| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E C Wolters, C M Franco. Mental dysfunction in Parkinson's disease. Parkinsonism & related disorders. vol 4. issue 3. 2012-10-02. PMID:18591098. |
the pathological hallmark of parkinson's disease (pd) is a degeneration of the dopamine (da) producing cells in the substantia nigra and the ventral tegmentum, resulting in a dopamine deficiency in the dopaminergic projection areas with defective functioning of specific cortico-subcortical extrapyramidal circuits. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark R Cookso. alpha-Synuclein and neuronal cell death. Molecular neurodegeneration. vol 4. 2012-10-02. PMID:19193223. |
both sporadic and familial parkinson disease are characterized by substantial loss of several groups of neurons, including the dopaminergic cells of the substantia nigra that are the target of most current symptomatic therapies. |
2012-10-02 |
2023-08-12 |
human |
| B Berger, J Nguyen-Legros, A M Thierr. Demonstration of horseradish peroxidase and fluorescent catecholamines in the same neuron. Neuroscience letters. vol 9. issue 4. 2012-10-02. PMID:19605235. |
after hrp injection into the striatum or into the nucleus accumbens of the rat, both fluorescent dopaminergic neurons labelled with hrp and non-fluorescent neurons labelled with hrp were observed in the substantia nigra or in the ventral tegmental area, respectively. |
2012-10-02 |
2023-08-12 |
rat |
| C M Gall, S J Gold, P J Isackson, K B Seroog. Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons. Molecular and cellular neurosciences. vol 3. issue 1. 2012-10-02. PMID:19912846. |
these results demonstrate that mrnas for nt-3 and bdnf are expressed by neurons in both the substantia nigra and ventral tegmental area of adult rat and suggest that trophic support for the dopaminergic neurons in these areas may arise from local synthesis. |
2012-10-02 |
2023-08-12 |
rat |
| U Havemann, K Kuschinsk. Neurochemical aspects of the opioid-induced 'catatonia'. Neurochemistry international. vol 4. issue 4. 2012-10-02. PMID:20487869. |
an activation of nigro-striatal and mesolimbic dopaminergic neurones seems to be of particular relevance in the behavioural stimulation, which is due to actions of opioids on receptors located within the substantia nigra (on endings of afferent neurones, localization iii in fig. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Torre, M E Celi. Alpha-MSH injected into the substantia nigra or intraventricularly alters behavior and the striatal dopaminergic activity. Neurochemistry international. vol 9. issue 1. 2012-10-02. PMID:20493104. |
alpha-msh injected into the substantia nigra or intraventricularly alters behavior and the striatal dopaminergic activity. |
2012-10-02 |
2023-08-12 |
rat |
| S Y Chai, M J Christie, P M Beart, F A Mendelsoh. Effects of nigral dopaminergic lesions and striatal excitotoxin lesions on brain converting enzyme. Neurochemistry international. vol 10. issue 1. 2012-10-02. PMID:20501090. |
in order to investigate whether ace was associated with dopaminergic projections from the substantia nigra or striatal projections, we performed unilateral excitotoxin lesions using n- methyl- d -asparate (nmda) (500 nmol) into the cpu and 6-hydroxydopamine (60hda) (8 ?g) lesions of the substantia nigra. |
2012-10-02 |
2023-08-12 |
Not clear |
| F Richard, R Labatut, D Weissmann, H Scarna, M Buda, J F Pujo. Further characterization of the tyrosine hydroxylase induction elicited by reserpine in the rat locus coeruleus and adrenals. Neurochemistry international. vol 14. issue 2. 2012-10-02. PMID:20504418. |
reserpine did not change the activity and amount of th in the region of the substantia nigra where dopaminergic neurons are located, except at a high dose (10 mg/kg): a significant elevation (+36%) of the th protein amount was then observed 2 days after treatment. |
2012-10-02 |
2023-08-12 |
rat |
| T Kuriyama, J Taguchi, K Kuriyam. Functional alterations in striatal cholinergic and striato-nigral gabaergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504575. |
furthermore, it was found that mptp treatment induced an increase of the gaba(a) receptor-benzodiazepine receptor-chloride channel complex in the substantia nigra in addition to that of dopaminergic d(2) receptor in the striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| P Galvani, M Colleoni, M Origgi, A Santagostin. Mitochondrial toxicity of iron and the protective role of ferritin on dopaminergic PC12 cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 9. issue 4. 2012-10-02. PMID:20650100. |
