| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Young Lee, Jeong Eun Lee, Jae Hyeon Park, In Chul Shin, Hyun Chul Ko. Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats. Toxicology letters. vol 213. issue 3. 2012-11-08. PMID:22842585. |
rosiglitazone, a ppar-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-ohda lesions in the substantia nigra of rats. |
2012-11-08 |
2023-08-12 |
mouse |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta), and noradrenergic neurons in the lc were determined. |
2012-11-07 |
2023-08-12 |
mouse |
| Ns Ambhore, S Antony, Jk Mali, Am Kanhed, Ar Bhalerao, S Bhojra. Pharmacological and biochemical interventions of cigarette smoke, alcohol, and sexual mating frequency on idiopathic rat model of Parkinson's disease. Journal of young pharmacists : JYP. vol 4. issue 3. 2012-11-01. PMID:23112537. |
earlier literature from different publisher suggested that nicotine and cigarette smoke can protect the dopaminergic neurons in the substantia nigra against mptp toxicity. |
2012-11-01 |
2023-08-12 |
rat |
| Ns Ambhore, S Antony, Jk Mali, Am Kanhed, Ar Bhalerao, S Bhojra. Pharmacological and biochemical interventions of cigarette smoke, alcohol, and sexual mating frequency on idiopathic rat model of Parkinson's disease. Journal of young pharmacists : JYP. vol 4. issue 3. 2012-11-01. PMID:23112537. |
in this study, we assessed the effect of the above three factors on an mptp-treated rat model and concluded that they have a neurodegenerative effect and were found to be toxic to dopaminergic neurons in the substantia nigra. |
2012-11-01 |
2023-08-12 |
rat |
| Beata Bekei, Honor May Rose, Michaela Herzig, Alexander Dose, Dirk Schwarzer, Philipp Selenk. In-cell NMR in mammalian cells: part 1. Methods in molecular biology (Clifton, N.J.). vol 895. 2012-10-24. PMID:22760311. |
this is never more relevant than for idps that exhibit pathological structural rearrangements under certain cellular conditions, as is the case for human α-synuclein in dopaminergic neurons of the substantia nigra in the course of parkinson's disease, for example. |
2012-10-24 |
2023-08-12 |
human |
| Pabla Aguirre, Pamela Urrutia, Victoria Tapia, Monica Villa, Irmgad Paris, Juan Segura-Aguilar, Marco T Núñe. The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 25. issue 4. 2012-10-22. PMID:22302610. |
hallmarks of idiopathic and some forms of familial parkinson’s disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. |
2012-10-22 |
2023-08-12 |
Not clear |
| Wayne A Cass, Laura E Peters, Anita M Fletcher, David M Yure. Evoked dopamine overflow is augmented in the striatum of calcitriol treated rats. Neurochemistry international. vol 60. issue 2. 2012-10-19. PMID:22133428. |
these results suggest that systemically administered calcitriol can upregulate dopaminergic release processes in the striatum and da levels in the substantia nigra. |
2012-10-19 |
2023-08-12 |
rat |
| Keiji Mori, Yoko S Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ot. Subventricular zone under the neuroinflammatory stress and Parkinson's disease. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22189676. |
this review summarizes the effects of neuroinflammatory stress on the subventricular zone (svz), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with parkinson's disease (pd), because the svz is under the control of dopaminergic afferents from the substantia nigra (sn). |
2012-10-17 |
2023-08-12 |
Not clear |
| Margarida Castro-Caldas, Andreia Neves Carvalho, Elsa Rodrigues, Colin Henderson, C Roland Wolf, Maria João Gam. Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Molecular neurobiology. vol 45. issue 3. 2012-10-17. PMID:22539231. |
parkinson's disease (pd) is a progressive movement disorder resulting from the death of dopaminergic neurons in the substantia nigra. |
2012-10-17 |
2023-08-12 |
mouse |
| P Szot, L Knight, A Franklin, C Sikkema, S Foster, C W Wilkinson, S S White, M A Raskin. Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling. Neuroscience. vol 216. 2012-10-17. PMID:22542679. |
