| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Noh, S Y Chang, S Y Wang, J M Chun. Dual function of Zn2+ on the intrinsic excitability of dopaminergic neurons in rat substantia nigra. Neuroscience. vol 175. 2012-06-01. PMID:21081151. |
dual function of zn2+ on the intrinsic excitability of dopaminergic neurons in rat substantia nigra. |
2012-06-01 |
2023-08-12 |
rat |
| S Walsh, D P Finn, E Dow. Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat. Neuroscience. vol 175. 2012-06-01. PMID:21145947. |
degeneration of dopaminergic neurons from the substantia nigra was also evident from 72 h after axonal lesion, and was accompanied by nigral microgliosis and astrocytosis by 2 weeks. |
2012-06-01 |
2023-08-12 |
human |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Andreas Heuer, Gaynor A Smith, Mariah J Lelos, Emma L Lane, Stephen B Dunnet. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22146593. |
in the present study we examine the consequences of injection of the toxin at three sites along the nigrostriatal tract (substantia nigra, medial forebrain bundle, and striatum) on a broad range of simple motor tasks, and on the dopaminergic pathology. |
2012-05-24 |
2023-08-12 |
mouse |
| Katarzyna Derwińska, Hanna Mierzewska, Alicja Goszczańska, Elżbieta Szczepanik, Zhilian Xia, Katarzyna Kuśmierska, Jolanta Tryfon, Anna Kutkowska-Kaźmierczak, Ewa Bocian, Tadeusz Mazurczak, Ewa Obersztyn, Paweł Stankiewic. Clinical improvement of the aggressive neurobehavioral phenotype in a patient with a deletion of PITX3 and the absence of L-DOPA in the cerebrospinal fluid. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22223473. |
pitx3(-/-) mice have a selective loss of dopaminergic neurons in the substantia nigra and ventral tegmental area, leading to the significantly reduced da levels in the nigrostriatal pathway and in the dorsal striatum and manifest anomalous striatum-dependent cognitive impairment and neurobehavioral activity. |
2012-05-22 |
2023-08-12 |
mouse |
| S Ares-Santos, N Granado, I Oliva, E O'Shea, E D Martin, M I Colado, R Moratall. Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine. Neurobiology of disease. vol 45. issue 2. 2012-05-18. PMID:22115942. |
in addition, d(1)r inactivation prevented meth-induced loss of dopaminergic neurons in the substantia nigra. |
2012-05-18 |
2023-08-12 |
mouse |
| X-Q Bao, X-C Kong, C Qian, D Zhan. FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models. Neuroscience. vol 202. 2012-05-18. PMID:22138155. |
the pathogenesis of parkinson's disease is characterized by progressive degeneration of dopaminergic neurons in substantia nigra (snpc). |
2012-05-18 |
2023-08-12 |
mouse |
| Hsin-Yi Huang, Shinn-Zong Lin, Wu-Fu Chen, Kuo-Wei Li, Jon-Son Kuo, Mei-Jen Wan. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase. Neurobiology of aging. vol 32. issue 9. 2012-05-17. PMID:19875195. |
although ucn is principally expressed in dopaminergic neurons in rat substantia nigra (sn), the function of ucn in modulating dopaminergic neuronal survival remains unclear. |
2012-05-17 |
2023-08-12 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
the morphology and total number of th(+) cells was analyzed for each a9 (substantia nigra) and a10 (ventral tegmental area) group of the midbrain dopaminergic cells. |
2012-05-17 |
2023-08-12 |
rat |
| Donna W Lee, Sarah A Notter, Mona Thiruchelvam, Daniel P Dever, Richard Fitzpatrick, Paul J Kostyniak, Deborah A Cory-Slechta, Lisa A Opanashu. Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 2. 2012-05-17. PMID:22094459. |
stereologic analyses revealed a significant loss of dopaminergic neurons within the substantia nigra and ventral tegmental area. |
2012-05-17 |
2023-08-12 |
Not clear |
| Almas Siddiqui, Jyothi K Mallajosyula, Anand Rane, Julie K Anderse. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21809503. |
we previously demonstrated that elevation of astrocytic monoamine oxidase b (mao-b) levels in adoxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observed in the parkinsonian midbrain (mallajosyula et al., 2008).these include a specific, selective and progressive loss of dopaminergic neurons of the substantia nigra (sn),selective decreases in mitochondrial complex i (ci) activity and increased oxidative stress. |
2012-05-07 |
2023-08-12 |
mouse |
| Chang Deng, Ran Tao, Shun-Zhi Yu, Hua Ji. Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner. Molecular medicine reports. vol 5. issue 3. 2012-05-03. PMID:22200816. |
parkinson's disease (pd) is a progressive neurodegenerative disorder with selective loss of dopaminergic neurons in the substantia nigra. |
2012-05-03 |
2023-08-12 |
Not clear |
| Ahrom Ham, Sung-Jin Lee, Jongheon Shin, Kyung-Ho Kim, Woongchon Ma. Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells. Neuroscience letters. vol 507. issue 2. 2012-04-26. PMID:22040670. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic (daergic) neurons in the substantia nigra and the subsequent depletion of dopamine (da). |
2012-04-26 |
2023-08-12 |
human |
| Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capel. Dopamine and α-synuclein dysfunction in Smad3 null mice. Molecular neurodegeneration. vol 6. 2012-04-24. PMID:21995845. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2012-04-24 |
2023-08-12 |
mouse |
| Yuzuru Imai, Bingwei L. Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder. Current opinion in neurobiology. vol 21. issue 6. 2012-04-23. PMID:22048001. |
parkinson's disease (pd), the most common movement disorder, is characterized by age-dependent degeneration of dopaminergic neurons in the substantia nigra of the mid-brain. |
2012-04-23 |
2023-08-12 |
Not clear |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum, and tyrosine hydroxylase (th) immunoreactivity and 4',6-diamidino-2-phenylindole (dapi)/fluoro-jade b staining in the substantia nigra were measured to assess dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
rat |
| Kenny K H Chung, Peter S Freestone, Janusz Lipsk. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. Journal of neurophysiology. vol 106. issue 6. 2012-04-16. PMID:21900507. |
expression and functional properties of trpm2 channels in dopaminergic neurons of the substantia nigra of the rat. |
2012-04-16 |
2023-08-12 |
rat |
| Tae Woo Kim, Younghye Moon, Kyungjin Kim, Jeong Eun Lee, Hyun Chul Koh, Im Joo Rhyu, Hyun Kim, Woong Su. Dissociation of progressive dopaminergic neuronal death and behavioral impairments by Bax deletion in a mouse model of Parkinson's diseases. PloS one. vol 6. issue 10. 2012-04-06. PMID:22043283. |
parkinson's disease (pd) is a common, late-onset movement disorder with selective degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2012-04-06 |
2023-08-12 |
mouse |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Par. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132113. |
parkinson's disease (pd) is caused by the selective loss of dopaminergic neurons in the substantia nigra (sn) and the depletion of striatal dopamine (da). |
2012-04-02 |
2023-08-12 |
mouse |
| B K Binukumar, Amanjit Bal, Kiran Dip Gil. Chronic dichlorvos exposure: microglial activation, proinflammatory cytokines and damage to nigrostriatal dopaminergic system. Neuromolecular medicine. vol 13. issue 4. 2012-03-26. PMID:21964614. |
dopaminergic cells in the substantia nigra are highly vulnerable to the neurodegenerative process of parkinson's disease. |
2012-03-26 |
2023-08-12 |
rat |