| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanxia Yang, Jiaze An, Yayun Wang, Wenjing Luo, Wei Wang, Xiaopeng Mei, Shengxi Wu, Jingyuan Che. Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787683. |
our previous studies showed chronic exposure to manganese chloride (mn) causes locomotor impairment and lesion of dopaminergic neurons in substantia nigra (sn). |
2012-01-23 |
2023-08-12 |
mouse |
| Y Masamizu, T Okada, K Kawasaki, H Ishibashi, S Yuasa, S Takeda, I Hasegawa, K Nakahar. Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9. Neuroscience. vol 193. 2012-01-18. PMID:21782903. |
injections of either aav8-egfp or aav9-egfp into the marmoset striatum resulted in egfp expression in local striatal neurons as a result of local infection, as well as expression in dopaminergic neurons of the substantia nigra via retrograde transport along nigrostriatal axonal projections. |
2012-01-18 |
2023-08-12 |
monkey |
| Erwin Swinnen, Sabrina Büttner, Tiago F Outeiro, Marie-Christine Galas, Frank Madeo, Joris Winderickx, Vanessa Franssen. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast. Biochemical Society transactions. vol 39. issue 5. 2012-01-17. PMID:21936837. |
pd (parkinson's disease) is a neurodegenerative disorder, caused by a selective loss of dopaminergic neurons in the substantia nigra, which affects an increasing number of the elderly population worldwide. |
2012-01-17 |
2023-08-12 |
Not clear |
| b' Jasna \\xc5\\xa0aponji\\xc4\\x8. [Selective stimulations and lesions of the rat brain nuclei as the models for research of the human sleep pathology mechanisms]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 51. 2012-01-17. PMID:22165729.' |
in spite of a long knowledge of their clinical description and brain pathology (lesions of the nb cholinergic neurons in basal forebrain, dopaminergic neurons in substantia nigra, etc. |
2012-01-17 |
2023-08-12 |
human |
| Che Brown Hutson, Carlos R Lazo, Farzad Mortazavi, Christopher C Giza, David Hovda, Marie-Francoise Chessele. Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat. Journal of neurotrauma. vol 28. issue 9. 2012-01-16. PMID:21644813. |
tbi alone increased microglial activation in the substantia nigra, and caused a 15% loss of dopaminergic neurons ipsilaterally. |
2012-01-16 |
2023-08-12 |
rat |
| Yin-Xiu Ding, Li-Chun Wei, Ya-Zhou Wang, Rong Cao, Xi Wang, Liang-Wei Che. Molecular manipulation targeting regulation of dopaminergic differentiation and proliferation of neural stem cells or pluripotent stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495963. |
parkinson's disease (pd) is a severe deliberating neurological disease caused by progressive degenerative death of dopaminergic neurons in the substantia nigra of midbrain. |
2012-01-12 |
2023-08-12 |
Not clear |
| Hiroyasu Sato, Shigeki Arawaka, Susumu Hara, Shingo Fukushima, Kaori Koga, Shingo Koyama, Takeo Kat. Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 46. 2012-01-12. PMID:22090514. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the appearance of fibrillar aggregates of insoluble α-synuclein (α-syn) called lewy bodies (lbs). |
2012-01-12 |
2023-08-12 |
rat |
| Andreas Ratzka, Olga Baron, Claudia Groth. FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. PloS one. vol 6. issue 8. 2011-12-30. PMID:21876757. |
in the central nervous system dopaminergic neurons of the substantia nigra and their axonal projections into the striatum progressively degenerate in parkinson's disease. |
2011-12-30 |
2023-08-12 |
mouse |
| Olga Corti, Suzanne Lesage, Alexis Bric. What genetics tells us about the causes and mechanisms of Parkinson's disease. Physiological reviews. vol 91. issue 4. 2011-12-13. PMID:22013209. |
it is due to the progressive degeneration of the dopaminergic neurons of the substantia nigra and is accompanied by the appearance of intraneuronal inclusions enriched in α-synuclein, the lewy bodies. |
2011-12-13 |
2023-08-12 |
Not clear |
| Michael S Remple, Courtney H Bradenham, C Chris Kao, P David Charles, Joseph S Neimat, Peter E Konra. Subthalamic nucleus neuronal firing rate increases with Parkinson's disease progression. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 9. 2011-12-08. PMID:21542021. |
parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic cells in the central nervous system, in particular the substantia nigra, resulting in an unrelenting loss of motor and nonmotor function. |
2011-12-08 |
2023-08-12 |
Not clear |
| Marie-Pierre Hinault, America Farina-Henriquez-Cuendet, Pierre Goloubinof. Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease. Neuro-degenerative diseases. vol 8. issue 6. 2011-12-07. PMID:21411979. |
parkinson's disease (pd) is a slowly progressive neurodegenerative disorder marked by the loss of dopaminergic neurons (in particular in the substantia nigra) causing severe impairment of movement coordination and locomotion, associated with the accumulation of aggregated α-synuclein (α-syn) into proteinaceous inclusions named lewy bodies. |
