| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilkay Camlidag, Ersoy Kocabicak, Bunyamin Sahin, Ali Jahanshahi, Lutfi Incesu, Dursun Aygun, Onur Yildiz, Yasin Temel, Umit Bele. Volumetric analysis of the subthalamic and red nuclei based on magnetic resonance imaging in patients with Parkinson's disease. The International journal of neuroscience. vol 124. issue 4. 2015-01-19. PMID:24020352. |
parkinson's disease (pd) is associated with degeneration of the dopaminergic neurons in the substantia nigra. |
2015-01-19 |
2023-08-12 |
Not clear |
| Hedieh Shahpasandzadeh, Blagovesta Popova, Alexandra Kleinknecht, Paul E Fraser, Tiago F Outeiro, Gerhard H Brau. Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions. The Journal of biological chemistry. vol 289. issue 45. 2015-01-17. PMID:25231978. |
parkinson disease is associated with the progressive loss of dopaminergic neurons from the substantia nigra. |
2015-01-17 |
2023-08-13 |
human |
| Shinji Oikawa, Hatasu Kobayashi, Yuki Kitamura, Hong Zhu, Kumi Obata, Yoshio Minabe, Maryia Dazortsava, Kyoko Ohashi, Saeko Tada-Oikawa, Hitoshi Takahashi, Kenichiro Yata, Mariko Murata, Tetsumori Yamashim. Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion. Free radical research. vol 48. issue 6. 2015-01-10. PMID:24697733. |
in parkinson's disease (pd), oxidative stresses cause cell death of dopaminergic neurons of the substantia nigra (sn), but its molecular mechanism still remains unclarified. |
2015-01-10 |
2023-08-13 |
monkey |
| Kazumasa Wakamatsu, Hitomi Tanaka, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin. Molecules (Basel, Switzerland). vol 19. issue 6. 2015-01-09. PMID:24936706. |
neuromelanin (nm) is produced in dopaminergic neurons of the substantia nigra (sn) and in noradrenergic neurons of the locus coeruleus (lc). |
2015-01-09 |
2023-08-13 |
Not clear |
| Jennifer Liao, Laura W Morin, S Tariq Ahma. Methods to characterize spontaneous and startle-induced locomotion in a rotenone-induced Parkinson's disease model of Drosophila. Journal of visualized experiments : JoVE. issue 90. 2015-01-09. PMID:25178101. |
parkinson's disease is a neurodegenerative disorder that results from the degeneration of dopaminergic neurons in the central nervous system, primarily in the substantia nigra. |
2015-01-09 |
2023-08-13 |
drosophila_melanogaster |
| Brent J Ryan, Lara L Lourenço-Venda, Mark J Crabtree, Ashley B Hale, Keith M Channon, Richard Wade-Martin. α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine. vol 67. 2015-01-06. PMID:24148766. |
parkinson disease (pd) is a multifactorial disease resulting in preferential death of the dopaminergic neurons in the substantia nigra. |
2015-01-06 |
2023-08-12 |
human |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. |
2015-01-05 |
2023-08-12 |
Not clear |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
this post-mortem study examines the cytoarchitecture of dopaminergic neurons of the substantia nigra in schizophrenia (n = 12) and depression (n = 13) compared to matched controls (n = 13). |
2015-01-05 |
2023-08-12 |
Not clear |
| Da-Wei Li, Zhi-Qiang Liu, Wei Chen, Min Yao, Guang-Ren L. Association of glycogen synthase kinase-3β with Parkinson's disease (review). Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24681994. |
the present review focuses on the involvement of this protein in parkinson's disease (pd), a common neurodegenerative disorder characterized by the gradually progressive and selective loss of dopaminergic neurons, and by intracellular inclusions known as lewy bodies (lbs) expressed in surviving neurons of the substantia nigra (sn). |
2015-01-05 |
2023-08-12 |
Not clear |
| Hideaki Matsui, Norihito Uemura, Hodaka Yamakado, Shunichi Takeda, Ryosuke Takahash. Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish. Journal of Parkinson's disease. vol 4. issue 2. 2014-12-28. PMID:24366926. |
despite the extensive distribution of these inclusion bodies, the middle diencephalic dopaminergic neurons were particularly susceptible to the effect of the toxins, suggesting that this cluster of dopaminergic neurons is analogous to the human substantia nigra. |
2014-12-28 |
2023-08-12 |
human |
| Joseph W Barter, Stephen Castro, Tatyana Sukharnikova, Mark A Rossi, Henry H Yi. The role of the substantia nigra in posture control. The European journal of neuroscience. vol 39. issue 9. 2014-12-17. PMID:24628921. |
