| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P.-P. Michel, E.-C. Hirsch, Y. Agi. [Parkinson's disease: cell death mechanisms] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690312. |
[parkinson's disease: cell death mechanisms] parkinson disease is a neurodegenerative disorder of aging characterized by a selective and progressive loss of dopaminergic neurons within the substantia nigra. |
2019-11-20 |
2023-08-12 |
Not clear |
| P.-P. Michel, E.-C. Hirsch, Y. Agi. [Parkinson's disease: cell death mechanisms] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690312. |
three populations of dopaminergic neurons seem to coexist in the substantia nigra of parkinsonian patients; (1) senescent neurons that are still spared by the pathological process; (2) sick neurons exhibiting generally a preserved morphology but showing evidence of biochemical and metabolic abnormalities; (3) neurons which have entered into a final state of agony and exhibit the hallmarks of apoptosis, a controlled form of cell death that requires the activation of a particular type of proteases, caspases. |
2019-11-20 |
2023-08-12 |
Not clear |
| F. Viallet, T. Witja. [Neuroplasticity and Parkinson's disease] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690314. |
after a brief survey of some general aspects of plasticity in the cns, the present tutorial review illustrates with recent data from the literature the modes of plastic changes during the course of ipd, either resulting from dopaminergic denervation (hyperactivity of remaining dopaminergic neurons with increase of their excitatory cholinergic innervation in the substantia nigra, enhancement of the corticostriatal glutamatergic synaptic activity at the striatal level) or due to dopaminergic treatment (change in phosphorylation state of the striatal glutamate receptors, internalization of d1 dopamine receptors). |
2019-11-20 |
2023-08-12 |
Not clear |
| Ph. Brachet, Ph. Damie. [Repair] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690315. |
this is the case with parkinson's disease, which results from a selective loss of dopaminergic neurons of the substantia nigra. |
2019-11-20 |
2023-08-12 |
human |
| Michela Ferrucci, Francesca Biagioni, Giorgio Vivacqua, Carla Letizia Busceti, Alessia Bartalucci, Paola Soldani, Loredana D'Este, Lorenzo Fumagalli, Francesco Forna. The neurobiology of the spinal cord in experimental parkinsonism and Parkinson's disease. Archives italiennes de biologie. vol 151. issue 4. 2019-11-20. PMID:24873929. |
thus, the clear-cut between degeneration of dopaminergic neurons in the substantia nigra and the loss of pyramidal motor system appears now more as a continuum of degeneration which converge in abnormal activity and cell pathology of motor neurons as a final common pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rosa Lippolis, Rosa Anna Siciliano, Consiglia Pacelli, Anna Ferretta, Maria Fiorella Mazzeo, Salvatore Scacco, Francesco Papa, Antonio Gaballo, Claudia Dell'Aquila, Michele De Mari, Sergio Papa, Tiziana Cocc. Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients. Biochimica et biophysica acta. vol 1852. issue 9. 2019-11-20. PMID:26096686. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. |
2019-11-20 |
2023-08-13 |
human |
| John P Kostrzewa, Rose Anna Kostrzewa, Richard M Kostrzewa, Ryszard Brus, Przemysław Nowa. Perinatal 6-Hydroxydopamine Modeling of ADHD. Current topics in behavioral neurosciences. vol 29. 2019-11-20. PMID:26475157. |
rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta substantia nigra, with comparable destruction of the nigrostriatal tract and lifelong ~99 % dopaminergic denervation of striatum, with lesser destructive effect on the ventral tegmental nucleus and associated lesser dopaminergic denervation of nucleus accumbens and prefrontal cortex. |
2019-11-20 |
2023-08-13 |
rat |
| YuHong Fu, George Paxinos, Charles Watson, Glenda M Hallida. The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration. Journal of chemical neuroanatomy. vol 76. issue Pt B. 2019-11-20. PMID:26859066. |
the substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration. |
2019-11-20 |
2023-08-13 |
human |
| Zhibin Wang, Xiao-Guang Luo, Chao Ga. Utility of susceptibility-weighted imaging in Parkinson's disease and atypical Parkinsonian disorders. Translational neurodegeneration. vol 5. 2019-11-20. PMID:27761236. |
