| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johanna Duda, Christina Pötschke, Birgit Lis. Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:26865375. |
dopamine-releasing neurons within the substantia nigra (sn da) are particularly vulnerable to degeneration compared to other dopaminergic neurons. |
2017-07-14 |
2023-08-13 |
Not clear |
| Anindita Bose, M Flint Bea. Mitochondrial dysfunction in Parkinson's disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27546335. |
the pathological hallmarks of the disease include the loss of dopaminergic neurons in the substantia nigra and the presence of lewy bodies that are made of α-synuclein. |
2017-07-14 |
2023-08-13 |
Not clear |
| Celia van der Merwe, Hayley Christy van Dyk, Lize Engelbrecht, Francois Hendrikus van der Westhuizen, Craig Kinnear, Ben Loos, Soraya Bardie. Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson's Disease from Mitochondrial Dysfunction and Cell Death. Molecular neurobiology. vol 54. issue 4. 2017-07-11. PMID:27003823. |
parkinson's disease (pd) is a neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. |
2017-07-11 |
2023-08-13 |
Not clear |
| Jonathan Boyd, Alice Ha. Deguelin and Its Role in Chronic Diseases. Advances in experimental medicine and biology. vol 929. 2017-07-10. PMID:27771933. |
pd is a neurodegenerative disorder, characterized by a substantial loss of dopaminergic neurons in the substantia nigra, as well the manifestation of symptoms such as bradykinesia, rigidity, and rest tremor. |
2017-07-10 |
2023-08-13 |
rat |
| Hong Jiang, Jun Wang, Jack Rogers, Junxia Xi. Brain Iron Metabolism Dysfunction in Parkinson's Disease. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27039308. |
understanding how iron accumulates in the substantia nigra (sn) and why it specifically targets dopaminergic (daergic) neurons is particularly warranted for pd, as this knowledge may provide new therapeutic avenues for a more targeted neurotherapeutic strategy for this disease. |
2017-07-07 |
2023-08-13 |
Not clear |
| James B Koprich, Tom H Johnston, Gabriela Reyes, Vanessa Omana, Jonathan M Brotchi. Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque. PloS one. vol 11. issue 11. 2017-07-06. PMID:27902767. |
when injected into 4 sites within each substantia nigra (7 μl per site, 1.7 x 1012 gp/ml), this vector provided expression lasting at least 4 months, and a 50% loss of nigral dopaminergic neurons and a 60% reduction in striatal dopamine. |
2017-07-06 |
2023-08-13 |
human |
| Mariela V Escande, Irene R E Taravini, Camila L Zold, Juan E Belforte, M Gustavo Mure. Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 21. 2017-07-03. PMID:27225760. |
here, we have used in vivo juxtacellular recordings and transgenic mice showing msn-type-specific expression of fluorescent proteins to examine striatal imbalance after lesioning dopaminergic neurons of the substantia nigra. |
2017-07-03 |
2023-08-13 |
mouse |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
notably, pbx1 and nfe2l1 levels are severely reduced in dopaminergic neurons of the substantia nigra of parkinson's disease (pd) patients and decreased nfe2l1 levels increases damage by oxidative stress in human midbrain cells. |
2017-06-28 |
2023-08-13 |
human |
| Yinxiu Ding, Zixin Zhang, Jiangbo Ma, Hechun Xia, Yin Wang, Yinming Liu, Quanrui Ma, Tao Sun, Juan Li. Directed differentiation of postnatal hippocampal neural stem cells generates nuclear receptor related‑1 protein‑ and tyrosine hydroxylase‑expressing cells. Molecular medicine reports. vol 14. issue 3. 2017-06-27. PMID:27432537. |
although the detailed underlying molecular mechanism remains to be elucidated, the major pathological feature of pd is the loss of dopaminergic (da) neurons of the substantia nigra. |
2017-06-27 |
2023-08-13 |
mouse |
| Matan Soll, Orit Bar Am, Atif Mahammed, Irena Saltsman, Silvia Mandel, Moussa B H Youdim, Zeev Gros. Neurorescue by a ROS Decomposition Catalyst. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27442690. |
the effect of the bis-sulfonated iron(iii) corrole (1-fe), a potent decomposition catalyst of reactive oxygen species, on rescuing sn4741 cells that were damaged by 6-hydroxydopamine (6-ohda) was investigated as an in vitro model system for studying cell death of dopaminergic neurons in the substantia nigra. |
2017-06-21 |
2023-08-13 |
Not clear |
