| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nada A Abumrad, Darren J Moor. Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36. The Journal of clinical investigation. vol 121. issue 9. 2011-10-31. PMID:21865651. |
parkinson disease (pd) is a relatively common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2011-10-31 |
2023-08-12 |
Not clear |
| Hardeep Gambhir, Rashmi Mathur, Madhuri Behar. Progressive impairment in motor skill learning at 12 and 20 weeks post 6-OHDA- SNc lesion in rats. Parkinsonism & related disorders. vol 17. issue 6. 2011-10-24. PMID:21367640. |
deficiency in skilled motor activity is primarily attributed to the loss of dopaminergic neurons in the pars compacta of substantia nigra (snc), which can be detected by performance of the rotarod test. |
2011-10-24 |
2023-08-12 |
rat |
| Yanning Cai, Hui Ding, Zhuqin Gu, Jinghong Ma, Piu Cha. Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population. Neuroscience letters. vol 498. issue 2. 2011-10-18. PMID:21565251. |
pitx3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for parkinson's disease (pd). |
2011-10-18 |
2023-08-12 |
Not clear |
| C V Fontanilla, Z Ma, X Wei, J Klotsche, L Zhao, P Wisniowski, R C Dodel, M R Farlow, W H Oertel, Y D. Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration. Neuroscience. vol 188. 2011-10-12. PMID:21571045. |
parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. |
2011-10-12 |
2023-08-12 |
mouse |
| Petranka Krumova, Erik Meulmeester, Manuel Garrido, Marilyn Tirard, He-Hsuan Hsiao, Guillaume Bossis, Henning Urlaub, Markus Zweckstetter, Sebastian Kügler, Frauke Melchior, Mathias Bähr, Jochen H Weishaup. Sumoylation inhibits alpha-synuclein aggregation and toxicity. The Journal of cell biology. vol 194. issue 1. 2011-09-29. PMID:21746851. |
importantly, this double mutant showed increased propensity for aggregation and cytotoxicity in a cell-based assay and increased cytotoxicity in dopaminergic neurons of the substantia nigra in vivo. |
2011-09-29 |
2023-08-12 |
Not clear |
| Gabriele Meloni, Milan Vašá. Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3. Free radical biology & medicine. vol 50. issue 11. 2011-09-22. PMID:21320589. |
the aggregation of α-synuclein (α-syn), the major component of intracellular lewy body inclusions in dopaminergic neurons of the substantia nigra, plays a critical role in the etiology of parkinson disease (pd). |
2011-09-22 |
2023-08-12 |
Not clear |
| Guadalupe Soria, Esther Aguilar, Raúl Tudela, Joaquim Mullol, Anna M Planas, Concepció Mari. In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson's disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6-hydroxydopamine rat model. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21410791. |
the neuropathological hallmark of parkinson's disease is the loss of dopaminergic neurons in the pars compacta of the substantia nigra (snc). |
2011-09-16 |
2023-08-12 |
rat |
| M Flint Bea. Neuroprotective effects of creatine. Amino acids. vol 40. issue 5. 2011-09-15. PMID:21448659. |
creatine produced dose-dependent neuroprotective effects against mptp toxicity reducing the loss of dopamine within the striatum and the loss of dopaminergic neurons in the substantia nigra. |
2011-09-15 |
2023-08-12 |
mouse |
| Isidre Ferrer, Anna Martinez, Rosa Blanco, Ester Dalfó, Margarita Carmon. Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:20862500. |
in spite of the relatively small decrease in the number of dopaminergic neurons in the substantia nigra, which does not reach thresholds causative of parkinsonism, levels of tyrosine hydroxylase and cannabinoid 1 receptor are reduced, whereas levels of adenosine receptor 2a are increased in the caudate in ppd. |
2011-09-08 |
2023-08-12 |
Not clear |
| Toyoko Arimoto, Dong-Young Choi, Xin Lu, Mei Liu, Xuan V Nguyen, Naiying Zheng, Charles A Stewart, Hyoung-Chun Kim, Guoying Bin. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiology of aging. vol 28. issue 6. 2011-09-08. PMID:21887889. |
interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. |
2011-09-08 |
2023-08-12 |
Not clear |
| Hironori Yokoyama, Ryohei Yano, Hayato Kuroiwa, Tatsuya Tsukada, Hiroto Uchida, Hiroyuki Kato, Jiro Kasahara, Tsutomu Arak. Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 25. issue 3. 2011-09-06. PMID:20957419. |