when the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (sn) have been lost. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ayse Ozkan, Hande Parlak, Gamze Tanriover, Sayra Dilmac, Seher Nasircilar Ulker, Ilknur Birsen, Aysel Aga. The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: The role of hemeoxygenase. Neurochemistry international. 2019-11-20. PMID:27984168. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2019-11-20 |
2023-08-13 |
mouse |
| Shu-Ying Liu, Piu Chan, A Jon Stoess. The underlying mechanism of prodromal PD: insights from the parasympathetic nervous system and the olfactory system. Translational neurodegeneration. vol 6. 2019-11-20. PMID:28239455. |
neurodegeneration of parkinson's disease (pd) starts in an insidious manner, 30-50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| A Gugliandolo, P Bramanti, E Mazzo. Mesenchymal stem cell therapy in Parkinson's disease animal models. Current research in translational medicine. vol 65. issue 2. 2019-11-20. PMID:28466824. |
parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, and as a consequence, by decreased dopamine levels in the striatum. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hilary A Marusak, Joshua R B Hatfield, Moriah E Thomason, Christine A Rabina. Reduced Ventral Tegmental Area-Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2019-11-20. PMID:28740870. |
here, we evaluate the impact of early threat exposure (violence, abuse) on functional connectivity of putative dopaminergic midbrain regions, the ventral tegmental area (vta) and substantia nigra (sn), giving rise to mesocorticolimbic and nigrostriatal pathways, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jun Shi, Qiong Cai, Jingxing Zhang, Xiaolie He, Yigang Liu, Rongrong Zhu, Lingjing Ji. AM1241 alleviates MPTP-induced Parkinson's disease and promotes the regeneration of DA neurons in PD mice. Oncotarget. vol 8. issue 40. 2019-11-20. PMID:28978077. |
the main pathological feature of parkinson's disease (pd) is the loss of dopaminergic neurons in the substantia nigra. |
2019-11-20 |
2023-08-13 |
mouse |
| b' R Krawczyk, I Klejbor, K Turlejski, B Ludkiewicz, J Mory\\xc5\\x9. Organisation of the dopamine neuronal subsets within midbrain of the feathertail glider (Acrobates pygmaeus, Acrobatidae, Marsupialia). Folia morphologica. vol 76. issue 4. 2019-11-20. PMID:29064551.' |
our study showed that the general distribution and characteristics of the dopaminergic cells within midbrain nuclei of the pygmy acrobat is similar to that in other species, but it lack the substantia nigra compact part - ventral tier and "tail" of the substantia nigra subnuclei. |
2019-11-20 |
2023-08-13 |
Not clear |
| Panchanan Maiti, Jayeeta Manna, Gary L Dunba. Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments. Translational neurodegeneration. vol 6. 2019-11-20. PMID:29090092. |
gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi X. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo. Translational neurodegeneration. vol 7. 2019-11-20. PMID:30128145. |
abnormal expression of major histocompatibility complex class i (mhc-i) is increased in dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Bing Hu, Qianqian Shi, Yu Guo, Xiyezi Diao, Heng Guo, Jinsong Zhang, Liang Yu, Hao Dai, Luonan Che. The oscillatory boundary conditions of different frequency bands in Parkinson's disease. Journal of theoretical biology. vol 451. 2019-11-18. PMID:29727632. |
the most important pathological change in pd is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which results in a decrease in the dopamine (da) content of the striatum. |
2019-11-18 |
2023-08-13 |
Not clear |
| Arun Sing. Oscillatory activity in the cortico-basal ganglia-thalamic neural circuits in Parkinson's disease. The European journal of neuroscience. vol 48. issue 8. 2019-11-14. PMID:29381817. |
degeneration of dopaminergic neurons in the substantia nigra increases the influence of the indirect pathway, resulting in motor dysfunction in parkinson's disease (pd). |
2019-11-14 |
2023-08-13 |
Not clear |
| Ying Liu, Zuneng L. Long non-coding RNA NEAT1 mediates the toxic of Parkinson's disease induced by MPTP/MPP+ via regulation of gene expression. Clinical and experimental pharmacology & physiology. vol 45. issue 8. 2019-11-14. PMID:29575151. |
parkinson's disease (pd) is a result of the loss of dopaminergic neurons in the substantia nigra and is expected to increase the economic burden on patients' families and societies. |
2019-11-14 |
2023-08-13 |
mouse |