| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Löw, Patrick Aebischer, Bernard L Schneide. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human gene therapy. vol 24. issue 6. 2014-04-17. PMID:23600720. |
surprisingly, single-stranded viral genomes persisted in nigral dopaminergic neurons within cell bodies and axon terminals in the striatum, and intact assembled aav capsid was enriched in nuclei of nigral neurons, 4 weeks after virus injections to the substantia nigra. |
2014-04-17 |
2023-08-12 |
Not clear |
| Karin Löw, Patrick Aebischer, Bernard L Schneide. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human gene therapy. vol 24. issue 6. 2014-04-17. PMID:23600720. |
6-hydroxydopamine (6-ohda)-induced degeneration of dopaminergic neurons in the substantia nigra reduced the number of viral genomes in the striatum, in line with viral genome persistence in axon terminals. |
2014-04-17 |
2023-08-12 |
Not clear |
| Minyoung Hwang, Ja-Myong Lee, Younghwa Kim, Dongho Geu. Functional Role of Parkin against Oxidative Stress in Neural Cells. Endocrinology and metabolism (Seoul, Korea). vol 29. issue 1. 2014-04-17. PMID:24741456. |
parkinson disease (pd) is caused by selective cell death of dopaminergic neurons in the substantia nigra. |
2014-04-17 |
2023-08-13 |
Not clear |
| Hugh H N Chan, Saravana Kumar, Lang Zhu. Neuroprotective and behavioural assessments of an imidazolium compound (DBZIM) in a rat model of Parkinson's disease induced by 6-OHDA. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23652161. |
furthermore, the degeneration of tyrosine hydroxylase immunopositive (th+) dopaminergic neurones in the substantia nigra par compacta (snc) was illustrated by immunohistochemistry. |
2014-04-14 |
2023-08-12 |
mouse |
| Johannes F G Neuhaus, Olivier R Baris, Simon Hess, Natasha Moser, Hannsjörg Schröder, Shankar J Chinta, Julie K Andersen, Peter Kloppenburg, Rudolf J Wiesne. Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24163249. |
accumulation of mitochondrial dna deletions is observed especially in dopaminergic neurons of the substantia nigra during ageing and even more in parkinson's disease. |
2014-04-11 |
2023-08-12 |
mouse |
| Junghwa Ryu, Rui Zhang, Bo-Hyun Hong, Eun-Jung Yang, Kyoung Ah Kang, Moonseok Choi, Ki Cheon Kim, Su-Jin Noh, Hee Soo Kim, Nam-Ho Lee, Jin Won Hyun, Hye-Sun Ki. Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity. PloS one. vol 8. issue 8. 2014-04-08. PMID:23976995. |
in the brains of pd patients, dopaminergic neuronal loss is observed in the substantia nigra. |
2014-04-08 |
2023-08-12 |
rat |
| Kai Gao, Xiong Deng, Wen Zheng, Zhi Song, Anding Zhu, Xiaofei Xiu, Hao Den. Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease. BMC neurology. vol 13. 2014-04-04. PMID:24063688. |
parkinson's disease (pd), the second most common neurodegenerative disease, is characterized by loss of dopaminergic neurons in the substantia nigra. |
2014-04-04 |
2023-08-12 |
Not clear |
| Janice M Beit. Parkinson's disease: a review. Frontiers in bioscience (Scholar edition). vol 6. 2014-03-21. PMID:24389262. |
resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal lewy bodies, idiopathic parkinson's disease is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals (e.g., synthetic heroin use). |
2014-03-21 |
2023-08-12 |
Not clear |
| Yasuhiko Izum. [Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 133. issue 9. 2014-03-20. PMID:23995806. |
parkinson disease is one of the most common neurodegenerative disorders and is characterized by the selective loss of dopaminergic neurons in the substantia nigra. |
2014-03-20 |
2023-08-12 |
Not clear |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
the proper functioning of the dopaminergic system requires the coordinated formation of projections extending from dopaminergic neurons in the substantia nigra (sn), ventral tegmental area (vta) and retrorubral field to a wide array of forebrain targets including the striatum, nucleus accumbens and prefrontal cortex. |
2014-03-20 |
2023-08-12 |
mouse |
| Anne-Sophie Van Rompuy, Evy Lobbestael, Anke Van der Perren, Chris Van den Haute, Veerle Baekeland. Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration. Journal of neuropathology and experimental neurology. vol 73. issue 2. 2014-03-13. PMID:24423640. |
