| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noelia Granado, Sara Ares-Santos, Rosario Moratall. Methamphetamine and Parkinson's disease. Parkinson's disease. vol 2013. 2013-03-12. PMID:23476887. |
the molecular basis of parkinson's disease is the loss of dopamine in the basal ganglia (caudate/putamen) due to the degeneration of dopaminergic neurons in the substantia nigra, which leads to the motor impairment characteristic of the disease. |
2013-03-12 |
2023-08-12 |
human |
| Noelia Granado, Sara Ares-Santos, Rosario Moratall. Methamphetamine and Parkinson's disease. Parkinson's disease. vol 2013. 2013-03-12. PMID:23476887. |
in rodents, methamphetamine exposure damages dopaminergic neurons in the substantia nigra, resulting in a significant loss of dopamine in the striatum. |
2013-03-12 |
2023-08-12 |
human |
| Arthur G Fitzmaurice, Shannon L Rhodes, Aaron Lulla, Niall P Murphy, Hoa A Lam, Kelley C O'Donnell, Lisa Barnhill, John E Casida, Myles Cockburn, Alvaro Sagasti, Mark C Stahl, Nigel T Maidment, Beate Ritz, Jeff M Bronstei. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 2. 2013-03-07. PMID:23267077. |
parkinson disease (pd) is a neurodegenerative disorder particularly characterized by the loss of dopaminergic neurons in the substantia nigra. |
2013-03-07 |
2023-08-12 |
mouse |
| Mi Jin Kim, Dae Won Kim, Hoon Jae Jeong, Eun Jeong Sohn, Min Jea Shin, Eun Hee Ahn, Soon Won Kwon, Young Nam Kim, Duk-Soo Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease. Biochimie. vol 94. issue 11. 2013-03-05. PMID:22809528. |
parkinson's disease (pd) is caused by various factors such as reactive oxygen species (ros), dysfunction of mitochondria, and aggregation of misfolded proteins, thereby leading to loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2013-03-05 |
2023-08-12 |
mouse |
| Franz Marxreiter, Martin Regensburger, Jürgen Winkle. Adult neurogenesis in Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 70. issue 3. 2013-03-04. PMID:22766974. |
the diagnosis of pd is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (sn). |
2013-03-04 |
2023-08-12 |
Not clear |
| Eun S Park, Sang R Kim, Byung K Ji. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain research bulletin. vol 89. issue 3-4. 2013-02-27. PMID:22796104. |
the present study examined whether capsaicin (cap), an agonist of transient receptor potential vanilloid subtype 1 (trpv1) can prevent 1-methyl-4-phenylpyridinium (mpp(+))-induced dopaminergic (da) neuronal death in the substantia nigra (sn). |
2013-02-27 |
2023-08-12 |
rat |
| Perumal Gurusamy, Kaliappan Muthukumar, Seenivasan Rajesh, Gurusamy Muneeswaran, Subbu Perumal, Chandran Karunakara. Theoretical investigation of quinone metabolites of dopamine interaction with DNA--insights into toxicological effects. Journal of structural biology. vol 180. issue 1. 2013-02-21. PMID:22634727. |
dopamine (3,4-dihydroxyphenylethylamine, da), an important neurotransmitter, exists in the cell bodies of the dopaminergic neurons of the substantia nigra. |
2013-02-21 |
2023-08-12 |
Not clear |
| Duk-Soo Kim, Eun Jeong Sohn, Dae Won Kim, Young Nam Kim, Seon Ae Eom, Ga Hyeon Yoon, Sung-Woo Cho, Sang-Hyun Lee, Hyun Sook Hwang, Yoon Shin Cho, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression. BMB reports. vol 45. issue 9. 2013-02-11. PMID:23010175. |
additionally, pep-1-p18 prevented dopaminergic neuronal cell death in the substantia nigra of a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced pd mouse model. |
2013-02-11 |
2023-08-12 |
mouse |
| Sa Suk Kim, Juhee Lim, Yeojin Bang, Jiyeong Gal, Sang-Uk Lee, Young-Chang Cho, Goo Yoon, Bok Yun Kang, Seung Hoon Cheon, Hyun Jin Cho. Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease. The Journal of nutritional biochemistry. vol 23. issue 10. 2013-02-07. PMID:22227268. |
lico-e also has neuroprotective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal dopaminergic neurodegeneration in mice, with up-regulation of ho-1 and nqo1 in the substantia nigra of the brain. |
2013-02-07 |
2023-08-12 |
mouse |
| Kimberlee D'Ardenne, Neir Eshel, Joseph Luka, Agatha Lenartowicz, Leigh E Nystrom, Jonathan D Cohe. Role of prefrontal cortex and the midbrain dopamine system in working memory updating. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 49. 2013-02-06. PMID:23086162. |