our western blot analysis and immunohistochemical study showed that the post-treatment with zonisamide prevented significantly dopaminergic cell damage, the depletion of tyrosine-hydroxylase (th) protein levels and the proliferation of microglia in the striatum and/or substantia nigra 8 days after mptp treatment. |
2011-09-06 |
2023-08-12 |
mouse |
| Cristian Taccioli, Jesper Tegnér, Vincenza Maselli, David Gomez-Cabrero, Gioia Altobelli, Warren Emmett, Francesco Lescai, Stefano Gustincich, Elia Stupk. ParkDB: a Parkinson's disease gene expression database. Database : the journal of biological databases and curation. vol 2011. 2011-09-02. PMID:21593080. |
parkinson's disease (pd) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. |
2011-09-02 |
2023-08-12 |
Not clear |
| Evangelos Sotiriou, Demetrios K Vassilatis, Miquel Vila, Leonidas Stefani. Selective noradrenergic vulnerability in α-synuclein transgenic mice. Neurobiology of aging. vol 31. issue 12. 2011-08-29. PMID:19152986. |
classical pathological signs of parkinson's disease (pd) include loss of dopaminergic neurons in substantia nigra (sn) and noradrenergic neurons in locus coeruleus (lc), and deposition of lewy bodies rich in the presynaptic protein alpha-synuclein (asyn). |
2011-08-29 |
2023-08-12 |
mouse |
| Torsten Falk, Xu Yue, Shiling Zhang, Alexander D McCourt, Brandon J Yee, Robert T Gonzalez, Scott J Sherma. Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease. Neuroscience letters. vol 496. issue 1. 2011-08-26. PMID:21507340. |
immunohistochemical analysis showed that vegf-b(186) treatment partially protected dopaminergic fibers in the striatum and demonstrated a partial rescue of the dopaminergic neurons in the caudal sub-region of the substantia nigra. |
2011-08-26 |
2023-08-12 |
rat |
| A Van der Perren, J Toelen, M Carlon, C Van den Haute, F Coun, B Heeman, V Reumers, L H Vandenberghe, J M Wilson, Z Debyser, V Baekeland. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene therapy. vol 18. issue 5. 2011-08-22. PMID:21326331. |
efficient and stable transduction of dopaminergic neurons in rat substantia nigra by raav 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. |
2011-08-22 |
2023-08-12 |
rat |
| A Van der Perren, J Toelen, M Carlon, C Van den Haute, F Coun, B Heeman, V Reumers, L H Vandenberghe, J M Wilson, Z Debyser, V Baekeland. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene therapy. vol 18. issue 5. 2011-08-22. PMID:21326331. |
in light of the further development of a viral vector-mediated rat model for pd, we performed a comprehensive comparison of the transduction and tropism for dopaminergic neurons (dns) in the adult wistar rat substantia nigra (sn) of seven raav vector serotypes (raav 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9). |
2011-08-22 |
2023-08-12 |
rat |
| Gabriele Gille, Heinz Reichman. Iron-dependent functions of mitochondria--relation to neurodegeneration. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 3. 2011-08-16. PMID:21161302. |
recent research demonstrated raised iron levels in individual dopaminergic neurons of the substantia nigra. |
2011-08-16 |
2023-08-12 |
Not clear |
| Alexandra Gaenslen, Irene Swid, Inga Liepelt-Scarfone, Jana Godau, Daniela Ber. The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 4. 2011-08-15. PMID:21370256. |
before the occurrence of motor symptoms permits the clinical diagnosis of parkinson's disease (pd), about or even more than 50% of the dopaminergic neurons of the substantia nigra have degenerated. |
2011-08-15 |
2023-08-12 |
Not clear |
| Zang-Hee Cho, Se-Hong Oh, Jong-Min Kim, Sung-Yeon Park, Dae-Hyuk Kwon, Hye-Jin Jeong, Young-Bo Kim, Je-Geun Chi, Chan-Woong Park, John Huston, Kendall H Lee, Beom S Jeo. Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 4. 2011-08-15. PMID:21506148. |
parkinson's disease (pd) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2011-08-15 |
2023-08-12 |
human |
| Delphine Michel-Monigadon, Virginie Bonnamain, Véronique Nerrière-Daguin, Anne-Sophie Dugast, Xavier Lévèque, Martine Plat, Eric Venturi, Philippe Brachet, Ignacio Anegon, Bernard Vanhove, Isabelle Neveu, Philippe Naveilha. Trophic and immunoregulatory properties of neural precursor cells: benefit for intracerebral transplantation. Experimental neurology. vol 230. issue 1. 2011-08-12. PMID:20470774. |
in addition to their immunosuppressive effect, in contrast to pnb, very few pnspc differentiated into tyrosine hydroxylase-positive neurons but the cells triggered an intense innervation of the striatum by rat dopaminergic fibers coming from the substantia nigra. |
2011-08-12 |
2023-08-12 |
human |