| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priscila Pereira Passos, Juliana Maria Carrazone Borba, Ana Paula Rocha-de-Melo, Rubem Carlos Araujo Guedes, Reginaldo Pereira da Silva, Waldenício Teixeira Melo Filho, Kátia Maria Marques Gouveia, Daniela Maria do Amaral Ferraz Navarro, Geanne Karla Novais Santos, Roseane Borner, Cristovam Wanderley Picanço-Diniz, Antonio Pereira, Miriam Stela Maris de Oliveira Costa, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. Journal of chemical neuroanatomy. vol 44. issue 2. 2013-01-04. PMID:22687395. |
the present study investigated whether essential fatty acid dietary restriction over two generations could differentially affect dopaminergic cell populations located in the substantia nigra rostro-dorso-medial (snrm) or caudo-ventro-lateral (sncv) regions which display distinct neurochemical profile and vulnerability to lesions under selected pathological conditions. |
2013-01-04 |
2023-08-12 |
rat |
| Shaoxiao Wang, Baoshan Xu, Liang-Chun Liou, Qun Ren, Shile Huang, Yan Luo, Zhaojie Zhang, Stephan N Wit. α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 40. 2012-12-31. PMID:22988096. |
parkinson disease (pd) results from the slow, progressive loss of dopaminergic neurons in the substantia nigra. |
2012-12-31 |
2023-08-12 |
human |
| Rachel Tesla, Hamilton Parker Wolf, Pin Xu, Jordan Drawbridge, Sandi Jo Estill, Paula Huntington, Latisha McDaniel, Whitney Knobbe, Aaron Burket, Stephanie Tran, Ruth Starwalt, Lorraine Morlock, Jacinth Naidoo, Noelle S Williams, Joseph M Ready, Steven L McKnight, Andrew A Piepe. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 42. 2012-12-31. PMID:23027932. |
we have further found that chemicals having efficacy in this in vivo screening assay also protect dopaminergic neurons of the substantia nigra following exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a mouse model of parkinson disease. |
2012-12-31 |
2023-08-12 |
mouse |
| Héctor De Jesús-Cortés, Pin Xu, Jordan Drawbridge, Sandi Jo Estill, Paula Huntington, Stephanie Tran, Jeremiah Britt, Rachel Tesla, Lorraine Morlock, Jacinth Naidoo, Lisa M Melito, Gelin Wang, Noelle S Williams, Joseph M Ready, Steven L McKnight, Andrew A Piepe. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 42. 2012-12-31. PMID:23027934. |
p7c3 blocks 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of parkinson disease (pd). |
2012-12-31 |
2023-08-12 |
mouse |
| Karin Löw, Patrick Aebische. Use of viral vectors to create animal models for Parkinson's disease. Neurobiology of disease. vol 48. issue 2. 2012-12-27. PMID:22227451. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2012-12-27 |
2023-08-12 |
Not clear |
| Jannette Rodriguez-Pallares, Juan Andres Parga, Belen Joglar, Maria Jose Guerra, Jose Luis Labandeira-Garci. Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson's disease. Age (Dordrecht, Netherlands). vol 34. issue 4. 2012-12-20. PMID:21713375. |
we have recently shown that angiotensin ii enhances dopaminergic degeneration by increasing levels of reactive oxygen species and neuroinflammation, and that there is an aging-related increase in angiotensin ii activity in the substantia nigra in rats, which may constitute a major factor in the increased risk of parkinson's disease with aging. |
2012-12-20 |
2023-08-12 |
rat |
| John W Wright, Joseph W Hardin. Importance of the brain Angiotensin system in Parkinson's disease. Parkinson's disease. vol 2012. 2012-12-06. PMID:23213621. |
the primary direct consequence of this disease is the loss of dopaminergic (da) neurons in the substantia nigra and striatum. |
2012-12-06 |
2023-08-12 |
Not clear |
| Paula Desplats, Brian Spencer, Leslie Crews, Pruthul Pathel, Dinorah Morvinski-Friedmann, Kori Kosberg, Scott Roberts, Christina Patrick, Beate Winner, Juergen Winkler, Eliezer Maslia. α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. The Journal of biological chemistry. vol 287. issue 38. 2012-12-04. PMID:22833673. |
parkinson disease is characterized by the loss of dopaminergic neurons mainly in the substantia nigra. |
2012-12-04 |
2023-08-12 |
rat |
| Dong-dong Li, Wan-qin Zhang, Zhe-hui Fen. [The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson's disease mice induced by MPTP]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 18. issue 4. 2012-12-03. PMID:21174803. |
