| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chi-Jing Choong, Hideki Mochizuk. Gene therapy targeting mitochondrial pathway in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 2. 2018-02-21. PMID:27638713. |
parkinson's disease (pd) presents a relative selective localization of pathology to substantia nigra and well-defined motor symptoms caused by dopaminergic degeneration that makes it an ideal target for gene therapy. |
2018-02-21 |
2023-08-13 |
Not clear |
| Satyndra Kumar Yadav, Sachchida Nand Rai, Surya Pratap Sing. Mucuna pruriens reduces inducible nitric oxide synthase expression in Parkinsonian mice model. Journal of chemical neuroanatomy. vol 80. 2018-02-20. PMID:27919828. |
our results demonstrated that mp protects the dopaminergic neurons from the no injury in substantia nigra. |
2018-02-20 |
2023-08-13 |
mouse |
| Junjun Zhao, Shuqing Yu, Yan Zheng, Hui Yang, Jianliang Zhan. Oxidative Modification and Its Implications for the Neurodegeneration of Parkinson's Disease. Molecular neurobiology. vol 54. issue 2. 2018-02-13. PMID:26843115. |
the major characteristics of pd include the loss of dopaminergic neurons in the substantia nigra and lewy body depositions. |
2018-02-13 |
2023-08-13 |
Not clear |
| Deniz Kirik, Erik Cederfjäll, Glenda Halliday, Åsa Petersé. Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands. Neurobiology of disease. vol 97. issue Pt B. 2018-02-12. PMID:27616425. |
several clinical trials have been performed to test the capacity of glial-cell line derived neurotrophic factor and neurturin to rescue degenerating dopaminergic neurons in the substantia nigra and their axon terminals in the striatum by delivery of these neurotrophic factors either as purified protein or by means of viral vector mediated gene delivery to the brain. |
2018-02-12 |
2023-08-13 |
Not clear |
| A D Surowka, M Töpperwien, M Bernhardt, J D Nicolas, M Osterhoff, T Salditt, D Adamek, M Szczerbowska-Boruchowsk. Combined in-situ imaging of structural organization and elemental composition of substantia nigra neurons in the elderly. Talanta. vol 161. 2018-02-07. PMID:27769419. |
human dopaminergic system in general, and substantia nigra (sn) neurons, in particular, are implicated in the pathologies underlying the human brain aging. |
2018-02-07 |
2023-08-13 |
human |
| Paraskevi Krashia, Alessandro Martini, Annalisa Nobili, Daniela Aversa, Marcello D'Amelio, Nicola Berretta, Ezia Guatteo, Nicola Biagio Mercur. On the properties of identified dopaminergic neurons in the mouse substantia nigra and ventral tegmental area. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27519559. |
on the properties of identified dopaminergic neurons in the mouse substantia nigra and ventral tegmental area. |
2018-02-01 |
2023-08-13 |
mouse |
| Hongliang Yi, Xiaohang Bao, Xiaotong Tang, Xiaotang Fan, Haiwei X. Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice. Journal of chemical neuroanatomy. vol 77. 2018-01-31. PMID:27211874. |
estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of parkinson's disease (pd) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (bdnf), and calretinin (cr) containing dopaminergic (da) neurons. |
2018-01-31 |
2023-08-13 |
mouse |
| Ambreen Fatima, Saba Khanam, Rahul Rahul, Smita Jyoti, Falaq Naz, Fahad Ali, Yasir Hasan Siddiqu. Protective effect of tangeritin in transgenic Drosophila model of Parkinson's disease. Frontiers in bioscience (Elite edition). vol 9. 2018-01-31. PMID:27814588. |
parkinson's disease (pd) is a neurodegenerative disorder caused due to the loss of dopaminergic neurons in substantia nigra region of midbrain. |
2018-01-31 |
2023-08-13 |
drosophila_melanogaster |
| Megan E Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M Sullivan, Siobhain M O'Mahony, John F Cryan, Gerard W O'Keeff. Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27266391. |
mesodiencephalic dopaminergic neurons in the ventral tegmental area (vta) regulate motivation and reward, whereas those in the substantia nigra (sn) are essential for motor control. |
2018-01-30 |
2023-08-13 |
rat |
| Yi-Ming Shao, Xiaohua Ma, Priyankar Paira, Aaron Tan, Deron Raymond Herr, Kah Leong Lim, Chee Hoe Ng, Gopalakrishnan Venkatesan, Karl-Norbert Klotz, Stephanie Federico, Giampiero Spalluto, Siew Lee Cheong, Yu Zong Chen, Giorgia Pastori. Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment. PloS one. vol 13. issue 1. 2018-01-29. PMID:29304113. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. |
2018-01-29 |
2023-08-13 |
human |
| L Yetnikoff, H N Lavezzi, R A Reichard, D S Zah. An update on the connections of the ventral mesencephalic dopaminergic complex. Neuroscience. vol 282. 2018-01-26. PMID:24735820. |
