| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Zhang, Hongmei Dai, Yuanying Deng, Jing Tian, Chen Zhang, Zhiping Hu, Guoying Bing, Lingling Zha. Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats. Toxicology. vol 336. 2015-12-15. PMID:26215101. |
cpf-treated rats exhibited significant reduction of dopaminergic neurons at 16d and 46 d after exposure, and a significant increase in the expression of microglia and astrocytes in the substantia nigra after cpf exposure. |
2015-12-15 |
2023-08-13 |
rat |
| Jie Zhang, Hongmei Dai, Yuanying Deng, Jing Tian, Chen Zhang, Zhiping Hu, Guoying Bing, Lingling Zha. Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats. Toxicology. vol 336. 2015-12-15. PMID:26215101. |
our findings indicate that neonatal exposure to cpf may induce long-term dopaminergic neuronal damage in the substantia nigra mediated by the activation of inflammatory response via nf-κb p. 65 and p. 38 mapk pathways in the nigrostriatal system. |
2015-12-15 |
2023-08-13 |
rat |
| Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huan. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-12-15. PMID:26664824. |
levels in the redox system, dopamine (da) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (sn) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of gsh + tet (or gsh) and/or l-3,4-dihydroxyphenylalanine (l-dopa) to pd rats. |
2015-12-15 |
2023-08-13 |
rat |
| Wei Fang, Guodong Gao, Haikang Zhao, Yi Xia, Xiaodong Guo, Nan Li, Yuqian Li, Yang Yang, Lei Chen, Qiang Wang, Lihong L. Role of the Akt/GSK-3β/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity. Brain research. vol 1602. 2015-12-14. PMID:25150591. |
earlier reports suggest that the main pathological change in pd is due to apoptosis of dopaminergic neuronal soma in the substantia nigra (sn). |
2015-12-14 |
2023-08-13 |
Not clear |
| Patricia Giuliani, Patrizia Ballerini, Silvana Buccella, Renata Ciccarelli, Michel P Rathbone, Silvia Romano, Iolanda D'Alimonte, Francesco Caciagli, Patrizia Di Iorio, Mieczyslaw Pokorsk. Guanosine protects glial cells against 6-hydroxydopamine toxicity. Advances in experimental medicine and biology. vol 837. 2015-12-14. PMID:25310956. |
increasing body of evidence indicates that neuron-neuroglia interaction may play a key role in determining the progression of neurodegenerative diseases including parkinson's disease (pd), a chronic pathological condition characterized by selective loss of dopaminergic (da) neurons in the substantia nigra. |
2015-12-14 |
2023-08-13 |
rat |
| Nobuhiko Fukuda, Saki Naito, Daiki Masukawa, Moemi Kaneda, Hiroshi Miyamoto, Takaya Abe, Yui Yamashita, Itaru Endo, Fumio Nakamura, Yoshio Goshim. Expression of ocular albinism 1 (OA1), 3, 4- dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal organs. Brain research. vol 1602. 2015-12-14. PMID:25601010. |
in addition, substantia nigra contains a large population of dopaminergic neurons. |
2015-12-14 |
2023-08-13 |
mouse |
| Jeffrey Graham, Douglas Hobson, Arjuna Ponnampala. High affinity hemoglobin and Parkinson's disease. Medical hypotheses. vol 83. issue 6. 2015-12-08. PMID:25468785. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain. |
2015-12-08 |
2023-08-13 |
human |
| Amanda L Sharpe, Erika Varela, Lynne Bettinger, Michael J Beckstea. Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. The international journal of neuropsychopharmacology. vol 18. issue 5. 2015-12-08. PMID:25522412. |
these studies examined the neurophysiological consequences of methamphetamine self-administration on girk channel-mediated currents in dopaminergic neurons in the substantia nigra and ventral tegmental area. |
2015-12-08 |
2023-08-13 |
mouse |
| Roberta Falcone, Tiziana Marilena Florio, Erica Di Giacomo, Elisabetta Benedetti, Loredana Cristiano, Andrea Antonosante, Alessia Fidoamore, Mara Massimi, Marcello Alecci, Rodolfo Ippoliti, Antonio Giordano, Annamaria Cimin. PPARβ/δ and γ in a rat model of Parkinson's disease: possible involvement in PD symptoms. Journal of cellular biochemistry. vol 116. issue 5. 2015-12-08. PMID:25530507. |
on these bases, in this work we used a 6-ohda hemi-lesioned rat model, inducing loss of dopaminergic neurons, to study the effects of the lesion at three time points from the lesion (1, 2, and 3 weeks), in relevant areas of pd motor symptoms, such as substantia nigra and globus pallidus and in the area of reward and mood control, the nucleus accumbens. |
2015-12-08 |
2023-08-13 |
rat |
| Jürgen Berg, Manfred Roch, Jennifer Altschüler, Christine Winter, Anne Schwerk, Andreas Kurtz, Barbara Steine. Human adipose-derived mesenchymal stem cells improve motor functions and are neuroprotective in the 6-hydroxydopamine-rat model for Parkinson's disease when cultured in monolayer cultures but suppress hippocampal neurogenesis and hippocampal memory function when cultured in spheroids. Stem cell reviews and reports. vol 11. issue 1. 2015-12-04. PMID:25120226. |
