| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ulrike Tisch, Yuval Aluf, Radu Ionescu, Morad Nakhleh, Rana Bassal, Noa Axelrod, Dorina Robertman, Yael Tessler, John P M Finberg, Hossam Haic. Detection of asymptomatic nigrostriatal dopaminergic lesion in rats by exhaled air analysis using carbon nanotube sensors. ACS chemical neuroscience. vol 3. issue 3. 2013-08-20. PMID:22860185. |
here we report on the breath-print of presymptomatic pd in rats, using a model with 50% lesion of dopaminergic neurons in substantia nigra. |
2013-08-20 |
2023-08-12 |
rat |
| Stefano Delli Pizzi, Cosmo Rossi, Vincenzo Di Matteo, Ennio Esposito, Simone Guarnieri, Maria Addolorata Mariggiò, Raffaella Franciotti, Massimo Caulo, Astrid Thomas, Marco Onofrj, Armando Tartaro, Laura Bonann. Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study. PloS one. vol 8. issue 2. 2013-08-15. PMID:23431380. |
systemic administration of a synthetic proteasome inhibitor (psi) in rats has been described as able to provide a model of parkinson's disease (pd), characterized by behavioral and biochemical modifications, including loss of dopaminergic neurons in the substantia nigra (sn), as assessed by post-mortem studies. |
2013-08-15 |
2023-08-12 |
rat |
| Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay J Bhatt, Lir-Wan Fa. Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. vol 308. 2013-08-13. PMID:23567316. |
our previous studies show that perinatal lipopolysaccharide (lps) exposure enhances adult susceptibility to rotenone-induced injury to the dopaminergic system in the substantia nigra (sn) of the adult rat brain. |
2013-08-13 |
2023-08-12 |
rat |
| Samuel S Shin, James W Bales, Hong Q Yan, Anthony E Kline, Amy K Wagner, James Lyons-Weiler, C Edward Dixo. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. Journal of neurotrauma. vol 30. issue 4. 2013-08-12. PMID:23094804. |
dopaminergic fibers originating within the substantia nigra and ventral tegmental area (vta) are important for reward learning, addiction, movement, and behavior. |
2013-08-12 |
2023-08-12 |
rat |
| Ahmed Sharaf, Kerstin Krieglstein, Björn Spitta. Distribution of microglia in the postnatal murine nigrostriatal system. Cell and tissue research. vol 351. issue 3. 2013-08-07. PMID:23250575. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn) and the subsequent loss of striatal target innervation. |
2013-08-07 |
2023-08-12 |
mouse |
| Fangfang Bi, Fang Li, Cao Huang, Hongxia Zho. Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity. International journal of biological sciences. vol 9. issue 2. 2013-08-05. PMID:23411763. |
parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. |
2013-08-05 |
2023-08-12 |
Not clear |
| Elzbieta Janda, Ciro Isidoro, Cristina Carresi, Vincenzo Mollac. Defective autophagy in Parkinson's disease: role of oxidative stress. Molecular neurobiology. vol 46. issue 3. 2013-07-30. PMID:22899187. |
genetic susceptibility factors of pd, such as mutations in parkin, pten-induced kinase 1, and dj-1 as well as the exposure to pesticides and heavy metals, both contribute to altered redox balance and degeneration of dopaminergic neurons in the substantia nigra. |
2013-07-30 |
2023-08-12 |
Not clear |
| Trent U Steidinger, Sunny R Slone, Huiping Ding, David G Standaert, Talene A Yacoubia. Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice. PloS one. vol 8. issue 2. 2013-07-29. PMID:23409128. |
we found that angiogenin overexpression using this approach does not reduce the mptp-induced degeneration of dopaminergic cells in the substantia nigra, nor limit the depletion of dopamine and its metabolites in the striatum. |
2013-07-29 |
2023-08-12 |
mouse |
| P Thakur, B Nehr. Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. Neuroscience. vol 231. 2013-07-25. PMID:23159314. |
loss of dopaminergic neurons in the substantia nigra region of the brain is the hallmark feature of pd, which is attributed to oxidative and inflammatory stress besides other diverse factors and hence drugs targeting these pathways hold promise as neuro-therapeutics. |
2013-07-25 |
2023-08-12 |
rat |
| Y Zhao, J Xiao, S Gong, J A Clara, M S Ledou. Neural expression of the transcription factor THAP1 during development in rat. Neuroscience. vol 231. 2013-07-25. PMID:23219941. |