this review covers the intrinsic organization and afferent and efferent connections of the midbrain dopaminergic complex, comprising the substantia nigra, ventral tegmental area and retrorubral field, which house, respectively, the a9, a10 and a8 groups of nigrostriatal, mesolimbic and mesocortical dopaminergic neurons. |
2018-01-26 |
2023-08-13 |
human |
| Yannick Vermeiren, Peter P De Dey. Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story. Neurochemistry international. vol 102. 2018-01-25. PMID:27899296. |
for almost half a century, the motor aspects have been attributed to lewy pathology (lp) predominantly in the substantia nigra (sn), causing a major loss of dopaminergic neurons. |
2018-01-25 |
2023-08-13 |
Not clear |
| Yu Yeon Jung, Nikita Katila, Sabita Neupane, Sina Shadfar, Uttam Ojha, Sunil Bhurtel, Sunil Srivastav, Dong Ju Son, Pil-Hoon Park, Do Young Yoon, Jin Tae Hong, Dong-Young Cho. Enhanced dopaminergic neurotoxicity mediated by MPTP in IL-32β transgenic mice. Neurochemistry international. vol 102. 2018-01-25. PMID:27956238. |
immunohistochemistry showed that overexpression of il-32β significantly increased mptp-mediated loss of dopaminergic neurons in the substantia nigra and deletion of tyrosine hydroxylase-positive fibers in the striatum. |
2018-01-25 |
2023-08-13 |
mouse |
| Pamela Mahe. Protective effects of fisetin and other berry flavonoids in Parkinson's disease. Food & function. vol 8. issue 9. 2018-01-24. PMID:28714503. |
parkinson's disease (pd) is an age-associated degenerative disease of the midbrain that results from the loss of dopaminergic neurons in the substantia nigra. |
2018-01-24 |
2023-08-13 |
human |
| Abhishek Singh, Dwaipayan Se. MicroRNAs in Parkinson's disease. Experimental brain research. vol 235. issue 8. 2018-01-23. PMID:28526930. |
loss of dopaminergic neurons in the substantia nigra of brain leads to impairment of motor activities as well as cognitive defects. |
2018-01-23 |
2023-08-13 |
Not clear |
| Pil Sung Gu, Minho Moon, Jin Gyu Choi, Myung Sook O. Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model. The Journal of nutritional biochemistry. vol 39. 2018-01-17. PMID:27741433. |
in addition, immunohistochemical analysis indicated that me exhibits the protective effects against dopaminergic neuronal damage induced by mptp/p in the substantia nigra and striatum. |
2018-01-17 |
2023-08-13 |
mouse |
| Thomas M Jeitner, Mike Kalogiannis, Boris F Krasnikov, Irving Gomolin, Morgan R Peltier, Graham R Mora. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 2. 2018-01-16. PMID:27026709. |
here, we report that chlorodopamine is toxic to dopaminergic neurons both in vivo and in vitro intrastriatal administration of 90 nmol chlorodopamine to mice resulted in loss of dopaminergic neurons from the substantia nigra and decreased ambulation-results that were comparable to those produced by the same dose of the parkinsonian poison, 1-methyl-4-phenylpyridinium (mpp+). |
2018-01-16 |
2023-08-13 |
mouse |
| Thomas M Jeitner, Mike Kalogiannis, Boris F Krasnikov, Irving Gomolin, Morgan R Peltier, Graham R Mora. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 2. 2018-01-16. PMID:27026709. |
overall, our findings suggest that chlorination of dopamine by hocl generates toxins that selectively kill dopaminergic neurons in the substantia nigra in a manner comparable to mpp+. |
2018-01-16 |
2023-08-13 |
mouse |
| Federico N Soria, Michel Engeln, Marta Martinez-Vicente, Christelle Glangetas, María José López-González, Sandra Dovero, Benjamin Dehay, Elisabeth Normand, Miquel Vila, Alexandre Favereaux, François Georges, Christophe Lo Bianco, Erwan Bezard, Pierre-Olivier Fernagu. Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration. Human molecular genetics. vol 26. issue 14. 2018-01-11. PMID:28520872. |
despite loss of gba1 and substrate accumulation, dat-gba1-ko mice displayed normal motor performances and preserved dopaminergic neurons despite robust microglial activation in the substantia nigra, without accumulation of endogenous alpha-synuclein with respect to wild-type mice. |
2018-01-11 |
2023-08-13 |
mouse |
| Tian Wang, Lijie Wang, Cuiting Li, Bing Han, Zhenhua Wang, Ji Li, Yan Lv, Shuyun Wang, Fenghua F. Hydroxysafflor Yellow A Improves Motor Dysfunction in the Rotenone-Induced Mice Model of Parkinson's Disease. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28097465. |
hsya treatment increased not only the number of th-containing dopaminergic neurons in substantia nigra, but also the dopamine content in the striatum in pd mice. |
2018-01-09 |
2023-08-13 |
mouse |