| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thierry Paillard, Yves Rolland, Philipe de Souto Barret. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review. Journal of clinical neurology (Seoul, Korea). vol 11. issue 3. 2015-07-16. PMID:26174783. |
exercise limits the alteration in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor commands and control by adaptive mechanisms involving dopamine and glutamate neurotransmission. |
2015-07-16 |
2023-08-13 |
Not clear |
| Stephen Mullin, Anthony H V Schapir. Pathogenic mechanisms of neurodegeneration in Parkinson disease. Neurologic clinics. vol 33. issue 1. 2015-07-15. PMID:25432720. |
the discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the substantia nigra that histologically characterize pd. |
2015-07-15 |
2023-08-13 |
Not clear |
| Ruixia Zhu, Ying Zhu, Xu Liu, Zhiyi H. Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson's disease: a meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 12. 2015-07-09. PMID:24942208. |
fibroblast growth factor 20 (fgf20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. |
2015-07-09 |
2023-08-13 |
Not clear |
| Yi Zhang, Weiren Dong, Suiqun Guo, Shu Zhao, Suifen He, Lihua Zhang, Yinjuan Tang, Haihong Wan. Lentivirus-mediated delivery of sonic hedgehog into the striatum stimulates neuroregeneration in a rat model of Parkinson disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 12. 2015-07-09. PMID:25030123. |
parkinson disease (pd) is a progressive neurodegenerative disorder in which the nigrostriatal pathway, consisting of dopaminergic neuronal projections from the substantia nigra to the striatum, degenerates. |
2015-07-09 |
2023-08-13 |
rat |
| Hong Zhao, Mei-Ling Xu, Qi Zhang, Zhao-Hui Guo, Ying Peng, Zheng-Yi Qu, Yong-Nan L. Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 12. 2015-07-09. PMID:25030124. |
it was previously reported that cytokines and neurotoxins released from activated inflammatory cells induced the loss of projecting dopaminergic neurons in the substantia nigra, which triggered the pathogenesis of pd. |
2015-07-09 |
2023-08-13 |
mouse |
| Huajun Jin, Arthi Kanthasamy, Dilshan S Harischandra, Vellareddy Anantharam, Ajay Rana, Anumantha Kanthasam. Targeted toxicants to dopaminergic neuronal cell death. Methods in molecular biology (Clifton, N.J.). vol 1254. 2015-07-08. PMID:25431070. |
parkinson's disease (pd ) is mainly characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra resulting in chronic deficits in motor functions. |
2015-07-08 |
2023-08-13 |
human |
| Mahmoud M Iravani, Mona Sadeghian, Sarah Rose, Peter Jenne. Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24781752. |
we examine if destruction of the locus coeruleus with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4) alters dopaminergic cell loss in substantia nigra (sn) initiated by lipopolysaccharide (lps) in the rat through an effect on glial cell activation. |
2015-07-07 |
2023-08-13 |
rat |
| Franziska Richter, Sheila M Fleming, Melanie Watson, Vincent Lemesre, Lee Pellegrino, Brian Ranes, Chunni Zhu, Farzad Mortazavi, Caitlin K Mulligan, Pedrom C Sioshansi, Sindalana Hean, Krystal De La Rosa, Richie Khanna, John Flanagan, David J Lockhart, Brandon A Wustman, Sean W Clark, Marie-Françoise Chessele. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 4. 2015-07-06. PMID:25037721. |
at2101 administered orally for 4 months to thy1-asyn mice improved motor and nonmotor function, abolished microglial inflammatory response in the substantia nigra, reduced α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduced the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates. |
2015-07-06 |
2023-08-13 |
mouse |
| Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schül. Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication. PloS one. vol 9. issue 11. 2015-07-06. PMID:25390032. |
parkinson disease (pd) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called lewy bodies. |
2015-07-06 |
2023-08-13 |
human |
| Hongcai Wang, Yan Chen, Jinbo Chen, Zhentao Zhang, Wansheng Lao, Xizhi Li, Jinsha Huang, Tao Wan. Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. PloS one. vol 9. issue 10. 2015-06-23. PMID:25303312. |
