| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuezhu Cai, Ju Qiao, Tatiana Knox, Sade Iriah, Praveen Kulkarni, Dan Madularu, Tom Morrison, Barbara Waszczak, Jochen C Hartner, Craig F Ferri. In search of early neuroradiological biomarkers for Parkinson's Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 -/- rats. Brain research. vol 1706. 2020-05-29. PMID:30389398. |
a mutation in the pink1 gene that alters its function can increase the risk for autosomal recessive familial pd and similarly, through genetic deletion of portions of the pink1 gene in animal models (i.e., "pink1 knock-out (-/-) rats) produces a progressive loss of dopaminergic neurons in the substantia nigra which is analogous to the pathological hallmarks in human pd patients. |
2020-05-29 |
2023-08-13 |
human |
| Yaping Chu, Scott Muller, Adriana Tavares, Olivier Barret, David Alagille, John Seibyl, Gilles Tamagnan, Ken Marek, Kelvin C Luk, John Q Trojanowski, Virginia M Y Lee, Jeffrey H Kordowe. Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31580415. |
the α-synuclein preformed fibrils resulted in lewy pathology in the ipsilateral substantia nigra with significant reduction (-29.30%) of dopaminergic neurons as compared with controls. |
2020-05-26 |
2023-08-13 |
monkey |
| Anett Illés, Péter Balicza, Anikó Gál, Klára Pentelényi, Dóra Csabán, András Gézsi, Viktor Molnár, Mária Judit Molná. Hereditary Parkinson’s disease as a new clinical manifestation of the damaged POLG gene Orvosi hetilap. vol 161. issue 20. 2020-05-26. PMID:32364361. |
now, it is known that mitochondrial dysfunction in parkinson's disease plays a key role in the loss of dopaminergic neurons in the substantia nigra. |
2020-05-26 |
2023-08-13 |
Not clear |
| Cristina Cocco, Giulia Corda, Carlo Lisci, Barbara Noli, Manolo Carta, Carla Brancia, Elias Manca, Carla Masala, Francesco Marrosu, Paolo Solla, Barbara Manconi, Paolo Bongioanni, Gian-Luca Ferr. VGF peptides as novel biomarkers in Parkinson's disease. Cell and tissue research. vol 379. issue 1. 2020-05-21. PMID:31713727. |
parkinson's disease (pd) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2020-05-21 |
2023-08-13 |
human |
| Liping Zhang, LingYu Zhang, Lin Li, Christian Hölsche. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 1. 2020-05-20. PMID:30741689. |
in addition, both drugs rescued the decrease of tyrosine hydroxylase (th) levels, reduced the accumulation of α-syn, alleviated the chronic inflammation response in the brain, reduced lipid peroxidation, and inhibited the mitochondrial mitophagy signaling pathway, and furthermore increased expression of the key growth factor gdnf that protects dopaminergic neurons in the substantia nigra (sn) and striatum. |
2020-05-20 |
2023-08-13 |
mouse |
| Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang, Taolei Su. Gold nanoclusters for Parkinson's disease treatment. Biomaterials. vol 194. 2020-05-18. PMID:30576972. |
in addition, immunohistochemical and western blot (wb) analyses indicate that auncs can significantly reverse dopaminergic (da) neuron loss in substantia nigra and striatum of sick mice. |
2020-05-18 |
2023-08-13 |
mouse |
| Antonio Martín-Bastida, Nicholas P Lao-Kaim, Andreas Antonios Roussakis, Graham E Searle, Yue Xing, Roger N Gunn, Stefan T Schwarz, Roger A Barker, Dorothee P Auer, Paola Piccin. Relationship between neuromelanin and dopamine terminals within the Parkinson's nigrostriatal system. Brain : a journal of neurology. vol 142. issue 7. 2020-05-18. PMID:31056699. |
parkinson's disease is characterized by the progressive loss of pigmented dopaminergic neurons in the substantia nigra and associated striatal deafferentation. |
2020-05-18 |
2023-08-13 |
human |
| Hye Ryeong Lim, Mai-Tram Vo, Dong Jun Kim, Unn Hwa Lee, Jong Hyuk Yoon, Hyung-Jun Kim, Jeongah Kim, Sang Ryong Kim, Jun Yeon Lee, Chae Ha Yang, Hee Young Kim, June-Seek Choi, Kijeong Kim, Esther Yang, Hyun Kim, Seongsoo Lee, Byung Ju Lee, Kyungjin Kim, Jeong Woo Park, Chang Man H. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861806. |