| Eduardo Maria Normando, Benjamin Michael Davis, Lies De Groef, Shereen Nizari, Lisa A Turner, Nivedita Ravindran, Milena Pahlitzsch, Jonathan Brenton, Giulia Malaguarnera, Li Guo, Satyanarayana Somavarapu, Maria Francesca Cordeir. The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson's disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27535749. |
dopaminergic cell death in the substantia nigra and accumulation of lewy bodies are the defining neuropathological hallmarks of the disease. |
2017-06-21 |
2023-08-13 |
Not clear |
| Federica Marcuzzi, Silvia Zucchelli, Maria Bertuzzi, Claudio Santoro, Gianluca Tell, Piero Carninci, Stefano Gustincic. Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra. Journal of neurochemistry. vol 139. issue 4. 2017-06-15. PMID:27488413. |
isoforms of the erythropoietin receptor in dopaminergic neurons of the substantia nigra. |
2017-06-15 |
2023-08-13 |
mouse |
| Federica Marcuzzi, Silvia Zucchelli, Maria Bertuzzi, Claudio Santoro, Gianluca Tell, Piero Carninci, Stefano Gustincic. Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra. Journal of neurochemistry. vol 139. issue 4. 2017-06-15. PMID:27488413. |
in the brain, epor has been shown to protect several neuronal cell types from cell death, including the a9 dopaminergic neurons (da) of the substantia nigra (sn). |
2017-06-15 |
2023-08-13 |
mouse |
| Yu Zhang, I-Wei Wu, Duygu Tosun, Eric Foster, Norbert Schuf. Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study. PloS one. vol 11. issue 10. 2017-06-15. PMID:27798653. |
in pd patients, high dti changes in the substantia nigra correlated with increasing dopaminergic deficits as well as with declining α-synuclein and total tau protein concentrations in cerebrospinal fluid. |
2017-06-15 |
2023-08-13 |
human |
| Xin Qi, Brandon Davis, Yung-Hsiao Chiang, Emily Filichia, Austin Barnett, Nigel H Greig, Barry Hoffer, Yu Lu. Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27317935. |
notably, deletion of the p53 gene in da neurons significantly reduced dopaminergic neuronal loss in substantia nigra, dopaminergic neuronal terminal loss at striatum and, additionally, decreased motor deficits in mice challenged with mptp. |
2017-06-14 |
2023-08-13 |
mouse |
| Elisabeth Dinter, Theodora Saridaki, Markus Nippold, Sarah Plum, Leonie Diederichs, Daniel Komnig, Luisa Fensky, Caroline May, Katrin Marcus, Aaron Voigt, Jörg B Schulz, Björn H Falkenburge. Rab7 induces clearance of α-synuclein aggregates. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27333324. |
using mass spectrometry, we identified rab7 in neuromelanin granules purified from human substantia nigra, indicating that rab7 might be involved in the biogenesis of these possibly protective, autophagosome-like organelles in dopaminergic neurons. |
2017-06-14 |
2023-08-13 |
human |
| Daniel Komnig, Jörg B Schulz, Arno Reich, Björn H Falkenburge. Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease. Journal of neurochemistry. vol 139. issue 5. 2017-06-14. PMID:27638043. |
fourteen days after the last mptp injection, the number of dopaminergic neurons in the lateral substantia nigra, assayed by stereological counting, was reduced by 39% in control mice and 53% in faim2-deficient mice. |
2017-06-14 |
2023-08-13 |
mouse |
| Nivedita Bhattacharjee, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Sabanum Choudhury, Anupom Bora. L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra. Neuroscience letters. vol 628. 2017-06-13. PMID:27283777. |
in rodent, elevated level of hcy in brain or infusion of the same directly into the substantia nigra (sn) potentiates dopaminergic neurodegeneration. |
2017-06-13 |
2023-08-13 |
mouse |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The astrocytic response to the dopaminergic denervation of the striatum. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27230040. |
increasing evidence suggests that the dopaminergic degeneration which characterizes parkinson's disease starts in the striatal dopamine terminals and progresses retrogradely to the body of dopamine cells in the substantia nigra. |
2017-06-09 |
2023-08-13 |
rat |
| Ewa B Romuk, Wioletta Szczurek, Przemysław G Nowak, Edyta Hudziec, Ewa Chwalińska, Ewa Birkne. Effects of Propofol on the Liver Oxidative-Antioxidant Balance in a Rat Model of Parkinson's Disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 25. issue 5. 2017-06-01. PMID:28028942. |
parkinson's disease is caused by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. |
2017-06-01 |
2023-08-13 |
rat |