using wireless multi-electrode recording, we measured single unit activity from gabaergic and dopaminergic neurons in the substantia nigra as unrestrained mice stood on an elevated platform while introducing continuous postural disturbances in the roll plane. |
2014-12-17 |
2023-08-12 |
mouse |
| Erica L Unger, Laura E Bianco, Byron C Jones, Richard P Allen, Christopher J Earle. Low brain iron effects and reversibility on striatal dopamine dynamics. Experimental neurology. vol 261. 2014-12-17. PMID:24999026. |
iron deficiency (id) in rodents leads to decreased ventral midbrain (vmb) iron concentrations and to changes in the dopamine (da) system that mimic many of the dopaminergic changes seen in rls patient where low substantia nigra iron is a known pathology of the disease. |
2014-12-17 |
2023-08-13 |
rat |
| Marta R S Carmo, Ana Paula F Menezes, Ana Carla L Nunes, Anna Pliássova, Anabela P Rolo, Carlos M Palmeira, Rodrigo A Cunha, Paula M Canas, Geanne M Andrad. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology. vol 81. 2014-12-15. PMID:24508709. |
parkinson's disease (pd) involves an initial loss of striatal dopaminergic terminals evolving into a degeneration of dopaminergic neurons in the substantia nigra (sn), which can be modeled by 6-hydroxydopamine (6-ohda) administration. |
2014-12-15 |
2023-08-12 |
rat |
| Ping Liu, Liang Sun, Xu-Li Zhao, Peng Zhang, Xue-Mei Zhao, Jian Zhan. PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease. Brain research. vol 1565. 2014-12-15. PMID:24747612. |
parkinson׳s disease (pd) is a common neurodegenerative disorder characterized by the selective degeneration of projecting dopaminergic neurons in the substantia nigra and diminished dopamine levels in the striatum. |
2014-12-15 |
2023-08-13 |
rat |
| Eun Jeong Sohn, Min Jea Shin, Dae Won Kim, Eun Hee Ahn, Hyo Sang Jo, Duk-Soo Kim, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson's disease model. Molecules and cells. vol 37. issue 3. 2014-12-12. PMID:24625574. |
in this study, we investigate whether tat-sag, fused with a tat domain, could protect sh-sy5y neuroblastoma cells against 1-methyl-4-phenylpyridinium (mpp(+)) and dopaminergic (da) neurons in the substantia nigra (sn) against 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (mptp) toxicity. |
2014-12-12 |
2023-08-12 |
mouse |
| Min Zhu, Wen-Wei Li, Chuan-Zhen L. Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+. CNS neuroscience & therapeutics. vol 20. issue 4. 2014-12-09. PMID:24351065. |
parkinson's disease (pd) is a common neurodegenerative disease, characterized by progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2014-12-09 |
2023-08-12 |
Not clear |
| C H Carriere, N H Kang, L P Nile. Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience. vol 267. 2014-12-09. PMID:24613722. |
rotenone, which is used as a pesticide and insecticide, has been shown to cause systemic inhibition of mitochondrial complex i activity, with consequent degeneration of dopaminergic neurons within the substantia nigra and striatum, as observed in parkinson's disease. |
2014-12-09 |
2023-08-12 |
rat |
| D Ouazia, L-C Levros, E Rassart, R R Desrosier. Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. Neuroscience. vol 267. 2014-12-09. PMID:24631677. |
parkinson's disease (pd) is a chronic and progressive neurological disorder that is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2014-12-09 |
2023-08-12 |
Not clear |
| Xinhong Xue, Hong Liu, Lifeng Qi, Xueli Li, Cunju Guo, Dianrong Gong, Huaiqian Q. Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease. Brain research bulletin. vol 103. 2014-12-03. PMID:24576689. |
parkinson's disease (pd) is a common neurodegenerative disorder, which is characterized by a loss of projecting dopaminergic neurons in the substantia nigra and diminished dopamine level in the striatum. |
2014-12-03 |
2023-08-12 |
mouse |
| Xinhong Xue, Hong Liu, Lifeng Qi, Xueli Li, Cunju Guo, Dianrong Gong, Huaiqian Q. Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease. Brain research bulletin. vol 103. 2014-12-03. PMID:24576689. |
the cytokines and neurotoxins released from the reactive immune cells induced the loss of the projecting dopaminergic neurons in the substantia nigra, which triggering the pathogenesis of pd. |
2014-12-03 |
2023-08-12 |
mouse |