drg2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (str), ventral tegmental area (vta), and substantia nigra (sn), and on neuronal cell bodies in high-density regions such as the hippocampus (hip), cerebellum, and cerebral cortex in the mouse brain. |
2020-05-15 |
2023-08-13 |
mouse |
| Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun W. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice. Toxicology. vol 426. 2020-05-14. PMID:31381935. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Rachael H Earls, Kelly B Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G Hazim, Jae-Kyung Le. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. Journal of neuroinflammation. vol 16. issue 1. 2020-05-14. PMID:31796095. |
), preceding the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
high fat diet suppresses peroxisome proliferator-activated receptors and reduces dopaminergic neurons in the substantia nigra. |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
tyrosine hydroxylase staining showed that the hfd resulted in fewer dopaminergic neurons in the substantia nigra (sn), but not the striatum. |
2020-05-14 |
2023-08-13 |
mouse |
| Varshesh Shah, Rajesh Alugolu, Abhishek Arora, Rukmini M Kandadai, Vijayasaradhi Mudumba, Rupam Borgohai. 3T MRI-SWI based volumetric analysis of the subthalamic and red nuclei in advanced Parkinson's disease. Journal of neurosurgical sciences. 2020-05-13. PMID:32401475. |
parkinson's disease (pd) is a neurodegenerative disease mainly involving the dopaminergic neurons of the substantia nigra. |
2020-05-13 |
2023-08-13 |
Not clear |
| E R Mingazov, E N Pavlova, S A Surkov, M V Ugrumo. Proteins of the Vesicular Cycle as a Marker of Neuroplasticity of Dopaminergic Neurons in the Substantia Nigra of the Brain. Doklady. Biochemistry and biophysics. vol 489. issue 1. 2020-05-12. PMID:32130610. |
proteins of the vesicular cycle as a marker of neuroplasticity of dopaminergic neurons in the substantia nigra of the brain. |
2020-05-12 |
2023-08-13 |
mouse |
| Dong Hwan Ho, Wongi Seol, Ilhong So. Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. Cell cycle (Georgetown, Tex.). vol 18. issue 4. 2020-05-05. PMID:30712480. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra and the presence of lewy bodies (lb) in neurons. |
2020-05-05 |
2023-08-13 |
mouse |
| Katarzyna Z Kuter, Łukasz Olech, Norbert A Denche. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. vol 47. 2020-04-27. PMID:30578987. |
partial degeneration of dopaminergic neurons in the substantia nigra (sn), induces locomotor disability in animals but with time it is spontaneously compensated for by neurons surviving in the tissue by increasing their functional efficiency. |
2020-04-27 |
2023-08-13 |
rat |
| Gülser Karadaban Emir, Yasemin Ünal, Nigar Yılmaz, Kürsad Tosun, Gülnihal Kutl. The association of low levels of nesfatin-1 and glucagon-like peptide-1 with oxidative stress in Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 12. 2020-04-27. PMID:31280388. |
in parkinson's disease (pd), oxidative stress plays a substantial role in degeneration of dopaminergic neurons at the substantia nigra. |
2020-04-27 |
2023-08-13 |
Not clear |
| Ankur Butala, Melissa Shepard, Greg Ponton. Neuropsychiatric aspects of Parkinson disease psychopharmacology: Insights from circuit dynamics. Handbook of clinical neurology. vol 165. 2020-04-17. PMID:31727232. |
parkinson disease (pd) is a neurodegenerative disorder with a complex pathophysiology characterized by the progressive loss of dopaminergic neurons within the substantia nigra. |
2020-04-17 |
2023-08-13 |
Not clear |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-14. PMID:32002951. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2020-04-14 |
2023-08-13 |
Not clear |
| Ankita Ravi Vaswani, Beatrice Weykopf, Cathleen Hagemann, Hans-Ulrich Fried, Oliver Brüstle, Sandra Blaes. Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons. eLife. vol 8. 2020-04-10. PMID:30689541. |
correct setup of the substantia nigra requires reelin-mediated fast, laterally-directed migration of dopaminergic neurons. |
2020-04-10 |
2023-08-13 |
Not clear |