| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anamitra Ghosh, Hariharan Saminathan, Arthi Kanthasamy, Vellareddy Anantharam, Huajun Jin, Gautam Sondarva, Dilshan S Harischandra, Ziqing Qian, Ajay Rana, Anumantha G Kanthasam. The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23754278. |
notably, a marked expression of pin1 was also observed in the substantia nigra of human pd brains along with a high co-localization of pin1 within dopaminergic neurons. |
2013-11-04 |
2023-08-12 |
mouse |
| Jeffrey R Liddell, Daniel Obando, Joe Liu, George Ganio, Irene Volitakis, Su San Mok, Peter J Crouch, Anthony R White, Rachel Cod. Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free radical biology & medicine. vol 60. 2013-11-01. PMID:23391576. |
parkinson disease (pd) is a neurodegenerative disease characterized by death of dopaminergic neurons in the substantia nigra region of the brain. |
2013-11-01 |
2023-08-12 |
Not clear |
| Patrick J Schultheis, Sheila M Fleming, Amy K Clippinger, Jada Lewis, Taiji Tsunemi, Benoit Giasson, Dennis W Dickson, Joseph R Mazzulli, Mark E Bardgett, Kristi L Haik, Osunde Ekhator, Anil Kumar Chava, John Howard, Matt Gannon, Elizabeth Hoffman, Yinhuai Chen, Vikram Prasad, Stephen C Linn, Rafael J Tamargo, Wendy Westbroek, Ellen Sidransky, Dimitri Krainc, Gary E Shul. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human molecular genetics. vol 22. issue 10. 2013-11-01. PMID:23393156. |
there was no change in the number of dopaminergic neurons in the substantia nigra or in striatal dopamine levels in aged atp13a2(-/-) mice. |
2013-11-01 |
2023-08-12 |
mouse |
| Lingling Zhang, LinHong Huang, Liangwei Chen, Dingjun Hao, Jianzong Che. Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease. Toxicology letters. vol 222. issue 2. 2013-10-31. PMID:23911879. |
we found that treatment of tsg protected dopaminergic neurons by preventing mptp-induced decreases in substantia nigra tyrosine hydroxylase (th)-positive cells and striatal dopaminergic transporter (dat) protein levels. |
2013-10-31 |
2023-08-12 |
mouse |
| Liya Qin, Yuxin Liu, Jau-Shyong Hong, Fulton T Crew. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. vol 61. issue 6. 2013-10-29. PMID:23536230. |
parkinson's disease is characterized by a progressive degeneration of substantia nigra (sn) dopaminergic neurons with age. |
2013-10-29 |
2023-08-12 |
mouse |
| Omar Ouachikh, Wisam Dieb, Franck Durif, Aziz Hafid. Differential behavioral reinforcement effects of dopamine receptor agonists in the rat with bilateral lesion of the posterior ventral tegmental area. Behavioural brain research. vol 252. 2013-10-28. PMID:23727149. |
the dopaminergic neuronal loss targets the substantia nigra and the ventral tegmental area (vta). |
2013-10-28 |
2023-08-12 |
rat |
| Marina Spanos, Julie Gras-Najjar, Jeremy M Letchworth, Audrey L Sanford, J Vincent Toups, Leslie A Somber. Quantitation of hydrogen peroxide fluctuations and their modulation of dopamine dynamics in the rat dorsal striatum using fast-scan cyclic voltammetry. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23556461. |
the dopaminergic neurons of the nigrostriatal dopamine (da) projection from the substantia nigra to the dorsal striatum become dysfunctional and slowly degenerate in parkinson's disease, a neurodegenerative disorder that afflicts more than one million americans. |
2013-10-22 |
2023-08-12 |
rat |
| Li Xie, Li-Fang Hu, Xing Qi Teo, Chi Xin Tiong, Valerio Tazzari, Anna Sparatore, Piero Del Soldato, Gavin Stewart Dawe, Jin-Song Bia. Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model. PloS one. vol 8. issue 4. 2013-10-22. PMID:23573240. |
parkinson's disease (pd), characterized by loss of dopaminergic neurons in the substantia nigra, is a neurodegenerative disorder of central nervous system. |
2013-10-22 |
2023-08-12 |
rat |
| Xue-zhong Li, Xiao-peng Chen, Kun Zhao, Long-mei Bai, Hong Zhang, Xiao-ping Zho. Therapeutic effects of valproate combined with lithium carbonate on MPTP-induced parkinsonism in mice: possible mediation through enhanced autophagy. The International journal of neuroscience. vol 123. issue 2. 2013-10-17. PMID:22978383. |
the number of dopaminergic neurons in the substantia nigra following mptp treatment was higher in the combined treatment group compared with the positive control group (p = .003). |
2013-10-17 |
2023-08-12 |
mouse |
| Alice Cronin-Golom. Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: introduction to the special section on nonmotor dysfunctions in Parkinson's disease. Behavioral neuroscience. vol 127. issue 2. 2013-10-01. PMID:23565933. |