finally, using the same paradigm, we conducted high-resolution fmri measurements in brainstem dopaminergic nuclei (ventral tegmental area and substantia nigra) and found phasic responses after presentation of context stimuli relative to other stimuli, consistent with the timing of a gating signal that regulates the encoding of representations in pfc. |
2013-02-06 |
2023-08-12 |
human |
| Olivier Pauly, Seyed-Ahmad Ahmadi, Annika Plate, Kai Boetzel, Nassir Nava. Detection of substantia nigra echogenicities in 3D transcranial ultrasound for early diagnosis of Parkinson disease. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286161. |
parkinson's disease (pd) is a neurodegenerative movement disorder caused by decay of dopaminergic cells in the substantia nigra (sn), which are basal ganglia residing within the midbrain area. |
2013-01-29 |
2023-08-12 |
Not clear |
| Sarah Ciccone, Emiliano Maiani, Giovanna Bellusci, Marc Diederich, Stefania Gonflon. Parkinson's disease: a complex interplay of mitochondrial DNA alterations and oxidative stress. International journal of molecular sciences. vol 14. issue 2. 2013-01-28. PMID:23348931. |
this pathology causes a significant loss of dopaminergic neurons in the substantia nigra. |
2013-01-28 |
2023-08-12 |
Not clear |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
parkinson disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2013-01-21 |
2023-08-12 |
mouse |
| Marco Timmer, Guido Nikkha. A novel strategy for intrastriatal dopaminergic cell transplantation: sequential "nest" grafting influences survival and behavioral recovery in a rat model of Parkinson's disease. Experimental cell research. vol 318. issue 20. 2013-01-17. PMID:23010385. |
in this proof-of-principle study we hypothesized that a first regular initial graft may create a "dopaminergic" environment similar to the perinatal substantia nigra and consequently stimulate a subsequent graft. |
2013-01-17 |
2023-08-12 |
rat |
| Ilya D Ionov, Nicholas N Severtse. Histamine- and haloperidol-induced catalepsy in aged mice: differential responsiveness to L-DOPA. Psychopharmacology. vol 223. issue 2. 2013-01-14. PMID:22526536. |
histamine was also found to damage the dopaminergic neurons in rat substantia nigra. |
2013-01-14 |
2023-08-12 |
mouse |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
parkinson's disease (pd) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-01-10 |
2023-08-12 |
rat |
| Philip Long, Parwez Samnakay, Peter Jenner, Sarah Ros. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22779921. |
osteopontin (opn) expression is reduced in surviving dopaminergic neurones in the substantia nigra (sn) in parkinson's disease (pd), and protects against mpp(+) -induced cell death in primary mesencephalic cultures and 6-ohda-induced cell loss in the rat, while inactivation of opn aggravates cell death. |
2013-01-09 |
2023-08-12 |
human |
| Dominik Pöltl, Stefan Schildknecht, Christiaan Karreman, Marcel Leis. Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology. vol 33. issue 4. 2013-01-04. PMID:22206971. |
the mitochondrial inhibitor 1-methyl-4-phenylpyridinium (mpp(+)) is the toxicologically relevant metabolite of 1-methyl-4-phenyltetrahydropyridine (mptp), which causes relatively selective degeneration of dopaminergic neurons in the substantia nigra. |
2013-01-04 |
2023-08-12 |
human |
| Ailing Ji, Huan Diao, Xiaohui Wang, Ruihua Yang, Jianbin Zhang, Wenjing Luo, Rui Cao, Zipeng Cao, Feng Wang, Tongjian Ca. n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. Neurotoxicology. vol 33. issue 4. 2013-01-04. PMID:22406923. |
in the present study, we found that n-3 polyunsaturated fatty acids can inhibit both microglial activation and dopaminergic injury in the substantia nigra of sprague-dawley rats induced by lipopolysaccharide, one of the major constituents of the outer membrane of gram-negative bacteria. |
2013-01-04 |
2023-08-12 |
rat |
| Priscila Pereira Passos, Juliana Maria Carrazone Borba, Ana Paula Rocha-de-Melo, Rubem Carlos Araujo Guedes, Reginaldo Pereira da Silva, Waldenício Teixeira Melo Filho, Kátia Maria Marques Gouveia, Daniela Maria do Amaral Ferraz Navarro, Geanne Karla Novais Santos, Roseane Borner, Cristovam Wanderley Picanço-Diniz, Antonio Pereira, Miriam Stela Maris de Oliveira Costa, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. Journal of chemical neuroanatomy. vol 44. issue 2. 2013-01-04. PMID:22687395. |
dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. |
2013-01-04 |
2023-08-12 |
rat |