| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-Hua Wang, Zhao-Hong Xuan, Shuo Tian, Guan-Hua D. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-19. PMID:25788961. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (da) neurons at the substantia nigra. |
2015-03-19 |
2023-08-13 |
Not clear |
| Kuo-Chen Wu, Ya-Hsuan Lu, Yi-Hsuan Peng, Ting-Fen Tsai, Yu-Han Kao, Hui-Ting Yang, Chun-Jung Li. Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 1. 2015-03-17. PMID:25248837. |
however, intrastriatal infusion of low-dose mptp caused more severe dopaminergic toxicity in the substantia nigra of both aged mice and oct1/2(-/-) mice. |
2015-03-17 |
2023-08-13 |
mouse |
| Chun Li, Xin Chen, Nan Zhang, Yangwen Song, Yang M. Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model rats. Neural regeneration research. vol 7. issue 5. 2015-03-16. PMID:25774170. |
gastrodin could protect dopaminergic neurons via inhibition of interleukin-1β expression and neuroinflammation in the substantia nigra. |
2015-03-16 |
2023-08-13 |
rat |
| Ran-Der Hwang, Lyle Wiemerslage, Christopher J LaBreck, Munzareen Khan, Kavitha Kannan, Xinglong Wang, Xiongwei Zhu, Daewoo Lee, Yih-Woei C Fridel. The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease. Neurobiology of disease. vol 69. 2015-03-12. PMID:24965893. |
parkinson's disease (pd), caused by selective loss of dopaminergic (da) neurons in the substantia nigra, is the most common movement disorder with no cure or effective treatment. |
2015-03-12 |
2023-08-13 |
human |
| Mohammad-Saeid Jami, Ramavati Pal, Esthelle Hoedt, Thomas A Neubert, Jan Petter Larsen, Simon Geir Mølle. Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons. BMC neuroscience. vol 15. 2015-03-12. PMID:25082231. |
parkinson's disease (pd) is the second most common neurodegenerative movement disorder, caused by preferential dopaminergic neuronal cell death in the substantia nigra, a process also influenced by oxidative stress. |
2015-03-12 |
2023-08-13 |
Not clear |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. |
2015-03-06 |
2023-08-13 |
rat |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
this study sought to investigate whether a homogenate of the substantia nigra of adult rats and/or basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons. |
2015-03-06 |
2023-08-13 |
rat |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
experimental findings indicate that the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons in the substantia nigra with the ability to secrete dopamine. |
2015-03-06 |
2023-08-13 |
rat |
| Silvia Marino, Rosella Ciurleo, Giuseppe Di Lorenzo, Marina Barresi, Simona De Salvo, Sabrina Giacoppo, Alessia Bramanti, Pietro Lanzafame, Placido Bramant. Magnetic resonance imaging markers for early diagnosis of Parkinson's disease. Neural regeneration research. vol 7. issue 8. 2015-03-06. PMID:25745453. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by selective and progressive degeneration, as well as loss of dopaminergic neurons in the substantia nigra. |
2015-03-06 |
2023-08-13 |
Not clear |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
these results indicate that transplantation of x-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of parkinson's disease in rats. |
2015-03-04 |
2023-08-13 |
rat |
| Li Zhou, Zhi-Yong Wang, Hui Lian, Hai-Yan Song, Yi-Min Zhang, Xiao-Li Zhang, Rui-Fang Fan, Li-Fei Zheng, Jin-Xia Zh. Altered expression of dopamine receptors in cholinergic motoneurons of the hypoglossal nucleus in a 6-OHDA-induced Parkinson's disease rat model. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25172664. |
however, the link between the degenerated dopaminergic neurons in the substantia nigra (sn) and lingual dysfunction remains unclear. |
2015-02-25 |
2023-08-13 |
rat |
| Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Ta. Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels. PloS one. vol 9. issue 1. 2015-02-20. PMID:24475238. |
we report that in human parkinson's brains increased iron concentrations in the substantia nigra are associated with upregulated levels of ndfip1 in dopaminergic neurons containing α-synuclein deposits. |
2015-02-20 |
2023-08-12 |
mouse |
| Karl Grenier, Maria Kontogiannea, Edward A Fo. Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy. The Journal of biological chemistry. vol 289. issue 43. 2015-02-12. PMID:25217637. |
parkinson disease (pd) is a complex neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. |
2015-02-12 |
2023-08-13 |
Not clear |
| Arvind K Shukla, Prakash Pragya, Hitesh S Chaouhan, D K Patel, M Z Abdin, Debapratim Kar Chowdhur. Mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24819147. |
parkinson's disease (pd) is a prevalent and devastating neurodegenerative disorder having limited cure options and strong association with the loss of dopaminergic neurons in the substantia nigra region of the mid brain. |
2015-02-09 |
2023-08-13 |
drosophila_melanogaster |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song L. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental neurology. vol 263. 2015-02-09. PMID:25263579. |
application of a potent activator of aldh2, alda-1, was effective in protecting against rotenone-induced apoptotic cell death in both sh-sy5y cells and primary cultured substantia nigra (sn) dopaminergic neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Mark Witcher, Rosalyn Moran, Stephen B Tatter, Adrian W Laxto. Neuronal oscillations in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 19. 2015-02-07. PMID:24896351. |
the pathological hallmark of pd is the loss of dopaminergic cells in the substantia nigra and other brain regions. |
2015-02-07 |
2023-08-13 |
Not clear |
| Angelique Camilleri, Neville Vassall. The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24703487. |
from the first postmortem account describing a lack of mitochondrial complex i in the substantia nigra of pd sufferers, the direct association between mitochondrial dysfunction and death of dopaminergic neurons has ever since been consistently corroborated. |
2015-02-06 |
2023-08-13 |
Not clear |
| Chien-Wei Feng, Zhi-Hong Wen, Shi-Ying Huang, Han-Chun Hung, Chun-Hong Chen, San-Nan Yang, Nan-Fu Chen, Hui-Min Wang, Chung-Der Hsiao, Wu-Fu Che. Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae. Zebrafish. vol 11. issue 3. 2015-02-04. PMID:24720843. |
parkinson's disease (pd) is a neurodegenerative disease that is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2015-02-04 |
2023-08-13 |
zebrafish |
| Nikolaus R McFarland, Hemi Dimant, Laura Kibuuka, Darius Ebrahimi-Fakhari, Cody A Desjardins, Karin M Danzer, Michael Danzer, Zhanyun Fan, Michael A Schwarzschild, Warren Hirst, Pamela J McLea. Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss. PloS one. vol 9. issue 1. 2015-01-28. PMID:24465863. |
chronic treatment with snx-0723 or the more potent, snx-9114 failed to reduce dopaminergic toxicity in the substantia nigra compared to vehicle. |
2015-01-28 |
2023-08-12 |
human |
| Lei-Lei Chen, Ju-Xian Song, Jia-Hong Lu, Zhen-Wei Yuan, Liang-Feng Liu, Siva Sundara Kumar Durairajan, Min L. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 3. 2015-01-26. PMID:24522518. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. |
2015-01-26 |
2023-08-12 |
drosophila_melanogaster |