2011-12-07 |
2023-08-12 |
Not clear |
| b' Mikhail S Shchepinov, Vivian P Chou, Erik Pollock, J William Langston, Charles R Cantor, Robert J Molinari, Amy B Manning-Bo\\xc4\\x9. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson\'s disease. Toxicology letters. vol 207. issue 2. 2011-11-30. PMID:21906664.' |
in the substantia nigra, a significant improvement was noted in the number of nigral dopaminergic neurons following mptp exposure in the d-pufa (79.5% control) vs. h-pufa (58.8% control) mice using unbiased stereological cell counting. |
2011-11-30 |
2023-08-12 |
mouse |
| Katherine C M Chew, Eng-Tat Ang, Yee Kit Tai, Fai Tsang, Shun Qiang Lo, Elijah Ong, Wei-Yi Ong, Han-Ming Shen, Kah-Leong Lim, Valina L Dawson, Ted M Dawson, Tuck Wah Soon. Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease. The Journal of biological chemistry. vol 286. issue 38. 2011-11-23. PMID:21795716. |
parkinson disease (pd), a prevalent neurodegenerative motor disorder, is characterized by the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched lewy body inclusions in the substantia nigra of the midbrain. |
2011-11-23 |
2023-08-12 |
Not clear |
| Eun-Yee Jung, Insop Shi. Differential DAergic Control of D1 and D2 Receptor Agonist Over Locomotor Activity and GABA Level in the Striatum. Experimental neurobiology. vol 20. issue 3. 2011-11-23. PMID:22110374. |
the striatum, which is the major input station of the basal ganglia in the brain, is regulated in part by dopaminergic input from the substantia nigra. |
2011-11-23 |
2023-08-12 |
mouse |
| Philippe Huot, Susan H Fox, Adrian Newman-Tancredi, Jonathan M Brotchi. Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson's disease: an approach to reducing dyskinesia without exacerbating parkinsonism? The Journal of pharmacology and experimental therapeutics. vol 339. issue 1. 2011-11-22. PMID:21784889. |
we propose that, in addition to selectivity for specific receptor subtypes, to target 5-ht(1a) and 5-ht(2a) receptors to alleviate dyskinesia, without worsening parkinsonism, it will be necessary to develop compounds that display anatomical selectivity, targeting corticostriatal transmission, while avoiding 5-ht receptors on ascending serotonergic and dopaminergic inputs from the raphe and substantia nigra, respectively. |
2011-11-22 |
2023-08-12 |
Not clear |
| Sandra Blaess, Gabriela O Bodea, Anna Kabanova, Soline Chanet, Emilie Mugniery, Amin Derouiche, Daniel Stephen, Alexandra L Joyne. Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural development. vol 6. 2011-11-15. PMID:21689430. |
the ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn) and neurons of the red nucleus (rn). |
2011-11-15 |
2023-08-12 |
Not clear |
| Sean Stephen O'Sullivan, Luke A Massey, David R Williams, Tamas Revesz, Andrew Lees, Janice Holto. Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy. BMJ case reports. vol 2009. 2011-11-10. PMID:21686637. |
the hypothesis most widely proposed to explain neurogenic bladder symptoms in pd is that cell loss in the substantia nigra may cause detrusor hyperactivity due to a loss in the d1 receptor-mediated tonic inhibition of the micturition reflex, although other causes including anti-parkinsonian medication cortical effects have been considered.1 we present the clinical and pathological findings of a patient with parkinsonism who presented with prominent dysautonomia and a poor response to dopaminergic medications and was considered to have possible multiple system atrophy parkinsonism (msa-p). |
2011-11-10 |
2023-08-12 |
Not clear |
| Ana I Rodriguez-Perez, Rita Valenzuela, Belen Joglar, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garci. Renin angiotensin system and gender differences in dopaminergic degeneration. Molecular neurodegeneration. vol 6. issue 1. 2011-11-10. PMID:21846363. |
it has been shown that the local renin angiotensin system (ras) plays a prominent role in sex differences in the development of chronic renal and cardiovascular diseases, and there is a local ras in the substantia nigra and dopaminergic cell loss is enhanced by angiotensin via type 1 (at1) receptors. |
2011-11-10 |
2023-08-12 |
Not clear |
| Martyna Songin, Joanna B Strosznajder, Magdalena Fitał, Katarzyna Kuter, Wacław Kolasiewicz, Przemysław Nowak, Krystyna Ossowsk. Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:20143200. |
parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. |
2011-11-08 |
2023-08-12 |
rat |
| Jeswinder Sian-Hülsmann, Silvia Mandel, Moussa B H Youdim, Peter Riedere. The relevance of iron in the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21138437. |
however, intensive investigations have provided a host of putative mechanisms that might contribute to the pathogenesis underlying the characteristic degeneration of the dopaminergic neurons in the substantia nigra (sn). |
2011-11-01 |
2023-08-12 |
Not clear |