the cell cycle was reactivated in cyclin d-expressing dopaminergic neurons from the substantia nigra (sn) of rats following stereotactic (st) infusion of rotenone. |
2015-06-23 |
2023-08-13 |
rat |
| Knud Larsen, Lone Bruhn Madsen, Leila Farajzadeh, Christian Bendixe. Splicing variants of porcine synphilin-1. Meta gene. vol 5. 2015-06-23. PMID:26101749. |
parkinson's disease (pd), idiopathic and familial, is characterized by degradation of dopaminergic neurons and the presence of lewy bodies (lb) in the substantia nigra. |
2015-06-23 |
2023-08-13 |
mouse |
| Candan Depboylu, Thomas W Rösler, Anderson de Andrade, Wolfgang H Oertel, Günter U Höglinge. Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease. Journal of neurochemistry. vol 133. issue 4. 2015-06-18. PMID:25581060. |
previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxydopamine-mouse model of parkinson's disease (pd). |
2015-06-18 |
2023-08-13 |
mouse |
| M Delenclos, L Carrascal, K Jensen, M Romero-Ramo. Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line. Neuroscience. vol 277. 2015-06-08. PMID:25090921. |
our data show that human a-syn, although not present at levels that were detectable by immunostaining in dopaminergic neurons of substantia nigra or noradrenergic neurons of locus coeruleus, was highly expressed in other pd relevant regions of the brain in different neuronal subtypes. |
2015-06-08 |
2023-08-13 |
mouse |
| S P Patil, P D Jain, P J Ghumatkar, R Tambe, S Sathay. Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience. vol 277. 2015-06-08. PMID:25108167. |
dopaminergic degeneration was evaluated by analyzing the tyrosine hydroxylase (th) by immunostaining and nissl staining of the substantia nigra (sn) region of the brain. |
2015-06-08 |
2023-08-13 |
mouse |
| Ye Lee Jun, Chang-Hwan Bae, Dongsoo Kim, Sungtae Koo, Seungtae Ki. Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model. Journal of ginseng research. vol 39. issue 2. 2015-06-05. PMID:26045688. |
the present study investigated a possible role of korean red ginseng (krg) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (sn) and striatum (st) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinson's disease mouse model. |
2015-06-05 |
2023-08-13 |
mouse |
| Annamaria Lanzillotta, Vanessa Porrini, Arianna Bellucci, Marina Benarese, Caterina Branca, Edoardo Parrella, Pier Franco Spano, Marina Pizz. NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases. Frontiers in neurology. vol 6. 2015-06-04. PMID:26042083. |
constitutive knockout of c-rel shatters the resilience of substantia nigra (sn) dopaminergic (da) neurons to aging and induces a parkinsonian like pathology in mice. |
2015-06-04 |
2023-08-13 |
mouse |
| J Mark Cooper, P B Oscar Wiklander, Joel Z Nordin, Raya Al-Shawi, Matthew J Wood, Mansi Vithlani, Anthony H V Schapira, J Paul Simons, Samir El-Andaloussi, Lydia Alvarez-Ervit. Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 12. 2015-06-03. PMID:25112864. |
this resulted in significant reductions in intraneuronal protein aggregates, including in dopaminergic neurones of the substantia nigra. |
2015-06-03 |
2023-08-13 |
mouse |
| Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that results mainly due to the death of dopaminergic neurons in the substantia nigra (sn), and subsequently has an effect on one's motor function and coordination. |
2015-06-02 |
2023-08-12 |
mouse |
| Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair R R Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer, Claudia Lodovichi, Charles Plessy, Piero Carninci, Stefano Gustincic. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC genomics. vol 15. 2015-05-28. PMID:25164183. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2015-05-28 |
2023-08-13 |
Not clear |
| Komal T Shaikh, Alvin Yang, Ekaterina Youshin, Susanne Schmi. Transgenic LRRK2 (R1441G) rats-a model for Parkinson disease? PeerJ. vol 3. 2015-05-28. PMID:26020005. |
parkinson disease (pd) is the most common movement disorder, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2015-05-28 |
2023-08-13 |
human |