[the effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of parkinson's disease mice induced by mptp]. |
2012-12-03 |
2023-08-12 |
mouse |
| Dong-dong Li, Wan-qin Zhang, Zhe-hui Fen. [The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson's disease mice induced by MPTP]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 18. issue 4. 2012-12-03. PMID:21174803. |
using strain c57/bl of cox-2 deficient mice, the effect of cyclooxygenase-2 (cox-2) on dopaminergic neurons in substantia nigra of parkinson's disease (pd) mice induced by intraperitoneal injections of mptp-hcl were investigated by immunocytochemistry(icc) . |
2012-12-03 |
2023-08-12 |
mouse |
| Megan L Fitzgerald, Eli Shobin, Virginia M Picke. Cannabinoid modulation of the dopaminergic circuitry: implications for limbic and striatal output. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 1. 2012-12-03. PMID:22265889. |
this receptor is located within the substantia nigra and ventral tegmental area, which respectively house the somata of nigrostriatal and mesocorticolimbic dopaminergic neurons. |
2012-12-03 |
2023-08-12 |
Not clear |
| Yanzhen Zhu, Jing Zhang, Yanjun Zen. Overview of tyrosine hydroxylase in Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483316. |
parkinson's disease (pd) is characterized by severe loss of dopaminergic neurons and depletion of dopamine in substantia nigra. |
2012-12-03 |
2023-08-12 |
Not clear |
| Guney Bademci, Jeffery M Vance, Liyong Wan. Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22583432. |
a hallmark of parkinson's disease (pd) is the loss of dopaminergic neurons in the substantia nigra. |
2012-12-03 |
2023-08-12 |
Not clear |
| Hyun Jung Lee, Sung Hee Jang, Hyeyoung Kim, Joo Heon Yoon, Kwang Chul Chun. PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1. Cellular and molecular life sciences : CMLS. vol 69. issue 19. 2012-11-30. PMID:22643835. |
parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. |
2012-11-30 |
2023-08-12 |
Not clear |
| I V Romanova, A Iu Chesnokova, A L Mikhrin. [Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 8. 2012-11-30. PMID:23155622. |
the increase of cart-peptide optical density was found immunohistochemically in nucleus accumbens neurons and in their terminals in substantia nigra in wistar rats after 28% reduction of dopaminergic neurons in a substantia nigra (in the model of lactacystin induced proteo some disfunction). |
2012-11-30 |
2023-08-12 |
rat |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| Saeyoung Park, Eungpil Kim, Seong-Eun Koh, Sungho Maeng, Won-Don Lee, Jinho Lim, Insop Shim, Young-Jay Le. Dopaminergic differentiation of neural progenitors derived from placental mesenchymal stem cells in the brains of Parkinson's disease model rats and alleviation of asymmetric rotational behavior. Brain research. vol 1466. 2012-11-20. PMID:22634376. |
parkinson's disease (pd) is caused by the progressive loss of dopaminergic neurons in the mesencephalic substantia nigra and is accompanied by behavioral abnormalities. |
2012-11-20 |
2023-08-12 |
human |
| Byoung Dae Lee, Valina L Dawson, Ted M Dawso. Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease. Trends in pharmacological sciences. vol 33. issue 7. 2012-11-09. PMID:22578536. |
parkinson's disease (pd) is caused by the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2012-11-09 |
2023-08-12 |
Not clear |
| Xiqun Chen, Guanhui Wu, Michael A Schwarzschil. Urate in Parkinson's disease: more than a biomarker? Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22580741. |
although appreciation of pd as a multisystem disorder has grown, loss of dopaminergic neurons in the substantia nigra remains a pathological and neurochemical hallmark, accounting for the substantial symptomatic benefits of dopamine replacement therapies. |
2012-11-08 |
2023-08-12 |
Not clear |
| Oi Wan Wan, Kenny K K Chun. The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701661. |
in addition, our animal model of pd indicates that attachment of cl1 to α-syn enhanced its toxicity to dopaminergic neurons in an age-dependent manner and induced the formation of lewy body-like α-syn aggregates in the substantia nigra. |
2012-11-08 |
2023-08-12 |
Not clear |