si-Dong Yang, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng Zhan. The benefits and mechanisms of exercise training for Parkinson's disease. Life sciences. vol 245. 2020-03-23. PMID:31981631. |
the main pathological characteristics of pd consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing lewy bodies in the substantia nigra. |
2020-03-23 |
2023-08-13 |
Not clear |
| Lucas E Cromberg, Trinidad M M Saez, María G Otero, Eugenia Tomasella, Matías Alloatti, Ana Damianich, Victorio Pozo Devoto, Juan Ferrario, Diego Gelman, Marcelo Rubinstein, Tomás L Falzon. Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors. Journal of neurochemistry. vol 149. issue 3. 2020-03-18. PMID:30664247. |
the process of locomotion is controlled by fine-tuned dopaminergic neurons in the substantia nigra pars-compacta (snpc) that projects their axons to the dorsal striatum regulating cortical innervations of medium spiny neurons. |
2020-03-18 |
2023-08-13 |
mouse |
| Sara Rezai Amin, Carole Gruszczynski, Bruno P Guiard, Jacques Callebert, Jean-Marie Launay, Franck Louis, Catalina Betancur, Vincent Vialou, Sophie Gautro. Viral vector-mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine-related behaviors and hallmarks of programmed cell death. Journal of neurochemistry. vol 150. issue 3. 2020-03-18. PMID:30748001. |
in this study, we report the anatomical, neurochemical, and behavioral consequences in mice of adeno-associated virus (aav)-mediated cre expression in the dopaminergic nuclei substantia nigra, at commonly used viral titers (3 × 10 |
2020-03-18 |
2023-08-13 |
mouse |
| Luan Pereira Diniz, Isadora Matias, Ana Paula Bérgamo Araujo, Matheus Nunes Garcia, Fernanda G Q Barros-Aragão, Soniza Vieira Alves-Leon, Jorge Marcondes de Souza, Débora Foguel, Cláudia Pinto Figueiredo, Carolina Braga, Luciana Romão, Flávia Carvalho Alcantara Gome. α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model. Journal of neurochemistry. vol 150. issue 2. 2020-03-18. PMID:31009074. |
parkinson's disease (pd) is characterized by selective death of dopaminergic neurons in the substantia nigra, degeneration of the nigrostriatal pathway, increases in glutamatergic synapses in the striatum and aggregation of α-synuclein. |
2020-03-18 |
2023-08-13 |
mouse |
| Khaled Youssef, Anurag Tandon, Pouya Reza. Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices. Integrative biology : quantitative biosciences from nano to macro. vol 11. issue 5. 2020-03-17. PMID:31251339. |
parkinson's disease (pd) is a progressive neurological disorder associated with the loss of dopaminergic neurons (dns) in the substantia nigra and the widespread accumulation of α-synuclein (α-syn) protein, leading to motor impairments and eventual cognitive dysfunction. |
2020-03-17 |
2023-08-13 |
caenorhabditis_elegans |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in dopamine transporter (dat)-cre mice, overexpression of comt, specifically in dopaminergic neurons of the substantia nigra, produced cataleptic behaviours associated with impaired motor coordination. |
2020-03-12 |
2023-08-13 |
mouse |
| Pradeep Paudel, Se Eun Park, Su Hui Seong, Hyun Ah Jung, Jae Sue Cho. Bromophenols from Journal of agricultural and food chemistry. vol 68. issue 8. 2020-03-11. PMID:32011134. |
bromophenols from progressive degeneration of dopaminergic neurons in the substantia nigra is the characteristic feature of parkinson's disease (pd) and the severity accelerates with aging. |
2020-03-11 |
2023-08-13 |
Not clear |
| Liangqin Shi, Chao Huang, Qihui Luo, Yu Xia, Heng Liu, Like Li, Wentao Liu, Wenjing Ma, Jing Fang, Li Tang, Wen Zeng, Zhengli Che. Pilot study: molecular risk factors for diagnosing sporadic Parkinson's disease based on gene expression in blood in MPTP-induced rhesus monkeys. Oncotarget. vol 8. issue 62. 2020-03-09. PMID:29285276. |
clinical diagnosis of parkinson's disease (pd) is characterized by the classical features of tremor, bradykinesia and rigidity, which are present only when more than 70%-80% degeneration of dopaminergic (da) neurons in the substantia nigra. |
2020-03-09 |
2023-08-13 |
monkey |
| Conor Owens-Walton, David Jakabek, Brian D Power, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C L Looi, Marnie Shaw, Oskar Hansso. Increased functional connectivity of thalamic subdivisions in patients with Parkinson's disease. PloS one. vol 14. issue 9. 2020-03-09. PMID:31483847. |
parkinson's disease (pd) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. |
2020-03-09 |
2023-08-13 |
Not clear |