| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Inga B Fricke, Thomas Viel, Maik M Worlitzer, Franziska M Collmann, Alexis Vrachimis, Andreas Faust, Lydia Wachsmuth, Cornelius Faber, Frédéric Dollé, Michael T Kuhlmann, Klaus Schäfers, Sven Hermann, Jens C Schwamborn, Andreas H Jacob. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:26950181. |
parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (sn), leading to severe impairment in motor and non-motor functions. |
2017-11-16 |
2023-08-13 |
mouse |
| Abdellatif Abbaoui, Omar El Hiba, Halima Gamran. Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat. Acta histochemica. vol 119. issue 5. 2017-11-16. PMID:28619286. |
the classic and evident symptoms of pd namely rigidity, tardiness of movement, and difficulty with walking, result from progressive dopaminergic neurons death within substantia nigra. |
2017-11-16 |
2023-08-13 |
rat |
| Rebecca Playne, Bronwen Conno. Understanding Parkinson's Disease through the Use of Cell Reprogramming. Stem cell reviews and reports. vol 13. issue 2. 2017-11-06. PMID:28083784. |
in order to gain novel insights into such a complex disease, cell-based models of pd should represent, as closely as possible, aged human dopaminergic neurons of the substantia nigra. |
2017-11-06 |
2023-08-13 |
human |
| Kyung Moon Lee, Yujeong Lee, Hye Jeong Chun, Ah Hyun Kim, Ju Yeon Kim, Joo Yeon Lee, Akihito Ishigami, Jaewon Le. Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27265894. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2017-11-03 |
2023-08-13 |
mouse |
| Danielle E Mor, Elpida Tsika, Joseph R Mazzulli, Neal S Gould, Hanna Kim, Malcolm J Daniels, Shachee Doshi, Preetika Gupta, Jennifer L Grossman, Victor X Tan, Robert G Kalb, Kim A Caldwell, Guy A Caldwell, John H Wolfe, Harry Ischiropoulo. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature neuroscience. vol 20. issue 11. 2017-11-02. PMID:28920936. |
parkinson's disease (pd) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of lewy body inclusions containing aggregated α-synuclein. |
2017-11-02 |
2023-08-13 |
mouse |
| J Gao, X-Y Kang, S Sun, L Li, B-L Zhang, Y-Q Li, D-S Ga. Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell death & disease. vol 7. 2017-10-31. PMID:27148690. |
glial cell line-derived neurotrophic factor (gdnf) has strong neuroprotective and neurorestorative effects on dopaminergic (da) neurons in the substantia nigra (sn); however, the underlying molecular mechanisms remain to be fully elucidated. |
2017-10-31 |
2023-08-13 |
Not clear |
| Merja H Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T Männistö, Raimo K Tuomine. Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. eNeuro. vol 4. issue 1. 2017-10-31. PMID:28303260. |
parkinson's disease (pd) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (daergic) neurons of the substantia nigra (sn) and the accumulation of intracellular inclusions containing α-synuclein. |
2017-10-31 |
2023-08-13 |
rat |
| Ting-Ting Huang, Dong-Lin Hao, Bo-Na Wu, Lun-Lin Mao, Jin Zhan. Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway. Biochemical and biophysical research communications. vol 493. issue 4. 2017-10-30. PMID:28986252. |
we showed that uric acid improved behavioral performances and cognition of pd mice, increased th-positive dopaminergic neurons and decreased gfap-positive astrocytes in substantia nigra (sn). |
2017-10-30 |
2023-08-13 |
mouse |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| DaeHan Ahn, Hyerim Chung, Ho-Won Lee, Kyunghun Kang, Pan-Woo Ko, Nam Sung Kim, Taejoon Par. Smart Gait-Aid Glasses for Parkinson's Disease Patients. IEEE transactions on bio-medical engineering. vol 64. issue 10. 2017-10-24. PMID:28113199. |
parkinson's disease (pd) is a chronic progressive disease caused by loss of dopaminergic neurons in the substantia nigra, degenerating the nervous system of a patient over time. |
2017-10-24 |
2023-08-13 |
Not clear |
| Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shi. Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and biophysical research communications. vol 493. issue 2. 2017-10-23. PMID:28939041. |
the overexpression of paris selectively leads to the loss of dopaminergic neurons (dn) and mitochondrial abnormalities in the substantia nigra (sn) of parkinson's disease (pd) models. |
2017-10-23 |
2023-08-13 |
mouse |
| Paromita Kundu, Manasi Das, Kalpalata Tripathy, Sanjeeb K Saho. Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease. ACS chemical neuroscience. vol 7. issue 12. 2017-10-20. PMID:27642670. |
