| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the number of dopaminergic neurons in the substantia nigra (sn), the serotonergic neurons in the dorsal raphe nucleus, and the cholinergic neurons in the tegmental nucleus significantly decreased as compared with normal group, whereas the noradrenergic neurons in the locus coeruleus substantially increased. |
2019-12-26 |
2023-08-13 |
rat |
| John P M Finberg, Miguel Schwartz, Raneen Jeries, Samih Badarny, Morad K Nakhleh, Enas Abu Daoud, Yelena Ayubkhanov, Manal Aboud-Hawa, Yoav Y Broza, Hossam Haic. Sensor Array for Detection of Early Stage Parkinson's Disease before Medication. ACS chemical neuroscience. vol 9. issue 11. 2019-12-23. PMID:29989795. |
in addition, early detection of pd can potentially enable the start of neuroprotective therapy before extensive loss of dopaminergic neurons of the substantia nigra occurs. |
2019-12-23 |
2023-08-13 |
human |
| Yunseon Jang, Hyosun Choo, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Min Jeong Ryu, Eung Seok Oh, Song-Yi Choi, Woosuk Chung, Gi Ryang Kweon, Jun Young He. Auraptene Mitigates Parkinson's Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species. International journal of molecular sciences. vol 20. issue 14. 2019-12-23. PMID:31336718. |
treatment with aur significantly increased the viability of substantia nigra (sn)-derived sn4741 embryonic dopaminergic neuronal cells and reduced rotenone-induced mitochondrial ros production. |
2019-12-23 |
2023-08-13 |
mouse |
| Yunseon Jang, Hyosun Choo, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Min Jeong Ryu, Eung Seok Oh, Song-Yi Choi, Woosuk Chung, Gi Ryang Kweon, Jun Young He. Auraptene Mitigates Parkinson's Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species. International journal of molecular sciences. vol 20. issue 14. 2019-12-23. PMID:31336718. |
aur treatment improved movement, consistent with the observed increase in the number of dopaminergic neurons in the substantia nigra. |
2019-12-23 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tomoko Kanzaki, Yoshimi Kotani, Mako Katoh, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. Journal of nutritional science and vitaminology. vol 65. issue 2. 2019-12-19. PMID:31061292. |
our previous study showed that the subcutaneous administration of auraptene (aur) suppresses inflammatory responses including the hyperactivation of microglia in the substantia nigra (sn) of the midbrain of lipopolysaccharide-induced parkinson's disease (pd)-like mice, as well as inhibits dopaminergic neuronal cell death in this region. |
2019-12-19 |
2023-08-13 |
mouse |
| Akihiko Ishihar. Mild hyperbaric oxygen: mechanisms and effects. The journal of physiological sciences : JPS. vol 69. issue 4. 2019-12-19. PMID:31062232. |
a decrease in dopaminergic neurons in the substantia nigra of mice with parkinson's disease was inhibited by exposure to mild hyperbaric oxygen. |
2019-12-19 |
2023-08-13 |
mouse |
| Miwako Kawamura, Shigeto Sato, Gen Matsumoto, Takahiro Fukuda, Kahori Shiba-Fukushima, Sachiko Noda, Masashi Takanashi, Nozomu Mori, Nobutaka Hattor. Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients. Neuroscience letters. vol 699. 2019-12-17. PMID:30684677. |
lewy bodies and pale bodies in dopaminergic neurons in the substantia nigra are pathological hallmarks of pd. |
2019-12-17 |
2023-08-13 |
mouse |
| Alevtina Zharikov, Qing Bai, Briana R De Miranda, Amber Van Laar, J Timothy Greenamyre, Edward A Burto. Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration. Neurobiology of disease. vol 125. 2019-12-16. PMID:30658149. |
stereological quantification of nissl-labeled neurons showed no evidence of neurodegeneration in the substantia nigra 12 months after inoculation with either vector, and we observed abundant dopaminergic neurons with minimal α-synuclein immunoreactivity that appeared otherwise unremarkable in the aav-sh[snca] group. |
2019-12-16 |
2023-08-13 |
rat |
| Alevtina Zharikov, Qing Bai, Briana R De Miranda, Amber Van Laar, J Timothy Greenamyre, Edward A Burto. Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration. Neurobiology of disease. vol 125. 2019-12-16. PMID:30658149. |
we conclude that long-term α-synuclein knockdown in the substantia nigra does not cause significant functional deficits in the ascending dopaminergic projection, or neurodegeneration. |
2019-12-16 |
2023-08-13 |
rat |
| Sandra Franco-Iborra, Thais Cuadros, Annabelle Parent, Jordi Romero-Gimenez, Miquel Vila, Celine Perie. Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30405116. |
