| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Tan, Zhi Song, Lamei Yuan, Wei Xiong, Xiong Deng, Bin Ni, Yong Chen, Hao Den. Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson's disease. Neuroscience letters. vol 612. 2016-06-28. PMID:26704436. |
parkinson's disease (pd) is the second most common neurodegenerative disorder after alzheimer's disease and is characterized by the degeneration of dopaminergic neurons in substantia nigra. |
2016-06-28 |
2023-08-13 |
Not clear |
| Qiaoying Huang, Xiaoxiao Du, Xin He, Qing Yu, Kunhua Hu, Wolfgang Breitwieser, Qingyu Shen, Shanshan Ma, Mingtao L. JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease. Experimental neurology. vol 277. 2016-06-27. PMID:26515688. |
furthermore, within the dopaminergic neurons of the substantia nigra in mptp-treated mice, jnk2/3 phosphorylates threonine 69 (thr69) of activating transcription factor-2 (atf2), a transcription factor of the atf/creb family, whereas the phosphorylation of thr71 is constitutive and remains unchanged. |
2016-06-27 |
2023-08-13 |
mouse |
| Yan-Hua Li, Qing He, Jie-zhong Yu, Chun-yun Liu, Ling Feng, Zhi Chai, Qing Wang, Hong-zhen Zhang, Guang-Xian Zhang, Bao-guo Xiao, Cun-gen M. Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model. Metabolic brain disease. vol 30. issue 5. 2016-06-24. PMID:26084861. |
our results for the first time showed that la administration improved motor dysfunction, protected dopaminergic neurons loss, and decreased α-synuclein accumulation in the substantia nigra (sn) area of brain. |
2016-06-24 |
2023-08-13 |
Not clear |
| Omidreza Jafarieh, Shadab Md, Mushir Ali, Sanjula Baboota, J K Sahni, Bhavna Kumari, Aseem Bhatnagar, Javed Al. Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting. Drug development and industrial pharmacy. vol 41. issue 10. 2016-06-15. PMID:25496439. |
parkinson disease (pd) is a common, progressive neurodegenerative disorder, characterized by marked depletion of striatal dopamine and degeneration of dopaminergic neurons in the substantia nigra. |
2016-06-15 |
2023-08-13 |
Not clear |
| Yukiko Ogura, Takeshi Izumi, Mitsuhiro Yoshioka, Toshiya Matsushim. Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick. Behavioural brain research. vol 294. 2016-06-14. PMID:26235329. |
as the ascending dopaminergic projections include the mesolimbic and nigrostriatal pathways, we targeted our lesions at the medial striatum (mst) and substantia nigra (sn). |
2016-06-14 |
2023-08-13 |
chicken |
| Jun-yu Li, Shan-shan Ma, Qiao-ying Huang, Ming-tao L. [The Function of Neuroinflammation in Parkinson Disease]. Sheng li ke xue jin zhan [Progress in physiology]. vol 46. issue 3. 2016-06-10. PMID:26521481. |
parkinson disease (pd) is the second most common neurodegenerative disorder, characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2016-06-10 |
2023-08-13 |
Not clear |
| Jonathan Murray Lovell, Judith Mylius, Henning Scheich, Michael Brosc. Stimulation of the Dopaminergic Midbrain as a Behavioral Reward in Instrumentally Conditioned Monkeys. Brain stimulation. vol 8. issue 5. 2016-06-09. PMID:26070295. |
since the mesocortical dopaminergic system of rodents has several differences to that found in primate species, including humans, there is the need for more exhaustively studying causative relationships between activation/stimulation of the ventral tegmental area (vta) and substantia nigra (sn) and behavior in monkeys. |
2016-06-09 |
2023-08-13 |
monkey |
| Yu Zhang, I-Wei Wu, Shannon Buckley, Christopher S Coffey, Eric Foster, Susan Mendick, John Seibyl, Norbert Schuf. Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 9. 2016-06-08. PMID:25920732. |
the depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing a dysregulation in striatal activity that ultimately leads to lack of movement control. |
2016-06-08 |
2023-08-13 |
Not clear |
| Abid Oueslati, Blaise Lovisa, John Perrin, Georges Wagnières, Hubert van den Bergh, Yanik Tardy, Hilal A Lashue. Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. PloS one. vol 10. issue 10. 2016-06-07. PMID:26484876. |
in the present study, we report that chronic pmb treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an aav-based rat genetic model of parkinson's disease (pd). |
