| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D B Hoban, L Howard, E Dow. GDNF-secreting mesenchymal stem cells provide localized neuroprotection in an inflammation-driven rat model of Parkinson's disease. Neuroscience. vol 303. 2016-05-10. PMID:26166730. |
injection of lps into the substantia nigra induced a pronounced local inflammatory response which resulted in 20% loss of nigrostriatal dopaminergic neurons and impaired contralateral motor function. |
2016-05-10 |
2023-08-13 |
rat |
| Kazuhiro Nakaso, Yosuke Horikoshi, Toru Takahashi, Takehiko Hanaki, Masato Nakasone, Yoshinori Kitagawa, Taisuke Koike, Tatsuya Matsur. Estrogen receptor-mediated effect of δ-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson's disease. Neuroscience letters. vol 610. 2016-05-09. PMID:26523792. |
erβ is expressed in neuronal cells, including dopaminergic neurons in the substantia nigra. |
2016-05-09 |
2023-08-13 |
mouse |
| Kazuhiro Nakaso, Yosuke Horikoshi, Toru Takahashi, Takehiko Hanaki, Masato Nakasone, Yoshinori Kitagawa, Taisuke Koike, Tatsuya Matsur. Estrogen receptor-mediated effect of δ-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson's disease. Neuroscience letters. vol 610. 2016-05-09. PMID:26523792. |
daily forced oral administration of δt3 inhibited the loss of dopaminergic neurons in the substantia nigra. |
2016-05-09 |
2023-08-13 |
mouse |
| Xian-Chang Sun, Xiao-Fan Ren, Lei Chen, Xian-Qi Gao, Jun-Xia Xie, Wen-Fang Che. Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt A. 2016-05-03. PMID:26455404. |
glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. |
2016-05-03 |
2023-08-13 |
rat |
| Xian-Chang Sun, Xiao-Fan Ren, Lei Chen, Xian-Qi Gao, Jun-Xia Xie, Wen-Fang Che. Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt A. 2016-05-03. PMID:26455404. |
the present study aimed to evaluate the protective effects of ginsenoside rg1 on lipopolysaccharide (lps)-induced microglia activation and dopaminergic neuronal degeneration in rat substantia nigra (sn) and its potential mechanisms. |
2016-05-03 |
2023-08-13 |
rat |
| Yi-Hsin Weng, Chu-Yu Chen, Kun-Jun Lin, Ying-Ling Chen, Tu-Hsueh Yeh, Ing-Tsung Hsiao, Ing-Jou Chen, Chin-Song Lu, Hung-Li Wan. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26363496. |
compared with wild-type mice, 16-month-old (r1441c) lrrk2 mice exhibited a significant reduction in the number of substantia nigra (sn) dopaminergic neurons. |
2016-04-29 |
2023-08-13 |
mouse |
| Mi Jin Kim, Meeyoung Park, Dae Won Kim, Min Jea Shin, Ora Son, Hyo Sang Jo, Hyeon Ji Yeo, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Duk-Soo Kim, Oh-Shin Kwon, Joon Kim, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Cho. Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model. Biomaterials. vol 64. 2016-04-26. PMID:26117230. |
parkinson's disease (pd) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. |
2016-04-26 |
2023-08-13 |
mouse |
| Seon Ae Eom, Dae Won Kim, Min Jea Shin, Eun Hee Ahn, Seok Young Chung, Eun Jeong Sohn, Hyo Sang Jo, Su-Jeong Jeon, Duk-Soo Kim, Hyeok Yil Kwon, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Cho. Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. BMB reports. vol 48. issue 7. 2016-04-25. PMID:25322954. |
parkinson's disease (pd) is a neurodegenerative disability caused by a decrease of dopaminergic neurons in the substantia nigra (sn). |
2016-04-25 |
2023-08-13 |
Not clear |
| Krystyna Stepień, Anna Dzierzega-Lecznar, Irena Ta. [The role of neuromelanin in Parkinson's disease--new concepts]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 11-12. 2016-04-23. PMID:18540183. |
progressive degeneration of dopaminergic neurons of the substantia nigra and the resulting dopamine deficiency in the striatum are neuropathological basis of the movement disorders in parkinson's disease (pd). |
2016-04-23 |
2023-08-12 |
Not clear |
| Bo Zhang, Kun Ma, Baixiang L. Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra. The Journal of toxicological sciences. vol 40. issue 4. 2016-04-19. PMID:26165640. |
increasing evidence indicates that atr plays a critical role in inducing physiological changes to the endocrine and reproductive systems, and further may affect the nigrostriatal dopaminergic system in the diencephalon, resulting in altered dopamine (da) levels in the striatum, transport and storage-related protein abnormalities in the synaptic terminals, motor function deficits, and degeneration of da neurons in the substantia nigra (sn). |
2016-04-19 |
2023-08-13 |
