| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Jin, Li-Min Zhang, Ke-Qiang Xie, Yang Ye, Linyin Fen. Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells. British journal of pharmacology. vol 164. issue 2b. 2012-03-20. PMID:21542832. |
paeoniflorin (pf) has ameliorative effects on learning and memory impairment and cerebral ischaemia in rats and has protective effects against the degeneration of dopaminergic neurons in substantia nigra. |
2012-03-20 |
2023-08-12 |
human |
| Ah-Reum Doo, Seung-Nam Kim, Seung-Tae Kim, Ji-Yeun Park, Sung-Hyun Chung, Bo-Young Choe, Younbyoung Chae, Hyejung Lee, Chang-Shik Yin, Hi-Joon Par. Bee venom protects SH-SY5Y human neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptotic cell death. Brain research. vol 1429. 2012-03-20. PMID:22078207. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by progressive selective loss of dopaminergic neurons in the substantia nigra. |
2012-03-20 |
2023-08-12 |
mouse |
| Marcia C L Pereira, Mariane Secco, Daniela E Suzuki, Luciana Janjoppi, Carolina O Rodini, Layla B Torres, Bruno H S Araújo, Esper A Cavalheiro, Mayana Zatz, Oswaldo Keith Okamot. Contamination of mesenchymal stem-cells with fibroblasts accelerates neurodegeneration in an experimental model of Parkinson's disease. Stem cell reviews and reports. vol 7. issue 4. 2012-03-16. PMID:21503590. |
in a rat model of pd induced by mptp neurotoxin, we first observed a significant bilateral preservation of dopaminergic neurons in the substantia nigra and prevention of motor deficits typically observed in pd such as hypokinesia, catalepsy, and bradykinesia, following intracerebral administration of human umbilical cord-derived msc (uc-msc) early after mptp injury. |
2012-03-16 |
2023-08-12 |
human |
| David E Vaillancourt, Matthew B Spraker, Janey Prodoehl, Xiaohong Joe Zhou, Deborah M Littl. Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging. Neurobiology of aging. vol 33. issue 1. 2012-03-13. PMID:20359780. |
dopaminergic neurons in the substantia nigra produce dopamine for the nigrostriatal pathway that facilitates motor function. |
2012-03-13 |
2023-08-12 |
Not clear |
| Jie Zhang, Ling-Ling Zhao, Zhi-Ping Hu, Jun Zhou, Li Deng, Fen Gu, Hong-Mei Dai, Min Huan. [Effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 12. 2012-03-13. PMID:22172267. |
[effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. |
2012-03-13 |
2023-08-12 |
rat |
| Jie Zhang, Ling-Ling Zhao, Zhi-Ping Hu, Jun Zhou, Li Deng, Fen Gu, Hong-Mei Dai, Min Huan. [Effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 12. 2012-03-13. PMID:22172267. |
to explore the effects of low-dose chlorpyrifos (cpf) exposure on dopaminergic (da) neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats. |
2012-03-13 |
2023-08-12 |
rat |
| Naomi Seki, Yuji Takahashi, Hiroyuki Tomiyama, Ekaterina Rogaeva, Shigeo Murayama, Yoshikuni Mizuno, Nobutaka Hattori, Connie Marras, Anthony E Lang, Peter St George-Hyslop, Jun Goto, Shoji Tsuj. Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease. Journal of human genetics. vol 56. issue 9. 2012-03-09. PMID:21796139. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by neurodegeneration, most notably of dopaminergic neurons in the substantia nigra. |
2012-03-09 |
2023-08-12 |
Not clear |
| Ye-Ming J Sun, Theresa Hoang, Judith A Neubauer, Arthur S Walter. Opioids protect against substantia nigra cell degeneration under conditions of iron deprivation: a mechanism of possible relevance to the Restless Legs Syndrome (RLS) and Parkinson's disease. Journal of the neurological sciences. vol 304. issue 1-2. 2012-03-06. PMID:21376342. |
cell cultures of the substantia nigra (sn) of sprague-dawley rats were established and the cells were determined to be primarily dopaminergic. |
2012-03-06 |
2023-08-12 |
rat |
| Wafa Sansar, Samir Ahboucha, Halima Gamran. Chronic lead intoxication affects glial and neural systems and induces hypoactivity in adult rat. Acta histochemica. vol 113. issue 6. 2012-02-16. PMID:20656334. |
glial changes in the frontal cortex were concomitant with reduced tyrosine hydroxylase immunoreactive neuronal processes, which seem to occur as a consequence of significantly reduced dopaminergic neurons within the nucleus of origin in the substantia nigra. |
2012-02-16 |
2023-08-12 |
rat |
| Eduardo Tolosa, Claustre Pont-Sunye. Progress in defining the premotor phase of Parkinson's disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21679972. |