using an in vitro dopaminergic pc12 cell line model, a possible pathogenic link has been investigated between this finding and increased levels of iron actually observed in the substantia nigra of parkinsonian patients. |
2012-10-02 |
2023-08-12 |
Not clear |
| Yasushi Takagi, Jun Takahash. Primate embryonic stem cells as a source of dopaminergic neurons: A novel transplantation for Parkinson's disease. Discovery medicine. vol 5. issue 26. 2012-10-02. PMID:20704914. |
extract: the most common neurodegenerative movement disorder in man is parkinson's disease (pd) and it is characterized by the loss of midbrain dopaminergic neurons in the substantia nigra of the brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| Xin Zhao, Quan Li, Lei Zhao, Xiaoping P. Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson's disease. Proteomics. Clinical applications. vol 1. issue 12. 2012-10-02. PMID:21136655. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) replicates many of the pathological hallmarks of parkinson's disease (pd) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| T F Oo, R E Burk. Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318771. |
apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jeanne Adiwinata Pawita. Prospect of cell therapy for Parkinson's disease. Anatomy & cell biology. vol 44. issue 4. 2012-10-02. PMID:22254154. |
the hallmark of parkinson's disease is on-going degeneration of dopaminergic neurons in the substantia nigra, which may be due to various etiologies. |
2012-10-02 |
2023-08-12 |
Not clear |
| Sebastián Hormigo, José de Anchieta de Castro E Horta Júnior, Ricardo Gómez-Nieto, Dolores E Lópe. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22754504. |
this is consistent with the existence of an important dopaminergic projection from the substantia nigra to the ic. |
2012-10-02 |
2023-08-12 |
rat |
| Henriqueta D Cardoso, Priscila P Passos, Claudia J Lagranha, Anete C Ferraz, Eraldo F Santos Júnior, Rafael S Oliveira, Pablo E L Oliveira, Rita de C F Santos, David F Santana, Juliana M C Borba, Ana P Rocha-de-Melo, Rubem C A Guedes, Daniela M A F Navarro, Geanne K N Santos, Roseane Borner, Cristovam W Picanço-Diniz, Eduardo I Beltrão, Janilson F Silva, Marcelo C A Rodrigues, Belmira L S Andrade da Cost. Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids. Frontiers in human neuroscience. vol 6. 2012-10-02. PMID:22969716. |
in our previous study on rat brains, we observed that a two-generation efa dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (sn) rostro-dorso-medial. |
2012-10-02 |
2023-08-12 |
rat |
| Li Xu, Li-Xing Liu, Wen-Fang Chen, Jun-Xia Xie, Wen-Xiu Huan. [The protective effect of ginsenoside Rg1 on dopaminergic neurons of substantia in the ovariectomized rat model of Parkinson's disease]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 24. issue 1. 2012-10-01. PMID:21141541. |
to investigate the neuroprotective effect of ginsenoside rg1 on dopaminergic neurons of substantia nigra in ovariectomized rat model of parkinson's disease and the possible mechanisms. |
2012-10-01 |
2023-08-12 |
rat |
| Binu Tharakan, Muralikrishnan Dhanasekaran, Bala V Manya. Differential effects of dopaminergic neurotoxins on DNA cleavage. Life sciences. vol 91. issue 1-2. 2012-09-24. PMID:22213117. |
parkinson's disease is a neurological disorder occurring due to the death of dopaminergic neurons in substantia nigra. |
2012-09-24 |
2023-08-12 |
Not clear |
| Jie Li, Junfeng Yang, Peng Zhao, Shen Li, Renyun Zhang, Xiaobin Zhang, Dan Liu, Benshu Zhan. Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 6. 2012-09-20. PMID:22200858. |
the key pathological feature of parkinson's disease (pd) is selective degeneration of the neuromelanin (nm)-pigmented dopaminergic neurons in the substantia nigra (sn). |
2012-09-20 |
2023-08-12 |
human |
| Zhi-Guo Zhang, Lin Wu, Ju-Lei Wang, Jian-Dong Yang, Jing Zhang, Jian Zhang, Li-Hong Li, Yi Xia, Li-Bo Yao, Huai-Zhou Qin, Guo-Dong Ga. Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. Molecular and cellular biochemistry. vol 364. issue 1-2. 2012-09-20. PMID:22278385. |
parkinson's disease (pd) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. |
2012-09-20 |
2023-08-12 |
Not clear |