in the present study we compared monolayer-cultured (amsc) and spheroid (smsc) msc following transplantation into the substantia nigra (sn) of 6-ohda lesioned rats regarding effects on the local microenvironment, degeneration of dopaminergic neurons, neurogenesis in the hippocampal dg as well as motor and memory function in the 6-ohda-rat model for pd. |
2015-12-04 |
2023-08-13 |
human |
| Blanca Estela Jaramillo-Loranca, Linda Garcés-Ramírez, Alicia Angélica Munguía Rosales, Carolina Luna Ramírez, Genaro Vargas Hernández, Oscar Morales-Dionisio, Kateri González-Elizalde, Gonzalo Flores, Sergio Zamudio, Fidel De La Cruz-Lópe. The sigma agonist 1,3-di-o-tolyl-guanidine reduces the morphological and behavioral changes induced by neonatal ventral hippocampus lesion in rats. Synapse (New York, N.Y.). vol 69. issue 4. 2015-12-04. PMID:25682743. |
sigma receptors have been located in brain areas involved in motor functions, including the dopaminergic projections from the substantia nigra to the striatum. |
2015-12-04 |
2023-08-13 |
rat |
| Wan-Pu Wang, Zhan-Long He, Shuai-Yao Lu, Min Yan, Yan Zhou, Tian-Hong Xie, Na Yin, Wen-Ju Wang, Dong-Hong Tang, Hong-Jun Li, Mao-Sheng Su. Dopaminergic neuron-like cells derived from bone marrow mesenchymal stem cells by Lmx1α and neurturin overexpression for autologous cytotherapy in hemiparkinsonian rhesus monkeys. Current stem cell research & therapy. vol 10. issue 2. 2015-12-02. PMID:25300822. |
they survived and retained dopaminergic function following stereotaxic injection into the mptp-lesioned right-side substantia nigra as indicated by spect measurement of dat activity. |
2015-12-02 |
2023-08-13 |
monkey |
| Hong Guo, Fang Shi, Meijiao Li, Qingqing Liu, Bin Yu, Limin H. Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system. BMC complementary and alternative medicine. vol 15. 2015-11-30. PMID:25994206. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2015-11-30 |
2023-08-13 |
Not clear |
| Zhiguo Che. Cell Therapy for Parkinson's Disease: New Hope from Reprogramming Technologies. Aging and disease. vol 6. issue 6. 2015-11-30. PMID:26618051. |
parkinson's disease (pd) is a neurodegenerative disease with the major pathology being the progressive loss of dopaminergic (da) midbrain neurons in the substantia nigra. |
2015-11-30 |
2023-08-13 |
Not clear |
| V Annese, C Barcia, F Ros-Bernal, A Gómez, C M Ros, V De Pablos, E Fernández-Villalba, M E De Stefano, M-T Herrer. Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism. Neuropathology and applied neurobiology. vol 39. issue 2. 2015-11-13. PMID:22443457. |
mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) represent elective experimental models of parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway is associated with prominent neuroinflammation, characterized by activated microglia and astrocytes in both substantia nigra (sn) and striatum. |
2015-11-13 |
2023-08-12 |
mouse |
| Elena González-Burgos, Carlos Fernandez-Moriano, M Pilar Gómez-Serranillo. Potential neuroprotective activity of Ginseng in Parkinson's disease: a review. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 1. 2015-11-12. PMID:25349145. |
parkinson's disease is a chronic, multifactorial and progressive neurologic condition that affects around six million people worldwide, normally over 60 years of age, and is characterized by neurodegeneration of dopaminergic neurons in the substantia nigra. |
2015-11-12 |
2023-08-13 |
Not clear |
| Michaela E Johnson, Larisa Bobrovskay. An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions. Neurotoxicology. vol 46. 2015-11-12. PMID:25514659. |
parkinson's disease (pd) is the second most common neurodegenerative disorder that is characterized by two major neuropathological hallmarks: the degeneration of dopaminergic neurons in the substantia nigra (sn) and the presence of lewy bodies in the surviving sn neurons, as well as other regions of the central and peripheral nervous system. |
2015-11-12 |
2023-08-13 |
Not clear |
| L Zhao, L X He, S N Huang, L J Gong, L Li, Y Y Lv, Z M Qia. Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease. Physiological research. vol 63. issue 5. 2015-11-09. PMID:24908088. |
here, we investigated the effects of longer duration (4 weeks) of low amplitude vibration (lav) training on the numbers of dopaminergic neurons in the substantia nigra by immunostaining and the levels of dopamine (da) and brain-derived neurotrophic factor (bdnf) in the striatum by hplc and elisa in the chronic mptp lesion mouse. |
2015-11-09 |
2023-08-13 |
mouse |
| Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Droui. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS genetics. vol 10. issue 12. 2015-11-06. PMID:25501001. |
rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. |
2015-11-06 |
2023-08-13 |
mouse |
| Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayam. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology. vol 28. issue 4. 2015-11-05. PMID:26538809. |
treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). |
2015-11-05 |
2023-08-13 |
mouse |