rat |
| Nancy G Hernandez-Chan, Michael J Bannon, Carlos E Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J Espadas-Alvarez, Yazmin M Flores-Martínez, Jose Ayala-Davila, Maria E Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella, Daniel Martinez-Fon. Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease. Journal of biomedical science. vol 22. 2016-04-18. PMID:26198255. |
the reduction of bdnf expression in parkinson's disease substantia nigra (sn) might contribute to the death of dopaminergic neurons because inhibiting bdnf expression in the sn causes parkinsonism in the rat. |
2016-04-18 |
2023-08-13 |
rat |
| Jia-Jia Xiao, Ming Yin, Ze-Jian Wang, Xiao-Ping Wan. Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats? Oxidative medicine and cellular longevity. vol 2015. 2016-04-08. PMID:26146528. |
although mounting evidence suggests that ceruloplasmin (cp) deficiency and iron deposition are pivotal factors responsible for exacerbating demise of dopaminergic neurons in the substantia nigra (sn) of the parkinsonism and neural stem cells (nscs) are believed to be excellent candidates for compensating the lost dopaminergic neurons, there are few researches to explore the change of cp expression and of iron deposition in the pathological microenvironment of sn after nscs transplantation and the ability of grafted nscs to differentiate directionally into dopaminergic neurons under the changed homeostasis. |
2016-04-08 |
2023-08-13 |
rat |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Richa Pahuja, Kavita Seth, Anshi Shukla, Rajendra Kumar Shukla, Priyanka Bhatnagar, Lalit Kumar Singh Chauhan, Prem Narain Saxena, Jharna Arun, Bhushan Pradosh Chaudhari, Devendra Kumar Patel, Sheelendra Pratap Singh, Rakesh Shukla, Vinay Kumar Khanna, Pradeep Kumar, Rajnish Kumar Chaturvedi, Kailash Chand Gupt. Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats. ACS nano. vol 9. issue 5. 2016-04-05. PMID:25825926. |
da nps were internalized in dopaminergic sh-sy5y cells and dopaminergic neurons in the substantia nigra and striatum, regions affected in pd. |
2016-04-05 |
2023-08-13 |
rat |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
parkinson's disease (pd) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. |
2016-04-05 |
2023-08-13 |
mouse |
| O Lindval. Clinical translation of stem cell transplantation in Parkinson's disease. Journal of internal medicine. vol 279. issue 1. 2016-03-31. PMID:26332959. |
recent studies demonstrate that standardized preparations of dopaminergic neurons of the correct substantia nigra phenotype can be generated from human embryonic stem cells in large numbers, and they will soon be available for patient application. |
2016-03-31 |
2023-08-13 |
human |
| Lorraine V Kalia, Anthony E Lan. Parkinson's disease. Lancet (London, England). vol 386. issue 9996. 2016-03-29. PMID:25904081. |
it has long been characterised by the classical motor features of parkinsonism associated with lewy bodies and loss of dopaminergic neurons in the substantia nigra. |
2016-03-29 |
2023-08-13 |
Not clear |
| K Hikishima, K Ando, Y Komaki, K Kawai, R Yano, T Inoue, T Itoh, M Yamada, S Momoshima, H J Okano, H Okan. Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. Neuroscience. vol 300. 2016-03-29. PMID:26012491. |
movement dysfunction in parkinson's disease (pd) is caused by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-03-29 |
2023-08-13 |
monkey |
| Kerstin Buck, Natalie Landeck, Ayse Ulusoy, Nour K Majbour, Omar M A El-Agnaf, Deniz Kiri. Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function. Neurobiology of disease. vol 78. 2016-03-28. PMID:25818009. |
for this purpose, we took advantage of recombinant adeno-associated viral (raav) vectors to deliver polo-like kinase (plk) 2 or plk3 in the substantia nigra and investigated whether increased levels of p(s129)-α-syn compromised the function and survival of nigral dopaminergic neurons. |
2016-03-28 |
2023-08-13 |
human |
| Daniel E Callan, Brian Falcone, Atsushi Wada, Raja Parasurama. Simultaneous tDCS-fMRI Identifies Resting State Networks Correlated with Visual Search Enhancement. Frontiers in human neuroscience. vol 10. 2016-03-25. PMID:27014014. |
resting state functional connectivity from the precuneus to the substantia nigra, a subcortical dopaminergic region, was found to correlate with future improvement in visual search task performance for the stim over the sham group during active stimulation in session 2. |
2016-03-25 |
2023-08-13 |
human |