long-term overexpression of human wild-type and t240r mutant parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration. |
2014-03-13 |
2023-08-12 |
human |
| N Emmanuel Díaz-Martínez, Elisa Tamariz, N Fabián Díaz, Claudia M García-Peña, Alfredo Varela-Echavarría, Iván Velasc. Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 8. 2014-03-06. PMID:23732989. |
one strategy to promote axonal growth of dopaminergic neurons from the substantia nigra (sn) to the striatum is degradation of inhibitory components such as chondroitin sulphate proteoglycans (cspg). |
2014-03-06 |
2023-08-12 |
rat |
| Aderbal S Aguiar, Fabrine S M Tristão, Majid Amar, Caroline Chevarin, Laurence Lanfumey, Raymond Mongeau, Olga Corti, Rui D Prediger, Rita Raisman-Vozar. Parkin-knockout mice did not display increased vulnerability to intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23588969. |
intranasal mptp induced parkinsonism in parkin⁺/⁺ mice, through depletion of striatal dopamine, decreased number of dopaminergic neurons in the substantia nigra, and decreased d-amphetamine-induced hyperlocomotion. |
2014-03-03 |
2023-08-12 |
mouse |
| Kiyoka Kinugawa, Yann Monnet, Catherine Béchade, Daniel Alvarez-Fischer, Etienne C Hirsch, Alain Bessis, Stéphane Huno. DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease. Journal of neuroinflammation. vol 10. 2014-03-03. PMID:23844828. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons (dn) in the substantia nigra (sn). |
2014-03-03 |
2023-08-12 |
mouse |
| Maik M A Worlitzer, Thomas Viel, Andreas H Jacobs, Jens C Schwambor. The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. The European journal of neuroscience. vol 38. issue 5. 2014-02-26. PMID:23734736. |
parkinson's disease is characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2014-02-26 |
2023-08-12 |
mouse |
| Chia-Hsin Liao, Shin-Yuan Chen, Jon-Son Kuo, Cheng-Yoong Pan. Reduction of motor disorder in 6-OHDA-induced severe parkinsonism rats by post treatment with granulocyte-colony stimulating factor. The Chinese journal of physiology. vol 56. issue 3. 2014-02-25. PMID:23656216. |
rats were killed on the 28th day and survival dopaminergic neurons in the substantia nigra, dopaminergic axons and dopaminergic receptor 2 in the striatum were examined. |
2014-02-25 |
2023-08-12 |
mouse |
| Sara Ailane, Philip Long, Peter Jenner, Sarah Ros. Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra. The European journal of neuroscience. vol 38. issue 3. 2014-02-19. PMID:23692556. |
the multifunctional protein osteopontin (opn) is expressed in the substantia nigra (sn) and protects nigral dopaminergic neurones against toxic insult in animal models of parkinson's disease, although the mechanisms involved are uncertain. |
2014-02-19 |
2023-08-12 |
rat |
| Akiyo Natsubori, Ken-Ichi Honma, Sato Honm. Differential responses of circadian Per2 rhythms in cultured slices of discrete brain areas from rats showing internal desynchronisation by methamphetamine. The European journal of neuroscience. vol 38. issue 4. 2014-02-19. PMID:23725367. |
when behavior rhythms were completely phase reversed, the brain was sampled for slice cultures and circadian bioluminescence rhythms were measured for 5 days in the scn and four areas of the dopaminergic system, the olfactory bulb, caudate putamen, parietal cortex and substantia nigra. |
2014-02-19 |
2023-08-12 |
rat |
| Ling Wang, Ying-Qi Zhai, Li-Li Xu, Chen Qiao, Xiu-Lan Sun, Jian-Hua Ding, Ming Lu, Gang H. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Experimental neurology. vol 251. 2014-02-19. PMID:24220636. |
parkinson's disease (pd), one of the most common neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2014-02-19 |
2023-08-12 |
mouse |
| Ling Wang, Ying-Qi Zhai, Li-Li Xu, Chen Qiao, Xiu-Lan Sun, Jian-Hua Ding, Ming Lu, Gang H. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Experimental neurology. vol 251. 2014-02-19. PMID:24220636. |
furthermore, we found that acute mptp administration aggravated the loss of dopaminergic neurons and increased the activation of glial cells in the substantia nigra of db/db mice. |
2014-02-19 |
2023-08-12 |
mouse |