parkinson's disease (pd) is the most widespread form of dementia where there is an age related degeneration of dopaminergic neurons in the substantia nigra region of the brain. |
2017-10-20 |
2023-08-13 |
mouse |
| Joanna A Korecka, Elizabeth B Moloney, Ruben Eggers, Barbara Hobo, Sanny Scheffer, Nienke Ras-Verloop, R Jeroen Pasterkamp, Dick F Swaab, August B Smit, Ronald E van Kesteren, Koen Bossers, Joost Verhaage. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28842419. |
in line with this, rgma induced selective degeneration of dopaminergic neurons in the substantia nigra (sn) and affected the integrity of the nigrostriatal system. |
2017-10-10 |
2023-08-13 |
mouse |
| Xiang-Jun Sheng, Hunag-Ju Tu, Wei-Lin Chien, Kai-Hsiang Kang, Dai-Hua Lu, Horng-Huei Liou, Ming-Jen Lee, Wen-Mei F. Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation. PloS one. vol 12. issue 8. 2017-10-09. PMID:28806787. |
administration of mg132, a peptide aldehyde proteasome inhibitor, significantly increased the expression of heme oxygenase-1 (ho-1) in rat dopaminergic neurons in the substantia nigra and in the sh-sy5y neuronal cell line. |
2017-10-09 |
2023-08-13 |
rat |
| Shida Zhou, Xinxing Du, Junxia Xie, Jun Wan. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PloS one. vol 12. issue 7. 2017-10-06. PMID:28672025. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and subsequent da depletion in the striatum. |
2017-10-06 |
2023-08-13 |
Not clear |
| Ana Tereza Di Lorenzo Alho, Claudia Kimie Suemoto, Lívia Polichiso, Edilaine Tampellini, Kátia Cristina de Oliveira, Mariana Molina, Glaucia Aparecida Bento Santos, Camila Nascimento, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferreti-Rebustini, Alexandre Valotta da Silva, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Helmut Heinsen, Lea Tenenholz Grinber. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26386691. |
the substantia nigra (sn), the source of major dopaminergic pathways in the brain, is particularly vulnerable to changes in the progression of several age-related neurodegenerative diseases. |
2017-09-29 |
2023-08-13 |
human |
| Kyung Ah Han, Woo Hyun Shin, Sungyeon Jung, Wongi Seol, Hyemyung Seo, CheMyong Ko, Kwang Chul Chun. Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation. Human molecular genetics. vol 26. issue 1. 2017-09-26. PMID:27798112. |
parkinson's disease (pd) is characterized by slow, progressive degeneration of dopaminergic neurons in the substantia nigra. |
2017-09-26 |
2023-08-13 |
Not clear |
| Maowen Ba, Guozhao Ma, Chao Ren, Xuwen Sun, Min Kon. Repetitive transcranial magnetic stimulation for treatment of lactacystin-induced Parkinsonian rat model. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881616. |
rtms could significantly alleviate the loss of tyrosine hydroxylase-positive dopaminergic neurons in lactacystin-lesioned substantia nigra and prevent the loss of striatal dopamine levels. |
2017-09-25 |
2023-08-13 |
rat |
| Daniel Komnig, Silke Imgrund, Arno Reich, Stefan Gründer, Björn H Falkenburge. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease. PloS one. vol 11. issue 11. 2017-09-18. PMID:27820820. |
we determined the number of dopaminergic neurons in the substantia nigra, assayed by stereological counting 14 days after the last mptp injection, the number of nissl positive neurons in the substantia nigra, and the concentration of catecholamines in the striatum. |
2017-09-18 |
2023-08-13 |
mouse |
| Laura Angioni, Cristina Cocco, Gian-Luca Ferri, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Hormones and behavior. vol 83. 2017-09-07. PMID:27189764. |
since oxytocin-saporin injected into the substantia nigra caused a marked reduction of neurons immunoreactive for tyrosine hydroxylase (e.g., nigrostriatal dopaminergic neurons) and for vesicular glutamate transporters vglut1, vglut2 and vglut3 (e.g., glutamatergic neurons), but not for glutamic acid decarboxylase (e.g., gabaergic neurons), together these findings suggest that oxytocin influences locomotor activity by acting on receptors localized presynaptically in nigral glutamatergic nerve terminals (which control the activity of nigral gabaergic efferent neurons projecting to brain stem nuclei controlling locomotor activity), rather than on receptors localized in the cell bodies/dendrites of nigrostriatal dopaminergic neurons. |
2017-09-07 |
2023-08-13 |
rat |