2016-06-07 |
2023-08-13 |
human |
| Abid Oueslati, Blaise Lovisa, John Perrin, Georges Wagnières, Hubert van den Bergh, Yanik Tardy, Hilal A Lashue. Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. PloS one. vol 10. issue 10. 2016-06-07. PMID:26484876. |
this treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. |
2016-06-07 |
2023-08-13 |
human |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
inflammation is an important pathogenic factor in parkinson's disease (pd), so that it can contribute to kill dopaminergic neurons of the substantia nigra and to enhance the dopaminergic denervation of the striatum. |
2016-05-31 |
2023-08-13 |
mouse |
| Yan Kong, Xijun Liang, Lin Liu, Dongdong Zhang, Chao Wan, Zhenji Gan, Liudi Yua. High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model. PloS one. vol 10. issue 9. 2016-05-31. PMID:26361355. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of lewy bodies. |
2016-05-31 |
2023-08-13 |
drosophila_melanogaster |
| Neha Sharma, Bimla Nehr. Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation. Neurochemistry international. vol 87. 2016-05-24. PMID:26055970. |
primary pathology underlying parkinson's disease (pd) is the loss of dopaminergic neurons in the substantia nigra (sn). |
2016-05-24 |
2023-08-13 |
Not clear |
| Marina Theodorou, Benedict Rauser, Jingzhong Zhang, Nilima Prakash, Wolfgang Wurst, Joel A Schic. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Human gene therapy methods. vol 26. issue 4. 2016-05-24. PMID:26107288. |
parkinson's disease is one of the most common neurodegenerative disorders characterized by cell death of dopaminergic neurons in the substantia nigra. |
2016-05-24 |
2023-08-13 |
mouse |
| Warunee Dansithong, Sharan Paul, Daniel R Scoles, Stefan M Pulst, Duong P Huyn. Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. PloS one. vol 10. issue 8. 2016-05-24. PMID:26317803. |
parkinson's disease (pd) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons of the substantia nigra. |
2016-05-24 |
2023-08-13 |
Not clear |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Günter U Höglinger, Daniel Alvarez-Fischer, Oscar Arias-Carrión, Miriam Djufri, Andrea Windolph, Ursula Keber, Andreas Borta, Vincent Ries, Rainer K W Schwarting, Dieter Scheller, Wolfgang H Oerte. A new dopaminergic nigro-olfactory projection. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26072303. |
in the present study, we demonstrate a dopaminergic innervation from neurons in the substantia nigra to the olfactory bulb by axonal tracing studies. |
2016-05-17 |
2023-08-13 |
rat |
| Günter U Höglinger, Daniel Alvarez-Fischer, Oscar Arias-Carrión, Miriam Djufri, Andrea Windolph, Ursula Keber, Andreas Borta, Vincent Ries, Rainer K W Schwarting, Dieter Scheller, Wolfgang H Oerte. A new dopaminergic nigro-olfactory projection. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26072303. |
injection of two dopaminergic neurotoxins-1-methyl-4-phenylpyridinium and 6-hydroxydopamine-into the olfactory bulb induced a decrease in the number of dopaminergic neurons in the substantia nigra. |
2016-05-17 |
2023-08-13 |
rat |
| Günter U Höglinger, Daniel Alvarez-Fischer, Oscar Arias-Carrión, Miriam Djufri, Andrea Windolph, Ursula Keber, Andreas Borta, Vincent Ries, Rainer K W Schwarting, Dieter Scheller, Wolfgang H Oerte. A new dopaminergic nigro-olfactory projection. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26072303. |
hence, we demonstrate for the first time the existence of a direct dopaminergic projection into the olfactory bulb and identify its origin in the substantia nigra in rats. |
2016-05-17 |
2023-08-13 |
rat |
| J C Koch, F Bitow, J Haack, Z d'Hedouville, J-N Zhang, L Tönges, U Michel, L M A Oliveira, T M Jovin, J Liman, L Tatenhorst, M Bähr, P Lingo. Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell death & disease. vol 6. 2016-05-10. PMID:26158517. |
many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals and axons precedes the demise of dopaminergic neurons in the substantia nigra, which finally results in the clinical symptoms of parkinson disease (pd). |
2016-05-10 |
2023-08-13 |
human |