however, in vivo, while tom20 overexpression exacerbated neurodegeneration in both substantia nigra (sn) pars compacta (pc) and striatum, overexpression of tim23 partially protected dopaminergic neurons in the snpc. |
2019-12-10 |
2023-08-13 |
Not clear |
| Tao Peng, Xiaoyan Liu, Jingtao Wang, Yu Liu, Zhenqiang Fu, Xingrong Ma, Junmin Li, Guifang Sun, Yangfei Ji, Jingjing Lu, Wencui Wan, Hong L. Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-09. PMID:31298038. |
parkinson's disease (pd) is a common age-related neurodegenerative disease resulted from the progressive degeneration of dopaminergic neurons in the pars compacta region of substantia nigra. |
2019-12-09 |
2023-08-13 |
mouse |
| b' Neringa Jucevi\\xc4\\x8di\\xc5\\xabt\\xc4\\x97, Indr\\xc4\\x97 Banaityt\\xc4\\x97, Antanas Vaitkus, Renata Balnyt\\xc4\\x9. Preclinical signs of Parkinson\'s disease: A possible association of Parkinson\'s disease with skin and hair features. Medical hypotheses. vol 127. 2019-12-06. PMID:31088630.' |
parkinson's disease (pd) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. |
2019-12-06 |
2023-08-13 |
human |
| Jessica H Hartman, Claudia Gonzalez-Hunt, Samantha M Hall, Ian T Ryde, Kim A Caldwell, Guy A Caldwell, Joel N Meye. Genetic Defects in Mitochondrial Dynamics in International journal of molecular sciences. vol 20. issue 13. 2019-12-03. PMID:31261893. |
genetic defects in mitochondrial dynamics in parkinson's disease (pd) is one of the most common neurodegenerative disorders involving devastating loss of dopaminergic neurons in the substantia nigra. |
2019-12-03 |
2023-08-13 |
Not clear |
| Ping-Yue Pan, Yingbo Zhu, Yuan Shen, Zhenyu Yu. Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease. Neurobiology of disease. vol 122. 2019-12-02. PMID:29723605. |
the disease is characterized pathologically by denervation of dopaminergic (daergic) nigrostriatal terminal and degeneration of daergic neurons in the substantia nigra par compacta (snpc); however, the precise molecular mechanism underlying disease pathogenesis remains poorly understood. |
2019-12-02 |
2023-08-13 |
human |
| Li Ling, Ye Jiang, Yongdan Liu, Huimin Li, Ahmed Bari, Riaz Ullah, Jinwei Xu. Role of gold nanoparticle from Cinnamomum verum against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mice model. Journal of photochemistry and photobiology. B, Biology. vol 201. 2019-11-29. PMID:31706085. |
pd is distinguishedwith loss of dopaminergic (da) neurons in the substantia nigra. |
2019-11-29 |
2023-08-13 |
mouse |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 24. issue 11. 2019-11-28. PMID:31185705. |
immunohistochemcial data showed that rotenone injections significantly increased the loss of dopaminergic neurons in the substantia nigra, and decreased the striatal expression of tyrosine hydroxylase. |
2019-11-28 |
2023-08-13 |
rat |
| Jan Kamiński, Adam N Mamelak, Kurtis Birch, Clayton P Mosher, Michele Tagliati, Ueli Rutishause. Novelty-Sensitive Dopaminergic Neurons in the Human Substantia Nigra Predict Success of Declarative Memory Formation. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29657115. |
novelty-sensitive dopaminergic neurons in the human substantia nigra predict success of declarative memory formation. |
2019-11-25 |
2023-08-13 |
human |
| Xiao-Yan Feng, Jingting Yang, Xiaoli Zhang, Jinxia Zh. Gastrointestinal non-motor dysfunction in Parkinson's disease model rats with 6-hydroxydopamine. Physiological research. vol 68. issue 2. 2019-11-25. PMID:30628835. |
parkinson's disease (pd) is a neurodegenerative disease with a progressive loss of mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2019-11-25 |
2023-08-13 |
rat |
| Shefri. Therapeutic advances in idiopathic Parkinsonism. Expert opinion on investigational drugs. vol 8. issue 10. 2019-11-20. PMID:11139811. |
efforts are being concentrated on understanding the causes and mechanisms involved in the death of dopaminergic neurones in the substantia nigra. |
2019-11-20 |
2023-08-12 |
Not clear |
| F. Artaud, P. Baruch, J. M. Stutzmann, M. Saffroy, G. Godeheu, L. Barbeito, D. Hervé, J. M. Studler, J. Glowinski, A. Chéram. Cholecystokinin: Corelease with dopamine from nigrostriatal neurons in the cat. The European journal of neuroscience. vol 1. issue 2. 2019-11-20. PMID:12106166. |
the activation of dopaminergic cells induced by the nigral application of alpha-methyl-para-tyrosine (10-4 m) stimulated the release of cck-li and dopamine in the ipsilateral caudate nucleus, whilst opposite effects were seen in the substantia nigra. |
2019-11-20 |
2023-08-12 |
cat |