direct administration of 6ohda into the lc results in the specific reduction of noradrenergic neurons in the lc (as measured by electrophysiology, immunoreactivity and in situ hybridization), the lateral tegmental neurons and dopaminergic neurons in the substantia nigra (sn) and ventral tegmental region were unaffected. |
2012-10-17 |
2023-08-12 |
mouse |
| Yu-bing Dai, Xin-jie Tan, Wan-fu Wu, Margaret Warner, Jan-Åke Gustafsso. Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 32. 2012-10-15. PMID:22826221. |
the dopaminergic neurons of the substantia nigra of lxrβ(-/-) mice were much more severely affected by mptp than were those of their wt littermates. |
2012-10-15 |
2023-08-12 |
mouse |
| Hideaki Matsui, Roberto Gavinio, Ryosuke Takahash. Medaka fish Parkinson's disease model. Experimental neurobiology. vol 21. issue 3. 2012-10-12. PMID:23055787. |
despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. |
2012-10-12 |
2023-08-12 |
human |
| Indrani Datta, Ramesh Bhond. Can mesenchymal stem cells reduce vulnerability of dopaminergic neurons in the substantia nigra to oxidative insult in individuals at risk to Parkinson's disease? Cell biology international. vol 36. issue 7. 2012-10-11. PMID:22417707. |
can mesenchymal stem cells reduce vulnerability of dopaminergic neurons in the substantia nigra to oxidative insult in individuals at risk to parkinson's disease? |
2012-10-11 |
2023-08-12 |
Not clear |
| Indrani Datta, Ramesh Bhond. Can mesenchymal stem cells reduce vulnerability of dopaminergic neurons in the substantia nigra to oxidative insult in individuals at risk to Parkinson's disease? Cell biology international. vol 36. issue 7. 2012-10-11. PMID:22417707. |
pd (parkinson's disease) is characterized by the selective loss of da (dopaminergic) neurons in the substantia nigra of the midbrain region, but not in the ventral tegmental area and other catecholaminergic cell group areas. |
2012-10-11 |
2023-08-12 |
Not clear |
| Y Kurauchi, A Hisatsune, Y Isohama, S Mishima, H Katsuk. Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor. British journal of pharmacology. vol 166. issue 3. 2012-10-10. PMID:22224485. |
because ho-1 induction has been suggested to protect dopaminergic neurons in the substantia nigra, we examined the effect of cape in experimental models of dopaminergic neurodegeneration. |
2012-10-10 |
2023-08-12 |
bee |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizab. Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotoxicity research. vol 22. issue 2. 2012-10-10. PMID:22528249. |
parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (sn). |
2012-10-10 |
2023-08-12 |
Not clear |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| Pu Pu, Wei-Dong L. C. elegans as a model system for Parkinson disease. Neuroscience bulletin. vol 22. issue 2. 2012-10-02. PMID:17687410. |
parkinson disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. |
2012-10-02 |
2023-08-12 |
caenorhabditis_elegans |
| Hong Yuan, Li-Wu Liang, Zheng-Jing Chen, Hui-Ru Ji, Mei-Kang Wang, Hai-Ying Zhang, Cao Li, Jian-Yang X. R-apomorphine protects against 6-hydroxydopamine-induced nigrostriatal damage in rat. Neuroscience bulletin. vol 22. issue 6. 2012-10-02. PMID:17690718. |
objective the aim of the present study was not only to assess the retrograde degenerative changes in the dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) after injection of 6-hydroxydopamine (6-ohda) into the striatum, but also to use this 6-ohda model of parkinson's disease to explore the possible neuroprotective effect of r-apomorphine (r-apo). |
2012-10-02 |
2023-08-12 |
rat |
| Rui Zheng, Hai-Yan Zhou, Sheng-Di Che. The role of synphilin-1 in the pathogenesis of Parkinson's disease. Neuroscience bulletin. vol 22. issue 4. 2012-10-02. PMID:17704840. |
parkinson's disease (pd) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic (daergic) neurons in the substantia nigra and the appearance of lewy bodies (lbs), whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin-1, alpha-synuclein and parkin. |
2012-10-02 |
2023-08-12 |
Not clear |