| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luisel R Lemkau, Gemma Comellas, Kathryn D Kloepper, Wendy S Woods, Julia M George, Chad M Rienstr. Mutant protein A30P α-synuclein adopts wild-type fibril structure, despite slower fibrillation kinetics. The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334684. |
in sporadic disease, wild-type as fibrillates and accumulates as lewy bodies within dopaminergic neurons of the substantia nigra. |
2012-09-20 |
2023-08-12 |
Not clear |
| Takafumi Hasegaw. ["Pathophysiology and clinical presentation of Parkinson's disease-up to date" pathomechanisms of Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 51. issue 11. 2012-09-18. PMID:22277521. |
the tetrad of parkinson's disease (pd) including tremor, rigidity, akinesia and postural instability are attributed to the loss of dopaminergic neurons in the substantia nigra. |
2012-09-18 |
2023-08-12 |
Not clear |
| Jun Kawamata, Syuuichirou Suzuki, Shun Shimoham. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Current drug targets. vol 13. issue 5. 2012-09-17. PMID:22300030. |
parkinson's disease (pd) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. |
2012-09-17 |
2023-08-12 |
Not clear |
| Ronald B Postuma, Jean-Francois Gagnon, Jacques Y Montplaisi. REM sleep behavior disorder: from dreams to neurodegeneration. Neurobiology of disease. vol 46. issue 3. 2012-09-14. PMID:22019718. |
recent studies in idiopathic rbd patients have demonstrated that olfaction, color vision, severity of rem atonia loss, transcranial ultrasound of the substantia nigra, and dopaminergic neuroimaging can predict development of neurodegenerative disease. |
2012-09-14 |
2023-08-12 |
Not clear |
| Xianzhi Zeng, Huijuan Shen, Junpeng Zhao, Qing Cai, Congrong Wang, Qunyuan X. Long-term changes in morphology, D2R expression and targets of regenerated dopaminergic terminals in the striatum after a partial lesion in the substantia nigra in the rat. Brain research. vol 1450. 2012-09-14. PMID:22424788. |
long-term changes in morphology, d2r expression and targets of regenerated dopaminergic terminals in the striatum after a partial lesion in the substantia nigra in the rat. |
2012-09-14 |
2023-08-12 |
rat |
| Mari Teraoka, Kazuhiro Nakaso, Chiaki Kusumoto, Satoshi Katano, Naoko Tajima, Atsushi Yamashita, Teppei Zushi, Satoru Ito, Tatsuya Matsur. Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells. Journal of clinical biochemistry and nutrition. vol 51. issue 2. 2012-09-11. PMID:22962530. |
parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing lewy bodies formation in the substantia nigra. |
2012-09-11 |
2023-08-12 |
Not clear |
| Garrett E Alexande. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues in clinical neuroscience. vol 6. issue 3. 2012-09-10. PMID:22033559. |
the characteristic motor impairments - bradykinesia, rigidity, and resting tremor - result from degenerative loss of midbrain dopamine (da) neurons in the substantia nigra, and are responsive to symptomatic treatment with dopaminergic medications and functional neurosurgery. |
2012-09-10 |
2023-08-12 |
human |
| Chenyou Sun, Xiaoming Ou, Jerry M Farley, Craig Stockmeier, Steven Bigler, Roberta Diaz Brinton, Jun Ming Wan. Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272610. |
allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of alzheimer's disease. |
2012-09-07 |
2023-08-12 |
mouse |
| S M Cardoso, A R Esteves, D M Arduín. Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22156537. |
parkinson's disease (pd) is a progressive neurodegenerative disorder where the loss of dopaminergic neurons in the substantia nigra and the presence of lewy bodies in surviving neurons are primary histopathological hallmarks. |
2012-08-29 |
2023-08-12 |
Not clear |
| Kay L Doubl. Neuronal vulnerability in Parkinson's disease. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166454. |
the classic motor symptoms of parkinson's disease result from the progressive death of dopaminergic neurons within the substantia nigra. |
2012-08-27 |
2023-08-12 |
human |
| Bradley Watmuff, Colin W Pouton, John M Hayne. In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384125. |
the obvious motor symptoms of parkinson's disease result from a loss of dopaminergic neurons from the substantia nigra. |
2012-08-27 |
2023-08-12 |
mouse |
| Andrew J Linsenbardt, Julie M Breckenridge, Gerald H Wilken, Heather Macarthu. Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D. Journal of neurochemistry. vol 122. issue 1. 2012-08-27. PMID:22486217. |
parkinson's disease is characterized by a deficiency in motor cortex modulation due to degeneration of pigmented dopaminergic neurons of the substantia nigra projecting to the striatum. |
2012-08-27 |
2023-08-12 |
Not clear |
| Carina J Bleickardt, Abigail L Lashomb, Carrie E Merkel, Robert A Hodgso. Adenosine A(2A) Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22191072. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra. |
2012-08-23 |
2023-08-12 |
mouse |
| Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Begoña Villar-Cheda, Ana I Rodríguez-Perez, Pablo Garrido-Gil, Maria J Guerr. Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra. Aging and disease. vol 2. issue 3. 2012-08-23. PMID:22396877. |
aging, angiotensin system and dopaminergic degeneration in the substantia nigra. |
2012-08-23 |
2023-08-12 |
mouse |
| Jana Godau, Anna Hussl, Praween Lolekha, A Jon Stoessl, Klaus Sepp. Neuroimaging: current role in detecting pre-motor Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 5. 2012-08-23. PMID:22508281. |
convergent evidence suggests a pre-motor period in parkinson's disease (pd) during which typical motor symptoms have not yet developed although dopaminergic neurons in the substantia nigra have started to degenerate. |
2012-08-23 |
2023-08-12 |
Not clear |
| Eduardo Riquelme, Jorge Abarca, Jorge M Campusano, Gonzalo Busto. An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22720191. |
an nr2b-dependent decrease in the expression of trkb receptors precedes the disappearance of dopaminergic cells in substantia nigra in a rat model of presymptomatic parkinson's disease. |
2012-08-23 |
2023-08-12 |
rat |
| Limin Mao, John Q Wan. Adult neural stem/progenitor cells in neurodegenerative repair. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 3. 2012-08-20. PMID:12817287. |
in addition to the subventricular zone and hippocampus where active cell division naturally occurs, adult neural progenitors with neurogenic potential exist in the striatum and the vicinity of dopaminergic neurons in the substantia nigra. |
2012-08-20 |
2023-08-12 |
human |
| C Venkateshappa, G Harish, Rajeswara Babu Mythri, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21971758. |
parkinson's disease (pd) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (sn) of the ventral mid brain leading to dopamine depletion in the striatum. |
2012-08-13 |
2023-08-12 |
human |
| Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsud. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21903118. |
sea0400 protected against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in mptp-treated mice. |
2012-08-01 |
2023-08-12 |
mouse |
| Yulin Deng, Yongqian Zhang, Yujuan Li, Shengyuan Xiao, Dewei Song, Hong Qing, Qin Li, Ali H Rajpu. Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in parkinsonian brains. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:22065205. |
parkinson's disease (pd) arises from the loss of dopaminergic neurons in the substantia nigra. |
2012-07-30 |
2023-08-12 |
human |