in addition to purkinje cells in the cerebellum, thap1-ir was also localized to pyramidal neurons in the cerebral cortex, relay neurons in the thalamus, medium spiny and cholinergic neurons in the striatum, dopaminergic neurons in the substantia nigra, and pyramidal and interneurons in the hippocampus. |
2013-07-25 |
2023-08-12 |
rat |
| T C H Leung, C N P Lui, L W Chen, W H Yung, Y S Chan, K K L Yun. Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats. ACS chemical neuroscience. vol 3. issue 1. 2013-07-24. PMID:22860178. |
parkinson's disease is caused by the degeneration of dopaminergic neurons in substantia nigra. |
2013-07-24 |
2023-08-12 |
rat |
| Kiyoka Kinugawa, Yann Monnet, Lixia Lu, Amaury J Bekaert, Clotilde Théry, Ziad Mallat, Etienne C Hirsch, Stéphane Huno. MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson's disease. Neurobiology of disease. vol 51. 2013-07-24. PMID:23194669. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by a loss of dopaminergic neurons (dn) in the substantia nigra (sn). |
2013-07-24 |
2023-08-12 |
mouse |
| Karl Grenier, Gian-Luca McLelland, Edward A Fo. Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up? Frontiers in neurology. vol 4. 2013-07-24. PMID:23882257. |
parkinson's disease (pd) is characterized by massive degeneration of dopaminergic neurons in the substantia nigra. |
2013-07-24 |
2023-08-12 |
Not clear |
| A L McCormack, S K Mak, D A Di Mont. Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra. Cell death & disease. vol 3. 2013-07-23. PMID:22647852. |
here we found that phospho-ser 129 and nitrated α-synuclein are also formed within dopaminergic neurons of the monkey substantia nigra as a result of normal aging. |
2013-07-23 |
2023-08-12 |
human |
| A L McCormack, S K Mak, D A Di Mont. Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra. Cell death & disease. vol 3. 2013-07-23. PMID:22647852. |
dopaminergic cell bodies immunoreactive for phospho-ser 129 and nitrated α-synuclein were rarely seen in adult mature animals but became significantly more frequent in the substantia nigra of old primates. |
2013-07-23 |
2023-08-12 |
human |
| Makoto Tanaka, Eriko Yamaguchi, Mami Takahashi, Kana Hashimura, Takao Shibata, Wataru Nakamura, Takahiro J Nakamur. Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neuroscience research. vol 74. issue 3-4. 2013-07-22. PMID:23044185. |
in this study, we examined the effects of dopaminergic neuronal loss in the substantia nigra (sn) on circadian rhythms of mice to assess whether age-related degeneration of the dopamine system influences circadian rhythm. |
2013-07-22 |
2023-08-12 |
mouse |
| Candan Depboylu, Matthias Höllerhage, Stefan Schnurrbusch, Patrik Brundin, Wolfgang H Oertel, André Schrattenholz, Günter U Höglinge. Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease. Neuroscience letters. vol 531. issue 2. 2013-07-22. PMID:23123776. |
in substantia nigra (sn), neuregulin-1-β1 phosphorylated erbb4 and protected dopaminergic neurons in a toxin-based mouse model of parkinson disease (pd). |
2013-07-22 |
2023-08-12 |
mouse |
| S Nakamura, N Kawai, Y Ohnuki, Y Saeki, J A M Korfage, G E J Langenbach, T Kitayama, M Watanabe, R Sano, K Tanne, E Tanak. Changes in activity and structure of jaw muscles in Parkinson's disease model rats. Journal of oral rehabilitation. vol 40. issue 3. 2013-07-22. PMID:23331038. |
parkinson's disease (pd), a major neurological disease, is characterised by a marked loss of dopaminergic neurons in the substantia nigra. |
2013-07-22 |
2023-08-12 |
rat |
| Jia Wang, Ning Song, Hong Jiang, Jun Wang, Junxia Xi. Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons. Biochimica et biophysica acta. vol 1832. issue 5. 2013-07-17. PMID:23376588. |
in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-intoxicated mice, salicylate application could not block dmt1+ire upregulation in dopaminergic neurons of substantia nigra. |
2013-07-17 |
2023-08-12 |
mouse |
| Etienne C Hirsc. [Future drug targets for Parkinson's disease]. Bulletin de l'Academie nationale de medecine. vol 196. issue 7. 2013-07-17. PMID:23815021. |
parkinson's disease is characterized by a triad of cardinal motor symptoms (bradykinesia, rigidity and tremor) resulting from the loss of dopaminergic neurons in the substantia nigra. |
2013-07-17 |
2023-08-12 |
Not clear |