also studies of the nigrostriatal dopaminergic pathways with neuroimaging show that substantia nigra degeneration occurs before motor symptoms onset. |
2012-02-16 |
2023-08-12 |
human |
| C Klein, J Hagenah, B Landwehrmeyer, T Münte, T Klockgethe. [The presymptomatic stage of neurodegenerative disorders]. Der Nervenarzt. vol 82. issue 8. 2012-02-13. PMID:21789693. |
a striking example is parkinson's disease, in which more than half of the dopaminergic neurons of the substantia nigra are lost before motor symptoms appear. |
2012-02-13 |
2023-08-12 |
Not clear |
| Juliane Proft, Jamshid Faraji, Jerrah C Robbins, Fabiola C R Zucchi, Xiaoxi Zhao, Gerlinde A Metz, Janice E A Brau. Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease. PloS one. vol 6. issue 10. 2012-02-13. PMID:22016808. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of α-synuclein into lewy bodies. |
2012-02-13 |
2023-08-12 |
rat |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
the trkb-positive dopaminergic neurons are less sensitive to mptp insult in the substantia nigra of adult c57/bl mice. |
2012-02-08 |
2023-08-12 |
mouse |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
tyrosine kinase receptors trkb and trkc mediate neuroprotective effects of the brain-derived neurotrophic factor (bdnf) and neurotrophins in the dopaminergic nigro-striatal system, but it is obscure about their responses or expression changes in the injured substantia nigra under parkinson's disease. |
2012-02-08 |
2023-08-12 |
mouse |
| Takashi Tateno, Hugh P C Robinso. The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration. Journal of neurophysiology. vol 106. issue 4. 2012-02-08. PMID:21697445. |
hyperpolarization-activated and cyclic nucleotide-gated (hcn) channels are expressed in dopaminergic (da) neurons of the ventral tegmental area (vta) as well as in da and gabaergic neurons of the substantia nigra (sn). |
2012-02-08 |
2023-08-12 |
rat |
| Fereshteh Mehraein, Reza Talebi, Behnamedin Jameie, Mohammad Taghi Joghataie, Zahra Madj. Neuroprotective effect of exogenous melatonin on dopaminergic neurons of the substantia nigra in ovariectomized rats. Iranian biomedical journal. vol 15. issue 1-2. 2012-02-06. PMID:21725499. |
neuroprotective effect of exogenous melatonin on dopaminergic neurons of the substantia nigra in ovariectomized rats. |
2012-02-06 |
2023-08-12 |
rat |
| b' A Anastas\\xc3\\xada, J Wojnacki, G A de Erausquin, D H Masc\\xc3\\xb. Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson\'s disease. Neuroscience. vol 195. 2012-02-06. PMID:21871541.' |
we previously reported that ecs protects the integrity of the rat nigrostriatal dopaminergic system against 6-hydroxydopamine (6-ohda)-induced toxicity; in order to shed light into its neuroprotective mechanism, we studied glial cell-line derived neurotrophic factor (gdnf) levels (the most efficient tf for dopaminergic neurons) in the substantia nigra (sn) and striatum of 6-ohda-injected animals with or without ecs treatment. |
2012-02-06 |
2023-08-12 |
human |
| Marcos Fernández, Sofía Negro, Karla Slowing, Ana Fernández-Carballido, Emilia Barci. An effective novel delivery strategy of rasagiline for Parkinson's disease. International journal of pharmaceutics. vol 419. issue 1-2. 2012-02-03. PMID:21807080. |
nissl-staining of brain sections showed selective degeneration of the substantia nigra (snc) dopaminergic neurons in rotenone-treated animals which was markedly reverted by rm microspheres. |
2012-02-03 |
2023-08-12 |
rat |
| Xueen Jia, Anna L Gharibyan, Anders Öhman, Yonggang Liu, Anders Olofsson, Ludmilla A Morozova-Roch. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. Journal of molecular biology. vol 414. issue 5. 2012-02-03. PMID:21986202. |
parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-syn)-containing lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. |
2012-02-03 |
2023-08-12 |
Not clear |
| Rajeswara Babu Mythri, C Venkateshappa, G Harish, Anita Mahadevan, Uday B Muthane, T C Yasha, M M Srinivas Bharath, S K Shanka. Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson's disease brains. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21484266. |
dopaminergic neurons die in parkinson's disease (pd) due to oxidative stress and mitochondrial dysfunction in the substantia nigra (sn). |
2012-02-01 |
2023-08-12 |
human |