disruptions of arousal, mood, sleep, and autonomic function before the first motor signs of pd implicate the lower brainstem, which is affected before the substantia nigra and dopaminergic system. |
2013-10-01 |
2023-08-12 |
Not clear |
| Maria Aguirregomozcorta, Maria Stamelou, Angelo Antonini, Petra Schwingenschuh, Liz Prvulovich, Mark J Edwards, John C Dickson, Kailash P Bhati. Patients with rest-tremor and scans with ipsilateral dopaminergic deficit. Journal of neurology. vol 260. issue 4. 2013-09-26. PMID:23196338. |
an explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. |
2013-09-26 |
2023-08-12 |
Not clear |
| Joanna A Korecka, Ruben Eggers, Dick F Swaab, Koen Bossers, Joost Verhaage. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restorative neurology and neuroscience. vol 31. issue 2. 2013-09-20. PMID:23271419. |
parkinson's disease (pd) is a movement disorder mainly characterized by progressive neurodegeneration of dopaminergic (daergic) neurons in the substantia nigra (sn). |
2013-09-20 |
2023-08-12 |
Not clear |
| Lingling Lu, Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, Hui Yan. Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats. Acta biochimica et biophysica Sinica. vol 45. issue 3. 2013-09-12. PMID:23291291. |
furthermore, over-expression of α-syn in rat brain partly mimics the neuropathological and behavioral features of pd by triggering the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-09-12 |
2023-08-12 |
rat |
| Ari M Chow, Derek W F Tang, Asad Hanif, Ian R Brow. Induction of heat shock proteins in cerebral cortical cultures by celastrol. Cell stress & chaperones. vol 18. issue 2. 2013-09-06. PMID:22865541. |
different brain regions are impacted, with alzheimer's affecting cells in the cerebral cortex, parkinson's targeting dopaminergic cells in the substantia nigra and als causing degeneration of cells in the spinal cord. |
2013-09-06 |
2023-08-12 |
human |
| Luisel R Lemkau, Gemma Comellas, Shin W Lee, Lars K Rikardsen, Wendy S Woods, Julia M George, Chad M Rienstr. Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. PloS one. vol 8. issue 3. 2013-09-06. PMID:23505409. |
parkinson's disease (pd) is pathologically characterized by the presence of lewy bodies (lbs) in dopaminergic neurons of the substantia nigra. |
2013-09-06 |
2023-08-12 |
Not clear |
| Bwarenaba B Kautu, Alejandro Carrasquilla, Matthew L Hicks, Kim A Caldwell, Guy A Caldwel. Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling. Neuroscience letters. vol 541. 2013-09-03. PMID:23485787. |
the loss of dopaminergic neurons in the substantia nigra is one of the pathological features of pd. |
2013-09-03 |
2023-08-12 |
human |
| Maria Xilouri, Oeystein Roed Brekk, Natalie Landeck, Pothitos M Pitychoutis, Themistoklis Papasilekas, Zoi Papadopoulou-Daifoti, Deniz Kirik, Leonidas Stefani. Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration. Brain : a journal of neurology. vol 136. issue Pt 7. 2013-08-29. PMID:23757764. |
overexpression of the lysosomal receptor through the nigral injection of recombinant adeno-associated virus vectors effectively ameliorated α-synuclein-induced dopaminergic neurodegeneration by increasing the survival of neurons located in the substantia nigra as well as the axon terminals located in the striatum, which was associated with a reduction in total α-synuclein levels and related aberrant species. |
2013-08-29 |
2023-08-12 |
human |
| X Cui, M Pelekanos, P-Y Liu, T H J Burne, J J McGrath, D W Eyle. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. vol 236. 2013-08-26. PMID:23352937. |
although the presence of the vitamin d receptor (vdr) has been noted in the human substantia nigra, there is a lack of direct evidence showing that vdr is present in dopaminergic cells. |
2013-08-26 |
2023-08-12 |
human |
| S S Karuppagounder, S K Madathil, M Pandey, R Haobam, U Rajamma, K P Mohanakuma. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. vol 236. 2013-08-26. PMID:23357119. |
reversal of neuronal death induced by rotenone as observed by increased tyrosine hydroxylase-positive cells and decreased tdt-mediated dutp nick end-labeling (tunel) staining in the substantia nigra confirmed the potential of quercetin to revamp dopaminergic cells following oxidative stress mediated programmed cell death and neuronal demise. |
2013-08-26 |
2023-08-12 |
rat |
| Hiroyasu Sato, Takeo Kato, Shigeki Arawak. The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23314528. |
the motor impairments of parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of α-synuclein (α-syn) called lewy bodies. |
2013-08-21 |
2023-08-12 |
Not clear |